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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 12, 2014, Pages 2685-2688

α-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists

(12) Kim, Ho Shin a Jin, Mi Kyoung a Kang, Sang Uk a Lim, Ju Ok a Tran, Phuong Thao a Hoang, Van Hai a Ann, Jihyae a Ha, Tae Hwan a Pearce, Larry V b Pavlyukovets, Vladimir A b Blumberg, Peter M b Lee, Jeewoo a

a Seoul National University (South Korea)

b NATIONAL CANCER INSTITUTE (United States)

Author keywords

Capsaicin; Resiniferatoxin; TRPV1 antagonist; Vanilloid receptor 1

Indexed keywords

METHYL GROUP; RESINIFERATOXIN; SIMPLIFIED RESINIFERATOXIN THIOUREA DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; DITERPENE; PROTEIN BINDING; THIOUREA; VANILLOID RECEPTOR; RESINIFERATOXIN THIOURE DERIVATIVE;

ALPHA METHYLATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHIRALITY; CHO CELL LINE; DRUG BINDING; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; METHYLATION; NONHUMAN; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CRICETULUS; DRUG EFFECTS; HAMSTER; RAT; STEREOISOMERISM; SYNTHESIS; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; EC50;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DITERPENES; HUMANS; METHYLATION; MOLECULAR STRUCTURE; PROTEIN BINDING; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TRPV CATION CHANNELS;

EID: 84900811725 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.04.054 Document Type: Article

Times cited : (6)

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