GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1

American Journal of Physiology - Endocrinology and Metabolism

Volumn 306, Issue 10, 2014, Pages

  Tie, Lu ^b   Chen, Lu Yuan ^c   Chen, Dan Dan ^a   Xie, He Hui ^a   Channon, Keith M ^d   Chen, Alex F ^a  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Diabetes; Endothelial progenitor cells; Guanosine triphosphate cyclohydrolase I; Oxidative stress; Wound healing

Indexed keywords

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; NITRIC OXIDE; SUPEROXIDE; THROMBOSPONDIN 1; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BONE MARROW; CELL COUNT; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION; WOUND CLOSURE; WOUND HEALING;

DIABETES; ENDOTHELIAL PROGENITOR CELLS; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; OXIDATIVE STRESS; WOUND HEALING;

ANIMALS; BIOPTERIN; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DOWN-REGULATION; ENDOTHELIAL CELLS; GTP CYCLOHYDROLASE; HEMATOPOIETIC STEM CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXIDATIVE STRESS; THROMBOSPONDIN 1; WOUND HEALING;

EID: 84900560149     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00696.2013     Document Type: Article

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