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Volumn 132, Issue 5, 2014, Pages 521-527

VEGFA and VEGFR2 gene polymorphisms and response to anti-vascular endothelial growth factor therapy

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; RANIBIZUMAB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

EID: 84900410891     PISSN: 21686165     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaophthalmol.2014.109     Document Type: Article
Times cited : (62)

References (41)
  • 1
    • 0037699954 scopus 로고    scopus 로고
    • The biology of vegf and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9(6):669-676.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 2
    • 33750946767 scopus 로고    scopus 로고
    • Emerging drugs for age-related macular degeneration
    • Augustin AJ, Offermann I. Emerging drugs for age-related macular degeneration. Expert Opin Emerg Drugs. 2006;11(4):725-740.
    • (2006) Expert Opin Emerg Drugs , vol.11 , Issue.4 , pp. 725-740
    • Augustin, A.J.1    Offermann, I.2
  • 3
    • 79956218863 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for neovascular age-related macular degeneration
    • CATT Research Group.
    • Martin DF,Maguire MG, Ying GS, Grunwald JE, Fine SL, Jaffe GJ; CATT Research Group. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;364(20):1897-1908.
    • (2011) N Engl J Med , vol.364 , Issue.20 , pp. 1897-1908
    • Martin, D.F.1    Maguire, M.G.2    Ying, G.S.3    Grunwald, J.E.4    Fine, S.L.5    Jaffe, G.J.6
  • 4
    • 84863320414 scopus 로고    scopus 로고
    • Comparison of age-related macular degeneration treatments trials (catt) research group. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: Two-year results
    • Martin DF,Maguire MG, Fine SL, et al; Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology. 2012;119(7):1388-1398.
    • (2012) Ophthalmology , vol.119 , Issue.7 , pp. 1388-1398
    • Martin, D.F.1    Maguire, M.G.2    Fine, S.L.3
  • 5
    • 84863327423 scopus 로고    scopus 로고
    • Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: One-year findings from the ivan randomized trial [published corrections appear in ophthalmology. 2012;119(8):1508 and 2013;120(9):1719]
    • IVAN Study Investigators
    • Chakravarthy U, Harding SP, Rogers CA, et al; IVAN Study Investigators. Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial [published corrections appear in Ophthalmology. 2012;119(8):1508 and 2013;120(9):1719] Ophthalmology. 2012;119(7):1399-1411.
    • (2012) Ophthalmology , vol.119 , Issue.7 , pp. 1399-1411
    • Chakravarthy, U.1    Harding, S.P.2    Rogers, C.A.3
  • 6
    • 84874654113 scopus 로고    scopus 로고
    • A randomised double-masked trial comparing the visual outcome after treatment with ranibizumab or bevacizumab in patients with neovascular age-related macular degeneration
    • MANTA Research Group
    • Krebs I, Schmetterer L, Boltz A, et al; MANTA Research Group. A randomised double-masked trial comparing the visual outcome after treatment with ranibizumab or bevacizumab in patients with neovascular age-related macular degeneration. Br J Ophthalmol. 2013;97(3):266-271.
    • (2013) Br J Ophthalmol , vol.97 , Issue.3 , pp. 266-271
    • Krebs, I.1    Schmetterer, L.2    Boltz, A.3
  • 7
    • 84870723784 scopus 로고    scopus 로고
    • Genetic studies of age-relatedmaculardegeneration: Lessons, challenges, and opportunities for disease management
    • Priya RR, Chew EY, SwaroopA. Genetic studies of age- relatedmaculardegeneration: lessons, challenges, and opportunities for disease management. Ophthalmology. 2012;119(12):2526-2536.
    • (2012) Ophthalmology , vol.119 , Issue.12 , pp. 2526-2536
    • Priya, R.R.1    Chew, E.Y.2    Swaroop, A.3
  • 8
    • 84864396563 scopus 로고    scopus 로고
    • Pharmacogenetics of antiangiogenic and antineovascular therapies of age-related macular degeneration
    • Agosta E, Lazzeri S, Orlandi P, et al. Pharmacogenetics of antiangiogenic and antineovascular therapies of age-related macular degeneration. Pharmacogenomics. 2012;13(9):1037-1053.
    • (2012) Pharmacogenomics , vol.13 , Issue.9 , pp. 1037-1053
    • Agosta, E.1    Lazzeri, S.2    Orlandi, P.3
  • 9
    • 84875209738 scopus 로고    scopus 로고
    • Pharmacogenetics for genes associated with age-related macular degeneration in the comparison of amd treatments trials (catt
    • Comparison of AMD Treatments Trials Research Group
    • Hagstrom SA, Ying GS, Pauer GJ, et al; Comparison of AMD Treatments Trials Research Group. Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT). Ophthalmology. 2013;120(3):593-599.
    • (2013) Ophthalmology , vol.120 , Issue.3 , pp. 593-599
    • Hagstrom, S.A.1    Ying, G.S.2    Pauer, G.J.3
  • 10
    • 33644843900 scopus 로고    scopus 로고
    • Functional candidate genes in age-related macular degeneration: Significant association with vegf, vldlr, and lrp6
    • Haines JL, Schnetz-Boutaud N, Schmidt S, et al. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci. 2006;47(1):329-335.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , Issue.1 , pp. 329-335
    • Haines, J.L.1    Schnetz-Boutaud, N.2    Schmidt, S.3
  • 11
    • 33749000285 scopus 로고    scopus 로고
    • Vegf polymorphisms are associated with neovascular age-related macular degeneration
    • Churchill AJ, Carter JG, Lovell HC, et al. VEGF polymorphisms are associated with neovascular age-related macular degeneration. Hum Mol Genet. 2006;15(19):2955-2961.
    • (2006) Hum Mol Genet , vol.15 , Issue.19 , pp. 2955-2961
    • Churchill, A.J.1    Carter, J.G.2    Lovell, H.C.3
  • 12
    • 70350572321 scopus 로고    scopus 로고
    • Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a polish population
    • Janik-Papis K, Zaras M, Krzyzanowska A, et al. Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population. Exp Mol Pathol. 2009;87(3):234-238.
    • (2009) Exp Mol Pathol , vol.87 , Issue.3 , pp. 234-238
    • Janik-Papis, K.1    Zaras, M.2    Krzyzanowska, A.3
  • 13
    • 84857366425 scopus 로고    scopus 로고
    • Homozygosity for the +674ct polymorphism on vegf gene is associated with age-related macular degeneration in a brazilian cohort
    • Almeida LN, Melilo-Carolino R, Veloso CE, et al. Homozygosity for the +674CT polymorphism on VEGF gene is associated with age-related macular degeneration in a Brazilian cohort. Graefes Arch Clin Exp Ophthalmol. 2012;250(2):185-189.
    • (2012) Graefes Arch Clin Exp Ophthalmol , vol.250 , Issue.2 , pp. 185-189
    • Almeida, L.N.1    Melilo-Carolino, R.2    Veloso, C.E.3
  • 14
    • 77956340398 scopus 로고    scopus 로고
    • Association of age-related macular degeneration with polymorphisms in vascular endothelial growth factor and its receptor
    • Galan A, Ferlin A, Caretti L, et al. Association of age-related macular degeneration with polymorphisms in vascular endothelial growth factor and its receptor. Ophthalmology. 2010;117(9):1769-1774.
    • (2010) Ophthalmology , vol.117 , Issue.9 , pp. 1769-1774
    • Galan, A.1    Ferlin, A.2    Caretti, L.3
  • 15
    • 84865035669 scopus 로고    scopus 로고
    • The rs2071559 aa vegfr-2 genotype frequency is significantly lower in neovascular age-related macular degeneration patients
    • doi:10.1100/2012/420190
    • Lazzeri S, Orlandi P, Figus M, et al. The rs2071559 AA VEGFR-2 genotype frequency is significantly lower in neovascular age-related macular degeneration patients. ScientificWorld-Journal. 2012:420190. doi:10.1100/2012/420190.
    • ScientificWorld-Journal , vol.2012 , pp. 420190
    • Lazzeri, S.1    Orlandi, P.2    Figus, M.3
  • 16
    • 43949097221 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration
    • Lin JM,Wan L, Tsai YY, et al. Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration. Am J Ophthalmol. 2008;145(6):1045-1051.
    • (2008) Am J Ophthalmol , vol.145 , Issue.6 , pp. 1045-1051
    • Lin, J.M.1    Wan, L.2    Tsai, Y.Y.3
  • 17
    • 36749029616 scopus 로고    scopus 로고
    • A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration
    • Richardson AJ, Islam FM, Guymer RH, CainM, Baird PN. A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration. Mol Vis. 2007;13:2148-2152.
    • (2007) Mol Vis , vol.13 , pp. 2148-2152
    • Richardson, A.J.1    Islam, F.M.2    Guymer, R.H.3    Cain, M.4    Baird, P.N.5
  • 18
    • 54949086693 scopus 로고    scopus 로고
    • Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: The rotterdam study
    • Boekhoorn SS, Isaacs A, Uitterlinden AG, et al. Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study. Ophthalmology. 2008;115(11):1899-1903.
    • (2008) Ophthalmology , vol.115 , Issue.11 , pp. 1899-1903
    • Boekhoorn, S.S.1    Isaacs, A.2    Uitterlinden, A.G.3
  • 19
    • 77649256105 scopus 로고    scopus 로고
    • Polymorphisms in the vegfa and vegfr-2 genes and neovascular age-related macular degeneration
    • Fang AM, Lee AY, Kulkarni M, OsbornMP, BrantleyMA Jr. Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. Mol Vis. 2009;15:2710-2719.
    • (2009) Mol Vis , vol.15 , pp. 2710-2719
    • Fang, A.M.1    Lee, A.Y.2    Kulkarni, M.3    Osborn, M.P.4    Brantley Jr., M.A.5
  • 20
    • 84864284003 scopus 로고    scopus 로고
    • Pooled-Analysis of the associations between three polymorphisms in the vegf gene and age-related macular degeneration
    • Lu Y, Shi Y, Xue C, Yin J, Huang Z. Pooled-Analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration. Mol Biol Rep. 2012;39(6):6547-6553.
    • (2012) Mol Biol Rep , vol.39 , Issue.6 , pp. 6547-6553
    • Lu, Y.1    Shi, Y.2    Xue, C.3    Yin, J.4    Huang, Z.5
  • 21
    • 33846543707 scopus 로고    scopus 로고
    • Vascular endothelial growth factor pharmacogenetics: A new perspective for anti-Angiogenic therapy
    • Pasqualetti G, Danesi R, Del Tacca M, Bocci G. Vascular endothelial growth factor pharmacogenetics: a new perspective for anti-Angiogenic therapy. Pharmacogenomics. 2007;8(1):49-66.
    • (2007) Pharmacogenomics , vol.8 , Issue.1 , pp. 49-66
    • Pasqualetti, G.1    Danesi, R.2    Del Tacca, M.3    Bocci, G.4
  • 22
    • 54549123309 scopus 로고    scopus 로고
    • Vegf-A splicing: The key to anti-Angiogenic therapeutics?
    • Harper SJ, Bates DO. VEGF-A splicing: the key to anti-Angiogenic therapeutics? Nat Rev Cancer. 2008;8(11):880-887.
    • (2008) Nat Rev Cancer , vol.8 , Issue.11 , pp. 880-887
    • Harper, S.J.1    Bates, D.O.2
  • 23
    • 84856059368 scopus 로고    scopus 로고
    • Cfh, vegf and htra1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration
    • McKibbinM, Ali M, Bansal S, et al. CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration. Br J Ophthalmol. 2012;96(2):208-212.
    • (2012) Br J Ophthalmol , vol.96 , Issue.2 , pp. 208-212
    • McKibbin, M.1    Ali, M.2    Bansal, S.3
  • 24
    • 80051763854 scopus 로고    scopus 로고
    • Genetic association with response to intravitreal ranibizumab in patients with neovascular amd
    • Kloeckener-Gruissem B, Barthelmes D, Labs S, et al. Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD. Invest Ophthalmol Vis Sci. 2011;52(7):4694-4702.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , Issue.7 , pp. 4694-4702
    • Kloeckener-Gruissem, B.1    Barthelmes, D.2    Labs, S.3
  • 25
    • 80054723793 scopus 로고    scopus 로고
    • Vegf gene polymorphism and response to intravitreal bevacizumab and triple therapy in age-related macular degeneration
    • Nakata I, Yamashiro K, Nakanishi H, Tsujikawa A, Otani A, Yoshimura N. VEGF gene polymorphism and response to intravitreal bevacizumab and triple therapy in age-related macular degeneration. Jpn J Ophthalmol. 2011;55(5):435-443.
    • (2011) Jpn J Ophthalmol , vol.55 , Issue.5 , pp. 435-443
    • Nakata, I.1    Yamashiro, K.2    Nakanishi, H.3    Tsujikawa, A.4    Otani, A.5    Yoshimura, N.6
  • 26
    • 84872022283 scopus 로고    scopus 로고
    • Variants in the vegfa gene and treatment outcome after anti-vegf treatment for neovascular age-related macular degeneration
    • Abedi F, Wickremasinghe S, Richardson AJ, et al. Variants in the VEGFA gene and treatment outcome after anti-VEGF treatment for neovascular age-related macular degeneration. Ophthalmology. 2013;120(1):115-121.
    • (2013) Ophthalmology , vol.120 , Issue.1 , pp. 115-121
    • Abedi, F.1    Wickremasinghe, S.2    Richardson, A.J.3
  • 27
    • 84875990285 scopus 로고    scopus 로고
    • Vegf-A polymorphisms predict short-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration
    • Lazzeri S, Figus M, Orlandi P, et al. VEGF-A polymorphisms predict short-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration. Pharmacogenomics. 2013;14(6):623-630.
    • (2013) Pharmacogenomics , vol.14 , Issue.6 , pp. 623-630
    • Lazzeri, S.1    Figus, M.2    Orlandi, P.3
  • 28
    • 84864495139 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor polymorphisms in the treatment success in patients with wet age-related macular degeneration
    • Boltz A, Rui M, Jonas JB, et al. Role of vascular endothelial growth factor polymorphisms in the treatment success in patients with wet age-related macular degeneration. Ophthalmology. 2012;119(8):1615-1620.
    • (2012) Ophthalmology , vol.119 , Issue.8 , pp. 1615-1620
    • Boltz, A.1    Rui, M.2    Jonas, J.B.3
  • 29
    • 0037307829 scopus 로고    scopus 로고
    • A computerized method of visual acuity testing: Adaptation of the early treatment of diabetic retinopathy study testing protocol
    • Beck RW, Moke PS, Turpin AH, et al. A computerized method of visual acuity testing: adaptation of the Early Treatment of Diabetic Retinopathy Study testing protocol. Am J Ophthalmol. 2003;135(2):194-205.
    • (2003) Am J Ophthalmol , vol.135 , Issue.2 , pp. 194-205
    • Beck, R.W.1    Moke, P.S.2    Turpin, A.H.3
  • 30
    • 32644470399 scopus 로고    scopus 로고
    • Normal macular thickness measurements in healthy eyes using stratus optical coherence tomography
    • Chan A, Duker JS, Ko TH, Fujimoto JG, Schuman JS. Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography. Arch Ophthalmol. 2006;124(2):193-198.
    • (2006) Arch Ophthalmol , vol.124 , Issue.2 , pp. 193-198
    • Chan, A.1    Duker, J.S.2    Ko, T.H.3    Fujimoto, J.G.4    Schuman, J.S.5
  • 31
    • 84864475126 scopus 로고    scopus 로고
    • CATT Research Group. Photographic assessment of baseline fundus morphologic features in the Comparison of Age-Related Macular Degeneration Treatments Trials
    • Grunwald JE, Daniel E, Ying GS, et al; CATT Research Group. Photographic assessment of baseline fundus morphologic features in the Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology. 2012;119(8):1634-1641.
    • (2012) Ophthalmology , vol.119 , Issue.8 , pp. 1634-1641
    • Grunwald, J.E.1    Daniel, E.2    Ying, G.S.3
  • 32
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc, B. 1995;57(1): 289-300.
    • (1995) J R Stat Soc, B , vol.57 , Issue.1 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 33
    • 84870723704 scopus 로고    scopus 로고
    • VIEW 1 and VIEW 2 Study Groups. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration
    • Heier JS, Brown DM, Chong V, et al; VIEW 1 and VIEW 2 Study Groups. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 2012;119(12):2537-2548.
    • (2012) Ophthalmology , vol.119 , Issue.12 , pp. 2537-2548
    • Heier, J.S.1    Brown, D.M.2    Chong, V.3
  • 34
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • ANCHOR Study Group
    • Brown DM, Kaiser PK, MichelsM, et al; ANCHOR Study Group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355(14):1432-1444.
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3
  • 35
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • MARINA Study Group
    • Rosenfeld PJ, Brown DM, Heier JS, et al; MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355(14):1419-1431.
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 36
    • 79955796065 scopus 로고    scopus 로고
    • Cfh, vegf, and pedf genotypes and the response to intravitreous injection of bevacizumab for the treatment of age-related macular degeneration
    • Imai D, Mori K, Horie-Inoue K, et al. CFH, VEGF, and PEDF genotypes and the response to intravitreous injection of bevacizumab for the treatment of age-related macular degeneration. J Ocul Biol Dis Infor. 2010;3(2):53-59.
    • (2010) J Ocul Biol Dis Infor , vol.3 , Issue.2 , pp. 53-59
    • Imai, D.1    Mori, K.2    Horie-Inoue, K.3
  • 37
    • 72749095160 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene variation and the response to photodynamic therapy in age-related macular degeneration
    • Immonen I, Seitsonen S, Tommila P, et al. Vascular endothelial growth factor gene variation and the response to photodynamic therapy in age-related macular degeneration. Ophthalmology. 2010;117(1):103-108.
    • (2010) Ophthalmology , vol.117 , Issue.1 , pp. 103-108
    • Immonen, I.1    Seitsonen, S.2    Tommila, P.3
  • 38
    • 84871882197 scopus 로고    scopus 로고
    • The c allele of-634g/c polymorphism in the vegfa gene is associated with increased vegfa gene expression in human retinal tissue
    • Vailati FB, Crispim D, Sortica DA, Souza BM, Brondani LA, Canani LH. The C allele of-634G/C polymorphism in the VEGFA gene is associated with increased VEGFA gene expression in human retinal tissue. Invest Ophthalmol Vis Sci. 2012;53(10):6411-6415.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , Issue.10 , pp. 6411-6415
    • Vailati, F.B.1    Crispim, D.2    Sortica, D.A.3    Souza, B.M.4    Brondani, L.A.5    Canani, L.H.6
  • 40
    • 33747832183 scopus 로고    scopus 로고
    • Fastsnp: An always up-to-date and extendable service for snp function analysis and prioritization
    • (web server issue
    • Yuan HY, Chiou JJ, Tseng WH, et al. FastSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res. 2006;34(web server issue):W635-W641.
    • (2006) Nucleic Acids Res , vol.34
    • Yuan, H.Y.1    Chiou, J.J.2    Tseng, W.H.3
  • 41
    • 84887989386 scopus 로고    scopus 로고
    • Alternative treatments to inhibit vegf in patientswith age-related choroidal neovascularisation (ivan) study group. Pharmacogenetic associations with vascular endothelial growth factor inhibition in participants with neovascular age-relatedmacular degeneration in the ivan study
    • Lotery AJ, Gibson J, Cree AJ, et al. Alternative Treatments to Inhibit VEGF in PatientsWith Age-Related Choroidal Neovascularisation (IVAN) Study Group. Pharmacogenetic associations with vascular endothelial growth factor inhibition in participants with neovascular age-relatedmacular degeneration in the IVAN Study. Ophthalmology. 2013;120(12):2637-2643.
    • (2013) Ophthalmology. , vol.120 , Issue.12 , pp. 2637-2643
    • Lotery, A.J.1    Gibson, J.2    Cree, A.J.3


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