Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 19, 2014, Pages 7066-7071

  Park, Heon ^a   Tsang, Mark ^a   Iritani, Brian M ^a   Bevan, Michael J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Birt Hogg Dub syndrome; Metabolism; Thymus

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATE; BIM PROTEIN; CD4 ANTIGEN; CD8 ANTIGEN; FOLLICULIN INTERACTING PROTEIN 1; HERMES ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; PROMYELOCYTIC LEUKEMIA PROTEIN; RAPAMYCIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; B LYMPHOCYTE DIFFERENTIATION; BIOGENESIS; CELL CYCLE ARREST; CELL MATURATION; CONTROLLED STUDY; ENERGY CONSUMPTION; GAMMA DELTA T LYMPHOCYTE; GENE LOSS; HOMEOSTASIS; INVARIANT NATURAL KILLER T CELL; LYMPHOCYTE PROLIFERATION; METABOLIC STRESS; MITOCHONDRION; MOUSE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; WILD TYPE;

BIRT-HOGG-DUBÉ SYNDROME; METABOLISM; THYMUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIRT-HOGG-DUBE SYNDROME; CARRIER PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; ENERGY METABOLISM; FEMALE; HOMEOSTASIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; THYMUS GLAND; TOR SERINE-THREONINE KINASES;

EID: 84900521157     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406473111     Document Type: Article

References (50)

1. Engel I, Kronenberg M (2012) Making memory at birth: Understanding the differentiation of natural killer T cells. Curr Opin Immunol 24(2):184-190.
2. Brennan PJ, Brigl M, Brenner MB (2013) Invariant natural killer T cells: An innate activation scheme linked to diverse effector functions. Nat Rev Immunol 13(2):101-117.
3. Van Kaer L, Parekh VV, Wu L (2013) Invariant natural killer T cells as sensors and managers of inflammation. Trends Immunol 34(2):50-58.
4. Constantinides MG, Bendelac A (2013) Transcriptional regulation of the NKT cell lineage. Curr Opin Immunol 25(2):161-167.
5. Godfrey DI, Stankovic S, Baxter AG (2010) Raising the NKT cell family. Nat Immunol 11(3):197-206.
6. Mycko MP, et al. (2009) Selective requirement for c-Myc at an early stage of V(alpha) 14i NKT cell development. J Immunol 182(8):4641-4648.
7. Dose M, et al. (2009) Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci USA 106(21):8641-8646.
8. Dose M, Gounari F (2009) The My(c)stery of iNKT cell ontogeny. Cell Cycle 8(19): 3082-3085.
9. McNab FW, et al. (2007) Peripheral NK1.1 NKT cells are mature and functionally distinct from their thymic counterparts. J Immunol 179(10):6630-6637.
10. Watarai H, et al. (2012) Development and function of invariant natural killer T cells producing T(h)2-and T(h)17-cytokines. PLoS Biol 10(2):e1001255.
11. Monticelli LA, et al. (2009) Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proc Natl Acad Sci USA 106(46):19461-19466.
12. Lee YJ, Holzapfel KL, Zhu J, Jameson SC, Hogquist KA (2013) Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat Immunol 14(11):1146-1154.
13. Egawa T, et al. (2005) Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22(6):705-716.
14. Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S (2005) Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc Natl Acad Sci USA 102(14):5114-5119.
15. D'Cruz LM, Knell J, Fujimoto JK, Goldrath AW (2010) An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells. Nat Immunol 11(3):240-249.
16. Lazarevic V, et al. (2009) The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nat Immunol 10(3):306-313.
17. Savage AK, et al. (2008) The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29(3):391-403.
18. Kovalovsky D, et al. (2008) The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol 9(9):1055-1064.
19. Townsend MJ, et al. (2004) T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20(4):477-494.
20. Kim PJ, et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177(10):6650-6659.
21. Wang L, et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol 40(9):2385-2390.
22. Park H, et al. (2012) Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development. Immunity 36(5):769-781.
23. Baba M, et al. (2006) Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci USA 103(42):15552-15557.
24. Linehan WM, Srinivasan R, Schmidt LS (2010) The genetic basis of kidney cancer: A metabolic disease. Nat Rev Urol 7(5):277-285.
25. Inoki K, Zhu T, Guan K-L (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115(5):577-590.
26. Gwinn DM, et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30(2):214-226.
27. Betschinger J, et al. (2013) Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell 153(2):335-347.
28. Baba M, et al. (2012) The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development. Blood 120(6):1254-1261.
29. Gleimer M, von Boehmer H, Kreslavsky T (2012) PLZF controls the expression of a limited number of genes essential for NKT cell function. Front Immunol 3:374.
30. Kovalovsky D, et al. (2010) PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals. J Immunol 184(12):6746-6755.
31. Wakao H, et al. (2007) A novel mouse model for invariant NKT cell study. J Immunol 179(6):3888-3895.
32. Mendiratta SK, et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6(4):469-477.
33. Griewank K, et al. (2007) Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 27(5):751-762.
34. Hager E, Hawwari A, Matsuda JL, Krangel MS, Gapin L (2007) Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. J Immunol 179(4):2228-2234.
35. Huntington ND, et al. (2007) Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol 8(8):856-863.
36. Moncada S, Erusalimsky JD (2002) Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol 3(3):214-220.
37. Takagi Y, et al. (2008) Interaction of Folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. Oncogene 27(40):5339-5347.
38. Gaur K, et al. (2013) The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis. Hum Mol Genet 22(2):284-299.
39. Rathmell JC (2004) B-cell homeostasis: Digital survival or analog growth? Immunol Rev 197:116-128.
40. Hasumi H, et al. (2008) Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene 415(1-2):60-67.
41. Kim J, Kundu M, Viollet B, Guan K-L (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13(2):132-141.
42. Yang K, Neale G, Green DR, He W, Chi H (2011) The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol 12(9):888-897.
43. Zhang D, Iyer LM, He F, Aravind L (2012) Discovery of novel DENN proteins: Implications for the evolution of eukaryotic intracellular membrane structures and human disease. Front Genet 3:283.
44. Behrends C, Sowa ME, Gygi SP, Harper JW (2010) Network organization of the human autophagy system. Nature 466(7302):68-76.
45. Jaber N, et al. (2012) Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci USA 109(6):2003-2008.
46. Kim J, et al. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152(1-2):290-303.
47. Parekh VV, et al. (2013) Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34. J Immunol 190(10):5086-5101.
48. Habib T, et al. (2007) Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol 179(4):717-731.
49. Dang CV (2013) MYC, metabolism, cell growth, and tumorigenesis. Cold Spring Harb Perspect Med 3(8).
50. Iritani BM, Eisenman RN (1999) c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc Natl Acad Sci USA 96(23):13180-13185.