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Volumn 465, Issue 2, 2013, Pages 333-341

Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates the relaxation of porcine pulmonary arteries to nitric oxide

Author keywords

cGMP; Disulfide bonds; Hypoxia; Pulmonary; Vasodilatation

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; CYSTEINE; DITHIOTHREITOL; GLUTATHIONE; GUANYLATE CYCLASE; NITRIC OXIDE; SOLUBLE GUANYLYL CYCLASE; THIOL DERIVATIVE; TRIS(2 CARBOXYETHYL)PHOSPHINE; UNCLASSIFIED DRUG;

EID: 84873480381     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1176-x     Document Type: Article
Times cited : (11)

References (43)
  • 1
    • 0020624788 scopus 로고
    • Soluble guanylate cyclase activation by nitric oxide and its reversal: Involvement of sulfhydryl group oxidation and reduction
    • 6132608 10.1016/0006-2952(83)90581-6 1:CAS:528:DyaL3sXhvFCjsrc%3D
    • Braughler JM (1983) Soluble guanylate cyclase activation by nitric oxide and its reversal: involvement of sulfhydryl group oxidation and reduction. Biochem Pharmacol 32:811-818
    • (1983) Biochem Pharmacol , vol.32 , pp. 811-818
    • Braughler, J.M.1
  • 3
    • 33947482089 scopus 로고
    • Dithiothreitol, a new protective reagent for SH groups
    • 14192894 10.1021/bi00892a002 1:CAS:528:DyaF2cXmvFCqsw%3D%3D
    • Cleland WW (1964) Dithiothreitol, a new protective reagent for SH groups. Biochemistry 3:480-482
    • (1964) Biochemistry , vol.3 , pp. 480-482
    • Cleland, W.W.1
  • 4
    • 77954490705 scopus 로고    scopus 로고
    • Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition
    • 20149081 10.1111/j.1538-7836.2010.03806.x 1:CAS:528:DC%2BC3cXpsVGrsbc%3D
    • Dangel O, Mergia E, Karlisch K, Groneberg D, Koesling D, Friebe A (2010) Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition. J Thromb Haemost 8:1343-1352
    • (2010) J Thromb Haemost , vol.8 , pp. 1343-1352
    • Dangel, O.1    Mergia, E.2    Karlisch, K.3    Groneberg, D.4    Koesling, D.5    Friebe, A.6
  • 5
    • 84863194133 scopus 로고    scopus 로고
    • Hydrogen peroxide enhances vasodilatation by increasing dimerization of cGMP-dependent protein kinase type Iα
    • 22498562 10.1253/circj.CJ-11-1368 1:CAS:528:DC%2BC38XhtFOktrrP
    • Dou D, Zheng X, Liu J, Xu X, YeL GY (2012) Hydrogen peroxide enhances vasodilatation by increasing dimerization of cGMP-dependent protein kinase type Iα. Circ J 76:1792-1798
    • (2012) Circ J , vol.76 , pp. 1792-1798
    • Dou, D.1    Zheng, X.2    Liu, J.3    Xu, X.4    Yel, G.Y.5
  • 6
    • 76049119067 scopus 로고    scopus 로고
    • A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase
    • 20007374 10.1073/pnas.0911083106 1:CAS:528:DC%2BC3cXltlGqtA%3D%3D
    • Fernhoff NB, Derbyshire ER, Marletta MA (2009) A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. Proc Natl Acad Sci USA 106:21602-21607
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 21602-21607
    • Fernhoff, N.B.1    Derbyshire, E.R.2    Marletta, M.A.3
  • 7
    • 71849103998 scopus 로고    scopus 로고
    • The function of NO-sensitive guanylyl cyclase: What we can learn from genetic mouse models
    • 19635579 10.1016/j.niox.2009.07.004 1:CAS:528:DC%2BD1MXhsVWqsbzJ
    • Friebe A, Koesling D (2009) The function of NO-sensitive guanylyl cyclase: what we can learn from genetic mouse models. Nitric Oxide 21:149-156
    • (2009) Nitric Oxide , vol.21 , pp. 149-156
    • Friebe, A.1    Koesling, D.2
  • 8
    • 34250653301 scopus 로고    scopus 로고
    • Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase
    • 17452643 10.1073/pnas.0609778104 1:CAS:528:DC%2BD2sXlslahsbs%3D
    • Friebe A, Mergia E, Dangel O, Lange A, Koesling D (2007) Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci USA 104:7699-7704
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7699-7704
    • Friebe, A.1    Mergia, E.2    Dangel, O.3    Lange, A.4    Koesling, D.5
  • 10
    • 77952889195 scopus 로고    scopus 로고
    • The multiple actions of NO
    • 10.1007/s00424-009-0773-9 1:CAS:528:DC%2BC3cXls1Wqsbc%3D
    • Gao Y (2010) The multiple actions of NO. Pflügers Archiv - Eur J Physiol 459:829-839
    • (2010) Pflügers Archiv - Eur J Physiol , vol.459 , pp. 829-839
    • Gao, Y.1
  • 11
    • 1642296624 scopus 로고    scopus 로고
    • Role of cGMP-dependent protein kinase in development of tolerance to nitric oxide in pulmonary veins of newborn lambs
    • 14660486 10.1152/ajplung.00314.2003 1:CAS:528:DC%2BD2cXjtlansb8%3D
    • Gao Y, Dhanakoti S, Trevino EM, Wang X, Sander FC, Portuga AD, Raj JU (2004) Role of cGMP-dependent protein kinase in development of tolerance to nitric oxide in pulmonary veins of newborn lambs. Am J Physiol Lung Cell Mol Physiol 286:L786-L792
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Gao, Y.1    Dhanakoti, S.2    Trevino, E.M.3    Wang, X.4    Sander, F.C.5    Portuga, A.D.6    Raj, J.U.7
  • 12
    • 78149476193 scopus 로고    scopus 로고
    • Regulation of the pulmonary circulation in the fetus and newborn
    • 20959617 10.1152/physrev.00032.2009 1:CAS:528:DC%2BC3cXhsFSqtbvE
    • Gao Y, Raj JU (2010) Regulation of the pulmonary circulation in the fetus and newborn. Physiol Rev 90:1291-1335
    • (2010) Physiol Rev , vol.90 , pp. 1291-1335
    • Gao, Y.1    Raj, J.U.2
  • 13
    • 75049085878 scopus 로고    scopus 로고
    • New insight into the functioning of nitric oxide-receptive guanylyl cyclase: Physiological and pharmacological implications
    • 20012469 10.1007/s11010-009-0318-8 1:CAS:528:DC%2BC3cXkt1KjtQ%3D%3D
    • Garthwaite J (2010) New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications. Mol Cell Biochem 334:221-232
    • (2010) Mol Cell Biochem , vol.334 , pp. 221-232
    • Garthwaite, J.1
  • 14
    • 0029122910 scopus 로고
    • Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-A]quinoxalin-1-one
    • 7544433 1:CAS:528:DyaK2MXnvVKhsr0%3D
    • Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B (1995) Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol 48:184-188
    • (1995) Mol Pharmacol , vol.48 , pp. 184-188
    • Garthwaite, J.1    Southam, E.2    Boulton, C.L.3    Nielsen, E.B.4    Schmidt, K.5    Mayer, B.6
  • 15
    • 61649094752 scopus 로고    scopus 로고
    • Soluble guanylate cyclase stimulation: An emerging option in pulmonary hypertension therapy
    • 20956121 10.1183/09059180.00011112 1:STN:280:DC%2BC3cbgtlOhsw%3D%3D
    • Ghofrani HA, Grimminger F (2009) Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy. Eur Respir Rev 18:35-41
    • (2009) Eur Respir Rev , vol.18 , pp. 35-41
    • Ghofrani, H.A.1    Grimminger, F.2
  • 16
    • 11144262112 scopus 로고    scopus 로고
    • Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries
    • 15345489 10.1152/ajpheart.00629.2004 1:CAS:528:DC%2BD2MXhtVCqs78%3D
    • Gupte SA, Kaminski PM, Floyd B, Agarwal R, Ali N, Ahmad M, Edwards J, Wolin MS (2005) Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries. Am J Physiol Heart Circ Physiol 288:H13-H21
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Gupte, S.A.1    Kaminski, P.M.2    Floyd, B.3    Agarwal, R.4    Ali, N.5    Ahmad, M.6    Edwards, J.7    Wolin, M.S.8
  • 17
    • 77953530947 scopus 로고    scopus 로고
    • Activation of glucose-6-phosphate dehydrogenase promotes acute hypoxic pulmonary artery contraction
    • 20363753 10.1074/jbc.M109.092916 1:CAS:528:DC%2BC3cXnt1CmtLs%3D
    • Gupte RS, Rawat DK, Chettimada S, Cioffi DL, Wolin MS, Gerthoffer WT, McMurtry IF, Gupte SA (2010) Activation of glucose-6-phosphate dehydrogenase promotes acute hypoxic pulmonary artery contraction. J Biol Chem 285:19561-19571
    • (2010) J Biol Chem , vol.285 , pp. 19561-19571
    • Gupte, R.S.1    Rawat, D.K.2    Chettimada, S.3    Cioffi, D.L.4    Wolin, M.S.5    Gerthoffer, W.T.6    McMurtry, I.F.7    Gupte, S.A.8
  • 18
    • 33744936788 scopus 로고    scopus 로고
    • Hypoxia promotes relaxation of bovine coronary arteries through lowering cytosolic NADPH
    • 16415080 10.1152/ajpheart.00615.2005 1:CAS:528:DC%2BD28XlvFShur8%3D
    • Gupte SA, Wolin MS (2006) Hypoxia promotes relaxation of bovine coronary arteries through lowering cytosolic NADPH. Am J Physiol Heart Circ Physiol 290:H2228-H2238
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Gupte, S.A.1    Wolin, M.S.2
  • 19
    • 0028360823 scopus 로고
    • A procedure for quantitative determination of tris(2-carboxyethyl)- phosphine, an odorless reducing agent more stable and effective than dithiothreitol
    • 7978256 10.1006/abio.1994.1290 1:CAS:528:DyaK2cXkslOlurc%3D
    • Han JC, Han GY (1994) A procedure for quantitative determination of tris(2-carboxyethyl)-phosphine, an odorless reducing agent more stable and effective than dithiothreitol. Anal Biochem 220:5-10
    • (1994) Anal Biochem , vol.220 , pp. 5-10
    • Han, J.C.1    Han, G.Y.2
  • 20
    • 0025001895 scopus 로고
    • Expression of soluble guanylyl cyclase. Catalytic activity requires two enzyme subunits
    • 1977619 10.1016/0014-5793(90)80489-6 1:CAS:528:DyaK3MXitVWjtQ%3D%3D
    • Harteneck C, Koesling D, Söling A, Schultz G, Böhme E (1990) Expression of soluble guanylyl cyclase. Catalytic activity requires two enzyme subunits. FEBS Lett 272:221-223
    • (1990) FEBS Lett , vol.272 , pp. 221-223
    • Harteneck, C.1    Koesling, D.2    Söling, A.3    Schultz, G.4    Böhme, E.5
  • 21
    • 33847232634 scopus 로고    scopus 로고
    • Redox control of calcium channels: From mechanisms to therapeutic opportunities
    • 17280484 10.1089/ars.2006.1446 1:CAS:528:DC%2BD2sXhtlWgu7k%3D
    • Hool LC, Corry B (2007) Redox control of calcium channels: from mechanisms to therapeutic opportunities. Antioxid Redox Signal 9:409-435
    • (2007) Antioxid Redox Signal , vol.9 , pp. 409-435
    • Hool, L.C.1    Corry, B.2
  • 22
    • 0141864392 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: In vivo and ex vivo evidence from ecSOD-deficient mice
    • 12933702 10.1161/01.RES.0000092140.81594.A8 1:CAS:528: DC%2BD3sXnsFSgsrc%3D
    • Jung O, Marklund SL, Geiger H, Pedrazzini T, Busse R, Brandes RP (2003) Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice. Circ Res 93:622-629
    • (2003) Circ Res , vol.93 , pp. 622-629
    • Jung, O.1    Marklund, S.L.2    Geiger, H.3    Pedrazzini, T.4    Busse, R.5    Brandes, R.P.6
  • 23
    • 0029821342 scopus 로고    scopus 로고
    • NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms
    • 8782594 10.1016/S0076-6879(96)68030-6 1:CAS:528:DyaK28XlvFeis74%3D
    • Keefer LK, Nims RW, Davies KM (1996) "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol 268:281-293
    • (1996) Methods Enzymol , vol.268 , pp. 281-293
    • Keefer, L.K.1    Nims, R.W.2    Davies, K.M.3
  • 24
    • 9644302988 scopus 로고    scopus 로고
    • CGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
    • 15505114 10.1161/01.HYP.0000147661.80059.ca 1:CAS:528: DC%2BD2cXpvVGlsrw%3D
    • Koeppen M, Feil R, Siegl D, Feil S, Hofmann F, Pohl U, de Wit C (2004) cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo. Hypertension 44:952-955
    • (2004) Hypertension , vol.44 , pp. 952-955
    • Koeppen, M.1    Feil, R.2    Siegl, D.3    Feil, S.4    Hofmann, F.5    Pohl, U.6    De Wit, C.7
  • 25
    • 77953508462 scopus 로고    scopus 로고
    • Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery
    • 10.1152/ajplung.00340.2009
    • Ma H, He Q, Dou D, Zheng X, Ying L, Wu Y, Raj JU, Gao Y (2011) Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery. Am J Physiol Lung Cell Mol Physiol 299:L117-L123
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.299
    • Ma, H.1    He, Q.2    Dou, D.3    Zheng, X.4    Ying, L.5    Wu, Y.6    Raj, J.U.7    Gao, Y.8
  • 26
    • 38149078912 scopus 로고    scopus 로고
    • PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure
    • 18006497 10.1074/jbc.M706218200 1:CAS:528:DC%2BD1cXhsFaqsg%3D%3D
    • Ma X, Sayed N, Baskaran P, Beuve A, van den Akker F (2008) PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure. J Biol Chem 283:1167-1178
    • (2008) J Biol Chem , vol.283 , pp. 1167-1178
    • Ma, X.1    Sayed, N.2    Baskaran, P.3    Beuve, A.4    Van Den Akker, F.5
  • 27
    • 33745217855 scopus 로고    scopus 로고
    • Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system
    • 16614755 10.1172/JCI27657 1:CAS:528:DC%2BD28XlsFWqsL8%3D
    • Mergia E, Friebe A, Dangel O, Russwurm M, Koesling D (2006) Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest 116:1731-1737
    • (2006) J Clin Invest , vol.116 , pp. 1731-1737
    • Mergia, E.1    Friebe, A.2    Dangel, O.3    Russwurm, M.4    Koesling, D.5
  • 28
    • 79960389753 scopus 로고    scopus 로고
    • Intermolecular disulfide bond to modulate protein function as a redox-sensing switch
    • 20177947 10.1007/s00726-010-0508-4 1:CAS:528:DC%2BC3MXlvFWgsbo%3D
    • Nagahara N (2011) Intermolecular disulfide bond to modulate protein function as a redox-sensing switch. Amino Acids 41:59-72
    • (2011) Amino Acids , vol.41 , pp. 59-72
    • Nagahara, N.1
  • 29
    • 82855181181 scopus 로고    scopus 로고
    • Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia
    • 21926339 10.1152/ajpheart.00624.2011 1:CAS:528:DC%2BC38XhtFWgtw%3D%3D
    • Neo BH, Kandhi S, Wolin MS (2011) Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia. Am J Physiol Heart Circ Physiol 301:H2295-H2304
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Neo, B.H.1    Kandhi, S.2    Wolin, M.S.3
  • 31
    • 36448973861 scopus 로고    scopus 로고
    • PKG regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins
    • 17891157 10.1038/sj.bjp.0707479 1:CAS:528:DC%2BD2sXhtlCrsbnN
    • Qi H, Zheng X, Qin X, Dou D, Xu H, Raj JU, Gao Y (2007) PKG regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br J Pharmacol 152:1060-1069
    • (2007) Br J Pharmacol , vol.152 , pp. 1060-1069
    • Qi, H.1    Zheng, X.2    Qin, X.3    Dou, D.4    Xu, H.5    Raj, J.U.6    Gao, Y.7
  • 32
    • 34548331154 scopus 로고    scopus 로고
    • CGMP-dependent protein kinase in regulation of basal tone and in nitroglycerin and nitric oxide induced relaxation in porcine coronary artery
    • 10.1007/s00424-007-0249-8 1:CAS:528:DC%2BD2sXpslarsrs%3D
    • Qin X, Zheng X, Qi H, Dou D, Raj JU, Gao Y (2007) cGMP-dependent protein kinase in regulation of basal tone and in nitroglycerin and nitric oxide induced relaxation in porcine coronary artery. Pflügers Archiv - Eur J Physiol 454:913-923
    • (2007) Pflügers Archiv - Eur J Physiol , vol.454 , pp. 913-923
    • Qin, X.1    Zheng, X.2    Qi, H.3    Dou, D.4    Raj, J.U.5    Gao, Y.6
  • 33
    • 35548977224 scopus 로고    scopus 로고
    • Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo
    • 17715400 10.1124/mol.107.036368 1:CAS:528:DC%2BD2sXht1Gls7nK
    • Rothkegel C, Schmidt PM, Atkins DJ, Hoffmann LS, Schmidt HH, Schröder H, Stasch JP (2007) Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo. Mol Pharmacol 72:1181-1190
    • (2007) Mol Pharmacol , vol.72 , pp. 1181-1190
    • Rothkegel, C.1    Schmidt, P.M.2    Atkins, D.J.3    Hoffmann, L.S.4    Schmidt, H.H.5    Schröder, H.6    Stasch, J.P.7
  • 34
    • 84856991347 scopus 로고    scopus 로고
    • Hypoxic pulmonary vasoconstriction
    • 22298659 10.1152/physrev.00041.2010 1:CAS:528:DC%2BC38Xjs12jtrc%3D
    • Sylvester JT, Shimoda LA, Aaronson PI, Ward JP (2012) Hypoxic pulmonary vasoconstriction. Physiol Rev 92:367-520
    • (2012) Physiol Rev , vol.92 , pp. 367-520
    • Sylvester, J.T.1    Shimoda, L.A.2    Aaronson, P.I.3    Ward, J.P.4
  • 35
    • 0024360030 scopus 로고
    • Endothelium and control of vascular function. State of the Art lecture
    • 2661425 10.1161/01.HYP.13.6.658 1:CAS:528:DyaL1MXksFSntL0%3D
    • Vanhoutte PM (1989) Endothelium and control of vascular function. State of the Art lecture. Hypertension 13:658-667
    • (1989) Hypertension , vol.13 , pp. 658-667
    • Vanhoutte, P.M.1
  • 36
    • 24044514657 scopus 로고    scopus 로고
    • Dimerization of nitric oxide-sensitive guanylyl cyclase requires the α1 N terminus
    • 15749699 10.1074/jbc.M412099200 1:CAS:528:DC%2BD2MXjsl2itbc%3D
    • Wagner C, Russwurm M, Jager R, Friebe A, Koesling D (2005) Dimerization of nitric oxide-sensitive guanylyl cyclase requires the α1 N terminus. J Biol Chem 280:17687-17693
    • (2005) J Biol Chem , vol.280 , pp. 17687-17693
    • Wagner, C.1    Russwurm, M.2    Jager, R.3    Friebe, A.4    Koesling, D.5
  • 37
    • 78449273112 scopus 로고    scopus 로고
    • 2+ and contractile responses in pulmonary and systemic vascular smooth muscle cells
    • 20713188 10.1016/j.resp.2010.08.008 1:CAS:528:DC%2BC3cXhsVGis7nK
    • 2+ and contractile responses in pulmonary and systemic vascular smooth muscle cells. Respir Physiol Neurobiol 174:192-200
    • (2010) Respir Physiol Neurobiol , vol.174 , pp. 192-200
    • Wang, Y.X.1    Zheng, Y.M.2
  • 38
    • 77649112162 scopus 로고    scopus 로고
    • Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells
    • 20019331 10.1161/CIRCRESAHA.109.206334 1:CAS:528:DC%2BC3cXitFCks7k%3D
    • Waypa GB, Marks JD, Guzy R, Mungai PT, Schriewer J, Dokic D, Schumacker PT (2010) Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circ Res 106:526-535
    • (2010) Circ Res , vol.106 , pp. 526-535
    • Waypa, G.B.1    Marks, J.D.2    Guzy, R.3    Mungai, P.T.4    Schriewer, J.5    Dokic, D.6    Schumacker, P.T.7
  • 40
    • 48449107159 scopus 로고    scopus 로고
    • Thiol chemistry and specificity in redox signaling
    • 18544350 10.1016/j.freeradbiomed.2008.05.004 1:CAS:528: DC%2BD1cXpslWktbY%3D
    • Winterbourn CC, Hampton MB (2008) Thiol chemistry and specificity in redox signaling. Free Radic Biol Med 45:549-561
    • (2008) Free Radic Biol Med , vol.45 , pp. 549-561
    • Winterbourn, C.C.1    Hampton, M.B.2
  • 41
    • 77149168173 scopus 로고    scopus 로고
    • Oxidant-redox regulation of pulmonary vascular responses to hypoxia and nitric oxide-cGMP signaling
    • 20160535 10.1097/CRD.0b013e3181c9f088
    • Wolin MS, Gupte SA, Neo BH, Gao Q, Ahmad M (2010) Oxidant-redox regulation of pulmonary vascular responses to hypoxia and nitric oxide-cGMP signaling. Cardiol Rev 18:89-93
    • (2010) Cardiol Rev , vol.18 , pp. 89-93
    • Wolin, M.S.1    Gupte, S.A.2    Neo, B.H.3    Gao, Q.4    Ahmad, M.5
  • 42
    • 84856750363 scopus 로고    scopus 로고
    • Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: Role of PKG and MYPT1
    • 10.1007/s00424-011-1040-4 1:CAS:528:DC%2BC38Xpslymug%3D%3D
    • Ying L, Xu X, Liu J, Dou D, Yu X, Ye L, He Q, Gao Y (2012) Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1. Pflügers Archiv - Eur J Physiol 463:257-268
    • (2012) Pflügers Archiv - Eur J Physiol , vol.463 , pp. 257-268
    • Ying, L.1    Xu, X.2    Liu, J.3    Dou, D.4    Yu, X.5    Ye, L.6    He, Q.7    Gao, Y.8
  • 43
    • 79957449176 scopus 로고    scopus 로고
    • Role of sulfhydryl-dependent dimerization of soluble guanylyl cyclase in relaxation of porcine coronary artery to nitric oxide
    • 21248051 10.1093/cvr/cvr016 1:CAS:528:DC%2BC3MXmsVOltbY%3D
    • Zheng X, Ying L, Liu J, Dou D, He Q, Leung SWS, Man RYK, Vanhoutte PM, Gao Y (2011) Role of sulfhydryl-dependent dimerization of soluble guanylyl cyclase in relaxation of porcine coronary artery to nitric oxide. Cardiovasc Res 90:565-572
    • (2011) Cardiovasc Res , vol.90 , pp. 565-572
    • Zheng, X.1    Ying, L.2    Liu, J.3    Dou, D.4    He, Q.5    Leung, S.W.S.6    Man, R.Y.K.7    Vanhoutte, P.M.8    Gao, Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.