The impact of Rho-kinase inhibitor, "Fasudil", intracoronary bolus administration to improve refractory coronary vasospasm

Cardiovascular Intervention and Therapeutics

Volumn 26, Issue 3, 2011, Pages 281-285

  Komiyama, Kota ^a   Tejima, Tamotsu ^a   Tanabe, Yasuhiro ^a   Nishimura, Takuro ^a   Kitamura, Ken ^a   Watanabe, Tomohiko ^a   Shimada, Hiroshi ^a   Iwasawa, Jin ^a   Matsushita, Noriko ^a   Ishikawa, Tae ^a   Hojo, Rintaro ^a   Hayashi, Takekuni ^a   Nakai, Mori ^a   Yoshimura, Hiromi ^a   Tatsumoto, Akiko ^a   Fukamizu, Seiji ^a   Sakurada, Harumizu ^a  

^a TOKYO METROPOLITAN HIROO HOSPITAL   (Japan)

Author keywords

Eril; Fasudil; Intracoronary administration; Spasm

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CATECHOLAMINE; FASUDIL; ISOSORBIDE DINITRATE; NICORANDIL; NITRIC ACID; NITROPRUSSIDE SODIUM; PACLITAXEL;

ACUTE HEART INFARCTION; ADULT; ANGIOCARDIOGRAPHY; ANGIOPLASTY; ARTERY LESION; ARTICLE; BOLUS INJECTION; CASE REPORT; COMPLETE HEART BLOCK; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; CORONARY ARTERY SPASM; CORONARY ARTERY THROMBOSIS; CORONARY STENT; DISEASE SEVERITY; DRUG ELUTING STENT; DRUG TREATMENT FAILURE; GUIDE WIRE; HEART CATHETERIZATION; HEMATOMA; HUMAN; INTRACORONARY INFUSION; INTRAVASCULAR ULTRASOUND; MALE; PACEMAKER; PATIENT TRANSPORT; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RECURRENT DISEASE; RIGHT CORONARY ARTERY; ST SEGMENT ELEVATION; THORAX PAIN; ULTRASOUND SCANNER; UNCONSCIOUSNESS;

EID: 84874212207     PISSN: 18684300     EISSN: 18684297     Source Type: Journal    
DOI: 10.1007/s12928-011-0071-2     Document Type: Article

References (16)

1. Kimura K, Ito M, Amano M, Chihara K, Iwamatsu A, Kaibuchi K, et al. Regulation of myosin phoshatase by Rho and Rho-associated kinase (Rho-kinase). Science. 1996; 273: 245-8.
2. Kureishi Y, Kobayashi S, Amano M, Kimura K, Kaibuchi K, Ito M, et al. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem. 1997; 272: 12257-60.
3. Shimokawa H. Rho-kinase as a novel therapeutic target in treatment of cardiovascular disease. J Cardiovasc Pharmacol. 2002; 39: 319-27.
4. Kugiyama K, Ohgushi M, Sugiyama S, Motoyama T, Kawano H, Hiraxhima O, et al. Supersensitive dilator response to nitroglycerin but not to atrial natriuretic peptide in spastic coronary arteries in coronary spastic angina. Am J Cardiol. 1997; 79: 606-10.
5. Antman E, Muller J, Goldberg S, MacAlpin R, Rubenfire M, Tabatznik B, Liang CS, Heupler F, Achuff S, Reichek N, Geltman E, Kerin NZ, Neff RK, Braunwald E. Nifedipine therapy for coronary-artery spasm. Experience in 127 patients. N Engl J Med. 1980; 302: 1269-73.
6. Aizawa T, Ogasawara K, Nakamura F, Hrosaka A, Sakuma T, Nagashima K, et al. Effect of nicorandil on coronary spasm. Am J Cardiol. 1989; 63: 75J-9J.
7. The Ministry of Health, Labour and Welfare circulatory organs disease consignment research expense. Research on role of crown spasm (10 public-5) in ischemic heart disease. Research report in 2000 fiscal year.
8. Katsumata N, Shimokawa H, Seto M, Kozai T, Yamawaki T, Kuwata K, et al. Enhanced myocin light chain phosphorylaions as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta. Circulation. 1997; 96: 4357-63.
9. Shimokawa H. Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models. Jpn Circ J. 2000; 64: 1-12.
10. Kamm KE, Stull JT. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol. 1985; 25: 593-620.
11. Taira N. Similarity and dissimilarity in the mode nd mechanism of action between nicorandil and classical nitrates: an overview. J Cardiovasc Pharmacol. 1987; 10(Suppl 8): 1-9.
12. Taira N. Nicorandil as a hybrid between nitrates and potassium channel activators. Am J Cardiol. 1989; 63: 18-24.
13. Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, et al. Phosphorylation and activation of myosin by Rho-assosicated kinase (Rho-kinase). J Biol Chem. 1996; 271(34): 20246-9.
14. Shimokawa H, Seto M, Katsumata N, Amano M, Kaibuchi K, Takeshita A, et al. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res. 1999; 43: 1029-39.
15. Otsuka T, Ibuki C, Suzuki T, Ishii K, Yoshida H, Kodani E, et al. Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina. Coron Artery Dis. 2008; 19: 105-10.
16. Mohri M, Shimokawa H, Hirakawa Y, Masumoto A, Takeshita A. Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm. J Am Coll Cardiol. 2003; 41: 15-9.