CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents

Cell Biology International

Volumn 38, Issue 6, 2014, Pages 737-746

  Zhou, Lingli ^a   Cai, Xiaoling ^a   Han, Xueyao ^a   Xu, Naihan ^b   Chang, Donald C ^c  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b TSINGHUA UNIVERSITY   (China)

^c HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Apoptosis; Bad; Bcl 2; Mcl 1; Microtubule interfering agents; Mitotic arrest

Indexed keywords

AGENTS AFFECTING CELL DIVISION; CASPASE 3; CELL CYCLE DEPENDENT KINASE 1; CYCLIN B1; MICROTUBULE INTERFERING AGENT; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; PROTEIN SERINE THREONINE KINASE; SERINE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAD PROTEIN, HUMAN; BAX PROTEIN, HUMAN; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; MCL1 PROTEIN, HUMAN; MYELOID LEUKEMIA FACTOR 1; NOCODAZOLE; TUBULIN MODULATOR;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; HELA CELL LINE; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; MICROTUBULE; MITOSIS; PHOSPHORYLATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 3; CYCLIN B1; CYCLIN-DEPENDENT KINASES; HELA CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MICROTUBULES; MITOSIS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NOCODAZOLE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TUBULIN MODULATORS;

EID: 84900823132     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10259     Document Type: Article

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