Synthesis, in vitro antimicrobial and cytotoxic activities of novel pyrimidine-benzimidazol combinations

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 12, 2014, Pages 2741-2743

  Chen, Peng Ju ^a   Yang, Ang ^a   Gu, Yi Fei ^a   Zhang, Xiao Song ^a   Shao, Kun Peng ^a   Xue, Deng Qi ^a   He, Peng ^a   Jiang, Teng Fei ^a   Zhang, Qiu Rong ^a   Liu, Hong Min ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Antimicrobial; Benzimidazole; Cytotoxic activities; Pyrimidine; Synthesis

Indexed keywords

ANTIINFECTIVE AGENT; BENZIMIDAZOLE DERIVATIVE; CYTOTOXIC AGENT; FLUCONAZOLE; FLUOROURACIL; LEVOFLOXACIN; PYRIMIDINE DERIVATIVE; 2 [[(1H BENZO[D]IMIDAZOL 2 YL)METHYL]THIO] 6 METHYLPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; PYRIMIDINE;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANCER CELL LINE; CANDIDA ALBICANS; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; STRUCTURE ACTIVITY RELATION; DRUG CYTOTOXICITY; DRUG DESIGN; BACTERIUM; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG EFFECTS; IC50; MICROBIAL SENSITIVITY TEST; SYNTHESIS; TUMOR CELL LINE;

STENOTROPHOMONAS MALTOPHILIA;

ANTI-INFECTIVE AGENTS; BACTERIA; BENZIMIDAZOLES; CANDIDA ALBICANS; CELL LINE, TUMOR; CELL SURVIVAL; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIMIDINES;

EID: 84900790886     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.037     Document Type: Article

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