Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Zhang, Chunfang ^a   Peng, Jinyong ^a   Wu, Shan ^a   Jin, Yue ^a   Xia, Fan ^a   Wang, Changyuan ^a   Liu, Kexin ^a   Sun, Huijun ^a   Liu, Mozhen ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Differentiation; Dioscin; ER; Lrp5; Osteoporosis; Proliferation

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; DIOSCIN; ESTROGEN DERIVATIVE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN BCL 2; RNA; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG; DIOSGENIN; DRUG DERIVATIVE; ESTROGEN RECEPTOR ALPHA, HUMAN; LRP5 PROTEIN, MOUSE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

DIOSCOREA; DIOSCOREA NIPPONICA; DIOSCOREA ZINGIBERENSIS;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DIOSGENIN; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; MICE; OSTEOBLASTS; OSTEOPOROSIS; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84900479853     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-21-30     Document Type: Article

References (47)

1. Costunolide stimulates the function of osteoblastic MC3T3-E1 cells. Lee YS, Choi EM, Int Immunopharmacol 2011 11 6 712 718 10.1016/j.intimp.2011.01.018 21296696
2. The bone-protective effect of genistein in the animal model of bilateral ovariectomy: roles of phytoestrogens and PTH/ PTHR1 against postmenopausal osteoporosis. Miao Q, Li JG, Miao S, Hu N, Zhang J, Zhang S, Xie YH, Wang JB, Wang SW, Int J Mol Sci 2012 13 56 70 22312238
3. Bovine lactoferrin improves bone mass and microstructure in ovariectomized rats via OPG/ RANKL/ RANK pathway. Hou JM, Xue Y, Lin QM, Acta Pharmacol Sin 2012 33 10 1277 1284 10.1038/aps.2012.83 22902986
4. Reaching a genetic and molecular understanding of skeletal development. Karsenty G, Wagner EF, Dev Cell 2002 2 4 389 406 10.1016/S1534-5807(02)00157-0 11970890 (Pubitemid 34436569)
5. Wnt/ beta-catenin signaling is a normal physiological response to mechanical loading in bone. Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, Kharode Y, Sauter L, Babij P, Brown EL, Hill AA, Akhter MP, Johnson ML, Recker RR, Komm BS, Bex FJ, J Biol Chem 2006 281 42 31720 31728 10.1074/jbc.M602308200 16908522 (Pubitemid 46043263)
6. Attenuated Wnt/ β-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Georgiou KR, King TJ, Scherer MA, Zhou H, Foster BK, Xian CJ, Bone 2012 50 6 1223 1233 10.1016/j.bone.2012.03.027 22484100
7. Wnt signaling in osteoblasts and bone diseases. Westendorf JJ, Kahler RA, Schroeder TM, Gene 2004 341 19 39 15474285 (Pubitemid 39335880)
8. Simvastatin induces estrogen receptor-alpha (ER-) in murine bone marrow stromal cells. Song C, Wang J, Song Q, Li X, Chen Z, Ma Q, Liu Z, Jia H, Dang G, J Bone Miner Metab 2008 26 213 217 10.1007/s00774-007-0820-6 18470660 (Pubitemid 351677840)
9. The effects of tualang honey on bone metabolism of postmenopausal women. Mohd Effendy N, Mohamed N, Muhammad N, Mohamad IN, Shuid AN, Evid Based Complement Alternat Med 2012 2012 938574 22973408
10. Functional adaptation in female rats: the role of estrogen signaling. Sample SJ, Racette MA, Hao Z, Thomas CF, Behan M, Muir P, PLoS One 2012 7 9 1 10
11. Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway. Lee CH, Huang YL, Liao JF, Chiou WF, Eur J Pharmacol 2012 676 1-3 26 33 22192930
12. Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ER expression and uterine wet weight in ovariectomized rats. Li X, Song QS, Wang JY, Leng HJ, Chen ZQ, Liu ZJ, Dang GT, Song CL, J Bone Miner Metab 2011 29 396 403 10.1007/s00774-010-0231-y 21063740
13. Statins modulate the levels of osteoprotegerin/ receptor activator of NFkappaB ligand mRNA in mouse bone-cell cultures. Kaji H, Kanatani M, Sugimoto T, Chihara K, Horm Metab Res 2005 37 10 589 592 10.1055/s-2005-870538 16278780 (Pubitemid 41597568)
14. Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice. Lu B, Xu Y, Xu L, Cong X, Yin L, Li H, Peng J, Environ Toxicol Pharmacol 2012 34 127 135 10.1016/j.etap.2012.03.010 22516057
15. Apoptosis induced by dioscin in hela cells. Cai J, Liu M, Wang Z, Ju Y, Biol Pharm Bull 2002 25 193 196 10.1248/bpb.25.193 11853164 (Pubitemid 39592103)
16. Structure-activity relationships of the saponins dioscin and dioscinin. Takechi M, Shimada S, Tanaka Y, Phytochemistry 1991 30 3943 3944 10.1016/0031-9422(91)83441-M
17. Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright. Li H, Huang W, Wen Y, Gong G, Zhao Q, Yu G, Fitoterapia 2010 81 1147 1156 10.1016/j.fitote.2010.07.016 20659537
18. Study on the best harvest time of Dioscorea nipponica Makino. Liu L, Jin D, Niu Z, Xu G, Chin Tradit Herb Drugs 2005 36 12 1879 1881
19. Effects of diosgenin on cell proliferation, differentiation and OPG/ RANKL mRNA expression of rat osteoblasts cultured in vitro. Jiang YZ, Wang JJ, Liang JC, Chen Y, CJTCMP 2010 25 1 134 136
20. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Qu X, Zhai Z, Liu X, Li H, Ouyang Z, Wu C, Liu G, Fan Q, Tang T, Qin A, Dai K, Biochem Biophys Res Commun 2014 443 2 658 665 10.1016/j.bbrc.2013.12.029 24333429
21. Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors Park JB, Zhang H, Lin CY, Chung CP, Byun Y, Park YS, Yang VC, J Surg Res 2012 174 2 278 283 10.1016/j.jss.2010.12.029 21324392
22. A green and efficient protocol for industrial-scale preparation of dioscin from Dioscorea nipponica Makino by two-step macroporous resin column chromatography. Yin L, Xu Y, Xu L, Qi Y, Han X, Peng J, Chem Eng J 2010 165 281 289 10.1016/j.cej.2010.09.045
23. Effects of panaxatriol saponins on the differentiation and apoptosis of MC3T3-E1 cells. Shen Y, Ji H, Li S, Ding L, Zhang Z, J Chin Pharm Univ 2010 41 273 277
24. Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells. Mok SK, Chen WF, Lai WP, Leung PC, Wang XL, Yao XS, Wong MS, Br J Pharmacol 2010 159 4 939 949 10.1111/j.1476-5381.2009.00593.x 20128811
25. Interplay between LXR and Wnt/ β-Catenin signaling in the negative regulation of peripheral myelin genes by oxysterols. Makoukji J, Shackleford G, Meffre D, Grenier J, Liere P, Lobaccaro JM, Schumacher M, Massaad C, J Neurosci 2011 31 9620 9629 10.1523/JNEUROSCI.0761-11.2011 21715627
26. Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells. Zhou H, Shang L, Li X, Zhang X, Gao G, Guo C, Chen B, Liu Q, Gong Y, Shao C, Exp Cell Res 2009 315 2953 2962 10.1016/j.yexcr.2009.07.030 19665018
27. The Prognostic Value of the Apoptosis Pathway in Colorectal Cancer: A Review of the Literature on Biomarkers Identified by Immunohistochemistry. Zeestraten EC, Benard A, Reimers MS, Schouten PC, Liefers GJ, van de Velde CJ, Kuppen PJ, Biomark Cancer 2013 5 13 29 24179395
28. Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts. Lamghari M, Tavares L, Camboa N, Barbosa MA, J Cell Biochem 2006 98 1123 1129 10.1002/jcb.20853 16479591 (Pubitemid 44128354)
29. Lrp5 functions in bone to regulate bone mass. Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG, Nat Med 2011 17 684 691 10.1038/nm.2388 21602802
30. Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells. Don MJ, Lin LC, Chiou WF, Phytomedicine 2012 19 6 551 561 10.1016/j.phymed.2012.01.006 22397994
31. Echinacoside promotes bone regeneration by increasing OPG/ RANKL ratio in MC3T3-E1 cells. Li F, Yang Y, Zhu P, Chen W, Qi D, Shi X, Zhang C, Yang Z, Li P, Fitoterapia 2012 83 8 1443 1450 10.1016/j.fitote.2012.08.008 22951288
32. Antigenic profile of osteoblasts present in human bone tissue sections. García-Martínez O, Reyes-Botella C, Aguilera-Castillo O, Vallecillo-Capilla MF, Ruiz C, Biosci Rep 2006 26 1 39 43 10.1007/s10540-006- 9006-z 16779666
33. Antigenic phenotype of cultured human osteoblast-like cells. Reyes-Botella C, Montes MJ, Vallecillo-Capilla MF, Olivares EG, Ruiz C, Cell Physiol Biochem 2002 12 5-6 359 364 12438772 (Pubitemid 35356711)
34. Simultaneous administration of fluoride and selenite regulates proliferation and apoptosis in murine osteoblast-like MC3T3-E1 cells by altering osteoprotegerin. Ren G, Wang K, Chang R, Su Y, Wang J, Su J, Han B, Biol Trace Elem Res 2011 144 1-3 1437 1448 21739163
35. Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation. Kühn MC, Willenberg HS, Schott M, Papewalis C, Stumpf U, Flohé S, Scherbaum WA, Schinner S, Mol Cell Endocrinol 2012 349 2 180 188 10.1016/j.mce.2011.10.018 22040599
36. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ, Cell 1997 89 309 319 10.1016/S0092-8674(00)80209-3 9108485 (Pubitemid 27199902)
37. A phytoestrogen diarylheptanoid mediates ER/ Akt/ GSK-3β-dependent activation of Wnt/ β-catenin signaling pathway. Bhukhai K, Suksen K, Bhummaphan N, Janjorn K, Thongon N, Tantikanlayaporn D, Piyachaturawat P, Suksamrarn A, Chairoungdua A, J Biol Chem 2012 287 43 36168 36178 10.1074/jbc.M112.344747 22936801
38. The novel estrogen receptor G-protein -coupled receptor 30 is expressed in human bone. Heino TJ, Chagin AS, Sävendahl L, J Endocrinol 2008 197 1 R6 10.1677/JOE-07-0629 18434348 (Pubitemid 351696258)
39. Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis. Braidman I, Baris C, Wood L, Selby P, Adams J, Freemont A, Hoyland J, Bone 2000 26 5 423 427 10.1016/S8756-3282(00)00246-5 10773580 (Pubitemid 30204461)
40. Association between estrogen receptor-β dinucleotide repeat polymorphism and incidence of femoral fracture. Honma N, Mori S, Zhou H, Ikeda S, Mieno MN, Tanaka N, Takubo K, Arai T, Sawabe M, Muramatsu M, Ito H, J Bone Miner Metab 2013 31 1 96 101 10.1007/s00774-012-0383-z 22948905
41. ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen. Howell A, Osborne CK, Morris C, Wakeling AE, Cancer 2000 89 4 817 825 10.1002/1097-0142(20000815)89:4<817::AID-CNCR14>3.0.CO;2-6 10951345 (Pubitemid 30658581)
42. Agonistic activity of ICI 182 780 on activation of GSK 3β/ AKT pathway in the rat uterus during the estrous cycle. Baranda-Avila N, Mendoza-Rodríguez CA, Morimoto S, Camacho-Arroyo I, Guerra-Araiza C, Langley E, Cerbón M, Steroids 2013 78 7 717 725 10.1016/j.steroids.2013. 03.003 23583603
43. Mutations in Lrp5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. Korvala J, Jüppner H, Mäkitie O, Sochett E, Schnabel D, Mora S, Bartels CF, Warman ML, Deraska D, Cole WG, Hartikka H, Ala-Kokko L, Männikkö M, BMC Med Genet 2012 13 26 22487062
44. Effects of pulsed electromagnetic fields on bone mass and Wnt/ β-Catenin signaling pathway in ovariectomized rats. Zhou J, He H, Yang L, Chen S, Guo H, Xia L, Liu H, Qin Y, Liu C, Wei X, Zhou Y, He C, Arch Med Res 2012 43 274 282 10.1016/j.arcmed.2012.06.002 22704852
45. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, Glass DA 2nd, Hartmann C, Li L, Hwang TH, Brayton CF, Lang RA, Karsenty G, Chan L, J Cell Biol 2002 157 303 314 10.1083/jcb.200201089 11956231 (Pubitemid 34839826)
46. Wnt/ beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Day TF, Guo X, Garrett-Beal L, Yang Y, Dev Cell 2005 8 739 750 10.1016/j.devcel. 2005.03.016 15866164 (Pubitemid 40585296)
47. BMP-2 modulates beta -catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts. Zhang M, Yan Y, Lim YB, Tang D, Xie R, Chen A, Tai P, Harris SE, Xing L, Qin YX, Chen D, J Cell Biochem 2009 108 896 10.1002/jcb.22319 19795382