Activation and inhibition of transient receptor potential TRPM3-induced gene transcription

British Journal of Pharmacology

Volumn 171, Issue 10, 2014, Pages 2645-2658

  Lesch, Andrea ^a   Rubil, Sandra ^a   Thiel, Gerald ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

AP 1; Egr 1; Lentivirus; Mefenamic acid; Neurosteroid; Pregnenolone sulfate; TRPM3

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; MEFENAMIC ACID; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; NIFEDIPINE; PREGNENOLONE; PREGNENOLONE SULFATE; PROGESTERONE; QUERCETIN; ROSIGLITAZONE; SPHINGOSINE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ELK 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; EGR1 PROTEIN, HUMAN; ELK1 PROTEIN, HUMAN; PROTEIN C FOS; PROTEIN C JUN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM3 PROTEIN, HUMAN;

ARTICLE; CELL NUCLEUS; CELL STIMULATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; TIME;

DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EARLY GROWTH RESPONSE PROTEIN 1; ETS-DOMAIN PROTEIN ELK-1; GENES, REPORTER; HEK293 CELLS; HUMANS; MEFENAMIC ACID; MEMBRANE TRANSPORT MODULATORS; PREGNENOLONE; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TRPM CATION CHANNELS;

EID: 84900824292     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12524     Document Type: Article

References (51)

1. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, et al. (2013). The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels. Br J Pharmacol 170: 1607-1651.
2. Al-Sarraj A, Thiel G, (2002). Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the EGF receptor and of extracellular signal-regulated protein kinase. Neurosci Lett 332: 111-114.
3. Al-Sarraj A, Thiel G, (2004). The zinc finger transcription factor Egr-1 is upregulated in arsenite-treated human keratinocytes. J Mol Med 82: 530-538.
4. 2+ entry and transient receptor potential channels by sigma-1 receptor ligands. Br J Pharmacol 168: 1445-1455.
5. Bauer I, Hohl M, Al-Sarraj A, Vinson C, Thiel G, (2005). Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase. Arch Biochem Biophys 438: 36-52.
6. Bauer I, Al Sarraj J, Vinson C, Larsen R, Thiel G, (2007). Interleukin-1β and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor α in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-Activated protein kinases. J Cell Biochem 100: 242-255.
7. Ciurtin C, Majeed Y, Naylor J, Sukumar P, English AA, Emery P, et al. (2010). TRPM3 channel stimulated by pregnenolone sulfate in synovial fibroblasts and negatively coupled to hyaluronan. BMC Musculoskelet Disord 11: 111.
8. 2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Nat Acad Sci U S A 107: 5208-5213.
9. Deisseroth K, Heist EK, Tsien RW, (1998). Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 392: 198-202.
10. Ekici M, Keim A, Rössler OG, Hohl M, Thiel G, (2012). Chromatin structure and expression of the AMPA receptor subunit GluR2 in human glioma cells: major role of REST and Sp1. J Cell Biochem 113: 528-543.
11. Eto K, Kaur V, Thomas MK, (2006). Regulation of insulin gene transcription by the immediate early response gene Egr-1. Endocrinology 147: 2923-2935.
12. Eto K, Kaur V, Thomas MK, (2007). Regulation of pancreatic duodenum homeobox-1 expression by early growth response-1. J Biol Chem 282: 5973-5983.
13. Gallin WJ, Greenberg ME, (1995). Calcium regulation of gene expression in neurons: the mode of entry matters. Curr Opin Neurobiol 5: 367-374.
14. Grimm C, Kraft R, Sauerbruch S, Schulz G, Harteneck C, (2003). Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278: 21493-21501.
15. Grimm C, Kraft R, Schultz G, Harteneck C, (2005). Activation of the meleastatin-related cation channel TRPM3 by d-erythro-sphingosine. Mol Pharmacol 67: 798-805.
16. Islam MS, (2011). TRP channels of islets. in: transient receptor potential channels. Adv Exp Med Biol 704: 811-830.
17. Kaufmann A, Keim A, Thiel G, (2013). Regulation of immediate-early gene transcription following activation of Gαq-coupled designer receptors. J Cell Biochem 114: 681-696.
18. Kaufmann K, Thiel G, (2002). Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator. J Cell Biochem 85: 381-391.
19. Keim A, Müller I, Thiel G, (2012). Efficient genetic manipulation of 1321N1 astrocytoma cells using lentiviral gene transfer. J Neurosci 206: 138-142.
20. Klose C, Straub I, Riehle M, Ranta F, Krautwurst D, Ullrich S, et al. (2011). Fenamates as TRP channel blocker: mefenamic acid selectively blocks TRPM3. Br J Pharmacol 162: 1757-1769.
21. Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, et al. (2003). Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3). J Biol Chem 278: 20890-20897.
22. Majeed Y, Agarwal AK, Naylor J, Seymour VAL, Jiang S, Muraki K, et al. (2010). Cis-isomerism and other chemical requirements of steroid agonists and partial agonists acting at TRPM3 channels. Br J Pharmacol 161: 430-441.
23. Majeed Y, Bahnasi Y, Seymour VAL, Wilson LA, Milligan CJ, Agarwal AK, et al. (2011). Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPM5 channels. Mol Pharmacol 79: 1023-1030.
24. Majeed Y, Tumova S, Green BL, Seymour VAL, Woods DM, Agarwal AK, et al. (2012). Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone. Cell Calcium 51: 1-11.
25. Mayer SI, Thiel G, (2009). Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB. Eur J Cell Biol 88: 19-33.
26. Mayer SI, Willars GB, Nishida E, Thiel G, (2008). Elk-1, CREB, and MKP-1 regulate Egr-1 expression in gonadotropin-releasing hormone stimulated gonadotrophs. J Cell Biochem 105: 1267-1278.
27. Mayer SI, Müller I, Mannebach S, Endo T, Thiel G, (2011). Signal transduction of pregnenolone sulfate in insulinoma cells. Activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors. J Biol Chem 286: 10084-10096.
28. Müller I, Mayer SI, Keim A, Thiel G, (2009). Lentiviraler Gentransfer: Analyse von transkriptioneller Aktivierung und DNA-Bindung. Biospektrum 15: 52-53.
29. Müller I, Endo T, Thiel G, (2010). Regulation of AP-1 activity in glucose-stimulated insulinoma cells. J Cell Biochem 110: 1481-1494.
30. 2+ channels and transient receptor potential melastatin 3 channels. Mol Pharmacol 80: 1179-1189.
31. 2+ signaling and gene transcription in glucose-stimulated insulinoma cells. Cell Calcium 52: 137-151.
32. Müller I, Rössler OG, Wittig C, Menger MD, Thiel G, (2012b). Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis and islet size. Endocrinology 153: 3040-3053.
33. Naylor J, Milligan CJ, Zeng F, Jones C, Beech DJ, (2008). Production of a specific extracellular inhibitor of TRPM3 channels. Br J Pharmacol 155: 567-573.
34. Naylor J, Li J, Milligan CJ, Zeng F, Sukumar P, Hou B, et al. (2010). Pregnenolone sulphate- and cholesterol-regulated channels coupled to vascular smooth muscle secretion and contraction. Circ Res 106: 1507-1515.
35. Oberwinkler J, Lis A, Giehl KM, Flockerzi V, Philipp SE, (2005). Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem 280: 22540-22548.
36. 2+ concentration, phosphorylation of ERK and activation of ternary complex factor. BMC Mol Biol 10: 40.
37. Rössler OG, Henss I, Thiel G, (2008). Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by Elk-1, ERK, MKP-1 and calcineurin in carbachol stimulated human neuroblastoma cells. Arch Biochem Biophys 470: 93-102.
38. Shaw PE, Saxton J, (2003). Ternary complex factors: prime targets for mitogen-Activated protein kinases. Int J Biochem Cell Biol 35: 1210-1226.
39. 2+ ions and c-Jun N-terminal protein kinase. Mol Pharmacol 78: 865-876.
40. 2+ rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1. J Cell Physiol 213: 36-44.
41. Steinmüller L, Cibelli G, Moll JR, Vinson C, Thiel G, (2001). Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities. Biochem J 360: 599-607.
42. Straub I, Mohr F, Konrad M, Philipp SE, Oberwinkler J, Schaefer M, (2013). Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br J Pharmacol 168: 1835-1850.
43. Thiel G, Rössler OG, (2011). Immediate-early transcriptional response to angiotensin II in human adrenocortical cells. Endocrinology 152: 4211-4223.
44. Thiel G, Kaufmann K, Magin A, Lietz M, Bach K, Cramer M, (2000). The human transcriptional repressor protein NAB1: expression and biological activity. Biochim Biophys Acta 1493: 289-301.
45. Thiel G, Lesch A, Keim A, (2012). Transcriptional response to calcium-sensing receptor stimulation. Endocrinology 153: 4716-4728.
46. Thiel G, Müller I, Rössler OG, (2013). Signal transduction via TRPM3 in pancreatic β-cells. J Mol Endocrinol 50: R75-R83.
47. Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori T, et al. (2011). Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes 60: 119-126.
48. Vriens J, Owsianik G, Hofmann T, Philipp SE, Stab J, Chen X, et al. (2011). TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 70: 482-494.
49. Wagner TFJ, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, et al. (2008). Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol 10: 1421-1430.
50. West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, et al. (2001). Calcium regulation of neuronal gene expression. Proc Natl Acad Sci U S A 98: 11024-11031.
51. Zamudio-Bulcock PA, Everett J, Harteneck C, Valenzuela CF, (2011). Activation of steroid-sensitive TRPM3 channels potentiates glutamaterigic transmission of cerebellar Purkinje neurons from developing rats. J Neurochem 119: 474-485.