Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

Journal of Biological Chemistry

Volumn 287, Issue 28, 2012, Pages 23332-23345

  Clausen, Thomas M ^a,b   Christoffersen, Stig ^c   Dahlbäck, Madeleine ^a,b   Langkilde, Annette Eva ^c   Jensen, Kamilla E ^a,b   Resende, Mafalda ^a,b   Agerbæk, Mette Ø ^a,b   Andersen, Daniel ^a,b   Berisha, Besim ^a,b   Ditlev, Sisse B ^a,b   Pinto, Vera V ^a,b   Nielsen, Morten A ^a,b   Theander, Thor G ^a,b   Larsen, Sine ^c   Salanti, Ali ^a,b  

^a Centre for Medical Parasitology   (Denmark)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN SULFATES; INTER-DOMAIN; IONIC INTERACTION; N-TERMINALS; NANOMOLAR AFFINITY; PARASITE-; PLASMODIUM FALCIPARUM; PREGNANT WOMAN; RECEPTOR BINDING; SINGLE DOMAINS; SMALL ANGLE X-RAY SCATTERING; STRUCTURAL REQUIREMENTS;

BINDING SITES; BIOSENSORS; RECOMBINANT PROTEINS; VACCINES;

DISEASES;

CHONDROITIN 4 SULFATE; PARASITE ANTIGEN; PROTEIN VAR2CSA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; GENE MUTATION; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTA MALARIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN DOMAIN; PROTEIN STRUCTURE; RAT;

ANIMALS; ANTIGENS, PROTOZOAN; BINDING SITES; CHONDROITIN SULFATES; FEMALE; HOST-PARASITE INTERACTIONS; HUMANS; IMMUNE SERA; IMMUNIZATION; KINETICS; MALARIA, FALCIPARUM; MODELS, MOLECULAR; MUTATION; PLACENTA; PLASMODIUM FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; X-RAY DIFFRACTION;

PLASMODIUM FALCIPARUM;

EID: 84863630102     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.348839     Document Type: Article

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