메뉴 건너뛰기




Volumn 298, Issue 5, 2010, Pages

High levels of fatty acids increase contractile function of neonatal rabbit hearts during reperfusion following ischemia

Author keywords

Cardiac efficiency; Cardioprotection; Fatty acid metabolism; Glucose metabolism

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; FATTY ACID; GLUCOSE; PALMITIC ACID;

EID: 77951819987     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00284.2009     Document Type: Article
Times cited : (18)

References (73)
  • 1
    • 0141922704 scopus 로고    scopus 로고
    • The clinical significance of the reoxygenation injury in pediatric heart surgery
    • Allen BS. The clinical significance of the reoxygenation injury in pediatric heart surgery. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 6: 116-127, 2003.
    • (2003) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu , vol.6 , pp. 116-127
    • Allen, B.S.1
  • 2
    • 2542503677 scopus 로고    scopus 로고
    • Pediatric myocardial protection: A cardioplegic strategy is the "solution."
    • Allen BS. Pediatric myocardial protection: a cardioplegic strategy is the "solution." Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 7: 141-154, 2004.
    • (2004) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu , vol.7 , pp. 141-154
    • Allen, B.S.1
  • 3
    • 3042852105 scopus 로고    scopus 로고
    • Pediatric myocardial protection: Where do we stand?
    • Allen BS. Pediatric myocardial protection: where do we stand? J Thorac Cardiovasc Surg 128: 11-13, 2004.
    • (2004) J Thorac Cardiovasc Surg , vol.128 , pp. 11-13
    • Allen, B.S.1
  • 6
    • 0030831493 scopus 로고    scopus 로고
    • Direct measurement of energy metabolism in the isolated working rat heart
    • DOI 10.1016/S1056-8719(97)86574-4, PII S105687199700021X
    • Barr RL, Lopaschuk GD. Direct measurement of energy metabolism in the isolated working rat heart. J Pharmacol Toxicol Methods 38: 11-17, 1997. (Pubitemid 27460595)
    • (1997) Journal of Pharmacological and Toxicological Methods , vol.38 , Issue.1 , pp. 11-17
    • Barr, R.L.1    Lopaschuk, G.D.2
  • 11
    • 0022261849 scopus 로고
    • Myocellular calcium regulation by the sarcolemmal membrane in the adult and immature rabbit heart
    • DOI 10.1007/BF01907907
    • Boucek RJ Jr, Shelton ME, Artman M, Landon E. Myocellular calcium regulation by the sarcolemmal membrane in the adult and immature rabbit heart. Basic Res Cardiol 80: 316-325, 1985. (Pubitemid 15015989)
    • (1985) Basic Research in Cardiology , vol.80 , Issue.3 , pp. 316-325
    • Boucek Jr., R.J.1    Shelton, M.E.2    Artman, M.3
  • 12
    • 34347352169 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy revisited
    • Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation 115: 3213-3223, 2007.
    • (2007) Circulation , vol.115 , pp. 3213-3223
    • Boudina, S.1    Abel, E.D.2
  • 13
    • 33746640458 scopus 로고    scopus 로고
    • Mitochondrial uncoupling: A key contributor to reduced cardiac efficiency in diabetes
    • Boudina S, Abel ED. Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda) 21: 250-258, 2006.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 250-258
    • Boudina, S.1    Abel, E.D.2
  • 14
    • 34548848059 scopus 로고    scopus 로고
    • Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    • Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 56: 2457-2466, 2007.
    • (2007) Diabetes , vol.56 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3    Sheng, X.4    Wright, J.J.5    Hu, X.X.6    Aziz, S.7    Johnson, J.I.8    Bugger, H.9    Zaha, V.G.10    Abel, E.D.11
  • 15
    • 27844457564 scopus 로고    scopus 로고
    • Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity
    • Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology 146: 5341-5349, 2005.
    • (2005) Endocrinology , vol.146 , pp. 5341-5349
    • Buchanan, J.1    Mazumder, P.K.2    Hu, P.3    Chakrabarti, G.4    Roberts, M.W.5    Yun, U.J.6    Cooksey, R.C.7    Litwin, S.E.8    Abel, E.D.9
  • 16
    • 33646008296 scopus 로고    scopus 로고
    • 2+ overload and left ventricular mechanical dysfunction
    • 2+ overload and left ventricular mechanical dysfunction. J Cardiovasc Electrophysiol 17, Suppl 1: S141-S148, 2006.
    • (2006) J Cardiovasc Electrophysiol , vol.17 , Issue.SUPPL. 1
    • Clanachan, A.S.1
  • 17
    • 0028148702 scopus 로고
    • Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism
    • Collins-Nakai RL, Noseworthy D, Lopaschuk GD. Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism. Am J Physiol Heart Circ Physiol 267: H1862-H1871, 1994. (Pubitemid 2164399)
    • (1994) AM.J.PHYSIOL. , vol.267 , Issue.5 PART 2
    • Collins-Nakai, R.L.1    Noseworthy, D.2    Lopaschuk, G.D.3
  • 18
    • 40049093526 scopus 로고    scopus 로고
    • Pediatric myocardial protection
    • Durandy Y. Pediatric myocardial protection. Curr Opin Cardiol 23: 85-90, 2008.
    • (2008) Curr Opin Cardiol , vol.23 , pp. 85-90
    • Durandy, Y.1
  • 19
    • 0032445521 scopus 로고    scopus 로고
    • Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation
    • Dyck JR, Barr AJ, Barr RL, Kolattukudy PE, Lopaschuk GD. Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation. Am J Physiol Heart Circ Physiol 275: H2122-H2129, 1998. (Pubitemid 128731581)
    • (1998) American Journal of Physiology , vol.275 , Issue.6 PART 2
    • Dyck, J.R.B.1    Barr, A.J.2    Barr, R.L.3    Kolattukudy, P.E.4    Lopaschuk, G.D.5
  • 21
    • 33750211736 scopus 로고    scopus 로고
    • Absence of malonyl coenzyme a decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury
    • DOI 10.1161/CIRCULATIONAHA.106.642009, PII 0000301720061017000011
    • Dyck JR, Hopkins TA, Bonnet S, Michelakis ED, Young ME, Watanabe M, Kawase Y, Jishage K, Lopaschuk GD. Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury. Circulation 114: 1721-1728, 2006. (Pubitemid 44607120)
    • (2006) Circulation , vol.114 , Issue.16 , pp. 1721-1728
    • Dyck, J.R.B.1    Hopkins, T.A.2    Bonnet, S.3    Michelakis, E.D.4    Young, M.E.5    Watanabe, M.6    Kawase, Y.7    Jishage, K.-I.8    Lopaschuk, G.D.9
  • 22
    • 34548400371 scopus 로고    scopus 로고
    • The δ-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation
    • DOI 10.1152/ajpheart.00418.2007
    • Forster K, Kuno A, Solenkova N, Felix SB, Krieg T. The delta-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation. Am J Physiol Heart Circ Physiol 293: H1604-H1608, 2007. (Pubitemid 47367206)
    • (2007) American Journal of Physiology - Heart and Circulatory Physiology , vol.293 , Issue.3
    • Forster, K.1    Kuno, A.2    Solenkova, N.3    Felix, S.B.4    Krieg, T.5
  • 24
    • 0029116032 scopus 로고
    • Myocardial protection in the immature heart
    • Hammon JW Jr. Myocardial protection in the immature heart. Ann Thorac Surg 60: 839-842, 1995.
    • (1995) Ann Thorac Surg , vol.60 , pp. 839-842
    • Hammon Jr., J.W.1
  • 27
    • 1142309743 scopus 로고    scopus 로고
    • New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway
    • Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res 61: 448-460, 2004.
    • (2004) Cardiovasc Res , vol.61 , pp. 448-460
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 28
    • 34548044947 scopus 로고    scopus 로고
    • Preconditioning and postconditioning: United at reperfusion
    • Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: united at reperfusion. Pharmacol Ther 116: 173-191, 2007.
    • (2007) Pharmacol Ther , vol.116 , pp. 173-191
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 31
    • 33644784921 scopus 로고    scopus 로고
    • Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    • DOI 10.2337/diabetes.55.02.06.db05-1164
    • How OJ, Aasum E, Severson DL, Chan WY, Essop MF, Larsen TS. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 55: 466-473, 2006. (Pubitemid 43343277)
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 466-473
    • How, O.-J.1    Aasum, E.2    Severson, D.L.3    Chan, W.Y.A.4    Essop, M.F.5    Larsen, T.S.6
  • 36
    • 0030199046 scopus 로고    scopus 로고
    • Calcium improves mechanical function and carbohydrate metabolism following ischaemia in isolated bi-ventricular working hearts from immature rabbits
    • DOI 10.1006/jmcc.1996.0140
    • Itoi T, Lopaschuk GD. Calcium improves mechanical function and carbohydrate metabolism following ischemia in isolated bi-ventricular working hearts from immature rabbits. J Mol Cell Cardiol 28: 1501-1514, 1996. (Pubitemid 26340904)
    • (1996) Journal of Molecular and Cellular Cardiology , vol.28 , Issue.7 , pp. 1501-1514
    • Itoi, T.1    Lopaschuk, G.D.2
  • 37
    • 0027508365 scopus 로고
    • The contribution of glycolysis, glucose oxidation, lactate oxidation, and fatty acid oxidation to ATP production in isolated biventricular working hearts from 2-week-old rabbits
    • Itoi T, Lopaschuk GD. The contribution of glycolysis, glucose oxidation, lactate oxidation, and fatty acid oxidation to ATP production in isolated biventricular working hearts from 2-week-old rabbits. Pediatr Res 34: 735-741, 1993. (Pubitemid 23352638)
    • (1993) Pediatric Research , vol.34 , Issue.6 , pp. 735-741
    • Itoi, T.1    Lopaschuk, G.D.2
  • 38
    • 34547872783 scopus 로고    scopus 로고
    • Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization
    • DOI 10.1152/ajpheart.00455.2007
    • Jaswal JS, Gandhi M, Finegan BA, Dyck JR, Clanachan AS. Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization. Am J Physiol Heart Circ Physiol 293: H1107-H1114, 2007. (Pubitemid 47254211)
    • (2007) American Journal of Physiology - Heart and Circulatory Physiology , vol.293 , Issue.2
    • Jaswal, J.S.1    Gandhi, M.2    Finegan, B.A.3    Dyck, J.R.B.4    Clanachan, A.S.5
  • 39
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long- Chain 3-ketoacyl coenzyme a thiolase
    • Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 86: 580-588, 2000. (Pubitemid 30165050)
    • (2000) Circulation Research , vol.86 , Issue.5 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 41
    • 0028956370 scopus 로고
    • Pyruvate dehydrogenase influences postischemic heart function
    • Lewandowski ED, White LT. Pyruvate dehydrogenase influences postischemic heart function. Circulation 91: 2071-2079, 1995.
    • (1995) Circulation , vol.91 , pp. 2071-2079
    • Lewandowski, E.D.1    White, L.T.2
  • 42
    • 0029998606 scopus 로고    scopus 로고
    • Cardiac efficiency is improved after ischemia by altering both the source and fate of protons
    • Liu B, Clanachan AS, Schulz R, Lopaschuk GD. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ Res 79: 940-948, 1996. (Pubitemid 26359235)
    • (1996) Circulation Research , vol.79 , Issue.5 , pp. 940-948
    • Liu, B.1    Clanachan, A.S.2    Schulz, R.3    Lopaschuk, G.D.4
  • 44
    • 0037138548 scopus 로고    scopus 로고
    • High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation
    • DOI 10.1016/S0735-1097(01)01803-4, PII S0735109701018034
    • Liu Q, Docherty JC, Rendell JC, Clanachan AS, Lopaschuk GD. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J Am Coll Cardiol 39: 718-725, 2002. (Pubitemid 34158171)
    • (2002) Journal of the American College of Cardiology , vol.39 , Issue.4 , pp. 718-725
    • Liu, Q.1    Docherty, J.C.2    Rendell, J.C.T.3    Clanachan, A.S.4    Lopaschuk, G.D.5
  • 45
    • 0141499890 scopus 로고    scopus 로고
    • Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase
    • Lopaschuk GD, Barr R, Thomas PD, Dyck JR. Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 93: e33-e37, 2003.
    • (2003) Circ Res , vol.93
    • Lopaschuk, G.D.1    Barr, R.2    Thomas, P.D.3    Dyck, J.R.4
  • 47
    • 0026454154 scopus 로고
    • The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia
    • Lopaschuk GD, Saddik M. The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia. Mol Cell Biochem 116: 111-116, 1992.
    • (1992) Mol Cell Biochem , vol.116 , pp. 111-116
    • Lopaschuk, G.D.1    Saddik, M.2
  • 48
    • 0025277333 scopus 로고
    • Energy substrate utilization by isolated working hearts from newborn rabbits
    • Lopaschuk GD, Spafford MA. Energy substrate utilization by isolated working hearts from newborn rabbits. Am J Physiol Heart Circ Physiol 258: H1274-H1280, 1990.
    • (1990) Am J Physiol Heart Circ Physiol , vol.258
    • Lopaschuk, G.D.1    Spafford, M.A.2
  • 49
    • 0026322397 scopus 로고
    • Glycolysis is predominant source of myocardial ATP production immediately after birth
    • Lopaschuk GD, Spafford MA, Marsh DR. Glycolysis is predominant source of myocardial ATP production immediately after birth. Am J Physiol Heart Circ Physiol 261: H1698-H1705, 1991.
    • (1991) Am J Physiol Heart Circ Physiol , vol.261
    • Lopaschuk, G.D.1    Spafford, M.A.2    Marsh, D.R.3
  • 50
    • 0028116128 scopus 로고
    • Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart
    • Lopaschuk GD, Witters LA, Itoi T, Barr R, Barr A. Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. J Biol Chem 269: 25871-25878, 1994. (Pubitemid 24336288)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.41 , pp. 25871-25878
    • Lopaschuk, G.D.1    Witters, L.A.2    Itoi, T.3    Barr, R.4    Barr, A.5
  • 51
    • 0030938190 scopus 로고    scopus 로고
    • Upregulation of 5'-AMP-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit
    • Makinde AO, Gamble J, Lopaschuk GD. Upregulation of 5′-AMPactivated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit. Circ Res 80: 482-489, 1997. (Pubitemid 27137284)
    • (1997) Circulation Research , vol.80 , Issue.4 , pp. 482-489
    • Makinde, A.-O.1    Gamble, J.2    Lopaschuk, G.D.3
  • 52
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
    • McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 93: 135-142, 1996.
    • (1996) Circulation , vol.93 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3    Lopaschuk, G.D.4
  • 53
    • 0022382585 scopus 로고
    • The role of lactate as an energy substrate for the brain during the early neonatal period
    • Medina JM. The role of lactate as an energy substrate for the brain during the early neonatal period. Biol Neonate 48: 237-244, 1985.
    • (1985) Biol Neonate , vol.48 , pp. 237-244
    • Medina, J.M.1
  • 54
    • 33644771338 scopus 로고    scopus 로고
    • Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance
    • Molero JC, Waring SG, Cooper A, Turner N, Laybutt R, Cooney GJ, James DE. Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance. Diabetes 55: 708-715, 2006. (Pubitemid 43343227)
    • (2006) Diabetes , vol.55 , Issue.3 , pp. 708-715
    • Molero, J.C.1    Waring, S.G.2    Cooper, A.3    Turner, N.4    Laybutt, R.5    Cooney, G.J.6    James, D.E.7
  • 55
    • 49349100948 scopus 로고    scopus 로고
    • Cardioprotection with alpha-tocopheryl phosphate: Amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation
    • Mukherjee S, Lekli I, Das M, Azzi A, Das DK. Cardioprotection with alpha-tocopheryl phosphate: amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation. Biochim Biophys Acta 1782: 498-503, 2008.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 498-503
    • Mukherjee, S.1    Lekli, I.2    Das, M.3    Azzi, A.4    Das, D.K.5
  • 56
    • 0026761747 scopus 로고
    • Triacylglycerol metabolism in hypoxic, glucose-deprived rat cardiomyocytes
    • Myrmel T, Forsdahl K, Larsen TS. Triacylglycerol metabolism in hypoxic, glucose-deprived rat cardiomyocytes. J Mol Cell Cardiol 24: 855-868, 1992.
    • (1992) J Mol Cell Cardiol , vol.24 , pp. 855-868
    • Myrmel, T.1    Forsdahl, K.2    Larsen, T.S.3
  • 57
    • 7244223450 scopus 로고    scopus 로고
    • GAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts
    • DOI 10.1074/jbc.M400347200
    • Onay-Besikci A, Altarejos JY, Lopaschuk GD. gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts. J Biol Chem 279: 44320-44326, 2004. (Pubitemid 39430836)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.43 , pp. 44320-44326
    • Onay-Besikci, A.1    Altarejos, J.Y.2    Lopaschuk, G.D.3
  • 60
    • 0023233051 scopus 로고
    • Global myocardial ischemia in the newborn, juvenile, and adult isolated isovolumic rabbit heart. Age-related differences in systolic function, diastolic stiffness, coronary resistance, myocardial oxygen consumption, and extracellular pH
    • Parrish MD, Payne A, Fixler DE. Global myocardial ischemia in the newborn, juvenile, and adult isolated isovolumic rabbit heart. Age-related differences in systolic function, diastolic stiffness, coronary resistance, myocardial oxygen consumption, and extracellular pH. Circ Res 61: 609-615, 1987. (Pubitemid 17157300)
    • (1987) Circulation Research , vol.61 , Issue.5 , pp. 609-615
    • Parrish, M.D.1    Payne, A.2    Fixler, D.E.3
  • 62
    • 0025991273 scopus 로고
    • Isolated, perfused neonatal rat heart preparation for studies of calcium and functional stability
    • Riva E, Hearse DJ. Isolated, perfused neonatal rat heart preparation for studies of calcium and functional stability. Ann Thorac Surg 52: 987-992, 1991.
    • (1991) Ann Thorac Surg , vol.52 , pp. 987-992
    • Riva, E.1    Hearse, D.J.2
  • 63
    • 0032189980 scopus 로고    scopus 로고
    • Pyruvate augments mechanical function via activation of the pyruvate dehydrogenase complex in reperfused ischemic immature rabbit hearts
    • DOI 10.1006/jsre.1998.5397
    • Saiki Y, Lopaschuk GD, Dodge K, Yamaya K, Morgan C, Rebeyka IM. Pyruvate augments mechanical function via activation of the pyruvate dehydrogenase complex in reperfused ischemic immature rabbit hearts. J Surg Res 79: 164-169, 1998. (Pubitemid 28467353)
    • (1998) Journal of Surgical Research , vol.79 , Issue.2 , pp. 164-169
    • Saiki, Y.1    Lopaschuk, G.D.2    Dodge, K.3    Yamaya, K.4    Morgan, C.5    Rebeyka, I.M.6
  • 66
    • 0025321502 scopus 로고
    • Ventricular energetics
    • Suga H. Ventricular energetics. Physiol Rev 70: 247-277, 1990.
    • (1990) Physiol Rev , vol.70 , pp. 247-277
    • Suga, H.1
  • 68
    • 34547588219 scopus 로고    scopus 로고
    • Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    • DOI 10.2337/db07-0093
    • Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 56: 2085-2092, 2007. (Pubitemid 47195821)
    • (2007) Diabetes , vol.56 , Issue.8 , pp. 2085-2092
    • Turner, N.1    Bruce, C.R.2    Beale, S.M.3    Hoehn, K.L.4    So, T.5    Rolph, M.S.6    Cooney, G.J.7
  • 69
    • 0019447240 scopus 로고
    • Influence of free fatty acids on myocardial oxygen consumption and ischemic injury
    • DOI 10.1016/0002-9149(81)90621-4
    • Vik-Mo H, Mjos OD. Influence of free fatty acids on myocardial oxygen consumption and ischemic injury. Am J Cardiol 48: 361-365, 1981. (Pubitemid 11019075)
    • (1981) American Journal of Cardiology , vol.48 , Issue.2 , pp. 361-365
    • Vik Mo, H.1    Mjos, O.D.2
  • 70
    • 0023472035 scopus 로고
    • Lactate metabolism of isolated, perfused fetal, and newborn pig hearts
    • Werner JC, Sicard RE. Lactate metabolism of isolated, perfused fetal, and newborn pig hearts. Pediatr Res 22: 552-556, 1987. (Pubitemid 18002062)
    • (1987) Pediatric Research , vol.22 , Issue.5 , pp. 552-556
    • Werner, J.C.1    Sicard, R.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.