Hepatitis B virus genotypes: Global distribution and clinical importance

World Journal of Gastroenterology

Volumn 20, Issue 18, 2014, Pages 5427-5434

  Sunbul, Mustafa ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

Anti viral therapy; Chronic hepatitis B; Genotypes; Hepatitis B virus; Viral mutation

Indexed keywords

HEPATITIS B (E) ANTIGEN; HEPATITIS B SURFACE ANTIGEN; INTERFERON; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; BIOLOGICAL MARKER; HEPATITIS B(E) ANTIGEN;

ARTICLE; CHRONICITY; DISEASE COURSE; GENE MUTATION; GENOTYPE; GENOTYPING TECHNIQUE; GEOGRAPHIC DISTRIBUTION; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS B VIRUS GENOTYPE A; HEPATITIS B VIRUS GENOTYPE B; HEPATITIS B VIRUS GENOTYPE C; HEPATITIS B VIRUS GENOTYPE D; HUMAN; IMMUNE RESPONSE; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; SEROCONVERSION; VIRAL CLEARANCE; ANTIVIRAL RESISTANCE; BLOOD; DRUG EFFECTS; GENETICS; HEALTH; IMMUNOLOGY; PATHOGENICITY; PHENOTYPE; TREATMENT OUTCOME; VIROLOGY;

ANTIVIRAL AGENTS; BIOLOGICAL MARKERS; DRUG RESISTANCE, VIRAL; GENOTYPE; GLOBAL HEALTH; HEPATITIS B; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; PHENOTYPE; TREATMENT OUTCOME;

EID: 84900458142     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i18.5427     Document Type: Article

References (64)

1. Huang CC, Kuo TM, Yeh CT, Hu CP, Chen YL, Tsai YL, Chen ML, Chou YC, Chang C. One single nucleotide difference alters the differential expression of spliced RNAs between HBV genotypes A and D. Virus Res 2013; 174: 18-26 [PMID: 23501362 DOI: 10.1016/j.virusres.2013.02.004]
2. Biswas A, Panigrahi R, Pal M, Chakraborty S, Bhattacharya P, Chakrabarti S, Chakravarty R. Shift in the hepatitis B virus genotype distribution in the last decade among the HBV carriers from eastern India: possible effects on the disease status and HBV epidemiology. J Med Virol 2013; 85: 1340-1347 [PMID: 23765773 DOI: 10.1002/jmv.23628]
3. Moura IF, Lopes EP, Alvarado-Mora MV, Pinho JR, Carrilho FJ. Phylogenetic analysis and subgenotypic distribution of the hepatitis B virus in Recife, Brazil. Infect Genet Evol 2013; 14: 195-199 [PMID: 23268113 DOI: 10.1016/ j.meegid.2012.11.022]
4. Shi W, Zhang Z, Ling C, Zheng W, Zhu C, Carr MJ, Higgins DG. Hepatitis B virus subgenotyping: history, effects of recombination, misclassifications, and corrections. Infect Genet Evol 2013; 16: 355-361 [PMID: 23538336 DOI: 10.1016/ j.meegid.2013.03.021]
5. Cooksley WG. Do we need to determine viral genotype in treating chronic hepatitis B? J Viral Hepat 2010; 17: 601-610 [PMID: 20529201 DOI: 10.1111/j.1365-2893.2010.01326.x]
6. Liu CJ, Kao JH. Global perspective on the natural history of chronic hepatitis B: role of hepatitis B virus genotypes A to J. Semin Liver Dis 2013; 33: 97-102 [PMID: 23749665 DOI: 10.1055/s-0033-1345716]
7. Sakamoto T, Tanaka Y, Orito E, Co J, Clavio J, Sugauchi F, Ito K, Ozasa A, Quino A, Ueda R, Sollano J, Mizokami M. Novel subtypes (subgenotypes) of hepatitis B virus genotypes B and C among chronic liver disease patients in the Philippines. J Gen Virol 2006; 87: 1873-1882 [PMID: 16760389]
8. Schaefer S. Hepatitis B virus taxonomy and hepatitis B virus genotypes. World J Gastroenterol 2007; 13: 14-21 [PMID: 17206751]
9. Allain JP. Epidemiology of Hepatitis B virus and genotype. J Clin Virol 2006; 36 Suppl 1: S12-S17 [PMID: 16831687]
10. Lin S, Liu C, Shang H, Chen H, Yang B, Chen J, Chen Y, Chen D, Ou Q. HBV serum markers of 49164 patients and their relationships to HBV genotype in Fujian Province of China. J Clin Lab Anal 2013; 27: 130-136 [PMID: 23424100 DOI: 10.1002/jcla.21573]
11. Sakamoto T, Tanaka Y, Watanabe T, Iijima S, Kani S, Sugiyama M, Murakami S, Matsuura K, Kusakabe A, Shinkai N, Sugauchi F, Mizokami M. Mechanism of the dependence of hepatitis B virus genotype G on co-infection with other genotypes for viral replication. J Viral Hepat 2013; 20: e27-e36 [PMID: 23490386 DOI: 10.1111/jvh.12022]
12. Ghosh S, Banerjee P, Deny P, Mondal RK, Nandi M, Roychoudhury A, Das K, Banerjee S, Santra A, Zoulim F, Chowdhury A, Datta S. New HBV subgenotype D9, a novel D/C recombinant, identified in patients with chronic HBeAg-negative infection in Eastern India. J Viral Hepat 2013; 20: 209-218 [PMID: 23383660 DOI: 10.1111/j.1365-2893.2012.01655.x]
13. Siburian MD, Utama A, Dhenni R, Arnelis N, Fanany I, Intan MD, Kurniasih TS, Andriani F, Afadlal S, Julianto EB, Rasman WS, Zubir N, Mathew G. High prevalence of hepatitis B virus genotype C/C1 in the Minangkabau ethnic group in Indonesia. Virol J 2013; 10: 27 [PMID: 23336976 DOI: 10.1186/1743-422X-10-27]
14. Prasetyo AA, Dirgahayu P, Sari Y, Hudiyono H, Kageyama S. Molecular epidemiology of HIV, HBV, HCV, and HTLV-1/2 in drug abuser inmates in central Javan prisons, Indonesia. J Infect Dev Ctries 2013; 7: 453-467 [PMID: 23771289 DOI: 10.3855/jidc.2965]
15. Ayari R, Lakhoua-Gorgi Y, Bouslama L, Safar I, Kchouk FH, Aouadi H, Jendoubi-Ayed S, Najjar T, Ayed K, Abdallah TB. Investigation of DNA sequence in the Basal core promoter, precore, and core regions of hepatitis B virus from Tunisia shows a shift in genotype prevalence. Hepat Mon 2012; 12: e6191 [PMID: 23346148 DOI: 10.5812/hepatmon.6191]
16. Sunbul M, Leblebicioglu H. Distribution of hepatitis B virus genotypes in patients with chronic hepatitis B in Turkey. World J Gastroenterol 2005; 11: 1976-1980 [PMID: 15800989]
17. Nabuco LC, Mello FC, Gomes Sde A, Perez RM, Soares JA, Coelho HS, Nogueira CA. Hepatitis B virus genotypes in Southeast Brazil and its relationship with histological features. Mem Inst Oswaldo Cruz 2012; 107: 785-789 [PMID: 22990965]
18. Shi YH. Correlation between hepatitis B virus genotypes and clinical outcomes. Jpn J Infect Dis 2012; 65: 476-482 [PMID: 23183198]
19. Kao JH. Molecular epidemiology of hepatitis B virus. Korean J Intern Med 2011; 26: 255-261 [PMID: 22016585 DOI: 10.3904/kjim.2011.26.3.255]
20. Sakai T, Shiraki K, Inoue H, Okano H, Deguchi M, Sugimoto K, Ohmori S, Murata K, Fujioka H, Takase K, Tameda Y, Nakano T. HBV subtype as a marker of the clinical course of chronic HBV infection in Japanese patients. J Med Virol 2002; 68: 175-181 [PMID: 12210405]
21. Kobayashi M, Suzuki F, Arase Y, Akuta N, Suzuki Y, Hosaka T, Saitoh S, Kobayashi M, Tsubota A, Someya T, Ikeda K, Matsuda M, Sato J, Kumada H. Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001. J Gastroenterol 2004; 39: 844-850 [PMID: 15565403]
22. Congly SE, Wong P, Al-Busafi SA, Doucette K, Fung SK, Ghali P, Fonseca K, Myers RP, Osiowy C, Coffin CS. Characterization of hepatitis B virus genotypes and quantitative hepatitis B surface antigen titres in North American tertiary referral liver centres. Liver Int 2013; 33: 1363-1369 [PMID: 23763288 DOI: 10.1111/liv.12222]
23. Komas NP, Vickos U, Hübschen JM, Béré A, Manirakiza A, Muller CP, Le Faou A. Cross-sectional study of hepatitis B virus infection in rural communities, Central African Republic. BMC Infect Dis 2013; 13: 286 [PMID: 23800310 DOI: 10.1186/1471-2334-13-286]
24. Khan A, Al Balwi MA, Tanaka Y, Hajeer A, Sanai FM, Al Abdulkarim I, Al Ayyar L, Badri M, Saudi D, Tamimi W, Mizokami M, Al Knawy B. Novel point mutations and mutational complexes in the enhancer II, core promoter and precore regions of hepatitis B virus genotype D1 associated with hepatocellular carcinoma in Saudi Arabia. Int J Cancer 2013; 133: 2864-2871 [PMID: 23740667 DOI: 10.1002/ ijc.28307]
25. Geramizadeh B, Nikeghbalian S, Kazemi K, Shamsaifar A, Bahador A, Salahi H, Malekhosseini SA, Kashtkar Jahromi M, Bakhshai Dehkordi A. Hepatocellular carcinoma in explanted livers of patients with genotype d HBV cirrhosis: report of the first experience from Iran. Arch Iran Med 2013; 16: 348-350 [PMID: 23725068]
26. Norouzi M, Ghorashi S, Abedi F, Nejatizadeh A, Ataei B, Malekzadeh R, Alavian S, Judaki M, Ghamari S, Namazi A, Rahimnia R, Khedive A, Jazayeri S. Identification of Hepatitis B Virus Surface Antigen (HBsAg) Genotypes and Variations in Chronic Carriers from Isfahan Province, Iran. Iran J Public Health 2012; 41: 104-111 [PMID: 23113154]
27. Oyunsuren T, Kurbanov F, Tanaka Y, Elkady A, Sanduijav R, Khajidsuren O, Dagvadorj B, Mizokami M. High frequency of hepatocellular carcinoma in Mongolia; association with mono-, or co-infection with hepatitis C, B, and delta viruses. J Med Virol 2006; 78: 1688-1695 [PMID: 17063518]
28. Yousif M, Kramvis A. Genotype D of hepatitis B virus and its subgenotypes: An update. Hepatol Res 2013; 43: 355-364 [PMID: 22978460 DOI: 10.1111/j.1872-034X.2012.01090]
29. Louisirirotchanakul S, Olinger CM, Arunkaewchaemsri P, Poovorawan Y, Kanoksinsombat C, Thongme C, Sa-Nguanmoo P, Krasae S, Theamboonlert A, Oota S, Fongsatitkul L, Puapairoj C, Promwong C, Weber B. The distribution of hepatitis B virus genotypes in Thailand. J Med Virol 2012; 84: 1541-1547 [PMID: 22930500 DOI: 10.1002/jmv.23363]
30. Lampertico P, Viganò M, Di Costanzo GG, Sagnelli E, Fasano M, Di Marco V, Boninsegna S, Farci P, Fargion S, Giuberti T, Iannacone C, Regep L, Massetto B, Facchetti F, Colombo M. Randomised study comparing 48 and 96 weeks peginterferon α-2a therapy in genotype D HBeAg-negative chronic hepatitis B. Gut 2013; 62: 290-298 [PMID: 22859496 DOI: 10.1136/gutjnl-2011-301430]
31. Baha W, Ennaji MM, Lazar F, Melloul M, El Fahime E, El Malki A, Bennani A. HBV genotypes prevalence, precore and basal core mutants in Morocco. Infect Genet Evol 2012; 12: 1157-1162 [PMID: 22579480 DOI: 10.1016/j.meegid.2012.04.026]
32. Torres C, Piñeiro y Leone FG, Pezzano SC, Mbayed VA, Campos RH. New perspectives on the evolutionary history of hepatitis B virus genotype F. Mol Phylogenet Evol 2011; 59: 114-122 [PMID: 21296172 DOI: 10.1016/j.ympev.2011.01.010]
33. Ragheb M, Elkady A, Tanaka Y, Murakami S, Attia FM, Hassan AA, Hassan MF, Shedid MM, Abdel Reheem HB, Khan A, Mizokami M. Multiple intra-familial transmission patterns of hepatitis B virus genotype D in north-eastern Egypt. J Med Virol 2012; 84: 587-595 [PMID: 22337297 DOI: 10.1002/jmv.23234]
34. Ali M, Idrees M, Ali L, Hussain A, Ur Rehman I, Saleem S, Afzal S, Butt S. Hepatitis B virus in Pakistan: a systematic review of prevalence, risk factors, awareness status and genotypes. Virol J 2011; 8: 102 [PMID: 21375760 DOI: 10.1186/1743-422X-8-102]
35. Davies J, Littlejohn M, Locarnini SA, Whiting S, Hajkowicz K, Cowie BC, Bowden DS, Tong SY, Davis JS. Molecular epidemiology of hepatitis B in the Indigenous people of northern Australia. J Gastroenterol Hepatol 2013; 28: 1234-1241 [PMID: 23432545 DOI: 10.1111/jgh.12177]
36. Sugauchi F, Mizokami M, Orito E, Ohno T, Kato H, Suzuki S, Kimura Y, Ueda R, Butterworth LA, Cooksley WG. A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: complete genome sequence and phylogenetic relatedness. J Gen Virol 2001; 82: 883-892 [PMID: 11257194]
37. Buti M, Rodriguez-Frias F, Jardi R, Esteban R. Hepatitis B virus genome variability and disease progression: the impact of pre-core mutants and HBV genotypes. J Clin Virol 2005; 34 Suppl 1: S79-S82 [PMID: 16461229]
38. Chen RY, Bowden S, Desmond PV, Dean J, Locarnini SA. Effects of interferon alpha therapy on the catalytic domains of the polymerase gene and basal core promoter, precore and core regions of hepatitis B virus. J Gastroenterol Hepatol 2003; 18: 630-637 [PMID: 12753143]
39. Xibing G, Xiaojuan Y, Juanhua W. PD-1 expression on CTL may be related to more severe liver damage in CHB patients with HBV genotype C than in those with genotype B infection. J Viral Hepat 2013; 20: e1-e2 [PMID: 23490376 DOI: 10.1111/jvh.12009]
40. Xibing G, Xiaojuan Y, Juanhua W, Zhong H. Relationship between HBV genotypes B, C and follicular helper T cells in patients with chronic hepatitis B and its significance. Hepat Mon 2013; 13: e6221 [PMID: 23585765 DOI: 10.5812/hepatmon. 6221]
41. Ogawa M, Hasegawa K, Naritomi T, Torii N, Hayashi N. Clinical features and viral sequences of various genotypes of hepatitis B virus compared among patients with acute hepatitis B. Hepatol Res 2002; 23: 167-177 [PMID: 12076712]
42. Suzuki Y, Kobayashi M, Ikeda K, Suzuki F, Arfase Y, Akuta N, Hosaka T, Saitoh S, Kobayashi M, Someya T, Matsuda M, Sato J, Watabiki S, Miyakawa Y, Kumada H. Persistence of acute infection with hepatitis B virus genotype A and treatment in Japan. J Med Virol 2005; 76: 33-39 [PMID: 15779048]
43. Zhang HW, Yin JH, Li YT, Li CZ, Ren H, Gu CY, Wu HY, Liang XS, Zhang P, Zhao JF, Tan XJ, Lu W, Schaefer S, Cao GW. Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China. Gut 2008; 57: 1713-1720 [PMID: 18755887 DOI: 10.1136/gut.2008.157149]
44. Wai CT, Fontana RJ, Polson J, Hussain M, Shakil AO, Han SH, Davern TJ, Lee WM, Lok AS. Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepat 2005; 12: 192-198 [PMID: 15720535]
45. Lin CL, Kao JH. The clinical implications of hepatitis B virus genotype: Recent advances. J Gastroenterol Hepatol 2011; 26 Suppl 1: 123-130 [PMID: 21199523 DOI: 10.1111/ j.1440-1746.2010.06541.x]
46. Boglione L, D'Avolio A, Cariti G, Milia MG, Simiele M, De Nicolò A, Ghisetti V, Di Perri G. Sequential therapy with entecavir and PEG-INF in patients affected by chronic hepatitis B and high levels of HBV-DNA with non-D genotypes. J Viral Hepat 2013; 20: e11-e19 [PMID: 23490378 DOI: 10.1111/jvh.12018]
47. Zhang Y, Wu Y, Ye S, Wang T, Zhao R, Chen F, Abe K, Jin X. The response to interferon is influenced by hepatitis B virus genotype in vitro and in vivo. Virus Res 2013; 171: 65-70 [PMID: 23123214 DOI: 10.1016/j.virusres.2012.10.027]
48. Fan HB, Guo YB, Zhu YF, Chen AS, Zhou MX, Li Z, Xu LT, Ma XJ, Yan FM. Hepatitis B Virus Genotype B and High Expression of Interferon Alpha Receptor β Subunit are Associated With Better Response to Pegylated Interferon Alpha 2a in Chinese Patients With Chronic Hepatitis B Infection. Hepat Mon 2012; 12: 333-338 [PMID: 22783345 DOI: 10.5812/ hepatmon.6173]
49. Lampertico P, Viganò M, Cheroni C, Facchetti F, Invernizzi F, Valveri V, Soffredini R, Abrignani S, De Francesco R, Colombo M. IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B. Hepatology 2013; 57: 890-896 [PMID: 22473858 DOI: 10.1002/hep.25749]
50. Liu CJ, Kao JH, Chen DS. Therapeutic implications of hepatitis B virus genotypes. Liver Int 2005; 25: 1097-1107 [PMID: 16343058]
51. Kao JH. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002; 17: 643-650 [PMID: 12100608]
52. Liu CJ, Kao JH. Genetic variability of hepatitis B virus and response to antiviral therapy. Antivir Ther 2008; 13: 613-624 [PMID: 18771045]
53. Wiegand J, Hasenclever D, Tillmann HL. Should treatment of hepatitis B depend on hepatitis B virus genotypes? A hypothesis generated from an explorative analysis of published evidence. Antivir Ther 2008; 13: 211-220 [PMID: 18505172]
54. Li W, Chen G, Yu X, Shi Y, Peng M, Wei J. Accumulation of the mutations in basal core promoter of hepatitis B virus subgenotype C1 increase the risk of hepatocellular carcinoma in Southern China. Int J Clin Exp Pathol 2013; 6: 1076-1085 [PMID: 23696925]
55. Sunbul M, Sugiyama M, Kurbanov F, Leblebicioglu H, Khan A, Elkady A, Tanaka Y, Mizokami M. Specific mutations of basal core promoter are associated with chronic liver disease in hepatitis B virus subgenotype D1 prevalent in Turkey. Microbiol Immunol 2013; 57: 122-129 [PMID: 23252849 DOI: 10.1111/1348-0421.12011]
56. Chen Y, Yu D, Zhang W, Qiu C, Xiang G, Dai W, Wu S, Wang X. HBV Subgenotype C2 Infection, A1762T/G1764A Mutations May Contribute To Hepatocellular Carcinoma with Cirrhosis in Southeast China. Iran J Public Health 2012; 41: 10-18 [PMID: 23304671]
57. Malmström S, Eilard A, Larsson SB, Hannoun C, Norkrans G, Lindh M. Genotype impact on long-term virological outcome of chronic hepatitis B virus infection. J Clin Virol 2012; 54: 321-326 [PMID: 22608364 DOI: 10.1016/j.jcv.2012.04.015]
58. Wong GL, Chan HL, Yiu KK, Lai JW, Chan VK, Cheung KK, Wong EW, Wong VW. Meta-analysis: The association of hepatitis B virus genotypes and hepatocellular carcinoma. Aliment Pharmacol Ther 2013; 37: 517-526 [PMID: 23305043 DOI: 10.1111/apt.12207]
59. Ghosh S, Mondal RK, Banerjee P, Nandi M, Sarkar S, Das K, Santra A, Banerjee S, Chowdhury A, Datta S. Tracking the naturally occurring mutations across the full-length genome of hepatitis B virus of genotype D in different phases of chronic e-antigen-negative infection. Clin Microbiol Infect 2012; 18: E412-E418 [PMID: 22827722 DOI: 10.1111/ j.1469-0691.2012.03975.x]
60. Kim DW, Lee SA, Hwang ES, Kook YH, Kim BJ. Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma. PLoS One 2012; 7: e47372 [PMID: 23071796 DOI: 10.1371/journal. pone.0047372]
61. Yin J, Zhang H, Li C, Gao C, He Y, Zhai Y, Zhang P, Xu L, Tan X, Chen J, Cheng S, Schaefer S, Cao G. Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area. Carcinogenesis 2008; 29: 1685-1691 [PMID: 18192693 DOI: 10.1093/carcin/ bgm301]
62. Ni YH, Chang MH, Wang KJ, Hsu HY, Chen HL, Kao JH, Yeh SH, Jeng YM, Tsai KS, Chen DS. Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma. Gastroenterology 2004; 127: 1733-1738 [PMID: 15578511]
63. Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118: 554-559 [PMID: 10702206]
64. Kim H, Lee SA, Kim DW, Lee SH, Kim BJ. Naturally occurring mutations in large surface genes related to occult infection of hepatitis B virus genotype C. PLoS One 2013; 8: e54486 [PMID: 23349904 DOI: 10.1371/journal.pone.0054486]