Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: Potential involvement of Na +/Ca 2+ exchanger

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 3, 2012, Pages

  Song, Jianliang ^a,b   Gao, Erhe ^b   Wang, Jufang ^a,b   Zhang, Xue Qian ^a,b   Chan, Tung O ^b   Koch, Walter J ^b   Shang, Xiying ^b   Joseph, Jeffrey I ^b   Peterson, Blaise Z ^c   Feldman, Arthur M ^b   Cheung, Joseph Y ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

ad renergic responsiveness; FXYD proteins; In vivo catheterization; Intracellular Ca 2+ and Na + Ca 2+ regulation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA1; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA2; CALCIUM CHANNEL L TYPE; CALCIUM ION; CALSEQUESTRIN; GLUTAMIC ACID; ISOPRENALINE; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SERINE; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM ION; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARRHYTHMOGENESIS; ARTICLE; BRADYCARDIA; CALCIUM CELL LEVEL; CHRONOTROPISM; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GROWTH INHIBITION; HEART; HEART FAILURE; HEART LEFT VENTRICLE MASS; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE POTENTIAL; HEART OUTPUT; HEART VENTRICLE ARRHYTHMIA; INOTROPISM; MALE; MEMBRANE STEADY POTENTIAL; MORTALITY; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; SODIUM CELL LEVEL; SURVIVOR; WILD TYPE;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; BRADYCARDIA; CALCIUM; CALCIUM CHANNELS, L-TYPE; FEMALE; GENE EXPRESSION; HEART FAILURE; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHOPROTEINS; POTASSIUM; RECEPTORS, ADRENERGIC, BETA; SODIUM; SODIUM-CALCIUM EXCHANGER;

EID: 84863012208     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00733.2011     Document Type: Article

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