The mechanism of intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Lou, Phing How ^a   Lucchinetti, Eliana ^a   Zhang, Liyan ^a   Affolter, Andreas ^b   Schaub, Marcus C ^c   Gandhi, Manoj ^a   Hersberger, Martin ^b   Warren, Blair E ^a   Lemieux, Hélène ^a   Sobhi, Hany F ^d   Clanachan, Alexander S ^a   Zaugg, Michael ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d Criminal Justice and Applied Social and Political Sciences Department   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITATE HYDRATASE; ACYLCARNITINE; CARNITINE OLEATE; CYTOCHROME C OXIDASE; HYDROGEN PEROXIDE; INTRALIIPD; INTRALIPID; LINOLEOYLCARNITINE; MITOGEN ACTIVATED PROTEIN KINASE 1; PALMITOYLCARNITINE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TIOPRONIN; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELLULAR SECRETION; CONCENTRATION RESPONSE; CONVALESCENCE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; HEART PROTECTION; ISCHEMIC POSTCONDITIONING; MALE; MITOCHONDRIAL ENERGY TRANSFER; NONHUMAN; RAT; REPERFUSION INJURY; RESPIROMETRY; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOTONIC AGENTS; CARNITINE; ELECTRON TRANSPORT COMPLEX IV; EMULSIONS; HEART; MALE; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; PALMITOYLCARNITINE; PHOSPHOLIPIDS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SOYBEAN OIL; VENTRICULAR FUNCTION, LEFT;

EID: 84900457655     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087205     Document Type: Article

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