Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families

Protein Science

Volumn 23, Issue 4, 2014, Pages 354-365

  Higgins, Matthew K ^a   Carrington, Mark ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Antigenic variation; Malaria; PfEMP1; Surface proteins; Trypanosomes; VSG

Indexed keywords

CYSTEINE; DUFFY BINDING PROTEIN; ERYTHROCYTE MEMBRANE PROTEIN 1; GLYCINE; GLYCOPHORIN A; GLYCOPHORIN C; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; LIPOPROTEIN; MEMBRANE PROTEIN; MICROORGANISM PROTEIN; PARASITE SURFACE PROTEIN; PROLINE; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; VARIANT SURFACE GLYCOPROTEIN; PROTOZOAL PROTEIN;

ANTIGENIC VARIATION; CRYSTALLIZATION; DISULFIDE BOND; HOST PARASITE INTERACTION; HUMAN; IMMUNE EVASION; INNATE IMMUNITY; LIGAND BINDING; MALARIA; MUTAGENESIS; NONHUMAN; PLASMODIUM; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; TRYPANOSOMA; TRYPANOSOMA BRUCEI; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC VARIABILITY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; GENETIC VARIATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; SEQUENCE ALIGNMENT; TRYPANOSOMA;

EID: 84900408965     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2428     Document Type: Review

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