Analogy between sphere forming ability and stemness of human hepatoma cells

Oncology Reports

Volumn 24, Issue 5, 2010, Pages 1147-1151

  Uchida, Yusuke ^a,b   Tanaka, Shinji ^a   Aihara, Arihiro ^a   Adikrisna, Rama ^a   Yoshitake, Kenichirou ^a   Matsumura, Satoshi ^a   Mitsunori, Yusuke ^a   Murakata, Ayano ^a   Noguchi, Norio ^a   Irie, Takumi ^a   Kudo, Atsushi ^a   Nakamura, Noriaki ^a   Lai, Paul B ^c   Arii, Shigeki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cancer stem cells; Chemoresistance; Hepatoma; p21; p27; Sphere

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CD133 ANTIGEN; CISPLATIN; EPITHELIAL CELL ADHESION MOLECULE; HERMES ANTIGEN; PROTEIN P27; THY 1 ANTIGEN;

ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CELL ACTIVITY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL FUNCTION; CONTROLLED STUDY; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

CARCINOMA, HEPATOCELLULAR; CELL GROWTH PROCESSES; CELL LINE, TUMOR; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPHENOTYPING; LIVER NEOPLASMS; NEOPLASTIC STEM CELLS; SPHEROIDS, CELLULAR; TRANSFECTION;

EID: 78149289037     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000966     Document Type: Article

References (29)

1. Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer and cancer stem cells. Nature 414: 105-111, 2001.
2. Chiba T, Kita K, Zheng Y-W, et al: Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 44: 240-251, 2006.
3. Kamohara Y, Haraguchi N, Mimori K, et al: The search for cancer stem cells in hepatocellular carcinoma. Surgery 144: 119-124, 2008.
4. Vermeulen L, Sprick MR, Kemper K, et al: Cancer stem cells-old concepts, new insights. Cell Death Differ 15: 947-958, 2008.
5. Dontu G, Abdallah WM, Foley JM, et al: In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17: 1253-1270, 2003.
6. Mani SA, Guo W, Liao MJ, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715, 2008.
7. Cicalese A, Bonizzi G, Pasi CE, et al: The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 138: 1083-1095, 2009.
8. + cancer stem cells in human liver cancer. Cancer Cell 13: 153-166, 2008.
9. Yang ZF, Ngai P, Ho DW, et al: Identification of local and circulating cancer stem cells in human liver cancer. Hepatology 47: 919-928, 2008. (Pubitemid 351449683)
10. Ma S, Lee TK, Zheng B-J, et al: CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/ PKB survival pathway. Oncogene 27: 1749-1758, 2008.
11. Yin S, Li J, Hu C, et al: CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer 120: 1444-1450, 2007.
12. Yamashita T, Ji J, Budhu A, et al: EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/ progenitor cell features. Gastroenterology 136: 1012-1024, 2009.
13. Zen Y, Fujii T, Yoshikawa S, et al: Histological and culture studies with respect to ABCG2 expression support the existence of a cancer cell hierarchy in human hepatocellular carcinoma. Am J Pathol 170: 1750-1762, 2007.
14. Zhu Z, Hao X, Yan M, et al: Cancer stem/progenitor cells are highly enriched in CD133(+) CD44(+) population in hepatocellular carcinoma. Int J Cancer 126: 2067-2078, 2010.
15. Aihara A, Tanaka S, Yasen M, et al: The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma. J Hepatol 52: 63-71, 2010.
16. Chi TY, Chen GG, Ho LK, et al: Establishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cells. Cancer Cell Int 5: 27, 2005.
17. Yamashita Y, Shimada M, Harimoto N, et al: cDNA microarray analysis in hepatocytes differentiation in Huh 7 cells. Cell Transplant 13: 793-799, 2004.
18. Sherr CJ and Roberts JM: CDK ihibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512, 1999.
19. Besson A, Dowdy SF and Roberts JM: CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14: 159-169, 2008.
20. Xing H, Wang S, Hu K, et al: Effect of the cyclin-dependent kinases inhibitor p27 on resistance of ovarian cancer multicellular spheroids to anticancer chemotherapy. J Cancer Res Clin Oncol 131: 511-519, 2005.
21. LaRue KEA, Khalil M and Freyer JP: Microenviromental regulation of proliferation in multicellular spheroids is mediated through differential expression of cyclin-dependent kinase inhibitors. Cancer Res 64: 1621-1631, 2004.
22. Leek RD, Stratford I and Harris AL: The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis and regulation by the insulin-signaling pathway. Cancer Res 65: 4147-4152, 2005.
23. WAF1 control of epithelial cell cycle and cell fate. Crit Rev Oral Biol Med 13: 453-464, 2002.
24. Coqueret O: New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol 13: 65-70, 2003.
25. Ito Y, Matsuura N, Sakon M, et al: Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence. Hepatology 30: 90-99, 1999.
26. Tannapfel A, Grund D, Katalinic A, et al: Decreased expression of p27 protein is associated with advanced tumor stage in hepatocellular carcinoma. Int J Cancer 89: 350-355, 2000.
27. Chu IM, Hengst L and Slingerland JM: The CDK inhibitor p27 in human cacner: prognostic potential and relevance to anti-cancer therapy. Nat Rev Cancer 8: 253-267, 2008.
28. Hong H, Takahashi K, Ichisaka T, et al: Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460: 1132-1135, 2009.
29. Kawamura T, Suzuki J, Wang YV, et al: Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460: 1140-1144, 2009.