Identification of compounds in the essential oil of nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice

International Journal of Molecular Sciences

Volumn 11, Issue 11, 2010, Pages 4771-4781

  Muchtaridi, ^a   Subarnas, Anas ^a   Apriyantono, Anton ^b   Mustarichie, Resmi ^a  

^a PADJADJARAN UNIVERSITY   (Indonesia)

^b BOGOR AGRICULTURAL UNIVERSITY   (Indonesia)

Author keywords

Essential oils; Gc ms; Inhalation; Nutmeg (myristica fragrans houtt.) seeds

Indexed keywords

ESSENTIAL OIL; FATTY ACID ESTER; MYRISTICIN; SAFROLE; TERPINEN 4 OL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG IDENTIFICATION; DRUG ISOLATION; IMMOBILIZATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; NUTMEG; PHYTOTOXICITY; PLANT SEED; TOXIC INHALATION; TOXICITY TESTING;

ESSENTIAL OILS; GC-MS; INHALATION; NUTMEG (MYRISTICA FRAGRANS HOUTT.) SEEDS;

ANIMALS; BENZYL COMPOUNDS; DIOXOLANES; LOCOMOTION; MICE; MYRISTICA FRAGRANS; OILS, VOLATILE; PLANT OILS; PYROGALLOL; SAFROLE; SEEDS;

MUS; MYRISTICA FRAGRANS;

EID: 78650972080     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms11114771     Document Type: Article

References (18)

1. van Gils, C.; Cox, P.A. Ethnobotany of nutmeg in the Spice Islands. J. Ethnopharmacol. 1994, 42, 117-124.
2. Olajide, O.A.; Ajayi, F.F.; Ekhelar, A.I.; Awe, S.O.; Makinde, J.M.; Alada, A.R. Biological effects of Myristica fragrans (nutmeg) extract. Phytother Res. 1999, 13, 344-345.
3. Sonavane, G.S.; Sarveiya, V.P.; Kasture, V.S.; Kasture, S.B. Anxiogenic activity of Myristica fragrans seeds. Pharmacol. Biochem. Behav. 2002, 71, 239-244.
4. Isogai, A.; Suzuki, A.; Tamura, S. Structure of dimeric phenoxy-propanoids from Myristica fragrans. Agar. Biol. Chem. 1973, 37, 193-194.
5. Stein, U.; Greyer, H.; Hentschel, H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci. Int. 2001, 118, 87-90.
6. Sonavane, A.; Vikram, S.; Veena, K.; Sanjay, B.K. Behavioural action of Myristica fragrans Houtt. seeds. Indian J. Pharmacol. 2001, 33, 417-424.
7. Hallstrom, H.; Thuvander, A. Toxicological evaluation of myristicin. Nat. Toxins 1997, 5, 186-192.
8. Oyen, N.X.D. Plant Resources of South-East Asia, Essential-oil Plants; Proscea: Bogor, Indonesia, 1999; Volume 12.
9. Buchbauer, G.; Jirovetz, L.; Jager, W.; Dietrich, H.; Plank, C. Aromatherapy: Evidence for sedative effects of the essential oil of lavender after inhalation. Z Naturforsch C 1991, 46, 1067-1072.
10. Buchbauer, G.; Jirovetz, L.; Jager, W.; Plank, C.; Dietrich, H. Fragrance compounds and essential oils with sedative effects upon inhalation. J. Pharm. Sci. 1993, 82, 660-664.
11. Beyer, J.; Ehlers, D.; Maurer, H.H. Abuse of nutmeg (Myristica fragrans Houtt.): Studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry. Ther. Drug Monit. 2006, 28, 568-575.
12. Foye W. Principles of Medicinal Chemistry; LEA & FEBRIGER.: Philadelphia, PA, USA, 1981; Volume 2, p. 931.
13. Hossain, S.J.; Hamamoto, K.; Aoshima, H.; Hara, Y. Effects of tea components on the response of GABA(A) receptors expressed in Xenopus Oocytes. J. Agric. Food Chem. 2002, 50, 3954-3960.
14. Aoshima, H.; Hossain, S.J.; Hamamoto, K.; Yokoyama, T.; Yamada, M.; Shingai, R. Kinetic analyses of alcohol-induced potentiation of the response of GABA(A) receptors composed of alpha(1) and beta(1) subunits. J. Biochem. 2001, 130, 703-709.
15. R.P. Identification of Essential Oil Components by Gas Chromatography/Mass Spectroscopy; Allured Publishing Corporation: Carol Stream, IL, USA, 1995.
16. Jirovetz, L.; Jager, W.; Buchbauer, G.; Nikiforov, A.; Raverdino, V. Investigations of animal blood samples after fragrance drug inhalation by gas chromatography/mass spectrometry with chemical ionization and selected ion monitoring. Biol. Mass Spectrom. 1991, 20, 801-803.
17. Jirovetz, L.; Buchbauer, G.; Jager, W.; Woidich, A.; Nikiforov, A. Analysis of fragrance compounds in blood samples of mice by gas chromatography, mass spectrometry, GC/FTIR and GC/AES after inhalation of sandalwood oil. Biomed. Chromatogr. 1992, 6, 133-134.
18. Kovar, K.A.; Gropper, B.; Friess, D.; Ammon, H.P. Blood levels of 1,8-cineole and locomotor activity of mice after inhalation and oral administration of rosemary oil. Planta Med. 1987, 53, 315-318.