The potential of iPS cells in synucleinopathy research

Stem Cells International

Volumn , Issue , 2012, Pages

  Linta, Leonhard ^a   Stockmann, Marianne ^a   Boeckers, Tobias M ^a   Kleger, Alexander ^a   Liebau, Stefan ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN;

CELL CULTURE; CELL DIFFERENTIATION; CELL THERAPY; CELL TYPE; HUMAN; IN VITRO STUDY; NUCLEAR REPROGRAMMING; PARKINSON DISEASE; PATHOGENESIS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SOMATIC CELL;

IPS;

EID: 84859742731     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2012/629230     Document Type: Review

References (40)

1. Sidhu A., Wersinger C., Vernier P., Does -synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB Journal 2004 18 6 637 647 (Pubitemid 38451786)
2. Burré J., Sharma M., Tsetsenis T., Buchman V., Etherton M. R., Sdhof T. C., -synuclein promotes SNARE-complex assembly in vivo and in vitro Science 2010 329 5999 1663 1667
3. Goedert M., Alpha-synuclein and neurodegenerative diseases Nature Reviews Neuroscience 2001 2 7 492 501 (Pubitemid 33676584)
4. Conway K. A., Harper J. D., Lansbury P. T., Accelerated in vitro fibril formation by a mutant -synuclein linked to early-onset Parkinson disease Nature Medicine 1998 4 11 1318 1320 (Pubitemid 28512115)
5. Chesselet M. F., In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease? Experimental Neurology 2008 209 1 22 27
6. Chandra S., Gallardo G., Fernndez-Chacn R., Schlter O. M., Sdhof T. C., -synuclein cooperates with CSP in preventing neurodegeneration Cell 2005 123 3 383 396 (Pubitemid 41546670)
7. Braak H., Thal D. R., Del Tredici K., Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases Journal of Neural Transmission 2011 118 5 809 819
8. Focke N. K., Helms G., Pantel P. M., Scheewe S., Knauth M., Bachmann C. G., Ebentheuer J., Dechent P., Paulus W., Trenkwalder C., Differentiation of typical and atypical Parkinson syndromes by quantitative MR imaging American Journal of Neuroradiology 2011 32 11 2087 2092
9. Liu Z., Hamamichi S., Lee B. D., Yang D., Ray A., Caldwell G. A., Caldwell K. A., Dawson T. M., Smith W. W., Dawson V. L., Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models Human Molecular Genetics 2011 20 20 3933 3942
10. Pienaar I. S., Gtz J., Feany M. B., Parkinson's disease: insights from non-traditional model organisms Progress in Neurobiology 2010 92 4 558 571
11. Hermann A., Maisel M., Wegner F., Liebau S., Kim D. W., Gerlach M., Schwarz J., Kim K. S., Storch A., Multipotent neural stem cells from the adult tegmentum with dopaminergic potential develop essential properties of functional neurons Stem Cells 2006 24 4 949 964 (Pubitemid 44464728)
12. Liebau S., Vaida B., Proepper C., Grissmer S., Storch A., Boeckers T. M., Dietl P., Wittekindt O. H., Formation of cellular projections in neural progenitor cells depends on SK3 channel activity Journal of Neurochemistry 2007 101 5 1338 1350 (Pubitemid 46718816)
13. Liebau S., Vaida B., Storch A., Boeckers T. M., Maturation of synaptic contacts in differentiating neural stem cells Stem Cells 2007 25 7 1720 1729 (Pubitemid 47121850)
14. Liebau S., Prpper C., Bckers T., Lehmann-Horn F., Storch A., Grissmer S., Wittekindt O. H., Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation Journal of Neurochemistry 2006 99 2 426 437 (Pubitemid 44477200)
15. Hermann A., Maisel M., Liebau S., Gerlach M., Kleger A., Schwarz J., Kim K. S., Antoniadis G., Lerche H., Storch A., Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells Journal of Neurochemistry 2006 98 2 629 640 (Pubitemid 44133164)
16. Trzaska K. A., Rameshwar P., Dopaminergic neuronal differentiation protocol for human mesenchymal stem cells Methods in Molecular Biology 2011 698 295 303
17. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S., Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Cell 2007 131 5 861 872 (Pubitemid 350138099)
18. Mller M., Stockmann S., Malan D., Ca2+-activated K+ -Channels -new tools to induce cardiac commitment from pluripotent stem cells in mice and men. Stem Cell Reviews and Reports. In press
19. Swistowski A., Peng J., Liu Q., Mali P., Rao M. S., Cheng L., Zeng X., Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions Stem Cells 2010 28 10 1893 1904
20. Aasen T., Raya A., Barrero M. J., Garreta E., Consiglio A., Gonzalez F., Vassena R., Bili J., Pekarik V., Tiscornia G., Edel M., Boué S., Belmonte J. C. I., Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes Nature Biotechnology 2008 26 11 1276 1284
21. Bar-Nur O., Russ H. A., Efrat S., Benvenisty N., Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells Cell Stem Cell 2011 9 1 17 23
22. Sommer C. A., Sommer A. G., Longmire T. A., Christodoulou C., Thomas D. D., Gostissa M., Alt F. W., Murphy G. J., Kotton D. N., Mostoslavsky G., Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector Stem Cells 2010 28 1 64 74
23. Sommer C. A., Stadtfeld M., Murphy G. J., Hochedlinger K., Kotton D. N., Mostoslavsky G., Induced pluripotent stem cell generation using a single lentiviral stem cell cassette Stem Cells 2009 27 3 543 549
24. Junying Y., Kejin H., Kim S. O., Shulan T., Stewart R., Slukvin I. I., Thomson J. A., Human induced pluripotent stem cells free of vector and transgene sequences Science 2009 324 5928 797 801
25. Zhou H., Wu S., Joo J. Y., Zhu S., Han D. W., Lin T., Trauger S., Bien G., Yao S., Zhu Y., Siuzdak G., Schler H. R., Duan L., Ding S., Generation of induced pluripotent stem cells using recombinant proteins Cell Stem Cell 2009 4 5 381 384
26. Warren L., Manos P. D., Ahfeldt T., Loh Y. H., Li H., Lau F., Ebina W., Mandal P. K., Smith Z. D., Meissner A., Daley G. Q., Brack A. S., Collins J. J., Cowan C., Schlaeger T. M., Rossi D. J., Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA Cell Stem Cell 2010 7 5 618 630
27. Hotta A., Cheung A. Y. L., Farra N., Vijayaragavan K., Séguin C. A., Draper J. S., Pasceri P., Maksakova I. A., Mager D. L., Rossant J., Bhatia M., Ellis J., Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency Nature Methods 2009 6 5 370 376
28. Di Stefano B., Maffioletti S. M., Gentner B., Ungaro F., Schira G., Naldini L., Broccoli V., A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells Stem Cells 2011 29 11 1684 1695
29. Zhang S. C., Wernig M., Duncan I. D., Brstle O., Thomson J. A., In vitro differentiation of transplantable neural precursors from human embryonic stem cells Nature Biotechnology 2001 19 12 1129 1133 (Pubitemid 33115698)
30. Koch P., Opitz T., Steinbeck J. A., Ladewig J., Brstle O., A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration Proceedings of the National Academy of Sciences of the United States of America 2009 106 9 3225 3230
31. Morizane A., Doi D., Kikuchi T., Nishimura K., Takahashi J., Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells Journal of Neuroscience Research 2011 89 2 117 126
32. Chambers S. M., Fasano C. A., Papapetrou E. P., Tomishima M., Sadelain M., Studer L., Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling Nature Biotechnology 2009 27 3 275 280
33. Stockmann M., Linta L., Fhr K. J., Developmental and functional nature of human iPSC derived motoneurons. Stem Cell Reviews and Reports. In press
34. Brennand K. J., Simone A., Jou J., Gelboin-Burkhart C., Tran N., Sangar S., Li Y., Mu Y., Chen G., Yu D., McCarthy S., Sebat J., Gage F. H., Modelling schizophrenia using human induced pluripotent stem cells Nature 2011 473 7346 221 225
35. Krencik R., Weick J. P., Liu Y., Zhang Z.-J., Zhang S.-C., Specification of transplantable astroglial subtypes from human pluripotent stem cells Nature Biotechnology 2011 29 6 528 534
36. Mazzulli J. R., Xu Y.-H., Sun Y., Knight A. L., McLean P. J., Caldwell G. A., Sidransky E., Grabowski G. A., Krainc D., Gaucher disease glucocerebrosidase and -synuclein form a bidirectional pathogenic loop in synucleinopathies Cell 2011 146 1 37 52
37. Devine M. J., Ryten M., Vodicka P., Thomson A. J., Burdon T., Houlden H., Cavaleri F., Nagano M., Drummond N. J., Taanman J.-W., Schapira A. H., Gwinn K., Hardy J., Lewis P. A., Kunath T., Parkinson's disease induced pluripotent stem cells with triplication of the -synuclein locus Nature Communications 2011 2 1 440
38. Kondo K., Obitsu S., Teshima R., -Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells Biological and Pharmaceutical Bulletin 2011 34 7 1078 1083
39. Nguyen H. N., Byers B., Cord B., Shcheglovitov A., Byrne J., Gujar P., Kee K., Schle B., Dolmetsch R. E., Langston W., Palmer T. D., Pera R. R., LRRK2 mutant iPSC-derived da neurons demonstrate increased susceptibility to oxidative stress Cell Stem Cell 2011 8 3 267 280
40. Soldner F., Laganire J., Cheng A. W., Hockemeyer D., Gao Q., Alagappan R., Khurana V., Golbe L. I., Myers R. H., Lindquist S., Zhang L., Guschin D., Fong L. K., Vu B. J., Meng X., Urnov F. D., Rebar E. J., Gregory P. D., Zhang H. S., Jaenisch R., Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations Cell 2011 146 2 318 331