Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Wijnen, Wino J ^a,b   Van Der Made, Ingeborg ^a   Van Den Oever, Stephanie ^a   Hiller, Monika ^a   De Boer, Bouke A ^a   Picavet, Daisy I ^a   Chatzispyrou, Iliana A ^a   Houtkooper, Riekelt H ^a   Tijsen, Anke J ^a   Hagoort, Jaco ^a   Van Veen, Henk ^a   Everts, Vincent ^a   Ruijter, Jan M ^a   Pinto, Yigal M ^a   Creemers, Esther E ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; MICRORNA; MICRORNA 30C; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; MIRN30D MICRORNA, MOUSE; MITOCHONDRIAL PROTEIN; RIBOSOME PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE ACTIVITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ASSAY; GENE FUNCTION; GENE IDENTIFICATION; GENE OVEREXPRESSION; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PROTEIN DEPLETION; RNA SEQUENCE; SEQUENCE ANALYSIS; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; DNA MICROARRAY; ECHOCARDIOGRAPHY; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; CARDIOMYOPATHY, DILATED; ECHOCARDIOGRAPHY; GENE EXPRESSION PROFILING; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRORNAS; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; TIME FACTORS;

EID: 84900421623     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096290     Document Type: Article

References (42)

1. Ambros V (2004) The functions of animal microRNAs. Nature 431: 350-355. 10.1038/nature02871 doi:10.1038/nature02871.
2. Dai Y, Khaidakov M, Wang X, Ding Z, Su W, et al. (2013) MicroRNAs Involved in the Regulation of Postischemic Cardiac Fibrosis. Hypertension 61: 751-756. doi:10.1161/HYPERTENSIONAHA.111.00654.
3. Lee R, Feinbaum R, Ambros V (2004) A short history of a short RNA. Cell 116: S89-92, 1. doi:10.1016/S0092-8674(04)00035-2.
4. Tijsen AJ, Pinto YM, Creemers EE (2012) Non-cardiomyocyte microRNAs in heart failure. Cardiovasc Res 93: 573-582. doi:10.1093/cvr/cvr344.
5. Pasquinelli AE (2012) MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet 13: 271-282. doi:10.1038/nrg3162.
6. van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, et al. (2008) Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A 105: 13027-13032. doi:10.1073/pnas.0805038105.
7. Matkovich SJ, Wang W, Tu Y, Eschenbacher WH, Dorn LE, et al. (2010) MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ Res 106 (1): 166-175. doi: 10.1161/CIRCRESAHA.109.202176
8. Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, et al. (2013) MicroRNA-34a regulates cardiac ageing and function. Nature 495: 107-110. doi:10.1038/nature11919.
9. el Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, et al. (2013) The hypoxia-inducible microRNA cluster miR- 199a, 214 targets myocardial PPARd and impairs mitochondrial fatty acid oxidation. Cell Metab 18(3):341-54. doi: 10.1016/j.cmet.2013.08.009.
10. Zhang Y, Yang L, Gao YF, Fan ZM, Cai XY, et al. (2013) MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2. Mol Cell Endocrinol 381(1-2):230-40. doi: 10.1016/j.mce.2013.08.004.
11. Das S, Ferlito M, Kent OA, Fox-Talbot K, Wang R, et al. (2012) Nuclear miRNA regulates the mitochondrial genome in the heart Circ Res 110: 1596-603. doi: 10.1161/CIRCRESAHA.112.267732.
12. Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, et al. (2009) miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res 104: 170-8, 6p. doi:10.1161/CIRCRESAHA.108.182535.
13. Jentzsch C, Leierseder S, Loyer X, Flohrschutz I, Sassi Y, et al. (2012) A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes. J Mol Cel l Cardiol 52: 13-20. doi :10.1016/j.yjmcc.2011.07.010.
14. Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, et al. (2013) Extracellular Matrix Secretion by Cardiac Fibroblasts: Role of microRNA-29b and microRNA-30c. Circ Res. doi:10.1161/CIRCRESAHA.113.302400.
15. Marchand A, Proust C, Morange PE, Lompre AM, Tregouet DA (2012) miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells. PLoS One 7: e44532. doi:10.1371/journal.pone.0044532.
16. Patel N, Tahara SM, Malik P, Kalra VK (2011) Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells. Biochem J 434: 473-482. doi:10.1042/BJ20101585.
17. Li J, Donath S, Li Y, Qin D, Prabhakar BS, Li P (2010) miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genet 6: e1000795. doi:10.1371/journal.pgen.1000795.
18. Zhou H, Xu X, Xun Q, Yu D, Ling J, et al. (2012) microRNA-30c negatively regulates endometrial cancer cells by targeting metastasis-associated gene-1. Oncol Rep 27: 807-812. doi:10.3892/or.2011.1574.
19. Bridge G, Monteiro R, Henderson S, Emuss V, Lagos D, et al. (2012) The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis. Blood 120: 5063-5072. blood-2012-04-423004 doi:10.1182/blood-2012- 04-423004.
20. Pan W, Zhong Y, Cheng C, Liu B, Wang L, et al. (2013) MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. PLoS One 8: e53950. doi:10.1371/journal.pone.0053950.
21. Soh J, Iqbal J, Queiroz J, Fernandez-Hernando C, Hussain MM (2013) MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat Med 19: 892-900. doi:10.1038/nm.3200.
22. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M (2007) MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 100: 416-424. doi:10.1161/01.RES.0000257913.42552.23.
23. Leptidis S, El AH, Lok SI, de WR, Olieslagers S, et al. (2013) A deep sequencing approach to uncover the miRNOME in the human heart. PLoS One 8: e57800. doi:10.1371/journal.pone.0057800.
24. Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, et al. (2007) MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 116: 258-267. doi:10.1161/CIRCULATIONAHA.107.687947. (Pubitemid 47196561)
25. Ruijter JM, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, et al. (2009) Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res 37: e45. doi:10.1093/nar/gkp045.
26. Ruijter JM, Pfaffl MW, Zhao S, Spiess AN, Boggy G, et al. (2013) Evaluation of qPCR curve analysis methods for reliable biomarker discovery: bias, resolution, precision, and implications. Methods 59: 32-46. S1046-2023(12). doi:10.1016/j.ymeth.2012.08.011.
27. De Boer BA, van den Berg G, Soufan AT, de Boer PA, Hagoort J, et al. (2012) Measurement and 3D-visualization of cell-cycle length using double labelling with two thymidine analogues applied in early heart development. PLoS One 7: e47719. doi:10.1371/journal.pone.0047719.
28. Huang dW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57. doi:10.1038/nprot.2008.211.
29. Huang dW, Sherman BT, Lempicki RA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13. doi:10.1093/nar/gkn923.
30. Houtkooper RH, Argmann C, Houten SM, Canto C, Jeninga EH, et al. (2011) The metabolic footprint of aging in mice. Sci Rep 1: 134. doi:10.1038/srep00134.
31. Ventura FV, Ruiter J, Ijlst L, de Almeida IT, Wanders RJ (2005) Differential inhibitory effect of long-chain acyl-CoA esters on succinate and glutamate transport into rat liver mitochondria and its possible implications for long-chain fatty acid oxidation defects. Mol Genet Metab 86: 344-352. S1096-7192. doi:10.1016/j.ymgme.2005.07.030.
32. Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, et al. (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497: 451-457. doi:10.1038/nature12188.
33. Stanley WC, Recchia FA, Lopaschuk GD (2005) Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85: 1093-1129. doi:10.1152/physrev.00006.2004. (Pubitemid 40894649)
34. Chen L, Knowlton AA (2011) Mitochondrial dynamics in heart failure. Congest Heart Fail 17: 257-261.
35. Casademont J, Miro O (2002) Electron transport chain defects in heart failure. Heart Fail Rev 7: 131-139. (Pubitemid 34624801)
36. Marin-Garcia J, Goldenthal MJ (2002) Understanding the impact of mitochondrial defects in cardiovascular disease: a review. J Card Fail 8: 347-361. (Pubitemid 35253206)
37. Scarpulla RC (2008) Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 88: 611-638. doi:10.1152/physrev.00025. 2007.
38. Rimbaud S, Garnier A, Ventura-Clapier R (2009) Mitochondrial biogenesis in cardiac pathophysiology. Pharmacol Rep 61: 131-138.
39. Cannino G, Di Liegro CM, Rinaldi AM (2007) Nuclear-mitochondrial interaction. Mitochondrion 7: 359-366. S1567-7249. doi:10.1016/j.mito.2007.07. 001.
40. Li H, Li S, Yu B, Liu S (2012) Expression of miR-133 and miR-30 in chronic atrial fibrillation in canines. Mol Med Rep 5: 1457-1460. doi:10.3892/mmr.2012.831.
41. Creemers EE, Pinto YM (2011) Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc Res 89: 265-272. doi:10.1093/cvr/cvq308.
42. Matkovich SJ, Van Booven DJ, Eschenbacher WH, Dorn GW (2011) RISC RNA sequencing for context-specific identification of in vivo microRNA targets. Circ Res 108: 18-26. doi:10.1161/CIRCRESAHA.110.233528.