Pooled-analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration

Molecular Biology Reports

Volumn 39, Issue 6, 2012, Pages 6547-6553

  Lu, Yan ^a   Shi, Yuhua ^a   Xue, Chunyan ^a   Yin, Jie ^a   Huang, Zhenping ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Age related macular degeneration; Meta analysis; Polymorphism; The vascular endothelial growth factor gene

Indexed keywords

VASCULOTROPIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; RETINA MACULA AGE RELATED DEGENERATION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; VASCULOTROPIN GENE;

CASE-CONTROL STUDIES; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MACULAR DEGENERATION; ODDS RATIO; POLYMORPHISM, GENETIC; SEQUENCE ANALYSIS, DNA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84864284003     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1483-5     Document Type: Article

References (22)

1. Owen CG, Fletcher AE, Donoghue M et al (2003) How big is the burden of visual loss caused by age related macular degeneration in the United Kingdom? Br J Ophthalmol 87:312-317 (Pubitemid 36307906)
2. Tong Y, Liao J, Zhang Y et al (2010) LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: A HuGE review and meta-analysis. Mol Vis 16:1958-1981
3. Marx J (2006) A clearer view of macular degeneration. Science 311:1704-1705
4. Ferrara N (1999) Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77:527-543 (Pubitemid 29426311)
5. Kaiser PK (2006) Antivascular endothelial growth factor agents and their development: therapeutic implications in ocular diseases. Am J Ophthalmol 142:660-668
6. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-188 (Pubitemid 17189972)
7. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719-748
8. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088-1101
9. Egger M, Davey Smith G, Schneider M et al (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629-634 (Pubitemid 27387172)
10. Haines JL, Schnetz-Boutaud N, Schmidt S et al (2006) Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci 47:329-335 (Pubitemid 46780832)
11. Brión M, Sanchez-Salorio M, Cortón M et al (2011) Genetic association study of age-related macular degeneration in the Spanish population. Acta Ophthalmol 89:e12-e22
12. Francis PJ, Hamon SC, Ott J et al (2009) Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss. J Med Genet 46:300-307
13. Galan A, Ferlin A, Caretti L et al (2010) Association of age-related macular degeneration with polymorphisms in vascular endothelial growth factor and its receptor. Ophthalmology 117:1769-1774
14. Richardson AJ, Islam FM, Guymer RH et al (2007) A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration. Mol Vis 13:2148-2152 (Pubitemid 350200387)
15. Lin JM, Wan L, Tsai YY et al (2008) Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration. Am J Ophthalmol 145:1045-1051
16. Janik-Papis K, Zaras M, Krzyzanowska A et al (2009) Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population. Exp Mol Pathol 87:234-238
17. Szaflik JP, Błasiak J, Krzyanowska A et al (2009) Distribution of the C-460T polymorphism of the vascular endothelial growth factor gene in age-related macular degeneration. Klin Oczna 111:125-127
18. Qu Y, Dai H, Zhou F et al (2011) Vascular endothelial growth factor gene polymorphisms and risk of neovascular age-related macular degeneration in a Chinese cohort. Ophthalmic Res 45:142-148
19. Churchill AJ, Carter JG, Lovell HC et al (2006) VEGF polymorphisms are associated with neovascular age-related macular degeneration. Hum Mol Genet 15:2955-2961 (Pubitemid 44446814)
20. Fang AM, Lee AY, Kulkarni M et al (2009) Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. Mol Vis 15:2710-2719
21. Almeida LN, Melilo-Carolino R, Veloso CE et al (2011) Homozygosity for the ?674CT polymorphism on VEGF gene is associated with age-related macular degeneration in a Brazilian cohort. Graefes Arch Clin Exp Ophthalmol. doi:10.1007/s00417-011-1807-5
22. Boekhoorn SS, Isaacs A, Uitterlinden AG et al (2008) Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study. Ophthalmology 115:1899-1903