Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats

American Journal of Physiology - Renal Physiology

Volumn 306, Issue 10, 2014, Pages

  He, Xiaofeng ^a,b   Liu, Yong ^a   Usa, Kristie ^a   Tian, Zhongmin ^c   Cowley, Allen W ^a   Liang, Mingyu ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Electron microscope; Hypertension; Kidney; Medullary thick ascending limb; Mitochondria

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HYPERTENSION; KIDNEY; KIDNEY CORTEX; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE; KIDNEY TUBULE BASEMENT MEMBRANE; KIDNEY TUBULE CELL; LIMB; MALE; MICROSCOPY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; RENOVASCULAR HYPERTENSION;

ELECTRON MICROSCOPE; HYPERTENSION; KIDNEY; MEDULLARY THICK ASCENDING LIMB; MITOCHONDRIA;

ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; HYPERTENSION; KIDNEY TUBULES, PROXIMAL; MALE; MICROSCOPY, ELECTRON; MITOCHONDRIA; RATS; RATS, INBRED DAHL; RATS, SPRAGUE-DAWLEY; SODIUM CHLORIDE, DIETARY;

EID: 84900812680     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00073.2014     Document Type: Article

References (27)

1. An J, Du J, Wei N, Guan T, Camara AK, Shi Y. Differential sensitivity to LPS-induced myocardial dysfunction in the isolated brown Norway and Dahl S rat hearts: roles of mitochondrial function, NF-κB activation, and TNF-α production. Shock 37: 325-332, 2012.
2. Bernal-Mizrachi C, Gates AC, Weng S, Imamura T, Knutsen RH, DeSantis P, Coleman T, Townsend RR, Muglia LJ, Semenkovich CF. Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature 435: 502-506, 2005.
3. Cowley AW Jr, Roman RJ. The role of the kidney in hypertension. JAMA 275: 1581-1589, 1996.
4. Cowley AW Jr. The genetic dissection of essential hypertension. Nat Rev Genet 7: 829-840, 2006.
5. Dahl LK, Heine M, Thompson K. Genetic influence of the kidneys on blood pressure. Evidence from chronic renal homografts in rats with opposite predispositions to hypertension. Circ Res 40: 94-101, 1974.
6. Dahly AJ, Hoagland KM, Flasch AK, Jha S, Ledbetter SR, Roman RJ. Antihypertensive effects of chronic anti-TGF-antibody therapy in Dahl S rats. Am J Physiol Regul Integr Comp Physiol 283: R757-R767, 2002.
7. Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr. Increased expression of NAD(P)H oxidase subunit p67phox in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Cell Metab 15: 201-208, 2012.
8. Garrett MR, Dene H, Rapp JP. Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. J Am Soc Nephrol 14: 1175-1187, 2003.
9. Haque MZ, Ares GR, Caceres PS, Ortiz PA. High salt differentially regulates surface NKCC2 expression in thick ascending limbs of Dahl salt-sensitive and salt-resistant rats. Am J Physiol Renal Physiol 300: F1096-F1104, 2011.
10. He W, Miao FJ, Lin DC, Schwandner RT, Wang Z, Gao J, Chen JL, Tian H, Ling L. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature 429: 188-193, 2004.
11. Johnson RJ, Gordon KL, Giachelli C, Kurth T, Skelton MM, Cowley AW Jr. Tubulointerstitial injury and loss of nitric oxide synthases parallel the development of hypertension in the Dahl-SS rat. J Hypertens 18: 1497-505, 2000.
12. Kumarasamy S, Gopalakrishnan K, Abdul-Majeed S, Partow-Navid R, Farms P, Joe B. Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria. Am J Physiol Heart Circ Physiol 304: H22-H32, 2013.
13. Liang M. Hypertension as a mitochondrial and metabolic disease. Kidney Int 80: 15-16, 2011.
14. Liesa M, Palacín M, Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev 89: 799-845, 2009.
15. Lu L, Li P, Yang C, Kurth T, Misale M, Skelton M, Moreno C, Roman RJ, Greene AS, Jacob HJ, Lazar J, Liang M, Cowley AW Jr. Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol Genomics 41: 63-70, 2010.
16. Mori T, Polichnowski A, Glocka P, Kaldunski M, Ohsaki Y, Liang M, Cowley AW Jr. High perfusion pressure accelerates renal injury in salt-sensitive hypertension. J Am Soc Nephrol 19: 1472-1482, 2008.
17. Peti-Peterdi J, Gevorgyan H, Lam L, Riquier-Brison A. Metabolic control of renin secretion. Pflügers Arch 465: 53-58, 2013.
18. Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo. Mol Biol Cell 22: 256-265, 2011.
19. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev 80: 135-172, 2000.
20. Roman RJ. Abnormal renal hemodynamics and pressure-natriuresis relationship in Dahl salt-sensitive rats. Am J Physiol Renal Fluid Electrolyte Physiol 251: F57-F65, 1986.
21. Taylor NE, Glocka P, Liang M, Cowley AW Jr. NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S rats. Hypertension 47: 692-698, 2006.
22. Tian Z, Greene AS, Usa K, Matus IR, Bauwens J, Pietrusz JL, Cowley AW Jr, Liang M. Renal regional proteomes in young Dahl salt-sensitive rats. Hypertension 51: 899-904, 2008.
23. Tian Z, Liu Y, Usa K, Mladinov D, Fang Y, Ding X, Greene AS, Cowley AW Jr, Liang M. Novel role of fumarate metabolism in dahl-salt sensitive hypertension. Hypertension 54: 255-260, 2009.
24. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664, 2005.
25. Yang C, Stingo FC, Ahn KW, Liu P, Vannucci M, Laud PW, Skelton M, O'Connor P, Kurth T, Ryan RP, Moreno C, Tsaih SW, Patone G, Hummel O, Jacob HJ, Liang M, Cowley AW Jr. Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat. Hypertension 61: 208-215, 2013.
26. Young CN, Cao X, Guruju MR, Pierce JP, Morgan DA, Wang G, Iadecola C, Mark AL, Davisson RL. ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. J Clin Invest 122: 3960-3964, 2012.
27. Zheleznova NN, Yang C, Ryan RP, Halligan BD, Liang M, Greene AS, Cowley AW Jr. Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick ascending limb of Henle in the Dahl salt-sensitive rat. Physiol Genomics 44: 829-842, 2012.