Hypertrophy and Heart Failure in Mice Overexpressing the Cardiac Sodium-Calcium Exchanger

Journal of Cardiac Failure

Volumn 13, Issue 4, 2007, Pages 318-329

  Roos, Kenneth P ^a   Jordan, Maria C ^a   Fishbein, Michael C ^a   Ritter, Matthew R ^b   Friedlander, Martin ^b   Chang, Helen C ^a   Rahgozar, Paymon ^a   Han, Tieyan ^a   Garcia, Alejandro J ^a   Maclellan, W Robb ^a   Ross, Robert S ^c   Philipson, Kenneth D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

E C coupling; Heart failure; hypertrophy; Na Ca exchanger; transgenic mice

Indexed keywords

SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; EXERCISE TOLERANCE; FEMALE; HEART CATHETERIZATION; HEART DISEASE; HEART FAILURE; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; HEMODYNAMIC STRESS; HETEROZYGOTE; HOMOZYGOTE; MALE; MORTALITY; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUERPERIUM; TRANSGENIC MOUSE; TREADMILL EXERCISE; WILD TYPE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CARDIOMEGALY; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEART FAILURE, CONGESTIVE; MALE; MICE; PHENOTYPE; SODIUM-CALCIUM EXCHANGER;

EID: 34248563772     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2007.01.004     Document Type: Article

References (52)

1. Houser S.R. When does spontaneous sarcoplasmic reticulum Ca2+ release cause a triggered arrhythmia? Cellular versus tissue requirements. Circ Res 87 (2000) 725-727
2. Mann D.L., and Bristow M.R. Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation 111 (2005) 2837-2849
3. Pogwizd S.M., Schlotthauer K., Li L., Yuan W.L., and Bers D.M. Arrhythmogenesis and contractile dysfunction in heart failure-roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res 88 (2001) 1159-1167
4. Sipido K.R., Volders P.G.A., Vos M.A., and Verdonck F. Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?. Cardiovasc Res 53 (2002) 782-805
5. Yano M., Ikeda Y., and Matsuzaki M. Altered intracellular Ca2+ handling in heart failure. J Clin Invest 115 (2005) 556-564
6. Bers D.M. Cardiac excitation-contraction coupling. Nature 415 (2002) 198-205
7. Hilgemann D.W. New insights into the molecular and cellular workings of the cardiac Na+/Ca2+ exchanger. Am J Physiol 287 (2004) C1167-C1172
8. Philipson K.D., and Nicoll D.A. Sodium-calcium exchange: a molecular perspective. Annu Rev Physiol 62 (2000) 111-133
9. Reuter H., Pott C., Goldhaber J.I., Henderson S.A., Philipson K.D., and Schwinger R.H.G. Na+-Ca2+exchange in the regulation of cardiac excitation-contraction coupling. Cardiovasc Res 67 (2005) 198-207
10. Gaughan J.P., Furukawa S., Jeevanandam V., Hefner C.A., Kubo H., Margulies K.B., et al. Sodium/calcium exchange contributes to contraction and relaxation in failed human ventricular myocytes. Amer J Physiol 277 (1999) H714-H724
11. Houser S.R., Piacentino V., and Weisser J. Abnormalities of calcium cycling in the hypertrophied and failing heart. J Mol Cell Cardiol 32 (2000) 1595-1607
12. Terracciano C.M.N., DeSouza A.I., Philipson K.D., and MacLeod K.T. Na+-Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes overexpressing the Na+-Ca2+ exchanger. J Physiol London 512 (1998) 651-667
13. Weisser-Thomas J., Piacentino V., Gaughan J.P., Margulies K., and Houser S.R. Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes. Cardiovasc Res 57 (2003) 974-985
14. Hampton T.G., Wang J.F., DeAngelis J., Amende I., Philipson K.D., and Morgan J.P. Enhanced gene expression of Na+/Ca2+ exchanger attenuates ischemic and hypoxic contractile dysfunction. Amer J Physiol 279 (2000) H2846-H2854
15. Hobai I.A., and ORourke B. Enhanced Ca2+-activated Na+-Ca2+ exchange activity in canine pacing-induced heart failure. Circ Res 87 (2000) 690-698
16. Kent R.L., Rozich J.D., McCollam P.L., McDermott D.E., Thacker U.F., Menick D.R., et al. Rapid expression of the Na+-Ca2+ exchanger in response to cardiac pressure overload - rapid communication. Am J Physiol 265 (1993) H1024-H1029
17. Schillinger W., Fiolet J.W., Schlotthauer K., and Hasenfuss G. Relevance of Na+-Ca2+ exchange in heart failure. Cardiovasc Res 57 (2003) 921-933
18. Studer R., Reinecke H., Bilger J., Eschenhagen T., Bohm M., Hasenfuss G., et al. Gene expression of the cardiac Na+-Ca2+ exchanger in end-stage human heart failure. Circ Res 75 (1994) 443-453
19. Wang Z.Y., Nolan B., Kutschke W., and Hill J.A. Na+-Ca2+ exchanger remodeling in pressure overload cardiac hypertrophy. J Biol Chem 276 (2001) 17706-17711
20. Zhang X.Q., Song J.L., Rothblum L.I., Lun M.Y., Wang X.J., Ding F., et al. Overexpression of Na+/Ca2+ exchanger alters contractility and SR Ca2+ content in adult rat myocytes. Amer J Physiol 281 (2001) H2079-H2088
21. Gomez A.M., Valdivia H.H., Cheng H., Lederer M.R., Santana L.F., Cannell M.B., et al. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276 (1997) 800-806
22. Schultz J.E.J., Glascock B.J., Witt S.A., Nieman M.L., Nattamai K.J., Liu L.H., et al. Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity. Am J Physiol 286 (2004) H1146-H1153
23. Weisser-Thomas J., Kubo H., Hefner C.A., Gaughan J.P., McGowan B.S., Ross R., et al. The Na+/Ca2+ exchanger/SR Ca2+ ATPase transport capacity regulates the contractility of normal and hypertrophied feline ventricular myocytes. J Card Failure 11 (2005) 380-387
24. Adachi-Akahane S., Lu L.Y., Li Z.P., Frank J.S., Philipson K.D., and Morad M. Calcium signaling in transgenic mice overexpressing cardiac Na+-Ca2+ exchanger. J Gen Physiol 109 (1997) 717-729
25. Goldhaber J.I., Henderson S.A., Reuter H., Pott C., and Philipson K.D. Effects of Na+-Ca2+ exchange expression on excitation-contraction coupling in genetically modified mice. Annals N Y Acad Sci 1047 (2005) 122-126
26. Pott C., Goldhaber J.I., and Philipson K.D. Genetic manipulation of cardiac Na+/Ca2+ exchange expression. Biochem Biophys Res Commun 322 (2004) 1336-1340
27. Baumer A.T., Flesch M., Kilter H., Philipson K.D., and Bohm M. Overexpression of the Na+-Ca2+ exchanger leads to enhanced inotropic responsiveness to Na+-channel agonist without sarcoplasmic reticulum protein changes in transgenic mice. Biochem Biophys Res Commun 249 (1998) 786-790
28. Cross H.R., Lu L.Y., Steenbergen C., Philipson K.D., and Murphy E. Overexpression of the cardiac Na+/Ca2+ exchanger increases susceptibility to ischemia/reperfusion injury in male, but not female, transgenic mice. Circ Res 83 (1998) 1215-1223
29. Linck B., Boknik P., Huke S., Kirchhefer U., Knapp J., Luss H., et al. Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na+-Ca2+ exchanger. J Pharmacol Exp Ther 294 (2000) 648-657
30. Stagg M.A., Malik A.H., MacLeod K.T., and Terracciano C.M.N. The effects of overexpression of the Na+/Ca2+ exchanger on calcium regulation in hypertrophied mouse cardiac myocytes. Cell Calcium 36 (2004) 111-118
31. Su Z., Bridge J.H.B., Philipson K.D., Spitzer K.W., and Barry W.H. Quantitation of Na Ca exchanger function in single ventricular myocytes. J Mol Cell Cardiol 31 (1999) 1125-1135
32. Sugishita K., Su Z., Li F.H., Philipson K.D., and Barry W.H. Gender influences [Ca2+](I) during metabolic inhibition in myocytes overexpressing the Na+-Ca2+ exchanger. Circulation 104 (2001) 2101-2106
33. Terracciano C.M.N., Philipson K.D., and MacLeod K.T. Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice. Cardiovasc Res 49 (2001) 38-47
34. Yao A.S., Su Z., Nonaka A., Zubair I., Lu L.Y., Philipson K.D., et al. Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes. Circ Res 82 (1998) 657-665
35. Reuter H., Han T., Motter C., Philipson K.D., and Goldhaber J.I. Mice overexpressing the cardiac sodium-calcium exchanger: Defects in excitation-contraction coupling. J Physiol London 544 (2004) 779-789
36. Ritter M.R., Dorrell M.I., Edmonds J., Friedlander S.F., and Friedlander M. Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Proc Nat Acad Sci U S A 99 (2002) 7455-7460
37. Shai S.Y., Harpf A.E., Babbitt C.J., Jordan M.C., Fishbein M.C., Chen J., et al. Cardiac myocyte-specific excision of the beta 1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res 90 (2002) 458-464
38. Tanaka N., Dalton N., Mao L., Rockman H.A., Peterson K.L., Gottshall K.R., et al. Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation 94 (1996) 1109-1117
39. Henderson S.A., Goldhaber J.I., So J.M., Han T., Motter C., Ngo A., et al. Functional adult myocardium in the absence of Na+-Ca2+ exchange. Cardiac-specific knockout of NCX1. Circ Res 95 (2004) 604-611
40. Huynh L., Scremin O.U., Jordan M.C., and Roos K.P. Rota-rod treadmill exercise enhances murine ventricular mass. [abstract]. FASEB J 15 (2001) A793
41. Keller R.S., Shai S.Y., Babbitt C.J., Pham C.G., Solaro R.J., Valencik M.L., et al. Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance. Am J Pathol 158 (2001) 1079-1090
42. Rockman H.A., Ross R.S., Harris A.N., Knowlton K.U., Steinhelper M.E., Field L.J., et al. Segregation of atrial-specific and inducible expression of an atrial natriutetic factor transgene and in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A 88 (1991) 8277-8281
43. Lim C.C., Liao R.L., Varma N., and Apstein C.S. Impaired lusitropy-frequency in the aging mouse: role of Ca2+-handling proteins and effects of isoproterenol. Amer J Physiol 277 (1999) H2083-H2090
44. Brodde O.E., Michel M.C., and Zerkowski H.R. Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure. Cardiovasc Res 30 (1995) 570-584
45. Feldman A.M., Tena R.G., Kessler P.D., Weisman H.F., Schulman S.P., Blumenthal R.S., et al. Diminished β-andrenergic receptor responsiveness and cardiac dilation in hearts of myopathic Syrian hamsters (BIO 53.58) are associated with a functional abnormality of the G stimulatory protein. Circ Res 81 (1990) 1341-1352
46. Sato M., Gong H., Terracciano C.M.N., Ranu H., and Harding S.E. Loss of β-adrenoceptor response in myocytes overexpressing the Na+/Ca2+-exchanger. J Molec Cell Cardiol 36 (2004) 43-48
47. Eghbali M., Deva R., Alioua A., Minosyan T.Y., Ruan H., Wang Y., et al. Molecular and functional signature of heart hypertrophy during pregnancy. Circ Res 96 (2005) 1208-1216
48. Wong A.Y.H., Kulandavelu S., Whiteley K.J., Qu D., Langille B.L., and Adamson S.L. Maternal cardiovascular changes during pregnancy and postpartum in mice. Am J Physiol 282 (2002) H918-H925
49. Haubold K.W., Allen D.L., Capetanaki Y., and Leinwand L.A. Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance. J Appl Physiol 95 (2003) 1617-1622
50. Despa S., Islam M.A., Pogwizd S.M., and Bers D.M. Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes. J Physiol London 539 (2002) 133-143
51. Pogwizd S.M., Sipido K.R., Verdonck F., and Bers D.M. Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis. Cardiovasc Res 57 (2003) 887-896
52. Baartscheer A., Schumacher C.A., Belterman C.N.W., Coronel R., and Fiolet J.W.T. [Na+](I) and the driving force of the Na+/Ca2+-exchanger in heart failure. Cardiovasc Res 57 (2003) 986-995