Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands

British Journal of Pharmacology

Volumn 168, Issue 6, 2013, Pages 1445-1455

  Amer, Mohamed S ^a,b   McKeown, Lynn ^a   Tumova, Sarka ^a   Liu, Ruifeng ^a   Seymour, Victoria A L ^a   Wilson, Lesley A ^a   Naylor, Jacqueline ^a   Greenhalgh, Katriona ^a   Hou, Bing ^a   Majeed, Yasser ^a   Turner, Paul ^a   Sedo, Alicia ^a   O'Regan, David J ^c   Li, Jing ^a   Bon, Robin S ^a   Porter, Karen E ^a   Beech, David J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b MENOUFIA UNIVERSITY   (Egypt)

^c LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

calcium channels; cationic channels; endothelial cells; histamine; hydrogen peroxide; Sigma 1 receptor; TRP channels; vascular endothelial growth factor

Indexed keywords

4 IBP; BD 1063; BD1063; HISTAMINE; HYDROGEN PEROXIDE; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; N ALLYLNORMETAZOCINE; OPIATE AGONIST; OPIATE ANTAGONIST; SIGMA 1 OPIATE RECEPTOR; SMALL INTERFERING RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOTHELIUM CELL; EVOKED RESPONSE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PATCH CLAMP; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SAPHENOUS VEIN;

CALCIUM SIGNALING; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HEK293 CELLS; HISTAMINE; HUMANS; KINETICS; LIGANDS; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT MODULATORS; PATCH-CLAMP TECHNIQUES; PROTEIN TRANSPORT; RECEPTORS, SIGMA; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRPC CATION CHANNELS; TRPM CATION CHANNELS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84874436590     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12041     Document Type: Article

References (36)

1. Aird WC, (2007). Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res 100: 158-173.
2. 2+ signalling in human vascular endothelial cells by hydrogen sulfide. Atherosclerosis 209: 374-380.
3. Bergers G, Hanahan D, (2008). Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8: 592-603.
4. Berridge MJ, (2003). Cardiac calcium signalling. Biochem Soc Trans 31 (Pt 5): 930-933.
5. Berridge MJ, Bootman MD, Roderick HL, (2003). Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4: 517-529.
6. Carmeliet P, (2005). Angiogenesis in life, disease and medicine. Nature 438: 932-936.
7. Chaudhuri P, Colles SM, Bhat M, Van Wagoner DR, Birnbaumer L, Graham LM, (2008). Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. Mol Biol Cell 19: 3203-3211.
8. Clapham DE, (2007). Calcium signaling. Cell 131: 1047-1058.
9. Damann N, Voets T, Nilius B, (2008). TRPs in our senses. Curr Biol 18: R880-R889.
10. Faehling M, Kroll J, Föhr KJ, Fellbrich G, Mayr U, Trischler G, et al. (2002). Essential role of calcium in vascular endothelial growth factor A-induced signaling: mechanism of the antiangiogenic effect of carboxyamidotriazole. FASEB J 16: 1805-1807.
11. Folkman J, (2007). Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6: 273-286.
12. Ge R, Tai Y, Sun Y, Zhou K, Yang S, Cheng T, et al. (2009). Critical role of TRPC6 channels in VEGF-mediated angiogenesis. Cancer Lett 283: 43-51.
13. Grimm C, Kraft R, Schultz G, Harteneck C, (2005). Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine. Mol Pharmacol 67: 798-805.
14. Hamdollah Zadeh MA, Glass CA, Magnussen A, Hancox JC, Bates DO, (2008). VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation 15: 605-614.
15. 2+ entry and endothelial hyperpermeability. Circ Res 102: 347-355.
16. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G, (1999). Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397: 259-263.
17. 2+ influx. Circ Res 96: 1282-1290.
18. Jiang LH, Gamper N, Beech DJ, (2011). Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets 12: 724-736.
19. 2+ entry and endothelial tube formation. Circ Res 108: 1190-1198.
20. 2+ stores stimulates the translocation of vanilloid transient receptor potential 4-C1 heteromeric channels to the plasma membrane. Arterioscler Thromb Vasc Biol 30: 2249-2255.
21. 2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation. J Biol Chem 278: 11002-11006.
22. Maurice T, Su TP, (2009). The pharmacology of sigma-1 receptors. Pharmacol Ther 124: 195-206.
23. 2+: clinical and therapeutic relevance. Biol Cell 97: 873-883.
24. Naylor J, Milligan CJ, Zeng F, Jones C, Beech DJ, (2008). Production of a specific extracellular inhibitor of TRPM3 channels. Br J Pharmacol 155: 567-573.
25. Naylor J, Li J, Milligan CJ, Zeng F, Sukumar P, Hou B, et al. (2010). Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circ Res 106: 1507-1515.
26. Naylor J, Al-Shawaf E, McKeown L, Manna PT, Porter KE, O'Regan D, et al. (2011). TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes. J Biol Chem 286: 5078-5086.
27. Nilius B, Droogmans G, (2001). Ion channels and their functional role in vascular endothelium. Physiol Rev 81: 1415-1459.
28. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L, (2006). VEGF receptor signalling-in control of vascular function. Nat Rev Mol Cell Biol 7: 359-371.
29. Su TP, Hayashi T, Maurice T, Buch S, Ruoho AE, (2010). The sigma-1 receptor chaperone as an inter-organelle signaling modulator. Trends Pharmacol Sci 31: 557-566.
30. Tagashira H, Bhuiyan S, Shioda N, Hasegawa H, Kanai H, Fukunaga K, (2010). Sigma1-receptor stimulation with fluvoxamine ameliorates transverse aortic constriction-induced myocardial hypertrophy and dysfunction in mice. Am J Physiol Heart Circ Physiol 299: H1535-H1545.
31. Venkatachalam K, Montell C, (2007). TRP channels. Annu Rev Biochem 76: 387-417.
32. Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, et al. (2008). Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol 10: 1421-1430.
33. Wong CO, Sukumar P, Beech DJ, Yao X, (2010). Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflugers Arch 460: 121-130.
34. Xu S, Touyz RM, (2006). Reactive oxygen species and vascular remodelling in hypertension: still alive. Can J Cardiol 22: 947-951.
35. Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, et al. (2006). Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol 2: 596-607.
36. Zeng F, Xu SZ, Jackson PK, McHugh D, Kumar B, Fountain SJ, et al. (2004). Human TRPC5 channel activated by a multiplicity of signals in a single cell. J Physiol 559 (Pt 3): 739-750.