-
1
-
-
0033539664
-
Axon pathology in Parkinson's disease and lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein
-
Galvin J.E., Uryu K., Lee V.M., Trojanowski J.Q. Axon pathology in Parkinson's disease and lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:13450-13455.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 13450-13455
-
-
Galvin, J.E.1
Uryu, K.2
Lee, V.M.3
Trojanowski, J.Q.4
-
2
-
-
84866436990
-
An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain
-
Pacheco C., Aguayo L.G., Opazo C. An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain. Front. Physiol. 2012, 297:3389-3399.
-
(2012)
Front. Physiol.
, vol.297
, pp. 3389-3399
-
-
Pacheco, C.1
Aguayo, L.G.2
Opazo, C.3
-
3
-
-
33846997878
-
Presynaptic a-synuclein aggregates, not lewy bodies, cause neurodegeneration in dementia with lewy bodies
-
Kramer M.L., Schulz-Schaeffer W.J. Presynaptic a-synuclein aggregates, not lewy bodies, cause neurodegeneration in dementia with lewy bodies. J. Neurosci. 2007, 27:1405-1410.
-
(2007)
J. Neurosci.
, vol.27
, pp. 1405-1410
-
-
Kramer, M.L.1
Schulz-Schaeffer, W.J.2
-
4
-
-
0032102455
-
The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
-
Clayton D.F., George J.M. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci. 1998, 21:249-254.
-
(1998)
Trends Neurosci.
, vol.21
, pp. 249-254
-
-
Clayton, D.F.1
George, J.M.2
-
5
-
-
61449084604
-
Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease
-
Kazantsev A.G., Kolchinsky A.M. Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease. Arch. Neurol. 2008, 65:1577-1581.
-
(2008)
Arch. Neurol.
, vol.65
, pp. 1577-1581
-
-
Kazantsev, A.G.1
Kolchinsky, A.M.2
-
6
-
-
77949848854
-
Prion-like transmission of protein aggregates in neurodegenerative diseases
-
Brundin P., Melki R., Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat. Rev. Mol. Cell Biol. 2010, 11:301-307.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 301-307
-
-
Brundin, P.1
Melki, R.2
Kopito, R.3
-
7
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H., Del Tredici K., Rub U., de Vos R.A., Jansen Steur E.N., Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 2003, 24:197-211.
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rub, U.3
de Vos, R.A.4
Jansen Steur, E.N.5
Braak, E.6
-
8
-
-
63849332293
-
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy
-
Chung C.Y., Koprich J.B., Siddiqi H., Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J. Neurosci. 2009, 29:3365-3373.
-
(2009)
J. Neurosci.
, vol.29
, pp. 3365-3373
-
-
Chung, C.Y.1
Koprich, J.B.2
Siddiqi, H.3
Isacson, O.4
-
9
-
-
80053609570
-
Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage
-
Bate B.C., Williams A. Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage. Neuropharmacology 2011, 61:1406-1412.
-
(2011)
Neuropharmacology
, vol.61
, pp. 1406-1412
-
-
Bate, B.C.1
Williams, A.2
-
10
-
-
79960009804
-
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies
-
Mazzulli J.R., Xu Y.H., Sun Y., Knight A.L., McLean P.J., Caldwell G.A., Sidransky E., Grabowski G.A., Krainc D. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 2011, 146:37-52.
-
(2011)
Cell
, vol.146
, pp. 37-52
-
-
Mazzulli, J.R.1
Xu, Y.H.2
Sun, Y.3
Knight, A.L.4
McLean, P.J.5
Caldwell, G.A.6
Sidransky, E.7
Grabowski, G.A.8
Krainc, D.9
-
11
-
-
77957347060
-
α-Synuclein promotes SNARE-complex assembly in vivo and in vitro
-
Burre J., Sharma M., Tsetsenis T., Buchman V., Etherton M.R., Sudhof T.C. α-Synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 2010, 329:1663-1667.
-
(2010)
Science
, vol.329
, pp. 1663-1667
-
-
Burre, J.1
Sharma, M.2
Tsetsenis, T.3
Buchman, V.4
Etherton, M.R.5
Sudhof, T.C.6
-
12
-
-
80052419902
-
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
-
Devine M.J., Ryten M., Vodicka P., Thomson A.J., Burdon T., Houlden H., Cavaleri F., Nagano M., Drummond N.J., Taanman J.W., Schapira A.H., Gwinn K., Hardy J., Lewis P.A., Kunathb T. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nat. Commun. 2011, 440(2):1-10.
-
(2011)
Nat. Commun.
, vol.440
, Issue.2
, pp. 1-10
-
-
Devine, M.J.1
Ryten, M.2
Vodicka, P.3
Thomson, A.J.4
Burdon, T.5
Houlden, H.6
Cavaleri, F.7
Nagano, M.8
Drummond, N.J.9
Taanman, J.W.10
Schapira, A.H.11
Gwinn, K.12
Hardy, J.13
Lewis, P.A.14
Kunathb, T.15
-
13
-
-
84859742731
-
The potential of iPS cells in synucleinopathy research
-
Linta L., Stockmann M., Boeckers T.M., Kleger A., Liebau S. The potential of iPS cells in synucleinopathy research. Stem Cells Int. 2012, 2012:629230.
-
(2012)
Stem Cells Int.
, vol.2012
, pp. 629230
-
-
Linta, L.1
Stockmann, M.2
Boeckers, T.M.3
Kleger, A.4
Liebau, S.5
-
14
-
-
84875398742
-
A review on therapeutic potential of Nigella sativa: a miracle herb
-
Ahmad A., Husain A., Mujeeb M., Khan S.A., Najmi A.K., Siddique N.A., Damanhouri Z.A., Anwar F. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac. J. Trop. Biomed. 2013, 3:337-352.
-
(2013)
Asian Pac. J. Trop. Biomed.
, vol.3
, pp. 337-352
-
-
Ahmad, A.1
Husain, A.2
Mujeeb, M.3
Khan, S.A.4
Najmi, A.K.5
Siddique, N.A.6
Damanhouri, Z.A.7
Anwar, F.8
-
15
-
-
84855810908
-
Thymoquinone: potential cure for inflammatory disorders and cancer
-
Woo C.C., Kumar A.P., Sethi G., Tan K.H.B. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem. Pharmacol. 2012, 83:443-451.
-
(2012)
Biochem. Pharmacol.
, vol.83
, pp. 443-451
-
-
Woo, C.C.1
Kumar, A.P.2
Sethi, G.3
Tan, K.H.B.4
-
16
-
-
75149187342
-
Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
-
Ismail M., Al-Naqeep G., Chan K.W. Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic. Biol. Med. 2010, 48:664-672.
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 664-672
-
-
Ismail, M.1
Al-Naqeep, G.2
Chan, K.W.3
-
17
-
-
84872774902
-
Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway
-
Peng L., Liu A., Shen Y., Xu H.Z., Yang S.Z., Ying X.Z., Liao W., Liu H.X., Lin Z.Q., Chen Q.Y., Cheng S.W., Shen W.D. Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway. Oncol. Rep. 2013, 29:571-578.
-
(2013)
Oncol. Rep.
, vol.29
, pp. 571-578
-
-
Peng, L.1
Liu, A.2
Shen, Y.3
Xu, H.Z.4
Yang, S.Z.5
Ying, X.Z.6
Liao, W.7
Liu, H.X.8
Lin, Z.Q.9
Chen, Q.Y.10
Cheng, S.W.11
Shen, W.D.12
-
18
-
-
65649116127
-
Thymoquinone protects dopaminergic neurons against MPP+ and rotenone
-
Radad K., Moldzio R., Taha M., Rausch W.D. Thymoquinone protects dopaminergic neurons against MPP+ and rotenone. Phytother. Res. 2009, 23:696-700.
-
(2009)
Phytother. Res.
, vol.23
, pp. 696-700
-
-
Radad, K.1
Moldzio, R.2
Taha, M.3
Rausch, W.D.4
-
19
-
-
84855906102
-
Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons
-
Ullah I., Ullah N., Naseer M.I., Lee H.Y., Kim M.O. Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons. BMC Neurosci. 2012, 13:11.
-
(2012)
BMC Neurosci.
, vol.13
, pp. 11
-
-
Ullah, I.1
Ullah, N.2
Naseer, M.I.3
Lee, H.Y.4
Kim, M.O.5
-
20
-
-
84865617768
-
Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress
-
Khan A., Vaibhav K., Javed H., Khan M.M., Tabassum R., Ahmed M.E., Srivastava P., Khuwaja G., Islam F., Siddiqui M.S., Shafi M.M., Islam F. Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress. Mol. Cell Biochem. 2012, 369:55-65.
-
(2012)
Mol. Cell Biochem.
, vol.369
, pp. 55-65
-
-
Khan, A.1
Vaibhav, K.2
Javed, H.3
Khan, M.M.4
Tabassum, R.5
Ahmed, M.E.6
Srivastava, P.7
Khuwaja, G.8
Islam, F.9
Siddiqui, M.S.10
Shafi, M.M.11
Islam, F.12
-
21
-
-
33746190607
-
Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus
-
Al-Majed A.A., Al-Omar F.A., Nagi M.N. Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. Eur. J. Pharmacol. 2006, 543:40-47.
-
(2006)
Eur. J. Pharmacol.
, vol.543
, pp. 40-47
-
-
Al-Majed, A.A.1
Al-Omar, F.A.2
Nagi, M.N.3
-
22
-
-
84876476066
-
Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity
-
Alhebshi A.H., Gotoh M., Suzuki I. Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity. Biochem. Biophys. Res. Commun. 2013, 433:362-367.
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.433
, pp. 362-367
-
-
Alhebshi, A.H.1
Gotoh, M.2
Suzuki, I.3
-
23
-
-
0034705044
-
Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles
-
Daly C., Sugimori M., Moreira J.E., Ziff E.B., Llinas R. Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:6120-6125.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6120-6125
-
-
Daly, C.1
Sugimori, M.2
Moreira, J.E.3
Ziff, E.B.4
Llinas, R.5
-
24
-
-
17844378691
-
Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction
-
Reddy P.H., Mani G., Park B.S., Jacques J., Murdoch G., Whetsell W., Kaye J., Manczak M. Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction. J. Alzheimers Dis. 2005, 7:103-117.
-
(2005)
J. Alzheimers Dis.
, vol.7
, pp. 103-117
-
-
Reddy, P.H.1
Mani, G.2
Park, B.S.3
Jacques, J.4
Murdoch, G.5
Whetsell, W.6
Kaye, J.7
Manczak, M.8
-
25
-
-
77949895956
-
Polyunsaturated fatty acids protect against prion-mediated synapse damage in vitro
-
Bate C., Tayebi M., Salmona M., Diomede L., Williams A. Polyunsaturated fatty acids protect against prion-mediated synapse damage in vitro. Neurotox. Res. 2010, 17:203-214.
-
(2010)
Neurotox. Res.
, vol.17
, pp. 203-214
-
-
Bate, C.1
Tayebi, M.2
Salmona, M.3
Diomede, L.4
Williams, A.5
-
26
-
-
78650066331
-
β-Synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain
-
Fujita M., Sugama S., Sekiyama K., Sekigawa A., Tsukui T., Nakai M., Waragai M., Takenouchi T., Takamatsu Y., Wei J., Rockenstein E., Laspada A.R., Masliah E., Inoue S., Hashimoto M.A. β-Synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. Nat. Commun. 2010, 1110:1-9.
-
(2010)
Nat. Commun.
, vol.1110
, pp. 1-9
-
-
Fujita, M.1
Sugama, S.2
Sekiyama, K.3
Sekigawa, A.4
Tsukui, T.5
Nakai, M.6
Waragai, M.7
Takenouchi, T.8
Takamatsu, Y.9
Wei, J.10
Rockenstein, E.11
Laspada, A.R.12
Masliah, E.13
Inoue, S.14
Hashimoto, M.A.15
-
27
-
-
0032734205
-
Mechanisms of synaptic vesicle recycling illuminated by fluorescent dyes
-
Cousin M.A., Robinson P.J. Mechanisms of synaptic vesicle recycling illuminated by fluorescent dyes. J. Neurochem. 1999, 73:2227-2239.
-
(1999)
J. Neurochem.
, vol.73
, pp. 2227-2239
-
-
Cousin, M.A.1
Robinson, P.J.2
-
29
-
-
4644359042
-
β-Synuclein gene alterations in dementia with Lewy bodies
-
Ohtake H., Limprasert P., Fan Y., Onodera O., Kakita A., Takahashi H., Bonner L.T., Tsuang D.W., Murray I.V.J., Lee V.M.-Y., Trojanowski J.Q., Ishikawa A., Idezuka J., Murata M., Toda T., Bird T.D., Leverenz J.B., Tsuji S., La Spada A.R. β-Synuclein gene alterations in dementia with Lewy bodies. Neurology 2004, 63:805-811.
-
(2004)
Neurology
, vol.63
, pp. 805-811
-
-
Ohtake, H.1
Limprasert, P.2
Fan, Y.3
Onodera, O.4
Kakita, A.5
Takahashi, H.6
Bonner, L.T.7
Tsuang, D.W.8
Murray, I.V.J.9
Lee, V.M.-Y.10
Trojanowski, J.Q.11
Ishikawa, A.12
Idezuka, J.13
Murata, M.14
Toda, T.15
Bird, T.D.16
Leverenz, J.B.17
Tsuji, S.18
La Spada, A.R.19
-
30
-
-
0041666437
-
Neuropharmacological activity of N. sativa L
-
Al-Naggar T.B., Gómez-Serranillos M.P., Carretero M.E., Villar A.M. Neuropharmacological activity of N. sativa L. J. Ethnopharmacol. 2003, 88:63-68.
-
(2003)
J. Ethnopharmacol.
, vol.88
, pp. 63-68
-
-
Al-Naggar, T.B.1
Gómez-Serranillos, M.P.2
Carretero, M.E.3
Villar, A.M.4
-
31
-
-
0030778952
-
A study of the anti-inflammatory activity of Nigella sativa L. and thymoquinone
-
Mutabagani A., El-Mahdy S.A.M. A study of the anti-inflammatory activity of Nigella sativa L. and thymoquinone. Saudi Pharm. J. 1997, 5:110-113.
-
(1997)
Saudi Pharm. J.
, vol.5
, pp. 110-113
-
-
Mutabagani, A.1
El-Mahdy, S.A.M.2
-
32
-
-
38949116268
-
Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats
-
Kanter M. Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats. Neurochem. Res. 2008, 33:579-588.
-
(2008)
Neurochem. Res.
, vol.33
, pp. 579-588
-
-
Kanter, M.1
-
33
-
-
84870367030
-
Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study
-
Alam S.S., Khan Z.I., Mustafa G., Kumar M., Islam F., Bhatnagar A., Ahmad F.J. Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study. Int. J. Nanomed. 2012, 7:5705-5718.
-
(2012)
Int. J. Nanomed.
, vol.7
, pp. 5705-5718
-
-
Alam, S.S.1
Khan, Z.I.2
Mustafa, G.3
Kumar, M.4
Islam, F.5
Bhatnagar, A.6
Ahmad, F.J.7
|