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Volumn 70, Issue 6, 2011, Pages 528-536

Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence

Author keywords

CHRNA4; deep sequencing; imaging genetics; nicotine dependence; nonsynonymous; rare variants

Indexed keywords

NICOTINIC RECEPTOR ALPHA4;

EID: 80051998030     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.04.017     Document Type: Article
Times cited : (54)

References (49)
  • 2
    • 68349133597 scopus 로고    scopus 로고
    • Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction
    • A.P. Govind, P. Vezina, and W.N. Green Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction Biochem Pharmacol 78 2009 756 765
    • (2009) Biochem Pharmacol , vol.78 , pp. 756-765
    • Govind, A.P.1    Vezina, P.2    Green, W.N.3
  • 3
    • 0026593533 scopus 로고
    • A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment
    • C.M. Flores, S.W. Rogers, L.A. Pabreza, B.B. Wolfe, and K.J. Kellar A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment Mol Pharmacol 41 1992 31 37
    • (1992) Mol Pharmacol , vol.41 , pp. 31-37
    • Flores, C.M.1    Rogers, S.W.2    Pabreza, L.A.3    Wolfe, B.B.4    Kellar, K.J.5
  • 4
    • 0027991930 scopus 로고
    • Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area
    • DOI 10.1016/0006-8993(94)90401-4
    • W.A. Corrigall, K.M. Coen, and K.L. Adamson Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area Brain Res 653 1994 278 284 (Pubitemid 24252850)
    • (1994) Brain Research , vol.653 , Issue.1-2 , pp. 278-284
    • Corrigall, W.A.1    Coen, K.M.2    Adamson, K.L.3
  • 5
    • 0032495515 scopus 로고    scopus 로고
    • Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
    • DOI 10.1038/34413
    • M.R. Picciotto, M. Zoli, R. Rimondini, C. Lena, L.M. Marubio, and E.M. Pich Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine Nature 391 1998 173 177 (Pubitemid 28092475)
    • (1998) Nature , vol.391 , Issue.6663 , pp. 173-177
    • Picciotto, M.R.1    Zoli, M.2    Rimondini, R.3    Lena, C.4    Marubio, L.M.5    Pich, E.M.6    Fuxe, K.7    Changeux, J.-P.8
  • 6
    • 0037275136 scopus 로고    scopus 로고
    • Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area
    • DOI 10.1038/sj.mp.4001197
    • S.R. Laviolette, and D. van der Kooy Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area Mol Psychiatry 8 2003 50 59 (Pubitemid 36188573)
    • (2003) Molecular Psychiatry , vol.8 , Issue.1 , pp. 50-59
    • Laviolette, S.R.1    Van Der Kooy, D.2
  • 7
    • 0028031691 scopus 로고
    • Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
    • DOI 10.1002/syn.890160105
    • M. Nisell, G.G. Nomikos, and T.H. Svensson Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area Synapse 16 1994 36 44 (Pubitemid 24013237)
    • (1994) Synapse , vol.16 , Issue.1 , pp. 36-44
    • Nisell, M.1    Nomikos, G.G.2    Svensson, T.H.3
  • 10
    • 33745611449 scopus 로고    scopus 로고
    • Efficacy of varenicline, an α 4 β 2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: A randomized controlled trial
    • D.E. Jorenby, J.T. Hays, N.A. Rigotti, S. Azoulay, E.J. Watsky, and K.E. Williams Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: A randomized controlled trial JAMA 296 2006 56 63
    • (2006) JAMA , vol.296 , pp. 56-63
    • Jorenby, D.E.1    Hays, J.T.2    Rigotti, N.A.3    Azoulay, S.4    Watsky, E.J.5    Williams, K.E.6
  • 11
    • 77951751034 scopus 로고    scopus 로고
    • Meta-analysis and imputation refines the association of 15q25 with smoking quantity
    • J.Z. Liu, F. Tozzi, D.M. Waterworth, S.G. Pillai, P. Muglia, and L. Middleton Meta-analysis and imputation refines the association of 15q25 with smoking quantity Nat Genet 42 2010 436 440
    • (2010) Nat Genet , vol.42 , pp. 436-440
    • Liu, J.Z.1    Tozzi, F.2    Waterworth, D.M.3    Pillai, S.G.4    Muglia, P.5    Middleton, L.6
  • 13
    • 77951711343 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify multiple loci associated with smoking behavior
    • Consortium TAG
    • Consortium TAG Genome-wide meta-analyses identify multiple loci associated with smoking behavior Nature genetics 42 2010 441 447
    • (2010) Nature Genetics , vol.42 , pp. 441-447
  • 14
    • 18144427933 scopus 로고    scopus 로고
    • Ethnic-and gender-specific association of the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) with nicotine dependence
    • DOI 10.1093/hmg/ddi132
    • M.D. Li, J. Beuten, J.Z. Ma, T.J. Payne, X.Y. Lou, and V. Garcia Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence Hum Mol Genet 14 2005 1211 1219 (Pubitemid 40613909)
    • (2005) Human Molecular Genetics , vol.14 , Issue.9 , pp. 1211-1219
    • Li, M.D.1    Beuten, J.2    Ma, J.Z.3    Payne, T.J.4    Lou, X.-Y.5    Garcia, V.6    Duenes, A.S.7    Crews, K.M.8    Elston, R.C.9
  • 15
    • 3042635325 scopus 로고    scopus 로고
    • A common haplotype of the nicotine acetylcholine receptor α4 subunit gene is associated with vulnerability to nicotine addiction in men
    • DOI 10.1086/422194
    • Y. Feng, T. Niu, H. Xing, X. Xu, C. Chen, and S. Peng A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men Am J Hum Genet 75 2004 112 121 (Pubitemid 38801907)
    • (2004) American Journal of Human Genetics , vol.75 , Issue.1 , pp. 112-121
    • Feng, Y.1    Niu, T.2    Xing, H.3    Xu, X.4    Chen, C.5    Peng, S.6    Wang, L.7    Laird, N.8    Xu, X.9
  • 16
    • 67849084986 scopus 로고    scopus 로고
    • Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans
    • L.P. Breitling, N. Dahmen, K. Mittelstrass, D. Rujescu, J. Gallinat, and C. Fehr Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans Pharmacogenomics J 9 2009 219 224
    • (2009) Pharmacogenomics J , vol.9 , pp. 219-224
    • Breitling, L.P.1    Dahmen, N.2    Mittelstrass, K.3    Rujescu, D.4    Gallinat, J.5    Fehr, C.6
  • 17
    • 78649627035 scopus 로고    scopus 로고
    • Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans
    • N.L. Saccone, T.H. Schwantes-An, J.C. Wang, R.A. Grucza, N. Breslau, and D. Hatsukami Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans Genes Brain Behav 9 2010 741 750
    • (2010) Genes Brain Behav , vol.9 , pp. 741-750
    • Saccone, N.L.1    Schwantes-An, T.H.2    Wang, J.C.3    Grucza, R.A.4    Breslau, N.5    Hatsukami, D.6
  • 19
    • 50849131997 scopus 로고    scopus 로고
    • Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence
    • M.D. Li, X.Y. Lou, G. Chen, J.Z. Ma, and R.C. Elston Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence Biol Psychiatry 64 2008 951 957
    • (2008) Biol Psychiatry , vol.64 , pp. 951-957
    • Li, M.D.1    Lou, X.Y.2    Chen, G.3    Ma, J.Z.4    Elston, R.C.5
  • 21
    • 71349087317 scopus 로고    scopus 로고
    • Meta-analysis of 15 genome-wide linkage scans of smoking behavior
    • S. Han, J. Gelernter, X. Luo, and B.Z. Yang Meta-analysis of 15 genome-wide linkage scans of smoking behavior Biol Psychiatry 67 2010 12 19
    • (2010) Biol Psychiatry , vol.67 , pp. 12-19
    • Han, S.1    Gelernter, J.2    Luo, X.3    Yang, B.Z.4
  • 22
    • 77951702343 scopus 로고    scopus 로고
    • Genetic heterogeneity in human disease
    • J. McClellan, and M.C. King Genetic heterogeneity in human disease Cell 141 2010 210 217
    • (2010) Cell , vol.141 , pp. 210-217
    • McClellan, J.1    King, M.C.2
  • 23
    • 71449105010 scopus 로고    scopus 로고
    • A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression
    • H.M. Knight, B.S. Pickard, A. Maclean, M.P. Malloy, D.C. Soares, and A.F. McRae A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression Am J Hum Genet 85 2009 833 846
    • (2009) Am J Hum Genet , vol.85 , pp. 833-846
    • Knight, H.M.1    Pickard, B.S.2    MacLean, A.3    Malloy, M.P.4    Soares, D.C.5    McRae, A.F.6
  • 25
    • 66449133837 scopus 로고    scopus 로고
    • Beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking
    • K.P. Cosgrove, J. Batis, F. Bois, P.K. Maciejewski, I. Esterlis, and T. Kloczynski beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking Arch Gen Psychiatry 66 2009 666 676
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 666-676
    • Cosgrove, K.P.1    Batis, J.2    Bois, F.3    MacIejewski, P.K.4    Esterlis, I.5    Kloczynski, T.6
  • 26
    • 57849147116 scopus 로고    scopus 로고
    • Dense genomewide linkage scan for alcohol dependence in African Americans: Significant linkage on chromosome 10
    • J. Gelernter, H.R. Kranzler, C. Panhuysen, R.D. Weiss, K. Brady, and J. Poling Dense genomewide linkage scan for alcohol dependence in African Americans: Significant linkage on chromosome 10 Biol Psychiatry 65 2009 111 115
    • (2009) Biol Psychiatry , vol.65 , pp. 111-115
    • Gelernter, J.1    Kranzler, H.R.2    Panhuysen, C.3    Weiss, R.D.4    Brady, K.5    Poling, J.6
  • 29
    • 34548606229 scopus 로고    scopus 로고
    • Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA)
    • DOI 10.1016/j.drugalcdep.2007.04.014, PII S0376871607001974
    • A. Pierucci-Lagha, J. Gelernter, G. Chan, A. Arias, J.F. Cubells, and L. Farrer Reliability of DSM-IV diagnostic criteria using the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Drug Alcohol Depend 91 2007 85 90 (Pubitemid 47398866)
    • (2007) Drug and Alcohol Dependence , vol.91 , Issue.1 , pp. 85-90
    • Pierucci-Lagha, A.1    Gelernter, J.2    Chan, G.3    Arias, A.4    Cubells, J.F.5    Farrer, L.6    Kranzler, H.R.7
  • 30
    • 0034118493 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data
    • J.K. Pritchard, M. Stephens, and P. Donnelly Inference of population structure using multilocus genotype data Genetics 155 2000 945 959 (Pubitemid 30397141)
    • (2000) Genetics , vol.155 , Issue.2 , pp. 945-959
    • Pritchard, J.K.1    Stephens, M.2    Donnelly, P.3
  • 31
    • 0033358548 scopus 로고    scopus 로고
    • Use of unlinked genetic markers to detect population stratification in association studies
    • DOI 10.1086/302449
    • J.K. Pritchard, and N.A. Rosenberg Use of unlinked genetic markers to detect population stratification in association studies Am J Hum Genet 65 1999 220 228 (Pubitemid 30470467)
    • (1999) American Journal of Human Genetics , vol.65 , Issue.1 , pp. 220-228
    • Pritchard, J.K.1    Rosenberg, N.A.2
  • 32
    • 0041817568 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies
    • D. Falush, M. Stephens, and J.K. Pritchard Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies Genetics 164 2003 1567 1587 (Pubitemid 37102217)
    • (2003) Genetics , vol.164 , Issue.4 , pp. 1567-1587
    • Falush, D.1    Stephens, M.2    Pritchard, J.K.3
  • 33
    • 17644416423 scopus 로고    scopus 로고
    • Practical population group assignment with selected informative markers: Characteristics and properties of Bayesian clustering via STRUCTURE
    • DOI 10.1002/gepi.20070
    • B.Z. Yang, H. Zhao, H.R. Kranzler, and J. Gelernter Practical population group assignment with selected informative markers: Characteristics and properties of Bayesian clustering via STRUCTURE Genet Epidemiol 28 2005 302 312 (Pubitemid 40559543)
    • (2005) Genetic Epidemiology , vol.28 , Issue.4 , pp. 302-312
    • Yang, B.-Z.1    Zhao, H.2    Kranzier, H.R.3    Gelernter, J.4
  • 34
    • 70350647033 scopus 로고    scopus 로고
    • Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations
    • P. Xie, H.R. Kranzler, J. Poling, M.B. Stein, R.F. Anton, and K. Brady Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations Arch Gen Psychiatry 66 2009 1201 1209
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 1201-1209
    • Xie, P.1    Kranzler, H.R.2    Poling, J.3    Stein, M.B.4    Anton, R.F.5    Brady, K.6
  • 35
    • 77955801615 scopus 로고    scopus 로고
    • Galaxy: A comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences
    • Galaxy Team
    • J. Goecks, A. Nekrutenko, J. Taylor Galaxy Team Galaxy: A comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences Genome Biol 11 2010 R86
    • (2010) Genome Biol , vol.11 , pp. 86
    • Goecks, J.1    Nekrutenko, A.2    Taylor, J.3
  • 36
    • 61449168010 scopus 로고    scopus 로고
    • A groupwise association test for rare mutations using a weighted sum statistic
    • B.E. Madsen, and S.R. Browning A groupwise association test for rare mutations using a weighted sum statistic PLoS Genet 5 2009 e1000384
    • (2009) PLoS Genet , vol.5 , pp. 1000384
    • Madsen, B.E.1    Browning, S.R.2
  • 37
    • 0036713510 scopus 로고    scopus 로고
    • Human non-synonymous SNPs: Server and survey
    • V. Ramensky, P. Bork, and S. Sunyaev Human non-synonymous SNPs: Server and survey Nucleic Acids Res 30 2002 3894 3900 (Pubitemid 35012462)
    • (2002) Nucleic Acids Research , vol.30 , Issue.17 , pp. 3894-3900
    • Ramensky, V.1    Bork, P.2    Sunyaev, S.3
  • 39
    • 0032198234 scopus 로고    scopus 로고
    • The long internal loop of the alpha 3 subunit targets nAChRs to subdomains within individual synapses on neurons in vivo
    • B.M. Williams, M.K. Temburni, M.S. Levey, S. Bertrand, D. Bertrand, and M.H. Jacob The long internal loop of the alpha 3 subunit targets nAChRs to subdomains within individual synapses on neurons in vivo Nat Neurosci 1 1998 557 562
    • (1998) Nat Neurosci , vol.1 , pp. 557-562
    • Williams, B.M.1    Temburni, M.K.2    Levey, M.S.3    Bertrand, S.4    Bertrand, D.5    Jacob, M.H.6
  • 41
    • 0035958852 scopus 로고    scopus 로고
    • The chaperone protein 14-3-3eta interacts with the nicotinic acetylcholine receptor alpha 4 subunit Evidence for a dynamic role in subunit stabilization
    • E.M. Jeanclos, L. Lin, M.W. Treuil, J. Rao, M.A. DeCoster, and R. Anand The chaperone protein 14-3-3eta interacts with the nicotinic acetylcholine receptor alpha 4 subunit Evidence for a dynamic role in subunit stabilization J Biol Chem 276 2001 28281 28290
    • (2001) J Biol Chem , vol.276 , pp. 28281-28290
    • Jeanclos, E.M.1    Lin, L.2    Treuil, M.W.3    Rao, J.4    Decoster, M.A.5    Anand, R.6
  • 42
    • 34848915528 scopus 로고    scopus 로고
    • Cyclic AMP-dependent protein kinase (PKA) phosphorylates Ser362 and 467 and protein kinase C phosphorylates Ser550 within the M3/M4 cytoplasmic domain of human nicotinic receptor α4 subunits
    • DOI 10.1111/j.1471-4159.2007.04853.x
    • V.V. Pollock, T.E. Pastoor, and L. Wecker Cyclic AMP-dependent protein kinase (PKA) phosphorylates Ser362 and 467 and protein kinase C phosphorylates Ser550 within the M3/M4 cytoplasmic domain of human nicotinic receptor alpha4 subunits J Neurochem 103 2007 456 466 (Pubitemid 47498046)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.2 , pp. 456-466
    • Pollock, V.V.1    Pastoor, T.E.2    Wecker, L.3
  • 43
    • 41149145063 scopus 로고    scopus 로고
    • It is not "either/or": Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
    • M.R. Picciotto, N.A. Addy, Y.S. Mineur, and D.H. Brunzell It is not "either/or": Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood Prog Neurobiol 84 2008 329 342
    • (2008) Prog Neurobiol , vol.84 , pp. 329-342
    • Picciotto, M.R.1    Addy, N.A.2    Mineur, Y.S.3    Brunzell, D.H.4
  • 44
    • 77958012303 scopus 로고    scopus 로고
    • Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström Test for Nicotine Dependence
    • J. Wessel, S.M. McDonald, D.A. Hinds, R.P. Stokowski, H.S. Javitz, and M. Kennemer Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström Test for Nicotine Dependence Neuropsychopharmacology 35 2010 2392 2402
    • (2010) Neuropsychopharmacology , vol.35 , pp. 2392-2402
    • Wessel, J.1    McDonald, S.M.2    Hinds, D.A.3    Stokowski, R.P.4    Javitz, H.S.5    Kennemer, M.6
  • 45
    • 50949095168 scopus 로고    scopus 로고
    • Methods for detecting associations with rare variants for common diseases: Application to analysis of sequence data
    • B. Li, and S.M. Leal Methods for detecting associations with rare variants for common diseases: Application to analysis of sequence data Am J Hum Genet 83 2008 311 321
    • (2008) Am J Hum Genet , vol.83 , pp. 311-321
    • Li, B.1    Leal, S.M.2
  • 46
    • 77954761157 scopus 로고    scopus 로고
    • Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes
    • R. Sherva, H.R. Kranzler, Y. Yu, M.W. Logue, J. Poling, and A.J. Arias Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes Neuropsychopharmacology 35 2010 1921 1931
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1921-1931
    • Sherva, R.1    Kranzler, H.R.2    Yu, Y.3    Logue, M.W.4    Poling, J.5    Arias, A.J.6
  • 47
    • 79952569929 scopus 로고    scopus 로고
    • TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood
    • F. Ducci, M. Kaakinen, A. Pouta, A.L. Hartikainen, J. Veijola, and M. Isohanni TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood Biol Psychiatry 69 2011 650 660
    • (2011) Biol Psychiatry , vol.69 , pp. 650-660
    • Ducci, F.1    Kaakinen, M.2    Pouta, A.3    Hartikainen, A.L.4    Veijola, J.5    Isohanni, M.6
  • 48
    • 33845364418 scopus 로고    scopus 로고
    • Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
    • DOI 10.1093/hmg/ddl426
    • J. Gelernter, Y. Yu, R. Weiss, K. Brady, C. Panhuysen, and B.Z. Yang Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations Hum Mol Genet 15 2006 3498 3507 (Pubitemid 44884117)
    • (2006) Human Molecular Genetics , vol.15 , Issue.24 , pp. 3498-3507
    • Gelernter, J.1    Yu, Y.2    Weiss, R.3    Brady, K.4    Panhuysen, C.5    Yang, B.-Z.6    Kranzler, H.R.7    Farrer, L.8
  • 49
    • 57849133597 scopus 로고    scopus 로고
    • Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample
    • W. Huang, T.J. Payne, J.Z. Ma, J. Beuten, R.T. Dupont, and N. Inohara Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample Neuropsychopharmacology 34 2009 319 330
    • (2009) Neuropsychopharmacology , vol.34 , pp. 319-330
    • Huang, W.1    Payne, T.J.2    Ma, J.Z.3    Beuten, J.4    Dupont, R.T.5    Inohara, N.6


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