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Volumn 460, Issue 2, 2014, Pages 223-235

Novel role of a family of major facilitator transporters in biofilm development and virulence of Candida albicans

Author keywords

Candida Albicans; Lipid homoeostasis; Quinidine drug resistance (QDR) transporters; Virulence

Indexed keywords

CARRIER PROTEIN; GREEN FLUORESCENT PROTEIN; PROTEIN QDR; UNCLASSIFIED DRUG;

EID: 84900512899     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140010     Document Type: Article
Times cited : (53)

References (68)
  • 2
    • 0038341642 scopus 로고    scopus 로고
    • Antifungal agents: Mechanisms of action
    • CrossRef PubMed
    • Odds, F. C., Brown, A. J. and Gow, N. A. (2003) Antifungal agents: mechanisms of action. Trends Microbiol. 11, 272-279 CrossRef PubMed
    • (2003) Trends Microbiol. , vol.11 , pp. 272-279
    • Odds, F.C.1    Brown, A.J.2    Gow, N.A.3
  • 3
    • 77749291956 scopus 로고    scopus 로고
    • Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: New substitutions and a review of the literature
    • CrossRef PubMed
    • Morio, F., Loge, C., Besse, B., Hennequin, C. and Le Pape, P. (2010) Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. Diagn. Microbiol. Infect. Dis. 66, 373-384 CrossRef PubMed
    • (2010) Diagn. Microbiol. Infect. Dis. , vol.66 , pp. 373-384
    • Morio, F.1    Loge, C.2    Besse, B.3    Hennequin, C.4    Le Pape, P.5
  • 4
    • 84867168091 scopus 로고    scopus 로고
    • Gain-of-function mutations in UPC2 are a frequent cause of ERG11upregulation in azole-resistant clinical isolates of Candida albicans
    • CrossRef PubMed
    • Flowers, S. A., Barker, K. S., Berkow, E. L., Toner, G., Chadwick, S. G., Gygax, S. E., Morschhäuser, J. and Rogers, P. D. (2012) Gain-of-function mutations in UPC2 are a frequent cause of ERG11upregulation in azole-resistant clinical isolates of Candida albicans. Eukaryot. Cell 11, 1289-1299 CrossRef PubMed
    • (2012) Eukaryot. Cell , vol.11 , pp. 1289-1299
    • Flowers, S.A.1    Barker, K.S.2    Berkow, E.L.3    Toner, G.4    Chadwick, S.G.5    Gygax, S.E.6    Morschhäuser, J.7    Rogers, P.D.8
  • 7
    • 73749084743 scopus 로고    scopus 로고
    • Fungal echinocandin resistance
    • CrossRef PubMed
    • Walker, L. A., Gow, N. A. and Munro, C. A. (2010) Fungal echinocandin resistance. Fungal Genet. Biol. 47, 117-126 CrossRef PubMed
    • (2010) Fungal Genet. Biol. , vol.47 , pp. 117-126
    • Walker, L.A.1    Gow, N.A.2    Munro, C.A.3
  • 8
    • 7944221862 scopus 로고    scopus 로고
    • Candida biofilm resistance
    • CrossRef PubMed
    • Mukherjee, P. K. and Chandra, J. (2004) Candida biofilm resistance. Drug Resist. Updates 7, 301-309 CrossRef PubMed
    • (2004) Drug Resist. Updates , vol.7 , pp. 301-309
    • Mukherjee, P.K.1    Chandra, J.2
  • 9
    • 0035992139 scopus 로고    scopus 로고
    • Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms
    • CrossRef PubMed
    • Ramage, G., Bachmann, S., Patterson, T. F., Wickes, B. L. and López-Ribot, J. L. (2002) Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms. J. Antimicrob. Chemother. 49, 973-980 CrossRef PubMed
    • (2002) J. Antimicrob. Chemother. , vol.49 , pp. 973-980
    • Ramage, G.1    Bachmann, S.2    Patterson, T.F.3    Wickes, B.L.4    López-Ribot, J.L.5
  • 10
    • 0028928549 scopus 로고
    • Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
    • CrossRef PubMed
    • Prasad, R., De Wergifosse, P., Goffeau, A. and Balzi, E. (1995) Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet. 27, 320-329 CrossRef PubMed
    • (1995) Curr. Genet. , vol.27 , pp. 320-329
    • Prasad, R.1    De Wergifosse, P.2    Goffeau, A.3    Balzi, E.4
  • 11
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
    • CrossRef PubMed
    • Sanglard, D., Ischer, F., Monod, M. and Bille, J. (1997) Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143, 405-416 CrossRef PubMed
    • (1997) Microbiology , vol.143 , pp. 405-416
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 12
    • 10444285332 scopus 로고    scopus 로고
    • Multidrug resistance in yeast Candida
    • CrossRef PubMed
    • Prasad, R. and Kapoor, K. (2005) Multidrug resistance in yeast Candida. Int. Rev. Cytol. 242, 215-248 CrossRef PubMed
    • (2005) Int. Rev. Cytol. , vol.242 , pp. 215-248
    • Prasad, R.1    Kapoor, K.2
  • 14
    • 0035042174 scopus 로고    scopus 로고
    • Resistance and adaptation to quinidine in Saccharomyces cerevisiae: Role of QDR1(YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance
    • CrossRef PubMed
    • Nunes, P. A., Tenreiro, S. and Sá-Correia, I. (2001) Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1(YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance. Antimicrob. Agents Chemother. 45, 1528-1534 CrossRef PubMed
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1528-1534
    • Nunes, P.A.1    Tenreiro, S.2    Sá-Correia, I.3
  • 15
    • 3042619287 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): Localization and function as a quinidine resistance determinant
    • CrossRef PubMed
    • Vargas, R. C., Tenreiro, S., Teixeira, M. C., Fernandes, A. R. and Śa-Correia, I. (2004) Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant. Antimicrob. Agents Chemother. 48, 2531-2537 CrossRef PubMed
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 2531-2537
    • Vargas, R.C.1    Tenreiro, S.2    Teixeira, M.C.3    Fernandes, A.R.4    Śa-Correia, I.5
  • 16
    • 11844282218 scopus 로고    scopus 로고
    • The yeast multidrug transporter Qdr3 (Ybr043c): Localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin
    • CrossRef PubMed
    • Tenreiro, S., Vargas, R. C., Teixeira, M. C., Magnani, C. and Sá-Correia, I. (2005) The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin. Biochem. Biophys. Res. Commun. 327, 952-959 CrossRef PubMed
    • (2005) Biochem. Biophys. Res. Commun. , vol.327 , pp. 952-959
    • Tenreiro, S.1    Vargas, R.C.2    Teixeira, M.C.3    Magnani, C.4    Sá-Correia, I.5
  • 17
    • 84872397343 scopus 로고    scopus 로고
    • Role of the yeast multidrug transporter Qdr2 in cation homeostasis and the oxidative stress response
    • CrossRef PubMed
    • Ŕios, G., Cabedo, M., Rull, B., Yenush, L., Serrano, R. and Mulet, J. M. (2013) Role of the yeast multidrug transporter Qdr2 in cation homeostasis and the oxidative stress response. FEMS Yeast Res. 13, 97-106 CrossRef PubMed
    • (2013) FEMS Yeast Res. , vol.13 , pp. 97-106
    • Ŕios, G.1    Cabedo, M.2    Rull, B.3    Yenush, L.4    Serrano, R.5    Mulet, J.M.6
  • 18
    • 33847188819 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake providing a physiological advantage to quinidine-stressed cells
    • CrossRef PubMed
    • Vargas, R. C., Garćia-Salcedo, R., Tenreiro, S., Teixeira, M. C., Fernandes, A. R., Ramos, J. and Sá-Correia, I. (2007) Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells. Eukaryot. Cell 6, 134-142 CrossRef PubMed
    • (2007) Eukaryot. Cell , vol.6 , pp. 134-142
    • Vargas, R.C.1    Garćia-Salcedo, R.2    Tenreiro, S.3    Teixeira, M.C.4    Fernandes, A.R.5    Ramos, J.6    Sá-Correia, I.7
  • 22
    • 0036894215 scopus 로고    scopus 로고
    • Drug susceptibilities of yeast cells are affected by membrane lipid composition
    • CrossRef PubMed
    • Mukhopadhyay, K., Kohli, A. and Prasad, R. (2002) Drug susceptibilities of yeast cells are affected by membrane lipid composition. Antimicrob. Agents Chemother. 46, 3695-3705 CrossRef PubMed
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3695-3705
    • Mukhopadhyay, K.1    Kohli, A.2    Prasad, R.3
  • 24
    • 69249213406 scopus 로고    scopus 로고
    • Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p
    • CrossRef PubMed
    • Ivnitski-Steele, I., Holmes, A. R., Lamping, E., Monk, B. C., Cannon, R. D. and Sklar, L. A. (2009) Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p. Anal. Biochem. 394, 87-91 CrossRef PubMed
    • (2009) Anal. Biochem. , vol.394 , pp. 87-91
    • Ivnitski-Steele, I.1    Holmes, A.R.2    Lamping, E.3    Monk, B.C.4    Cannon, R.D.5    Sklar, L.A.6
  • 25
    • 0347694571 scopus 로고    scopus 로고
    • Functional characterization of Candida albicansABC transporter Cdr1p
    • CrossRef PubMed
    • Shukla, S., Saini, P., Smriti Jha, S., Ambudkar, S. V. and Prasad, R. (2003) Functional characterization of Candida albicansABC transporter Cdr1p. Eukaryot. Cell 2, 1361-1375 CrossRef PubMed
    • (2003) Eukaryot. Cell , vol.2 , pp. 1361-1375
    • Shukla, S.1    Saini, P.2    Smriti Jha, S.3    Ambudkar, S.V.4    Prasad, R.5
  • 26
    • 5044225522 scopus 로고    scopus 로고
    • The SAT1 flipper, an optimized tool for gene disruption in Candida albicans
    • CrossRef PubMed
    • Reuss, O., Vik, A., Kolter, R. and Morschhauser, J. (2004) The SAT1 flipper, an optimized tool for gene disruption in Candida albicans. Gene 341, 119-127 CrossRef PubMed
    • (2004) Gene , vol.341 , pp. 119-127
    • Reuss, O.1    Vik, A.2    Kolter, R.3    Morschhauser, J.4
  • 27
    • 11144270183 scopus 로고    scopus 로고
    • TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2
    • CrossRef PubMed
    • Coste, A. T., Karababa, M., Ischer, F., Bille, J. and Sanglard, D. (2004) TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2. Eukaryot. Cell 3, 1639-1652 CrossRef PubMed
    • (2004) Eukaryot. Cell , vol.3 , pp. 1639-1652
    • Coste, A.T.1    Karababa, M.2    Ischer, F.3    Bille, J.4    Sanglard, D.5
  • 29
    • 0032524635 scopus 로고    scopus 로고
    • ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p
    • CrossRef PubMed
    • Decottignies, A., Grant, A. M., Nichols, J. W., de Wet, H., McIntosh, D. B. and Goffeau, A. (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J. Biol. Chem. 273, 12612-12622 CrossRef PubMed
    • (1998) J. Biol. Chem. , vol.273 , pp. 12612-12622
    • Decottignies, A.1    Grant, A.M.2    Nichols, J.W.3    De Wet, H.4    McIntosh, D.B.5    Goffeau, A.6
  • 30
    • 34447579240 scopus 로고    scopus 로고
    • Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae
    • CrossRef PubMed
    • Lamping, E., Monk, B. C, Niimi, K., Holmes, A. R., Tsao, S., Tanabe, K., Niimi, M., Uehara, Y and Cannon, R. D. (2007) Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae. Eukaryot. Cell 6, 1150-1165 CrossRef PubMed
    • (2007) Eukaryot. Cell , vol.6 , pp. 1150-1165
    • Lamping, E.1    Monk, B.C.2    Niimi, K.3    Holmes, A.R.4    Tsao, S.5    Tanabe, K.6    Niimi, M.7    Uehara, Y.8    Cannon, R.D.9
  • 31
    • 38649112299 scopus 로고    scopus 로고
    • Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: Both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts
    • CrossRef PubMed
    • Pasrija, R., Panwar, S. L. and Prasad, R. (2008) Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts. Antimicrob. Agents Chemother. 52, 694-704 CrossRef PubMed
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 694-704
    • Pasrija, R.1    Panwar, S.L.2    Prasad, R.3
  • 32
    • 12344269924 scopus 로고    scopus 로고
    • GO:TermFinder-open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes
    • CrossRef PubMed
    • Boyle, E. I., Weng, S., Gollub, J., Jin, H., Botstein, D., Cherry, J. M. and Sherlock, G. (2004) GO:TermFinder-open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics 20, 3710-3715 CrossRef PubMed
    • (2004) Bioinformatics , vol.20 , pp. 3710-3715
    • Boyle, E.I.1    Weng, S.2    Gollub, J.3    Jin, H.4    Botstein, D.5    Cherry, J.M.6    Sherlock, G.7
  • 33
    • 23044462516 scopus 로고    scopus 로고
    • Functional analysis of CaIPT1, a sphingolipid biosynthetic gene involved in multidrug resistance and morphogenesis of Candida albicans
    • CrossRef PubMed
    • Prasad, T, Saini, P., Gaur, N. A., Vishwakarma, R. A., Khan, L. A., Haq, Q. M. and Prasad, R. (2005) Functional analysis of CaIPT1, a sphingolipid biosynthetic gene involved in multidrug resistance and morphogenesis of Candida albicans. Antimicrob. Agents Chemother. 49, 3442-3452 CrossRef PubMed
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 3442-3452
    • Prasad, T.1    Saini, P.2    Gaur, N.A.3    Vishwakarma, R.A.4    Khan, L.A.5    Haq, Q.M.6    Prasad, R.7
  • 34
    • 63349084704 scopus 로고    scopus 로고
    • In vitro growth and analysis of Candida biofilms
    • CrossRef PubMed
    • Chandra, J., Mukherjee, P. K. and Ghannoum, M. A. (2008) In vitro growth and analysis of Candida biofilms. Nat. Protoc. 3, 1909-1924 CrossRef PubMed
    • (2008) Nat. Protoc. , vol.3 , pp. 1909-1924
    • Chandra, J.1    Mukherjee, P.K.2    Ghannoum, M.A.3
  • 35
    • 80053441165 scopus 로고    scopus 로고
    • Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence
    • CrossRef PubMed
    • Desai, C, Mavrianos, J. and Chauhan, N. (2011) Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence. Eukaryot. Cell 10, 1370-1374 CrossRef PubMed
    • (2011) Eukaryot. Cell , vol.10 , pp. 1370-1374
    • Desai, C.1    Mavrianos, J.2    Chauhan, N.3
  • 36
    • 78649716032 scopus 로고    scopus 로고
    • Phospholipidome of Candida: Each species of Candida has distinctive phospholipid molecular species
    • CrossRef PubMed
    • Singh, A., Prasad, T, Kapoor, K., Mandal, A., Roth, M., Welti, R. and Prasad, R. (2010) Phospholipidome of Candida: each species of Candida has distinctive phospholipid molecular species. OMICS 14, 665-677 CrossRef PubMed
    • (2010) OMICS , vol.14 , pp. 665-677
    • Singh, A.1    Prasad, T.2    Kapoor, K.3    Mandal, A.4    Roth, M.5    Welti, R.6    Prasad, R.7
  • 37
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • CrossRef PubMed
    • Bligh, E.G. and Dyer, W.J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917 CrossRef PubMed
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 38
    • 79955777587 scopus 로고    scopus 로고
    • Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints
    • CrossRef PubMed
    • Singh, A. and Prasad, R. (2011) Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints. PLoS ONE 6, e19266 CrossRef PubMed
    • (2011) PLoS ONE , vol.6
    • Singh, A.1    Prasad, R.2
  • 39
    • 33750953277 scopus 로고    scopus 로고
    • Proteomic analysis of detergent-resistant membranes from Candida albicans
    • CrossRef PubMed
    • Insenser, M., Nombela, C, Molero, G. and Gil, C. (2006) Proteomic analysis of detergent-resistant membranes from Candida albicans. Proteomics 6, S74-S81 CrossRef PubMed
    • (2006) Proteomics , vol.6
    • Insenser, M.1    Nombela, C.2    Molero, G.3    Gil, C.4
  • 40
    • 0034724182 scopus 로고    scopus 로고
    • Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast
    • CrossRef PubMed
    • Bagnat, M., Keranen, S., Shevchenko, A., Shevchenko, A. and Simons, K. (2000) Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc. Natl. Acad. Sci. U.S.A. 97, 3254-3259 CrossRef PubMed
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 3254-3259
    • Bagnat, M.1    Keranen, S.2    Shevchenko, A.3    Shevchenko, A.4    Simons, K.5
  • 41
    • 78650664669 scopus 로고    scopus 로고
    • Palmitoylation regulates raft affinity for the majority of integral raft proteins
    • CrossRef PubMed
    • Levental, I., Lingwood, D., Grzybek, M., Coskun, U. and Simons, K. (2010) Palmitoylation regulates raft affinity for the majority of integral raft proteins. Proc. Natl. Acad. Sci. U.S.A. 107, 22050-22054 CrossRef PubMed
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 22050-22054
    • Levental, I.1    Lingwood, D.2    Grzybek, M.3    Coskun, U.4    Simons, K.5
  • 42
    • 3543099503 scopus 로고    scopus 로고
    • Palmitoylation of intracellular signaling proteins: Regulation and function
    • CrossRef PubMed
    • Smotrys J, E. and Linder, M, E. (2004) Palmitoylation of intracellular signaling proteins: regulation and function. Annu. Rev. Biochem. 73, 559-587 CrossRef PubMed
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 559-587
    • Smotrys, J.E.1    Linder, M.E.2
  • 43
    • 0029655688 scopus 로고    scopus 로고
    • Effects of shear stress and substrate loading rate on Pseudomonas aeruginosa biofilm thickness and density
    • CrossRef
    • Peyton, B. M. (1996) Effects of shear stress and substrate loading rate on Pseudomonas aeruginosa biofilm thickness and density. Water Res. 30, 29-36 CrossRef
    • (1996) Water Res. , vol.30 , pp. 29-36
    • Peyton, B.M.1
  • 44
    • 0036208102 scopus 로고    scopus 로고
    • In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry
    • CrossRef PubMed
    • Kohli, A., Smriti Mukhopadhyay K, Rattan, A. and Prasad, R. (2002) In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry. Antimicrob. Agents Chemother. 46, 1046-1052 CrossRef PubMed
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1046-1052
    • Kohli, A.1    Smriti Mukhopadhyay, K.2    Rattan, A.3    Prasad, R.4
  • 45
    • 27844543339 scopus 로고    scopus 로고
    • Membrane raft lipid constituents affect drug susceptibilities of Candida albicans
    • CrossRef PubMed
    • Pasrija, R., Prasad, T. and Prasad, R. (2005) Membrane raft lipid constituents affect drug susceptibilities of Candida albicans. Biochem. Soc. Trans. 33, 1219-1223 CrossRef PubMed
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 1219-1223
    • Pasrija, R.1    Prasad, T.2    Prasad, R.3
  • 46
    • 53149143909 scopus 로고    scopus 로고
    • Biofilm lifestyle of Candida: A mini review
    • CrossRef PubMed
    • Seneviratne, C. J., Jin, L and Samaranayake, L. P. (2008) Biofilm lifestyle of Candida: a mini review. Oral Dis. 14, 582-590 CrossRef PubMed
    • (2008) Oral Dis. , vol.14 , pp. 582-590
    • Seneviratne, C.J.1    Jin, L.2    Samaranayake, L.P.3
  • 47
    • 77349103477 scopus 로고    scopus 로고
    • Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans
    • CrossRef PubMed
    • Chen, Y L, Montedonico, A. E., Kauffman, S., Dunlap, J. R., Menn, F. M. and Reynolds, T. B. (2010) Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans. Mol. Microbiol. 75, 1112-1132 CrossRef PubMed
    • (2010) Mol. Microbiol. , vol.75 , pp. 1112-1132
    • Chen, Y.L.1    Montedonico, A.E.2    Kauffman, S.3    Dunlap, J.R.4    Menn, F.M.5    Reynolds, T.B.6
  • 48
    • 77954095162 scopus 로고    scopus 로고
    • Systematic screens of a Candida albicanshomozygous deletion library decouple morphogenetic switching and pathogenicity
    • CrossRef PubMed
    • Noble, S. M., French, S., Kohn, L. A., Chen, V. and Johnson, A. D. (2010) Systematic screens of a Candida albicanshomozygous deletion library decouple morphogenetic switching and pathogenicity. Nat. Genet. 42, 590-598 CrossRef PubMed
    • (2010) Nat. Genet. , vol.42 , pp. 590-598
    • Noble, S.M.1    French, S.2    Kohn, L.A.3    Chen, V.4    Johnson, A.D.5
  • 49
    • 80155127200 scopus 로고    scopus 로고
    • Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation
    • CrossRef PubMed
    • Lattif, A. A., Mukherjee, P. K., Chandra, J., Roth, M. R., Welti, R., Rouabhia, M. and Ghannoum, MA. (2011) Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation. Microbiology 157, 3232-3242 CrossRef PubMed
    • (2011) Microbiology , vol.157 , pp. 3232-3242
    • Lattif, A.A.1    Mukherjee, P.K.2    Chandra, J.3    Roth, M.R.4    Welti, R.5    Rouabhia, M.6    Ghannoum, M.A.7
  • 50
    • 33745145484 scopus 로고    scopus 로고
    • Quorum sensing in dimorphic fungi: Farnesol and beyond
    • CrossRef PubMed
    • Nickerson, K. W., Atkin, A. L. and Hornby, J. M. (2006) Quorum sensing in dimorphic fungi: farnesol and beyond. Appl. Environ. Microbiol. 72, 3805-3813 CrossRef PubMed
    • (2006) Appl. Environ. Microbiol. , vol.72 , pp. 3805-3813
    • Nickerson, K.W.1    Atkin, A.L.2    Hornby, J.M.3
  • 51
    • 79959572449 scopus 로고    scopus 로고
    • The metabolic basis of Candida albicans morphogenesis and quorum sensing
    • CrossRef PubMed
    • Han, T. L, Cannon, R. D. and Villas-Bôas, S. G. (2011) The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genet. Biol. 48, 747-763 CrossRef PubMed
    • (2011) Fungal Genet. Biol. , vol.48 , pp. 747-763
    • Han, T.L.1    Cannon, R.D.2    Villas-Bôas, S.G.3
  • 52
    • 34147176061 scopus 로고    scopus 로고
    • Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans
    • CrossRef PubMed
    • Navarathna, D. H., Hornby, J. M., Krishnan, N., Parkhurst, A., Duhamel, G. E. and Nickerson, K. W. (2007) Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. Infect. Immun. 75, 1609-1618 CrossRef PubMed
    • (2007) Infect. Immun. , vol.75 , pp. 1609-1618
    • Navarathna, D.H.1    Hornby, J.M.2    Krishnan, N.3    Parkhurst, A.4    Duhamel, G.E.5    Nickerson, K.W.6
  • 54
    • 84888229319 scopus 로고    scopus 로고
    • Contributions of Aspergillus fumigatesATP-binding cassette transporter proteins to drug resistance and virulence
    • CrossRef PubMed
    • Paul, S., Diekema, D. and Moye-Rowley, W. S. (2013) Contributions of Aspergillus fumigatesATP-binding cassette transporter proteins to drug resistance and virulence. Eukaryot. Cell 12, 1619-1628 CrossRef PubMed
    • (2013) Eukaryot. Cell , vol.12 , pp. 1619-1628
    • Paul, S.1    Diekema, D.2    Moye-Rowley, W.S.3
  • 55
    • 0041764578 scopus 로고    scopus 로고
    • Mechanism of fluconazole resistance in Candida albicans biofilms: Phase-specific role of efflux pumps and membrane sterols
    • CrossRef PubMed
    • Mukherjee, P. K., Chandra, J., Kuhn, D. M. and Ghannoum, M. A. (2003) Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infect. Immun. 71, 4333-4340 CrossRef PubMed
    • (2003) Infect. Immun. , vol.71 , pp. 4333-4340
    • Mukherjee, P.K.1    Chandra, J.2    Kuhn, D.M.3    Ghannoum, M.A.4
  • 57
    • 79960574755 scopus 로고    scopus 로고
    • A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis
    • CrossRef PubMed
    • Trofa, D., Soghier, L., Long, C., Nosanchuk, J. D., Gacser, A. and Goldman, D. L. (2011) A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis. Mycopathologia 172, 169-178 CrossRef PubMed
    • (2011) Mycopathologia , vol.172 , pp. 169-178
    • Trofa, D.1    Soghier, L.2    Long, C.3    Nosanchuk, J.D.4    Gacser, A.5    Goldman, D.L.6
  • 58
    • 79957518864 scopus 로고    scopus 로고
    • In vitro interactions of Candida parapsilosis wild type and lipase deficient mutants with human monocyte derived dendritic cells
    • CrossRef PubMed
    • Nagy, I., Filkor, K., Németh, T., Hamari, Z., Vágvö lgyi, C. and Gácser, A. (2011) In vitro interactions of Candida parapsilosis wild type and lipase deficient mutants with human monocyte derived dendritic cells. BMC Microbiol. 11, 122 CrossRef PubMed
    • (2011) BMC Microbiol. , vol.11 , pp. 122
    • Nagy, I.1    Filkor, K.2    Németh, T.3    Hamari, Z.4    Vágvölgyi, C.5    Gácser, A.6
  • 60
    • 0033958143 scopus 로고    scopus 로고
    • Potential role of phospholipases in virulence and fungal pathogenesis
    • CrossRef PubMed
    • Ghannoum, M. A. (2000) Potential role of phospholipases in virulence and fungal pathogenesis. Clin. Microbiol. Rev. 13, 122-143 CrossRef PubMed
    • (2000) Clin. Microbiol. Rev. , vol.13 , pp. 122-143
    • Ghannoum, M.A.1
  • 63
    • 33748460170 scopus 로고    scopus 로고
    • Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicansreduces cell-associated phospholipase A2 activity and attenuates virulence
    • CrossRef PubMed
    • Theiss, S., Ishdorj, G., Brenot, A., Kretschmar, M., Lan, C. Y, Nichterlein, T., Hacker, J., Nigam, S., Agabian, N. and Köhler, G. A. (2006) Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicansreduces cell-associated phospholipase A2 activity and attenuates virulence. Int. J. Med. Microbiol. 296, 405-420 CrossRef PubMed
    • (2006) Int. J. Med. Microbiol. , vol.296 , pp. 405-420
    • Theiss, S.1    Ishdorj, G.2    Brenot, A.3    Kretschmar, M.4    Lan, C.Y.5    Nichterlein, T.6    Hacker, J.7    Nigam, S.8    Agabian, N.9    Köhler, G.A.10
  • 64
    • 4143131048 scopus 로고    scopus 로고
    • Candida albicansbiofilms: A developmental state associated with specific and stable gene expression patterns
    • CrossRef PubMed
    • Garćia-Sánchez, S., Aubert, S., Iraqui, I., Janbon, G., Ghigo, J. M. and d'Enfert, C. (2004) Candida albicansbiofilms: a developmental state associated with specific and stable gene expression patterns. Eukaryot. Cell 3, 536-545 CrossRef PubMed
    • (2004) Eukaryot. Cell , vol.3 , pp. 536-545
    • Garćia-Sánchez, S.1    Aubert, S.2    Iraqui, I.3    Janbon, G.4    Ghigo, J.M.5    D'Enfert, C.6
  • 67
    • 84865611209 scopus 로고    scopus 로고
    • A novel role for the transcription factor Cwt1p as a negative regulator of nitrosative stress in Candida albicans
    • CrossRef PubMed
    • Sellam, A., Tebbji, F., Whiteway, M. and Nantel, A. (2012) A novel role for the transcription factor Cwt1p as a negative regulator of nitrosative stress in Candida albicans. PLoS ONE 7, e43956 CrossRef PubMed
    • (2012) PLoS ONE , vol.7
    • Sellam, A.1    Tebbji, F.2    Whiteway, M.3    Nantel, A.4
  • 68
    • 18844393429 scopus 로고    scopus 로고
    • Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans
    • CrossRef PubMed
    • Liu, T. T., Lee, R. E., Barker, K. S., Lee, R. E., Wei, L., Homayouni, R. and Rogers, P. D. (2005) Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrob. Agents Chemother. 49, 2226-2236 CrossRef PubMed
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 2226-2236
    • Liu, T.T.1    Lee, R.E.2    Barker, K.S.3    Lee, R.E.4    Wei, L.5    Homayouni, R.6    Rogers, P.D.7


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