Kinesin spindle protein inhibitors with diaryl amine scaffolds: Crystal packing analysis for improved aqueous solubility

ACS Medicinal Chemistry Letters

Volumn 5, Issue 5, 2014, Pages 566-571

  Takeuchi, Tomoki ^a   Oishi, Shinya ^a   Kaneda, Masato ^a   Ohno, Hiroaki ^a   Nakamura, Shinya ^b   Nakanishi, Isao ^b   Yamane, Masayoshi ^c   Sawada, Jun Ichi ^c   Asai, Akira ^c   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Aqueous solubility; crystal packing; diphenylamine; kinesin spindle protein

Indexed keywords

ANILINE; ANTINEOPLASTIC AGENT; BIPHENYL DERIVATIVE; CARBAZOLE DERIVATIVE; DIARYL AMINE; DIPHENYLAMINE DERIVATIVE; KINESIN INHIBITOR; KINESIN SPINDLE PROTEIN INHIBITOR; NITROGEN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL LINE; CELL PROLIFERATION; CRYSTAL; CRYSTAL PACKING; CRYSTAL STRUCTURE; HYDROGEN BOND; KINETICS; MELTING POINT; MOLECULAR MODEL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOLUBILITY; SPINDLE POLE; SYNTHESIS;

EID: 84900457624     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500016j     Document Type: Article

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