The repressive effect of miR-148a on TGF beta-SMADs signal pathway is involved in the glabridin-induced inhibition of the cancer stem cells-like properties in hepatocellular carcinoma cells

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Jiang, Fei ^a   Mu, Juan ^a   Wang, Xingxing ^a   Ye, Xianqing ^a   Si, Lu ^a   Ning, Shilong ^a   Li, Zhong ^a   Li, Yuan ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLABRIDIN; MICRORNA; MICRORNA 148A; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ISOFLAVONE DERIVATIVE; MIRN148 MICRORNA, HUMAN; PHENOL DERIVATIVE;

3' UNTRANSLATED REGION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER STEM CELL; CD44 GENE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; EPCAM GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; ONCOGENE; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; CARCINOGENESIS; CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARCINOGENESIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOFLAVONES; LIVER NEOPLASMS; MICRORNAS; NEOPLASTIC STEM CELLS; PHENOLS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84900563675     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096698     Document Type: Article

References (36)

1. Tsochatzis EA, Meyer T, Burroughs AK (2012) Hepatocellular carcinoma. N Engl J Med 366: 92; author reply 92-93.
2. Eaves CJ (2008) Cancer stem cells: Here, there, everywhere? Nature 456: 581-582.
3. Kim HM, Haraguchi N, Ishii H, Ohkuma M, Okano M, et al. (2012) Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon. Ann Surg Oncol 19 Suppl 3: S539-548.
4. Vaya J, Belinky PA, Aviram M (1997) Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Radic Biol Med 23: 302-313. (Pubitemid 27276611)
5. Kwon HS, Oh SM, Kim JK (2008) Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. Clin Exp Immunol 151: 165-173.
6. Kang JS, Yoon YD, Cho IJ, Han MH, Lee CW, et al. (2005) Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. J Pharmacol Exp Ther 312: 1187-1194.
7. Yu XQ, Xue CC, Zhou ZW, Li CG, Du YM, et al. (2008) In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sci 82: 68-78. (Pubitemid 350251394)
8. Tamir S, Eizenberg M, Somjen D, Stern N, Shelach R, et al. (2000) Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Cancer Res 60: 5704-5709.
9. Hsu YL, Wu LY, Hou MF, Tsai EM, Lee JN, et al. (2011) Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. Mol Nutr Food Res 55: 318-327.
10. Cohen MM, Jr. (2003) TGF beta/Smad signaling system and its pathologic correlates. Am J Med Genet A 116A: 1-10.
11. Inagaki Y, Okazaki I (2007) Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis. Gut 56: 284-292.
12. Vittal R, Fan L, Greenspan DS, Mickler EA, Gopalakrishnan B, et al. (2013) IL-17 induces type V collagen overexpression and EMT via TGF-beta-dependent pathways in obliterative bronchiolitis. Am J Physiol Lung Cell Mol Physiol 304: L401-414.
13. Jia Q, Zhang X, Deng T, Gao J (2013) Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90(+)CD133(+) liver cancer stem cells. Cell Reprogram 15: 143-150.
14. Bueno L, de Alwis DP, Pitou C, Yingling J, Lahn M, et al. (2008) Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice. Eur J Cancer 44: 142-150. (Pubitemid 350256941)
15. Zhong Z, Carroll KD, Policarpio D, Osborn C, Gregory M, et al. (2010) Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells. Clin Cancer Res 16: 1191-1205.
16. Bhola NE, Balko JM, Dugger TC, Kuba MG, Sanchez V, et al. (2013) TGF-beta inhibition enhances chemotherapy action against triple-negative breast cancer. J Clin Invest 123: 1348-1358.
17. Ji J, Wang XW (2012) Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Semin Oncol 39: 461-472.
18. Yamashita T, Honda M, Nakamoto Y, Baba M, Nio K, et al. (2013) Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma. Hepatology 57: 1484-1497.
19. Song YJ, Zhang SS, Guo XL, Sun K, Han ZP, et al. (2013) Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment. Cancer Lett 339: 70-81.
20. Liu W, Feng JQ, Shen XM, Wang HY, Liu Y, et al. (2012) Two stem cell markers, ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1, predict the transformation of oral leukoplakia to cancer: a long-term follow-up study. Cancer 118: 1693-1700.
21. Koleske AJ, Baltimore D, Lisanti MP (1995) Reduction of caveolin and caveolae in oncogenically transformed cells. Proc Natl Acad Sci U S A 92: 1381-1385.
22. Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, et al. (2008) Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A 105: 2445-2450. (Pubitemid 351520533)
23. Brandl M, Seidler B, Haller F, Adamski J, Schmid RM, et al. (2010) IKKa controls canonical TGFb-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells. J Cell Sci 123: 4231-4239.
24. Yan H, Dong X, Zhong X, Ye J, Zhou Y, et al. (2013) Inhibitions of epithelial to mesenchymal transition and cancer stem cells-like properties are involved in miR-148a-mediated anti-metastasis of hepatocellular carcinoma. Mol Carcinog.
25. + parenchymal cells in the liver: Histology and culture. World J Gastroenterol 15: 4896-4906.
26. Uchida Y, Tanaka S, Aihara A, Adikrisna R, Yoshitake K, et al. (2010) Analogy between sphere forming ability and stemness of human hepatoma cells. Oncology Reports 24: 1147-1151.
27. Yao CJ, Yeh CT, Lee LM, Chuang SE, Yeh CF, et al. (2012) Elimination of Cancer Stem-Like "Side Population" Cells in Hepatoma Cell Lines by Chinese HerbalMixture "Tien-Hsien Liquid". Evidence-Based Complementary and Alternative Medicine: epub ahead of print.
28. Veratti E, Rossi T, Giudice S, Benassi L, Bertazzoni G, et al. (2011) 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. Anticancer Res 31: 2209-2215.
29. Tsai YM, Yang CJ, Hsu YL, Wu LY, Tsai YC, et al. (2011) Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway. Integr Cancer Ther 10: 341-349.
30. Nabekura T, Yamaki T, Ueno K, Kitagawa S (2008) Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. Cancer Chemother Pharmacol 62: 867-873.
31. Wu K, Ding J, Chen C, Sun W, Ning BF, et al. (2012) Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology 56: 2255-2267.
32. Augello C, Vaira V, Caruso L, Destro A, Maggioni M, et al. (2012) MicroRNA profiling of hepatocarcinogenesis identifies C19MC cluster as a novel prognostic biomarker in hepatocellular carcinoma. Liver Int 32: 772-782.
33. Liu WH, Tao KS, You N, Liu ZC, Zhang HT, et al. (2011) Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells. PLoS One 6: e23311.
34. Zhang H, Li Y, Huang Q, Ren X, Hu H, et al. (2011) MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. Cell Death Differ 18: 1702-1710.
35. Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, et al. (2008) Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 47: 897-907. (Pubitemid 351449681)
36. Takagi S, Nakajima M, Mohri T, Yokoi T (2008) Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J Biol Chem 283: 9674-9680.