An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

DMM Disease Models and Mechanisms

Volumn 7, Issue 5, 2014, Pages 561-569

  Sun, Yiguo ^a   Tong, Xiaoling ^a   Chen, Honghong ^a   Huang, Tao ^a   Shao, Qing ^a   Huang, Weixiong ^a   Laird, Dale W ^a   Bai, Donglin ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Atrial fibrillation; Connexin40; Gap junctions; Genetics; Germline mutation

Indexed keywords

CONNEXIN 40; CONNEXIN 43; FLUORESCENT PROTEIN 583; GAP JUNCTION PROTEIN; MUTANT PROTEIN; PHOTOPROTEIN;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONNEXIN40 GENE; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; GAP JUNCTION; GENE; GENE EXPRESSION; GENE MUTATION; GENETIC PREDISPOSITION; GERMLINE MUTATION; HEART ATRIUM FIBRILLATION; HELA CELL LINE; HUMAN; HUMAN CELL; HYPOTHESIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SOMATIC MUTATION; WILD TYPE; ADULT; ANIMAL; CELL FRACTIONATION; CHEMISTRY; DOMINANT GENE; GENETICS; METABOLISM; MOUSE; MUTATION; PROTEIN TRANSPORT; RAT;

ADULT; ANIMALS; ATRIAL FIBRILLATION; CONNEXIN 43; CONNEXINS; ENDOPLASMIC RETICULUM; GAP JUNCTIONS; GENES, DOMINANT; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; MICE; MUTANT PROTEINS; MUTATION; PROTEIN TRANSPORT; RATS; SUBCELLULAR FRACTIONS;

EID: 84900464300     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.013813     Document Type: Article

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