A novel strategy for the treatment of chronic wounds based on the topical administration of rhEGF-loaded lipid nanoparticles: In vitro bioactivity and in vivo effectiveness in healing-impaired db/db mice

Journal of Controlled Release

Volumn 185, Issue 1, 2014, Pages 51-61

  Gainza, Garazi ^a,b   Pastor, Marta ^a,b   Aguirre, José Javier ^c   Villullas, Silvia ^d   Pedraz, José Luis ^a,b   Hernandez, Rosa Maria ^a,b   Igartua, Manoli ^a,b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c HOSPITAL TXAGORRITXU   (Spain)

^d Biopraxis Research AIE   (Spain)

Author keywords

Chronic wounds; EGF (epidermal growth factor); Lipid nanoparticles; NLC (nanostructured lipid carriers); SLN (solid lipid nanoparticles); Tissue engineering

Indexed keywords

EMULSIFICATION; ENCAPSULATION; MAMMALS; TISSUE ENGINEERING;

CHRONIC WOUNDS; EPIDERMAL GROWTH FACTORS; LIPID NANOPARTICLES; NANOSTRUCTURED LIPID CARRIERS; SOLID LIPID NANOPARTICLE (SLN);

NANOPARTICLES;

DRUG CARRIER; NANOMATERIAL; RECOMBINANT EPIDERMAL GROWTH FACTOR; RECOMBINANT HUMAN EPIDERMAL GROWTH FACTOR; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG; EPIDERMAL GROWTH FACTOR; LIPID; NANOPARTICLE; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CHRONIC WOUND; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; EMULSION; EPITHELIZATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; STRATUM CORNEUM; SUSTAINED DRUG RELEASE; ULTRASOUND; VISCOSITY; WOUND CLOSURE; WOUND HEALING; WOUND HEALING IMPAIRMENT; 3T3 CELL LINE; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECTS; HUMAN; ULTRASTRUCTURE;

3T3 CELLS; ANIMALS; CELL LINE; CELL PROLIFERATION; DRUG CARRIERS; EPIDERMAL GROWTH FACTOR; HUMANS; LIPIDS; MALE; MICE; MICE, INBRED BALB C; NANOPARTICLES; RECOMBINANT PROTEINS; WOUND HEALING;

EID: 84900514063     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.04.032     Document Type: Article

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