ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury

Journal of Neuroscience Research

Volumn 92, Issue 7, 2014, Pages 884-892

  Wang, Ruihua ^a,b   Hong, Jun ^b,c   Lu, Miaomiao ^b,d   Neil, Jessica E ^e   Vitek, Michael P ^e   Liu, Xiaozhi ^b,f   Warner, David S ^b   Li, Fengqiao ^e   Sheng, Huaxin ^b  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c TANGSHAN GONGREN HOSPITAL   (China)

^d ZHENGZHOU UNIVERSITY   (China)

^e Optimal Screening Vehicles Division   (United States)

^f TIANJIN FIFTH CENTRAL HOSPITAL   (China)

Author keywords

ApoE; Mimetic; Outcome; Rat; Spinal cord injury

Indexed keywords

APOLIPOPROTEIN E; COG 1410; COG 1410C; NEUROPROTECTIVE AGENT; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG; COG1410;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY WEIGHT; CONTROLLED STUDY; CONVALESCENCE; DEMYELINATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MORTALITY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL NECROSIS; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; RAT MODEL; SCORING SYSTEM; SPINAL CORD INJURY; TISSUE INJURY; WEIGHT REDUCTION; WHITE MATTER LESION; ANIMAL; CELL DEATH; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; LEUKOENCEPHALOPATHIES; MOVEMENT DISORDERS; NERVE CELL; NEUROLOGIC EXAMINATION; PATHOLOGY; SPINAL CORD INJURIES; WISTAR RAT;

ANIMALS; APOLIPOPROTEINS E; BODY WEIGHT; CELL DEATH; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; LEUKOENCEPHALOPATHIES; MALE; MICROGLIA; MOVEMENT DISORDERS; NEUROLOGIC EXAMINATION; NEURONS; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SPINAL CORD INJURIES;

EID: 84900429986     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23371     Document Type: Article

References (42)

1. Aono M, Lee Y, Grant ER, Zivin RA, Pearlstein RD, Warner DS, Bennett ER, Laskowitz DT. 2002. Apolipoprotein E protects against NMDA excitotoxicity. Neurobiol Dis 11:214-220.
2. Bales KR. 2010. Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease. Neuropharmacology 59:295-302.
3. Basso DM, Beattle MS, Bresnahan JC. 1995. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21.
4. Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM. 1985. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76:1501-1513.
5. Bu G. 2009. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 10:333-44.
6. Christensen DJ, Ohkubo N, Oddo J, Van Kanegan MJ, Neil J, Li F, Colton CA, Vitek MP. 2011. Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. J Immunol 186:2535-2542.
7. Colton CA, Brown CM, Cook D, Needham LK, Xu Q, Czapoga M, Saunders AM, Rasheed K, Vitek MP. 2002. APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiol Aging 23:777-785.
8. de Assis Gondim F, Lopes AC Jr, Rodrigues CL, de Graca JR, Rola FH. 2002. Gastric emptying and gastrointestinal motility abnormalities after spinal cord injury. Arch Phys Med Rehabil 83:1479.
9. Fullerton SM, Shirman GA, Strittmatter WJ, Matthew WD. 2001. Impairment of the blood-nerve and blood-brain barriers in apolipoprotein E knockout mice. Exp Neurol 169:13-22.
10. Gao J, Wang H, Sheng H, Lynch JR, Warner DS, Durham L, Vitek MP, Laskowitz DT. 2006. A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. Neurocrit Care 4:25-31.
11. Hiruma S, Otsuka K, Satou T, Hashimoto S. 1999. Simple and reproducible model of rat spinal cord injury induced by a controlled cortical impact device. Neurol Res 21:313-323.
12. Hoane MR, Pierce JL, Holand MA, Birky ND, Dang T, Vitek MP, Mckenna SE. 2007. The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury. J Neurotrauma 24:1108-1118.
13. Hoane MR, Kaufman N, Vitek MP, McKenna SE. 2009. COG1410 improves cognitive performance and reduces cortical neuronal loss in the traumatically injured brain. J Neurotrauma 26:121-129.
14. Horsburgh K, McCulloch J, Nilsen M, McCracken E, Large C, Roses AD, Nicoll JA. 2000. Intraventricular infusion of apolipoprotein E ameliorates acute neuronal damage after global cerebral ischemia in mice. J Cereb Blood Flow Metab 20:458-462.
15. Ignatius MJ, Gebickie-Harter PJ, Skene JH, Schilling JW, Weisgraber KH, Mahley RW, Shooter EM. 1986. Expression of apolipoprotein E during nerve degeneration and regeneration. Proc Natl Acad Sci U S A 83:1125-1129.
16. Kaufman NA, Beare JE, Tan AA, Vitek MP, Mckenna SE, Hoane MR. 2010. COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat. Behav Brain Res 214:395-401.
17. Koch S, Donarski N, Goetze K, Krechel M, Stuerenburg HJ, Buhmann C, Beisiegel U. 2001. Characterization of four lipoprotein classes in human cerebrospinal fluid. J Lipid Res 42:1143-1151.
18. Laskowitz DT, Goel S, Bennett ER, Matthew WD. 1997. Apolipoprotein E suppresses glial cell secretion of TNF alpha. J Neuroimmunol 76:70-74.
19. Laskowitz DT, Sheng H, Bart RD, Joyner KA, Roses AD, Warner DS. 1997. Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia. J Cereb Blood Flow Metab 17:753-758.
20. Laskowitz DT, Matthew WD, Bennett ER, Schmechel D, Herbstreith MH, Goel S, McMillian MK. 1998. Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. Neuroreport 9:615-618.
21. Laskowitz DT, Lee DM, Schmechel D, Staats HF. 2000. Altered immune responses in apolipoprotein E-deficient mice. J Lipid Res 41:613-620.
22. Laskowitz DT, Thekdi AD, Thekdi SD, Han SK, Myers JK, Pizzo SV, Bennett ER. 2001. Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. Exp Neurol 167:74-85.
23. Laskowitz DT, Fillit H, Yeung N, Toku K, Vitek MP. 2006. Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease. Acta Neurol Scand Suppl 185:15-20.
24. Laskowitz DT, Mckenna SE, Song P, Wang H Durham L, Yeung N, Christensen D, Vitek MP. 2007. COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma 24:1093-1107.
25. Laskowitz DT, Song P, Wang H, Mace B, Sullivan PM, Vitek MP, Dawson HN. 2010. Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. J Neurotrauma 27:1983-1995.
26. Laskowitz DT, Lei B, Dawson HN, Wang H, Ballows ST, Christensen DJ, Vitek MP, James ML. 2012. The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage. Neurocrit Care 16:316-326.
27. Li FQ, Sempowski GD, McKenna SE, Laskowitz DT, Colton CA, Vitek MP. 2006. Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. J Pharmacol Exp Ther 318:956-965.
28. Lynch JR, Morgan D, Mance J, Matthew WD, Laskowitz DT. 2001. Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol 114:107-113.
29. Lynch JR, Pineda JA, Morgan D, Zhang L, Warner DS, Benveniste H, Laskowitz. 2002. Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol 51:113-117.
30. Lynch JR, Wang H, Mace B, Leinenweber S, Warner DS, Bennett ER, Vitek MP, McKenna S, Laskowitz DT. 2005. A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. Exp Neurol 192:109-116.
31. Mahley RW. 1988. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240:622-630.
32. Nakai M, Kawamata T, Taniguchi T, Maeda K, Tanaka C. 1996. Expression of apolipoprotein E mRNA in rat microglia. Neurosci Lett 211:41-44.
33. Nathan BP, Jiang Y, Wong GK, Shen F, Brewer GJ, Struble RG. 2002. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res 928:96-105.
34. Resnick DK, Schmitt C, Miranpuri GS, Dhodda VK, Lsaacson J, Vemuganti R. 2004. Molecular evidence of repair and plasticity following spinal cord injury. Neuroreport 15:837-839.
35. Seitz A, Kragol M, Aglow E, Showe L, Heber-Karz E. 2003. Apolipoprotein E expression after spinal cord injury in the mouse. J Neurosci Res 71:417-426.
36. Seitz A, Gourevitch D, Zhang XM, Clark L, Chen P, Kragol M, Levenkova N, Rux J, Samulewicz S, Heber-Katz E. 2005. Hum Mol Genet 14:2661-2670.
37. Sheng H, Laskiwitz DT, Mackensen GB, Kudo M, Pearlstein RD, Warner DS. 1999. Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse. Stroke 30:1118-1124.
38. Snipes GJ, McGuire CB, Norden JJ, Freeman JA. 1986. Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells. Proc Natl Acad Sci U S A 83:1130-1134.
39. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD. 1993. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 90:1977-1981.
40. Wang H, Anderson LG, Lascola CD, James ML, Venkatraman TN, Bennett ER, Acheson SK, Vitek MP, Laskowitz DT. 2013. ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Exp Neurol 241:67-74.
41. Willems Van Dijk K, Hofker MH, Havekes LM. 2000. Use of transgenic mice to study the role of apolipoprotein E in lipid metabolism and atherosclerosis. Int J Tissue React 22:49-58.
42. Xhignesse M, Lussier-Cacan S, Sing CF, Kessling AM, Davignon J. 1991. Influences of common variants of apolipoprotein E on measures of lipid metabolism in a sample selected for health. Arterioscler Thromb 11:1100-1110.