Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 7, 2014, Pages

  Wang, JuFang ^a   Song, Jianliang ^a   Gao, Erhe ^a   Zhang, Xue Qian ^a   Gu, Tongda ^a   Yu, Daohai ^a   Koch, Walter J ^a   Feldman, Arthur M ^a   Cheung, Joseph Y ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

FXYD proteins; In vivo hemodynamics; Ischemic cardiomyopathy

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM CHANNEL L TYPE; CATECHOLAMINE; DOXYCYCLINE; ISOPRENALINE; PHOSPHOLEMMAN; PHOSPHOPROTEIN; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGER 1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FEMALE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; IN VIVO STUDY; INOTROPISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY;

FXYD PROTEINS; IN VIVO HEMODYNAMICS; INTRACELLULAR CA2+ REGULATION; ISCHEMIC CARDIOMYOPATHY;

ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PHOSPHOPROTEINS; RECOVERY OF FUNCTION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-CALCIUM EXCHANGER; SODIUM-POTASSIUM-EXCHANGING ATPASE; STROKE VOLUME; UP-REGULATION; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 84900539108     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00861.2013     Document Type: Article

References (49)

1. 2+ exchanger, phospholemman. J Biol Chem 280: 19875-19882, 2005.
2. Barnabei MS, Palpant NJ, Metzger JM. Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains. Physiol Genomics 42A: 103-113, 2010.
3. Barrick CJ, Rojas M, Schoonhoven R, Smyth SS, Threadgill DW. Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal-and background-dependent development of concentric left ventricular hypertrophy. Am J Physiol Heart Circ Physiol 292: H2119-H2130, 2007.
4. Bell JR, Kennington E, Fuller W, Dighe K, Donoghue P, Clark JE, Jia LG, Tucker AL, Moorman JR, Marber MS, Eaton P, Dunn MJ, Shattock MJ. Characterisation of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na/K ATPase activity. Am J Physiol Heart Circ Physiol 294: H613-H621, 2008.
5. Bers DM. Cardiac excitation-contraction coupling. Nature 415: 198-205, 2002.
6. Bibert S, Roy S, Schaer D, Horisberger JD, Geering K. Phosphorylation of phospholemman (FXYD1) by protein kinases A and C modulates distinct Na, K-ATPase isozymes. J Biol Chem 283: 476-486, 2008.
7. Bossuyt J, Ai X, Moorman JR, Pogwizd SM, Bers DM. Expression and phosphorylation of the Na-pump regulatory subunit phospholemman in heart failure. Circ Res 97: 558-565, 2005.
8. Bossuyt J, Despa S, Han F, Hou Z, Robia SL, Lingrel JB, Bers DM. Isoform-specificity of the Na/K-ATPase association and regulation by phospholemman. J Biol Chem 284: 26749-26757, 2009.
9. Cheung JY, Zhang XQ, Song J, Gao E, Rabinowitz JE, Chan TO, Wang J. Phospholemman: a novel cardiac stress protein. Clin Transl Sci 3: 189-196, 2010.
10. +-ATPase by pPhospholemman (FXYD1). Adv Exp Med Biol 961: 175-190, 2013.
11. Chu G, Ferguson DG, Edes I, Kiss E, Sato Y, Kranias EG. Phospholamban ablation and compensatory responses in the mammalian heart. Ann NY Acad Sci 853: 49-62, 1998.
12. Davis J, Maillet M, Miano JM, Molkentin JD. Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research. Circ Res 111: 761-777, 2012.
13. Despa S, Bossuyt J, Han F, Ginsburg KS, Jia LG, Kutchai H, Tucker AL, Bers DM. Phospholemman-phosphorylation mediates the β-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res 97: 252-259, 2005.
14. Despa S, Tucker A, Bers D. PLM-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during β-adrenergic stimulation in mouse ventricular myocytes. Circulation 117: 1849-1855, 2008.
15. Fuller W, Eaton P, Bell JR, Shattock MJ. Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. FASEB J 18: 197-199, 2004.
16. Fuller W, Howie J, McLatchie L, Weber R, Hastie CJ, Burness K, Pavlovic D, Shattock MJ. FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine69 is a novel substrate for protein kinase C. Am J Physiol Cell Physiol 296: C1346-C1355, 2009.
17. Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL, Koch WJ. A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res 107: 1445-1453, 2010.
18. Guo K, Wang X, Gao G, Huang C, Elmslie KS, Peterson BZ. Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels. Am J Physiol Cell Physiol 299: C1203-C1211, 2010.
19. Hasenfuss G. Alteration of calcium-regulatory proteins in heart failure. Cardiovasc Res 37: 279-289, 1998.
20. Hasenfuss G, Schillinger W. Is modulation of sodium-calcium exchange a therapeutic option in heart failure? Circ Res 95: 225-227, 2004.
21. 2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. J Clin Invest 100: 380-389, 1997.
22. Hobai IA, Maack C, O'Rourke B. Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure. Circ Res 95: 292-299, 2004.
23. Levesque PC, Hume JR. ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes. Cardiovasc Res 29: 336-343, 1995.
24. Li X, Mikhalkova D, Gao E, Zhang J, Myers V, Zincarelli C, Lei Y, Song J, Koch WJ, Peppel K, Cheung JY, Feldman AM, Chan TO. Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density. Am J Physiol Heart Circ Physiol 301: H1932-H1940, 2011.
25. 2+ exchange current in guinea pig, mouse and rat ventricular myocytes. Am J Physiol Cell Physiol 290: C601-C608, 2006.
26. 2+ load attributable to the predominance of forward mode block. Circ Res 102: 1398-1405, 2008.
27. Palmer CJ, Scott BT, Jones LR. Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium. J Biol Chem 266: 11126-11130, 1991.
28. Presti CF, Jones LR, Lindemann JP. Isoproterenol-induced phosphorylation of a 15-kilodalton sarcolemmal protein in intact myocardium. J Biol Chem 260: 3860-3867, 1985.
29. Rembold CM, Ripley ML, Meeks MK, Geddis LM, Kutchai HC, Marassi FM, Cheung JY, Moorman JR. Serine68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxation. J Vasc Res 42: 483-491, 2005.
30. Roos KP, Jordan MC, Fishbein MC, Ritter MR, Friedlander M, Chang HC, Rahgozar P, Han T, Garcia AJ, Maclellan WR, Ross RS, Philipson KD. Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger. J Cardiac Failure 13: 318-329, 2007.
31. Shah AP, Siedlecka U, Gandhi A, Navaratnarajah M, Al-Saud SA, Yacoub MH, Terracciano CM. Genetic background affects function and intracellular calcium regulation of mouse hearts. Cardiovasc Res 87: 683-693, 2010.
32. Sipido KR, Volders PGA, Vos MA, Verdonck F. Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovasc Res 53: 782-805, 2002.
33. 2+ exchanger. Am J Physiol Heart Circ Physiol 302: H770-H781, 2012.
34. 2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol 288: H2342-H2354, 2005.
35. 2+]i transients in adult rat myocytes. Am J Physiol Heart Circ Physiol 283: H576-H583, 2002.
36. +-ATPase. Am J Physiol Heart Circ Physiol 295: H1615-H1625, 2008.
37. 2+ exchange. Am J Physiol Heart Circ Physiol 291: H2199-H2209, 2006.
38. van den Borne SW, van de Schans VA, Strzelecka AE, Vervoort-Peters HT, Lijnen PM, Cleutjens JP, Smits JF, Daemen MJ, Janssen BJ, Blankesteijn WM. Mouse strain determines the outcome of wound healing after myocardial infarction. Cardiovasc Res 84: 273-282, 2009.
39. Waalas SI, Czernik AJ, Olstad OK, Sletten K, Walaas O. Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain. Biochem J 304: 635-640, 1994.
40. 2+ contents and action potential duration. Am J Physiol Heart Circ Physiol 297: H590-H601, 2009.
41. 2+ exchanger does not aggravate myocardial dysfunction induced by transverse aortic constriction. J Cardiac Failure 19: 60-70, 2013.
42. 2+ exchange. Am J Physiol Heart Circ Physiol 300: H859-H868, 2011.
43. Wang J, Gao E, Song J, Zhang XQ, Li J, Koch WJ, Tucker AL, Philipson KD, Chan TO, Feldman AM, Cheung JY. Phospholemman and β-adrenergic stimulation in the heart. Am J Physiol Heart Circ Physiol 298: H807-H815, 2010.
44. Wang X, Gao G, Guo K, Yarotskyy V, Huang C, Elmslie KS, Peterson BZ. Phospholemman modulates the gating of cardiac L-type calcium channels. Biophys J 98: 1149-1159, 2010.
45. 2+ exchanger. Role of phosphorylation. J Biol Chem 281: 7784-7792, 2006.
46. + pump activity in post-infarction myocytes. J Appl Physiol 100: 212-220, 2006.
47. Zhang XQ, Ng YC, Moore RL, Musch TI, Cheung JY. In situ SR function in postinfarction myocytes. J Appl Physiol 87: 2143-2150, 1999.
48. 2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol 284: H225-H233, 2003.
49. Zhou YY, Wang SQ, Zhu WZ, Chruscinski A, Kobilka BK, Ziman B, Wang S, Lakatta EG, Cheng H, Xiao RP. Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology. Am J Physiol Heart Circ Physiol 279: H429-H436, 2000.