Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels

American Journal of Physiology - Cell Physiology

Volumn 299, Issue 5, 2010, Pages

  Guo, Kai ^a,b   Wang, Xianming ^b   Gao, Guofeng ^b   Huang, Congxin ^a   Elmslie, Keith S ^b   Peterson, Blaise Z ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Activation; Ca v1.2; Deactivation; FXYD1; Inactivation

Indexed keywords

CALCIUM CHANNEL L TYPE;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MOTIF;

ALANINE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CALCIUM CHANNELS, L-TYPE; CELL LINE; HUMANS; ION CHANNEL GATING; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PATCH-CLAMP TECHNIQUES; PHOSPHOPROTEINS; THREONINE;

EID: 78349301164     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00149.2010     Document Type: Article

References (38)

1. 2+ exchanger, phospholemman. J Biol Chem 280: 19875-19882, 2005.
2. Aldrich RW, Corey DP, Stevens CF. A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306: 436-441, 1983.
3. Bezanilla F. The voltage sensor in voltage-dependent ion channels. Physiol Rev 80: 555-592, 2000. (Pubitemid 30164943)
4. Catterall WA. Structure and function of voltage-gated ion channels. Annu Rev Biochem 64: 493-531, 1995.
5. Catterall WA, Hulme JT, Jiang X, Few WP. Regulation of sodium and calcium channels by signaling complexes. J Recept Signal Transduct Res 26: 577-598, 2006. (Pubitemid 44849906)
6. Cornelius F, Mahmmoud YA. Functional modulation of the sodium pump: the regulatory proteins "Fixit". News Physiol Sci 18: 119-124, 2003.
7. Crambert G, Fuzesi M, Garty H, Karlish S, Geering K. Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties. Proc Natl Acad Sci USA 99: 11476-11481, 2002. (Pubitemid 34920950)
8. Crambert G, Geering K. FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase. Sci STKE 2003: RE1, 2003.
9. Creighton TE, Freedman RB. A model catalyst of protein disulphide bond formation. Curr Biol 3: 790-793, 1993.
10. Despa S, Bossuyt J, Han F, Ginsburg KS, Jia LG, Kutchai H, Tucker AL, Bers DM. Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res 97: 252-259, 2005. (Pubitemid 41105451)
11. Elmslie KS, Jones SW. Concentration dependence of neurotransmitter effects on calcium current kinetics in frog sympathetic neurones. J Physiol 481: 35-46, 1994.
12. Garty H, Karlish SJ. Role of FXYD proteins in ion transport. Annu Rev Physiol 68: 431-459, 2006.
13. 2+ current. Circ Res 64: 977-990, 1989.
14. Kwok TC, Hui K, Kostelecki W, Ricker N, Selman G, Feng ZP, Roy PJ. A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels. PLoS Genet 4: e1000067, 2008. (Pubitemid 351811504)
15. Li C, Grosdidier A, Crambert G, Horisberger JD, Michielin O, Geering K. Structural and functional interaction sites between Na,K-ATPase and FXYD proteins. J Biol Chem 279: 38895-38902, 2004. (Pubitemid 39296050)
16. Li GR, Yang B, Feng J, Bosch RF, Carrier M, Nattel S. Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes. Am J Physiol Heart Circ Physiol 276: H98-H106, 1999. (Pubitemid 29065627)
17. Marban E, Robinson SW, Wier WG. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J Clin Invest 78: 1185-1192, 1986. (Pubitemid 17181555)
18. McDonald TF, Pelzer S, Trautwein W, Pelzer DJ. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 74: 365-507, 1994. (Pubitemid 24127646)
19. i transients in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol 286: H1322-H1330, 2004.
20. Mohler PJ, Wehrens XH. Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda) 22: 342-350, 2007.
21. Palmer CJ, Scott BT, Jones LR. Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium. J Biol Chem 266: 11126-11130, 1991.
22. 2+-dependent inactivation of L-type calcium channels. Neuron 22: 549-558, 1999.
23. Pietrobon D, Hess P. Novel mechanism of voltage-dependent gating in L-type calcium channels. Nature 346: 651-655, 1990. (Pubitemid 20266396)
24. Sanguinetti MC, Bennett PB. Antiarrhythmic drug target choices and screening. Circ Res 93: 491-499, 2003.
25. Seisenberger C, Specht V, Welling A, Platzer J, Pfeifer A, Kuhbandner S, Striessnig J, Klugbauer N, Feil R, Hofmann F. Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem 275: 39193-39199, 2000. (Pubitemid 32058936)
26. Shinoda T, Ogawa H, Cornelius F, Toyoshima C. Crystal structure of the sodium-potassium pump at 2.4 A resolution. Nature 459: 446-450, 2009.
27. Silverman BZ, Fuller W, Eaton P, Deng J, Moorman JR, Cheung JY, James AF, Shattock MJ. Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase. Cardiovasc Res 65: 93-103, 2005. (Pubitemid 40038482)
28. 2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol 288: H2342-H2354, 2005.
29. Sweadner KJ, Rael E. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics 68: 41-56, 2000.
30. Teriete P, Franzin CM, Choi J, Marassi FM. Structure of the Na,K-ATPase regulatory protein FXYD1 in micelles. Biochemistry 46: 6774-6783, 2007. (Pubitemid 46906407)
31. 2+ exchange. Am J Physiol Heart Circ Physiol 291: H2199-H2209, 2006.
32. 2+ exchanger. J Biol Chem 281: 32004-32014, 2006.
33. Wang X, Gao G, Guo K, Yarotskyy V, Huang C, Elmslie KS, Peterson BZ. Phospholemman modulates the gating of cardiac L-type calcium channels. Biophys J 98: 1149-1159, 2010.
34. Wang X, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ. Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents. Biophys J 89: 1731-1743, 2005. (Pubitemid 41233530)
35. V1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation. J Physiol 587: 551-565, 2009.
36. 2+ exchanger. Role of phosphorylation. J Biol Chem 281: 7784-7792, 2006.
37. + pump activity in postinfarction myocytes. J Appl Physiol 100: 212-220, 2006.
38. 2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol 284: H225-H233, 2003.