메뉴 건너뛰기




Volumn 10, Issue , 2014, Pages 777-789

Addressing the unmet needs of patients with persistent negative symptoms of schizophrenia: Emerging pharmacological treatment options

Author keywords

7 alpha nicotinic acetylcholine receptor agonists; Glycine reuptake inhibitors; Metabotropic glutamate receptor 2 (mGluR2); Negative symptoms; NMDA receptor; Schizophrenia

Indexed keywords

ACETYLCYSTEINE; AMISULPRIDE; ANTIDEPRESSANT AGENT; ASENAPINE; BENZOIC ACID; BITOPERTIN; BRADANICLINE; CLOZAPINE; CYCLOSERINE; DEXTRO ALANINE; DEXTRO SERINE; ENCENICLINE; GLYCINE; GRANISETRON; LAMOTRIGINE; MEMANTINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; NICOTINIC RECEPTOR; OLANZAPINE; ONDANSETRON; POMAGLUMETAD METHIONIL; PREGNENOLONE; PSYCHOSTIMULANT AGENT; SARCOSINE; SILDENAFIL; TROPISETRON;

EID: 84900404460     PISSN: 11766328     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/NDT.S43404     Document Type: Review
Times cited : (70)

References (136)
  • 1
    • 57049101401 scopus 로고    scopus 로고
    • Deficit schizophrenia: An update
    • Kirkpatrick B, Galderisi S. Deficit schizophrenia: an update. World Psychiatry. 2008;7(3):143-147.
    • (2008) World Psychiatry. , vol.7 , Issue.3 , pp. 143-147
    • Kirkpatrick, B.1    Galderisi, S.2
  • 2
    • 0019945902 scopus 로고
    • Negative symptoms in schizophrenia. Definition and reliability
    • Andreasen NC. Negative symptoms in schizophrenia. Definition and reliability. Arch Gen Psychiatry. 1982;39(7):784-788.
    • (1982) Arch Gen Psychiatry. , vol.39 , Issue.7 , pp. 784-788
    • Andreasen, N.C.1
  • 3
    • 79952122958 scopus 로고    scopus 로고
    • Toward the next generation of negative symptom assessments: The collaboration to advance negative symptom assessment in schizophrenia
    • Blanchard JJ, Kring AM, Horan WP, Gur R. Toward the next generation of negative symptom assessments: the collaboration to advance negative symptom assessment in schizophrenia. Schizophr Bull. 2011;37(2): 291-299.
    • (2011) Schizophr Bull. , vol.37 , Issue.2 , pp. 291-299
    • Blanchard, J.J.1    Kring, A.M.2    Horan, W.P.3    Gur, R.4
  • 4
    • 77749291977 scopus 로고    scopus 로고
    • Negative symptoms in schizophrenia: Avolition and Occam's razor
    • Foussias G, Remington G. Negative symptoms in schizophrenia: avolition and Occam's razor. Schizophr Bull. 2010;36(2):359-369.
    • (2010) Schizophr Bull. , vol.36 , Issue.2 , pp. 359-369
    • Foussias, G.1    Remington, G.2
  • 5
    • 77952108456 scopus 로고    scopus 로고
    • Intrinsic motivation and learning in a schizophrenia spectrum sample
    • Choi J, Medalia A. Intrinsic motivation and learning in a schizophrenia spectrum sample. Schizophr Res. 2010;118(1-3):12-19.
    • (2010) Schizophr Res. , vol.118 , Issue.1-3 , pp. 12-19
    • Choi, J.1    Medalia, A.2
  • 6
    • 0031776804 scopus 로고    scopus 로고
    • The role of negative symptoms and cognitive dysfunction in schizophrenia outcome
    • Tamminga CA, Buchanan RW, Gold JM. The role of negative symptoms and cognitive dysfunction in schizophrenia outcome. Int Clin Psychopharmacol. 1998;13(Suppl 3):S21-S26.
    • (1998) Int Clin Psychopharmacol. , vol.13 , Issue.SUUPL. 3
    • Tamminga, C.A.1    Buchanan, R.W.2    Gold, J.M.3
  • 7
    • 0033864933 scopus 로고    scopus 로고
    • Differentiating primary from secondary negative symptoms in schizophrenia: A study of neuroleptic-naive patients before and after treatment
    • Peralta V, Cuesta MJ, Martinez-Larrea A, Serrano JF. Differentiating primary from secondary negative symptoms in schizophrenia: a study of neuroleptic-naive patients before and after treatment. Am J Psychiatry. 2000;157(9):1461-1466.
    • (2000) Am J Psychiatry. , vol.157 , Issue.9 , pp. 1461-1466
    • Peralta, V.1    Cuesta, M.J.2    Martinez-Larrea, A.3    Serrano, J.F.4
  • 9
    • 81955167927 scopus 로고    scopus 로고
    • Persistent negative symptoms in first-episode schizophrenia: A prospective three-year follow-up study
    • Chang WC, Hui CL, Tang JY, et al. Persistent negative symptoms in first-episode schizophrenia: a prospective three-year follow-up study. Schizophr Res. 2011;133(1-3):22-28.
    • (2011) Schizophr Res. , vol.133 , Issue.1-3 , pp. 22-28
    • Chang, W.C.1    Hui, C.L.2    Tang, J.Y.3
  • 10
    • 79960818995 scopus 로고    scopus 로고
    • Negative symptoms and their predictors in schizophrenia within the Northern Finland 1966 Birth Cohort
    • Mäkinen J, Miettunen J, Jääskeläinen E, Veijola J, Isohanni M, Koponen H. Negative symptoms and their predictors in schizophrenia within the Northern Finland 1966 Birth Cohort. Psychiatr Res. 2010;178(1): 121-125.
    • (2010) Psychiatr Res. , vol.178 , Issue.1 , pp. 121-125
    • Mäkinen, J.1    Miettunen, J.2    Jääskeläinen, E.3    Veijola, J.4    Isohanni, M.5    Koponen, H.6
  • 11
    • 84858068941 scopus 로고    scopus 로고
    • No gender differences in social outcome in patients suffering from schizophrenia
    • Galderisi S, Bucci P, Üçok A, Peuskens J. No gender differences in social outcome in patients suffering from schizophrenia. Eur Psychiatry. 2012;27(6):406-408.
    • (2012) Eur Psychiatry. , vol.27 , Issue.6 , pp. 406-408
    • Galderisi, S.1    Bucci, P.2    Üçok, A.3    Peuskens, J.4
  • 12
    • 77950307734 scopus 로고    scopus 로고
    • Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: Findings from the CLAMORS study
    • CLAMORS Study Collaborative Group
    • Bobes J, Arango C, Garcia-Garcia M, Rejas J; CLAMORS Study Collaborative Group. Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: findings from the CLAMORS study. J Clin Psychiatry. 2010;71(3):280-286.
    • (2010) J Clin Psychiatry. , vol.71 , Issue.3 , pp. 280-286
    • Bobes, J.1    Arango, C.2    Garcia-Garcia, M.3    Rejas, J.4
  • 13
    • 0035971441 scopus 로고    scopus 로고
    • A five-year followup study of deficit and nondeficit schizophrenia
    • Tek C, Kirkpatrick B, Buchanan RW. A five-year followup study of deficit and nondeficit schizophrenia. Schizophr Res. 2001;49(3):253-260.
    • (2001) Schizophr Res. , vol.49 , Issue.3 , pp. 253-260
    • Tek, C.1    Kirkpatrick, B.2    Buchanan, R.W.3
  • 14
    • 1642283731 scopus 로고    scopus 로고
    • Practice guideline for the treatment of patients with schizophrenia, second edition
    • for the American Psychiatric Association, Steering Committee on Practice Guidelines
    • Lehman AF, Lieberman JA, Dixon LB, et al; for the American Psychiatric Association, Steering Committee on Practice Guidelines. Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry. 2004;161(suppl 2):1-56.
    • (2004) Am J Psychiatry. , vol.161 , Issue.SUUPL. 2 , pp. 1-56
    • Lehman, A.F.1    Lieberman, J.A.2    Dixon, L.B.3
  • 15
    • 0028864078 scopus 로고
    • The reliability of distinguishing primary versus secondary negative symptoms
    • Flaum M, Andreasen N. The reliability of distinguishing primary versus secondary negative symptoms. Compr Psychiatry. 1995;36(6): 421-427.
    • (1995) Compr Psychiatry. , vol.36 , Issue.6 , pp. 421-427
    • Flaum, M.1    Andreasen, N.2
  • 16
    • 0032697694 scopus 로고    scopus 로고
    • Negative parkinsonian, depressive and catatonic symptoms in schizophrenia: A conflict of paradigms revisited
    • Peralta V, Cuesta MJ. Negative parkinsonian, depressive and catatonic symptoms in schizophrenia: a conflict of paradigms revisited. Schizophr Res. 1999;40(3):245-253.
    • (1999) Schizophr Res. , vol.40 , Issue.3 , pp. 245-253
    • Peralta, V.1    Cuesta, M.J.2
  • 17
    • 35748969317 scopus 로고    scopus 로고
    • The cognitive and negative symptoms in schizophrenia trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    • Buchanan RW, Javitt DC, Marder SR, et al. The cognitive and negative symptoms in schizophrenia trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am J Psychiatry. 2007;164(10):1593-1602.
    • (2007) Am J Psychiatry. , vol.164 , Issue.10 , pp. 1593-1602
    • Buchanan, R.W.1    Javitt, D.C.2    Marder, S.R.3
  • 19
    • 84877115130 scopus 로고    scopus 로고
    • Categorical and dimensional approaches to negative symptoms of schizophrenia: Focus on long-term stability and functional outcome
    • Galderisi S, Bucci P, Mucci A, et al. Categorical and dimensional approaches to negative symptoms of schizophrenia: focus on long-term stability and functional outcome. Schizophr Res. 2013;147(1):157-162.
    • (2013) Schizophr Res. , vol.147 , Issue.1 , pp. 157-162
    • Galderisi, S.1    Bucci, P.2    Mucci, A.3
  • 20
    • 84886952819 scopus 로고    scopus 로고
    • Amotivation and functional outcomes in early schizophrenia
    • Fervaha G, Foussias G, Agid O, Remington G. Amotivation and functional outcomes in early schizophrenia. Psychiatry Res. 2013;210(2):665-668.
    • (2013) Psychiatry Res. , vol.210 , Issue.2 , pp. 665-668
    • Fervaha, G.1    Foussias, G.2    Agid, O.3    Remington, G.4
  • 21
    • 84900456431 scopus 로고    scopus 로고
    • Negative symptoms across the schizophrenia spectrum: Phenomenological and neurobiological perspectives
    • In: Ritsner MS, editor. Volume II: Phenotypic and Endophenotypic Presentations. New York, NY: Springer
    • Foussias G, et al. Negative symptoms across the schizophrenia spectrum: Phenomenological and neurobiological perspectives. In: Ritsner MS, editor. Handbook of Schizophrenia Spectrum Disorders, Volume II: Phenotypic and Endophenotypic Presentations. New York, NY: Springer; 2011:1-32.
    • (2011) Handbook of Schizophrenia Spectrum Disorders , pp. 1-32
    • Foussias, G.1
  • 22
    • 77951573608 scopus 로고    scopus 로고
    • Anhedonia and emotional experience in schizophrenia: Neural and behavioral indicators
    • Dowd EC, Barch DM. Anhedonia and emotional experience in schizophrenia: neural and behavioral indicators. Biol Psychiatry. 2010;67(10):902-911.
    • (2010) Biol Psychiatry. , vol.67 , Issue.10 , pp. 902-911
    • Dowd, E.C.1    Barch, D.M.2
  • 23
    • 54149091651 scopus 로고    scopus 로고
    • Reward processing in schizophrenia: A deficit in the representation of value
    • Gold JM, Waltz JA, Prentice KJ, Morris SE, Heerey EA. Reward processing in schizophrenia: a deficit in the representation of value. Schizophr Bull. 2008;34(5):835-847.
    • (2008) Schizophr Bull. , vol.34 , Issue.5 , pp. 835-847
    • Gold, J.M.1    Waltz, J.A.2    Prentice, K.J.3    Morris, S.E.4    Heerey, E.A.5
  • 24
    • 72449177826 scopus 로고    scopus 로고
    • The functional neuroanatomy of symptom dimensions in schizophrenia: A qualitative and quantitative review of a persistent question
    • Goghari VM, Sponheim SR, MacDonald AW 3rd. The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question. Neurosci Biobehav Rev. 2010;34(3):468-486.
    • (2010) Neurosci Biobehav Rev. , vol.34 , Issue.3 , pp. 468-486
    • Goghari, V.M.1    Sponheim, S.R.2    McDonald III, A.W.3
  • 25
    • 77954621044 scopus 로고    scopus 로고
    • Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia
    • Harvey PO, Armony J, Malla A, Lepage M. Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia. J Psychiatr Res. 2010;44(11):707-716.
    • (2010) J Psychiatr Res. , vol.44 , Issue.11 , pp. 707-716
    • Harvey, P.O.1    Armony, J.2    Malla, A.3    Lepage, M.4
  • 26
    • 30344455038 scopus 로고    scopus 로고
    • Dysfunction of ventral striatal reward prediction in schizophrenia
    • Juckel G, Schlagenhauf F, Koslowski M, et al. Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage. 2006;29(2): 409-416.
    • (2006) Neuroimage. , vol.29 , Issue.2 , pp. 409-416
    • Juckel, G.1    Schlagenhauf, F.2    Koslowski, M.3
  • 27
    • 33749645423 scopus 로고    scopus 로고
    • Cognitive dysfunction in schizophrenia: Convergence of gamma-aminobutyric acid and glutamate alterations
    • Lewis DA, Moghaddam B. Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch Neurol. 2006;63(10):1372-1376.
    • (2006) Arch Neurol. , vol.63 , Issue.10 , pp. 1372-1376
    • Lewis, D.A.1    Moghaddam, B.2
  • 28
    • 0027406714 scopus 로고
    • Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: Differential actions on firing pattern related to anatomical localization
    • Murase S, Mathé JM, Grenhoff J, Svensson TH. Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization. J Neural Transm Gen Sect. 1993;91(1):13-25.
    • (1993) J Neural Transm Gen Sect. , vol.91 , Issue.1 , pp. 13-25
    • Murase, S.1    Mathé, J.M.2    Grenhoff, J.3    Svensson, T.H.4
  • 29
    • 0027458104 scopus 로고
    • Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists
    • Witkin JM. Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists. Life Sci. 1993;53(24):PL405-PL410.
    • (1993) Life Sci. , vol.53 , Issue.24
    • Witkin, J.M.1
  • 30
    • 0031712747 scopus 로고    scopus 로고
    • Glutamatergic regulation of basal and stimulus-activated dopamine release in the prefrontal cortex
    • Takahata R, Moghaddam B. Glutamatergic regulation of basal and stimulus-activated dopamine release in the prefrontal cortex. J Neurochem. 1998;71(4):1443-1449.
    • (1998) J Neurochem. , vol.71 , Issue.4 , pp. 1443-1449
    • Takahata, R.1    Moghaddam, B.2
  • 31
    • 84859100879 scopus 로고    scopus 로고
    • Role of thalamic projection in NMDA receptor-induced disruption of cortical slow oscillation and short-term plasticity
    • Kiss T, Hoffmann WE, Scott L, et al. Role of thalamic projection in NMDA receptor-induced disruption of cortical slow oscillation and short-term plasticity. Front Psychiatry. 2011;2:14.
    • (2011) Front Psychiatry. , vol.2 , pp. 14
    • Kiss, T.1    Hoffmann, W.E.2    Scott, L.3
  • 32
    • 0034094275 scopus 로고    scopus 로고
    • Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex
    • Tomitaka S, Tomitaka M, Tolliver BK, Sharp FR. Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex. Eur J Neurosci. 2000;12(4):1420-1430.
    • (2000) Eur J Neurosci. , vol.12 , Issue.4 , pp. 1420-1430
    • Tomitaka, S.1    Tomitaka, M.2    Tolliver, B.K.3    Sharp, F.R.4
  • 33
    • 0037475156 scopus 로고    scopus 로고
    • Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: Modulation by a group II selective metabotropic glutamate receptor agonist LY379268
    • Lorrain DS, Baccei CS, Bristow LJ, Anderson JJ, Varney MA. Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268. Neuroscience. 2003;117(3):697-706.
    • (2003) Neuroscience. , vol.117 , Issue.3 , pp. 697-706
    • Lorrain, D.S.1    Baccei, C.S.2    Bristow, L.J.3    Anderson, J.J.4    Varney, M.A.5
  • 35
    • 84873396022 scopus 로고    scopus 로고
    • The Clinical Assessment Interview for Negative Symptoms (CAINS): Final development and validation
    • Kring AM, Gur RE, Blanchard JJ, Horan WP, Reise SP. The Clinical Assessment Interview for Negative Symptoms (CAINS): final development and validation. Am J Psychiatry. 2013;170(2):165-172.
    • (2013) Am J Psychiatry. , vol.170 , Issue.2 , pp. 165-172
    • Kring, A.M.1    Gur, R.E.2    Blanchard, J.J.3    Horan, W.P.4    Reise, S.P.5
  • 36
    • 84869864467 scopus 로고    scopus 로고
    • Next-generation negative symptom assessment for clinical trials: Validation of the Brief Negative Symptom Scale
    • Strauss GP, Keller WR, Buchanan RW, et al. Next-generation negative symptom assessment for clinical trials: validation of the Brief Negative Symptom Scale. Schizophr Res. 2012a;142(1-3):88-92.
    • (2012) Schizophr Res. , vol.142 , Issue.1-3 , pp. 88-92
    • Strauss, G.P.1    Keller, W.R.2    Buchanan, R.W.3
  • 37
    • 0031431410 scopus 로고    scopus 로고
    • The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: Combined results of the North American trials
    • Marder SR, Davis JM, Chouinard G. The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: combined results of the North American trials. J Clin Psychiatry. 1997;58(12):538-546.
    • (1997) J Clin Psychiatry. , vol.58 , Issue.12 , pp. 538-546
    • Marder, S.R.1    Davis, J.M.2    Chouinard, G.3
  • 38
    • 34548682554 scopus 로고    scopus 로고
    • Revisiting the 5 dimensions of the Positive and Negative Syndrome Scale
    • Levine SZ, Rabinowitz J. Revisiting the 5 dimensions of the Positive and Negative Syndrome Scale. J Clin Psychopharmacol. 2007;27(5): 431-436.
    • (2007) J Clin Psychopharmacol. , vol.27 , Issue.5 , pp. 431-436
    • Levine, S.Z.1    Rabinowitz, J.2
  • 39
    • 84899868447 scopus 로고    scopus 로고
    • Defining and measuring negative symptoms of schizophrenia in clinical trials
    • Epub 11 November (DOI: 10.1016/j.euroneuro.2013.10.016)
    • Marder SR, Kirkpatrick B. Defining and measuring negative symptoms of schizophrenia in clinical trials. Eur Neuropsychopharmacol. 2013; Epub 11 November (DOI: 10.1016/j.euroneuro.2013.10.016).
    • (2013) Eur Neuropsychopharmacol.
    • Marder, S.R.1    Kirkpatrick, B.2
  • 40
    • 79952141373 scopus 로고    scopus 로고
    • Methodological issues in negative symptom trials
    • Marder SR, Daniel DG, Alphs L, Awad G. Methodological issues in negative symptom trials. Schizophr Bull. 2011;37(2):250-254.
    • (2011) Schizophr Bull. , vol.37 , Issue.2 , pp. 250-254
    • Marder, S.R.1    Daniel, D.G.2    Alphs, L.3    Awad, G.4
  • 41
    • 84886283569 scopus 로고    scopus 로고
    • Issues and perspectives in designing clinical trials for negative symptoms in schizophrenia
    • Marder SR, Alphs L, Anghelescu I, et al. Issues and perspectives in designing clinical trials for negative symptoms in schizophrenia. Schizophr Res. 2013;150(2-3):328-333.
    • (2013) Schizophr Res. , vol.150 , Issue.2-3 , pp. 328-333
    • Marder, S.R.1    Alphs, L.2    Anghelescu, I.3
  • 42
    • 84863866584 scopus 로고    scopus 로고
    • Negative symptoms and psychosocial functioning in schizophrenia: Neglected but important targets for treatment
    • Hunter R, Barry S. Negative symptoms and psychosocial functioning in schizophrenia: Neglected but important targets for treatment. Eur Psychiatry. 2012;27(6):432-436.
    • (2012) Eur Psychiatry. , vol.27 , Issue.6 , pp. 432-436
    • Hunter, R.1    Barry, S.2
  • 43
    • 84860835479 scopus 로고    scopus 로고
    • Factors involved in the level of functioning of patients with schizophrenia according to latent variable modeling
    • EGOFORS Initiative
    • Llorca PM, Blanc O, Samalin L, Bosia M, Cavallaro R; EGOFORS Initiative. Factors involved in the level of functioning of patients with schizophrenia according to latent variable modeling. Eur Psychiatry. 2012;27(6):396-400.
    • (2012) Eur Psychiatry. , vol.27 , Issue.6 , pp. 396-400
    • Llorca, P.M.1    Blanc, O.2    Samalin, L.3    Bosia, M.4    Cavallaro, R.5
  • 44
    • 0029918481 scopus 로고    scopus 로고
    • What are the functional consequences of neurocognitive deficits in schizophrenia?
    • Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 1996;153(3):321-330.
    • (1996) Am J Psychiatry. , vol.153 , Issue.3 , pp. 321-330
    • Green, M.F.1
  • 45
    • 24944456746 scopus 로고    scopus 로고
    • Patient outcomes in schizophrenia I: Correlates with sociodemographic variables, psychopathology, and side effects
    • Hofer A, Baumgartner S, Edlinger M, et al. Patient outcomes in schizophrenia I: correlates with sociodemographic variables, psychopathology, and side effects. Eur Psychiatry. 2005;20(5-6):386-394.
    • (2005) Eur Psychiatry. , vol.20 , Issue.5-6 , pp. 386-394
    • Hofer, A.1    Baumgartner, S.2    Edlinger, M.3
  • 46
    • 33846276906 scopus 로고    scopus 로고
    • Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia
    • Rosenheck RA, Leslie DL, Sindelar J, et al. Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia. Am J Psychiatry. 2006;163(12):2080-2089.
    • (2006) Am J Psychiatry. , vol.163 , Issue.12 , pp. 2080-2089
    • Rosenheck, R.A.1    Leslie, D.L.2    Sindelar, J.3
  • 47
    • 84860834493 scopus 로고    scopus 로고
    • Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: Analysis of CATIE data
    • Rabinowitz J, Levine SZ, Garibaldi G, Bugarski-Kirola D, Berardo CG, Kapur S. Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data. Schizophr Res. 2012;137(1-3):147-150.
    • (2012) Schizophr Res. , vol.137 , Issue.1-3 , pp. 147-150
    • Rabinowitz, J.1    Levine, S.Z.2    Garibaldi, G.3    Bugarski-Kirola, D.4    Berardo, C.G.5    Kapur, S.6
  • 48
    • 84886238591 scopus 로고    scopus 로고
    • Association of prominent positive and prominent negative symptoms and functional health, well-being, healthcare-related quality of life and family burden: A CATIE analysis
    • Rabinowitz J, Berardo CG, Bugarski-Kirola D, Marder S. Association of prominent positive and prominent negative symptoms and functional health, well-being, healthcare-related quality of life and family burden: A CATIE analysis. Schizophr Res. 2013;150(2-3):339-342.
    • (2013) Schizophr Res. , vol.150 , Issue.2-3 , pp. 339-342
    • Rabinowitz, J.1    Berardo, C.G.2    Bugarski-Kirola, D.3    Marder, S.4
  • 49
    • 14844321950 scopus 로고    scopus 로고
    • Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: A longitudinal first-episode study with 7-year follow-up
    • Milev P, Ho BC, Arndt S, Andreasen NC. Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up. Am J Psychiatry. 2005;162(3):495-506.
    • (2005) Am J Psychiatry. , vol.162 , Issue.3 , pp. 495-506
    • Milev, P.1    Ho, B.C.2    Arndt, S.3    Andreasen, N.C.4
  • 50
    • 80052633733 scopus 로고    scopus 로고
    • Prediction of longitudinal functional outcomes in schizophrenia: The impact of baseline motivational deficits
    • Foussias G, Mann S, Zakzanis KK, van Reekum R, Agid O, Remington G. Prediction of longitudinal functional outcomes in schizophrenia: the impact of baseline motivational deficits. Schizophr Res. 2011;132(1):24-27.
    • (2011) Schizophr Res. , vol.132 , Issue.1 , pp. 24-27
    • Foussias, G.1    Mann, S.2    Zakzanis, K.K.3    van Reekum, R.4    Agid, O.5    Remington, G.6
  • 51
    • 70349432151 scopus 로고    scopus 로고
    • Determinants of everyday outcomes in schizophrenia: The influences of cognitive impairment, functional capacity, and symptoms
    • Leifker FR, Bowie CR, Harvey PD. Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms. Schizophr Res. 2009;115(1):82-87.
    • (2009) Schizophr Res. , vol.115 , Issue.1 , pp. 82-87
    • Leifker, F.R.1    Bowie, C.R.2    Harvey, P.D.3
  • 52
    • 84875236131 scopus 로고    scopus 로고
    • Self-efficacy and functional status in schizophrenia: Relationship to insight, cognition and negative symptoms
    • Kurtz MM, Olfson RH, Rose J. Self-efficacy and functional status in schizophrenia: relationship to insight, cognition and negative symptoms. Schizophr Res. 2013;145(1-3):69-74.
    • (2013) Schizophr Res. , vol.145 , Issue.1-3 , pp. 69-74
    • Kurtz, M.M.1    Olfson, R.H.2    Rose, J.3
  • 53
    • 0024393725 scopus 로고
    • Negative symptoms and emotions in schizophrenia
    • Bouricius JK. Negative symptoms and emotions in schizophrenia. Schizophr Bull. 1989;15(2):201-208.
    • (1989) Schizophr Bull. , vol.15 , Issue.2 , pp. 201-208
    • Bouricius, J.K.1
  • 54
    • 0027185943 scopus 로고
    • Psychosocial functioning and subjective experience in schizophrenia
    • Brekke JS, Levin S, Wolkon GH, Sobel E, Slade E. Psychosocial functioning and subjective experience in schizophrenia. Schizophr Bull. 1993;19(3):599-608.
    • (1993) Schizophr Bull. , vol.19 , Issue.3 , pp. 599-608
    • Brekke, J.S.1    Levin, S.2    Wolkon, G.H.3    Sobel, E.4    Slade, E.5
  • 55
    • 80052793580 scopus 로고    scopus 로고
    • Insight and negative symptoms as predictors of functioning in a work setting in patients with schizophrenia
    • Erickson M, Jaafari N, Lysaker P. Insight and negative symptoms as predictors of functioning in a work setting in patients with schizophrenia. Psychiatry Res. 2011;189(2):161-165.
    • (2011) Psychiatry Res. , vol.189 , Issue.2 , pp. 161-165
    • Erickson, M.1    Jaafari, N.2    Lysaker, P.3
  • 56
    • 0028920148 scopus 로고
    • Negative symptoms and vocational impairment in schizophrenia: Repeated measurements of work performance over six months
    • Lysaker P, Bell M. Negative symptoms and vocational impairment in schizophrenia: repeated measurements of work performance over six months. Acta Psychiatr Scand. 1995;91(3):205-208.
    • (1995) Acta Psychiatr Scand. , vol.91 , Issue.3 , pp. 205-208
    • Lysaker, P.1    Bell, M.2
  • 57
    • 75749144324 scopus 로고    scopus 로고
    • Longitudinal associations between negative symptoms and social functioning in schizophrenia: The moderating role of employment status and setting
    • Weinberg D, Shahar G, Davidson L, McGlashan TH, Fennig S. Longitudinal associations between negative symptoms and social functioning in schizophrenia: the moderating role of employment status and setting. Psychiatry. 2009;72(4):370-381.
    • (2009) Psychiatry. , vol.72 , Issue.4 , pp. 370-381
    • Weinberg, D.1    Shahar, G.2    Davidson, L.3    McGlashan, T.H.4    Fennig, S.5
  • 58
    • 84868201269 scopus 로고    scopus 로고
    • Negative symptoms and depression predict lower psychological well-being in individuals with schizophrenia
    • Strauss GP, Sandt AR, Catalano LT, Allen DN. Negative symptoms and depression predict lower psychological well-being in individuals with schizophrenia. Compr Psychiatry. 2012b;53(8):1137-1144.
    • (2012) Compr Psychiatry. , vol.53 , Issue.8 , pp. 1137-1144
    • Strauss, G.P.1    Sandt, A.R.2    Catalano, L.T.3    Allen, D.N.4
  • 59
    • 80052216057 scopus 로고    scopus 로고
    • Negative symptoms and social cognition: Identifying targets for psychological interventions
    • Lincoln TM, Mehl S, Kesting ML, Rief W. Negative symptoms and social cognition: identifying targets for psychological interventions. Schizophr Bull. 2011;37(suppl 2):S23-S32.
    • (2011) Schizophr Bull. , vol.37 , Issue.SUUPL. 2
    • Lincoln, T.M.1    Mehl, S.2    Kesting, M.L.3    Rief, W.4
  • 61
    • 33845797866 scopus 로고    scopus 로고
    • Negative symptoms of schizophrenia: A problem that will not go away
    • Stahl SM, Buckley PF. Negative symptoms of schizophrenia: a problem that will not go away. Acta Psychiatrica Scand. 2007;115(1):4-11.
    • (2007) Acta Psychiatrica Scand. , vol.115 , Issue.1 , pp. 4-11
    • Stahl, S.M.1    Buckley, P.F.2
  • 62
    • 0032811066 scopus 로고    scopus 로고
    • Predictors of burden and infectious illness in schizophrenia caregivers
    • Dyck DG, Short R, Vitaliano PP. Predictors of burden and infectious illness in schizophrenia caregivers. Psychosom Med. 1999;61(4):411-419.
    • (1999) Psychosom Med. , vol.61 , Issue.4 , pp. 411-419
    • Dyck, D.G.1    Short, R.2    Vitaliano, P.P.3
  • 63
    • 0030854159 scopus 로고    scopus 로고
    • Positive and negative symptom behaviors and caregiver burden in the relatives of persons with schizophrenia
    • Provencher HL, Mueser KT. Positive and negative symptom behaviors and caregiver burden in the relatives of persons with schizophrenia. Schizophr Res. 1997;26(1):71-80.
    • (1997) Schizophr Res. , vol.26 , Issue.1 , pp. 71-80
    • Provencher, H.L.1    Mueser, K.T.2
  • 64
    • 84869863703 scopus 로고    scopus 로고
    • Executive functioning during full and partial remission (positive and negative symptomatic remission) of schizophrenia
    • Braw Y, Benozio A, Levkovitz Y. Executive functioning during full and partial remission (positive and negative symptomatic remission) of schizophrenia. Schizophr Res. 2012;142(1-3):122-128.
    • (2012) Schizophr Res. , vol.142 , Issue.1-3 , pp. 122-128
    • Braw, Y.1    Benozio, A.2    Levkovitz, Y.3
  • 65
    • 60549091905 scopus 로고    scopus 로고
    • Recovery in the outpatient setting: 36-month results from the Schizophrenia Outpatients Health Outcomes (SOHO) study
    • Novick D, Haro JM, Suarez D, Vieta E, Naber D. Recovery in the outpatient setting: 36-month results from the Schizophrenia Outpatients Health Outcomes (SOHO) study. Schizophr Res. 2009;108(1-3):223-230.
    • (2009) Schizophr Res. , vol.108 , Issue.1-3 , pp. 223-230
    • Novick, D.1    Haro, J.M.2    Suarez, D.3    Vieta, E.4    Naber, D.5
  • 66
    • 84871932147 scopus 로고    scopus 로고
    • Attaining and sustaining remission of predominant negative symptoms
    • Levine SZ, Leucht S. Attaining and sustaining remission of predominant negative symptoms. Schizophr Res. 2013;143(1):60-64.
    • (2013) Schizophr Res. , vol.143 , Issue.1 , pp. 60-64
    • Levine, S.Z.1    Leucht, S.2
  • 67
    • 79955429050 scopus 로고    scopus 로고
    • Evidence-based guidelines for the pharmacological treatment of schizophrenia: Recommendations from the British Association for Psychopharmacology
    • Schizophrenia Consensus Group of British Association for Psychopharmacology
    • Barnes TR; Schizophrenia Consensus Group of British Association for Psychopharmacology. Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2011;25(5):567-620.
    • (2011) J Psychopharmacol. , vol.25 , Issue.5 , pp. 567-620
    • Barnes, T.R.1
  • 68
    • 77956864079 scopus 로고    scopus 로고
    • Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: Meta-analysis
    • Singh SP, Singh V, Kar N, Chan K. Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta-analysis. Br J Psychiatry. 2010;197(3):174-179.
    • (2010) Br J Psychiatry. , vol.197 , Issue.3 , pp. 174-179
    • Singh, S.P.1    Singh, V.2    Kar, N.3    Chan, K.4
  • 70
    • 84856270110 scopus 로고    scopus 로고
    • Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis
    • Hecht EM, Landy DC. Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis. Schizophr Res. 2012;134(2-3):202-206.
    • (2012) Schizophr Res. , vol.134 , Issue.2-3 , pp. 202-206
    • Hecht, E.M.1    Landy, D.C.2
  • 71
    • 13444271621 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, multicenter trial of selegiline augmentation of antipsychotic medication to treat negative symptoms in outpatients with schizophrenia
    • Bodkin JA, Siris SG, Bermanzohn PC, Hennen J, Cole JO. Double-blind, placebo-controlled, multicenter trial of selegiline augmentation of antipsychotic medication to treat negative symptoms in outpatients with schizophrenia. Am J Psychiatry. 2005;162(2):388-390.
    • (2005) Am J Psychiatry. , vol.162 , Issue.2 , pp. 388-390
    • Bodkin, J.A.1    Siris, S.G.2    Bermanzohn, P.C.3    Hennen, J.4    Cole, J.O.5
  • 72
    • 40549123370 scopus 로고    scopus 로고
    • Efficacy of selegiline add on therapy to risperidone in the treatment of the negative symptoms of schizophrenia: A double-blind randomized placebo-controlled study
    • Amiri A, Noorbala AA, Nejatisafa AA, et al. Efficacy of selegiline add on therapy to risperidone in the treatment of the negative symptoms of schizophrenia: a double-blind randomized placebo-controlled study. Hum Psychopharmacol. 2008;23(2):79-86.
    • (2008) Hum Psychopharmacol. , vol.23 , Issue.2 , pp. 79-86
    • Amiri, A.1    Noorbala, A.A.2    Nejatisafa, A.A.3
  • 74
    • 70449641202 scopus 로고    scopus 로고
    • Second-generation antipsychotics for schizophrenia: Can we resolve the conflict?
    • Leucht S, Kissling W, Davis JM. Second-generation antipsychotics for schizophrenia: can we resolve the conflict? Psychol Med. 2009;39: 1591-1602.
    • (2009) Psychol Med. , vol.39 , pp. 1591-1602
    • Leucht, S.1    Kissling, W.2    Davis, J.M.3
  • 75
    • 84886297495 scopus 로고    scopus 로고
    • Pharmacological approaches to treating negative symptoms: A review of clinical trials
    • Arango C, Garibaldi G, Marder SR. Pharmacological approaches to treating negative symptoms: A review of clinical trials. Schizophr Res. 2013;150(2-3):346-352.
    • (2013) Schizophr Res. , vol.150 , Issue.2-3 , pp. 346-352
    • Arango, C.1    Garibaldi, G.2    Marder, S.R.3
  • 76
    • 84900405461 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence (NICE), National Collaborating Centre for Mental Health. National Clinical Guideline Number 82. Leicester, UK: The British Psychological Society and The Royal College of Psychiatrists
    • National Institute for Health and Clinical Excellence (NICE), National Collaborating Centre for Mental Health. The NICE Guideline on Core Interventions in the Treatment and Management of Schizophrenia in Adults in Primary and Secondary Care (Updated Edition). National Clinical Guideline Number 82. Leicester, UK: The British Psychological Society and The Royal College of Psychiatrists; 2010.
    • (2010) The NICE Guideline on Core Interventions in the Treatment and Management of Schizophrenia in Adults in Primary and Secondary Care (Updated Edition).
  • 77
    • 84855339931 scopus 로고    scopus 로고
    • Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia
    • Buchanan RW, Panagides J, Zhao J, et al. Asenapine versus olanzapine in people with persistent negative symptoms of schizophrenia. J Clin Psychopharmacol. 2012;32(1):36-45.
    • (2012) J Clin Psychopharmacol. , vol.32 , Issue.1 , pp. 36-45
    • Buchanan, R.W.1    Panagides, J.2    Zhao, J.3
  • 78
    • 84886251333 scopus 로고    scopus 로고
    • Long-term effects of asenapine or olanzapine in patients with persistent negative symptoms of schizophrenia: A pooled analysis
    • Potkin SG, Phiri P, Szegedi A, Zhao J, Alphs L, Cazorla P. Long-term effects of asenapine or olanzapine in patients with persistent negative symptoms of schizophrenia: A pooled analysis. Schizophr Res. 2013;150(2-3):442-449.
    • (2013) Schizophr Res. , vol.150 , Issue.2-3 , pp. 442-449
    • Potkin, S.G.1    Phiri, P.2    Szegedi, A.3    Zhao, J.4    Alphs, L.5    Cazorla, P.6
  • 80
    • 84900411478 scopus 로고    scopus 로고
    • Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: A randomized, double-blind, proof-of-concept study
    • Epub 2 April (DOI: 10.1001/jamapsychiatry.2014.163)
    • Umbricht D, Alberati D, Martin-Facklam M, et al. Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study. JAMA Psychiatry. 2014; Epub 2 April (DOI: 10.1001/jamapsychiatry.2014.163).
    • (2014) JAMA Psychiatry.
    • Umbricht, D.1    Alberati, D.2    Martin-Facklam, M.3
  • 81
    • 77949447469 scopus 로고    scopus 로고
    • Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis
    • Tsai GE, Lin PY. Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis. Curr Pharm Des. 2010;16(5):522-537.
    • (2010) Curr Pharm Des. , vol.16 , Issue.5 , pp. 522-537
    • Tsai, G.E.1    Lin, P.Y.2
  • 82
    • 80052996482 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia
    • Singh SP, Singh V. Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs. 2011;25(10): 859-885.
    • (2011) CNS Drugs. , vol.25 , Issue.10 , pp. 859-885
    • Singh, S.P.1    Singh, V.2
  • 83
    • 1542617755 scopus 로고    scopus 로고
    • Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia
    • Tsai G, Lane HY, Yang P, Chong MY, Lange N. Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry. 2004;55(5):452-456.
    • (2004) Biol Psychiatry. , vol.55 , Issue.5 , pp. 452-456
    • Tsai, G.1    Lane, H.Y.2    Yang, P.3    Chong, M.Y.4    Lange, N.5
  • 84
    • 27744529018 scopus 로고    scopus 로고
    • Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: A randomized, double-blind, placebo-controlled study
    • Lane HY, Chang YC, Liu YC, Chiu CC, Tsai GE. Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study. Arch Gen Psychiatry. 2005;62(11):1196-1204.
    • (2005) Arch Gen Psychiatry. , vol.62 , Issue.11 , pp. 1196-1204
    • Lane, H.Y.1    Chang, Y.C.2    Liu, Y.C.3    Chiu, C.C.4    Tsai, G.E.5
  • 85
    • 33748751382 scopus 로고    scopus 로고
    • Glycine transporter 1 inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia
    • Lane HY, Huang CL, Wu PL, et al. Glycine transporter 1 inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia. Biol Psychiatry. 2006;60(6):645-649.
    • (2006) Biol Psychiatry. , vol.60 , Issue.6 , pp. 645-649
    • Lane, H.Y.1    Huang, C.L.2    Wu, P.L.3
  • 86
    • 36849071470 scopus 로고    scopus 로고
    • Sarcosine (N-methylglycine) treatment for acute schizophrenia: A randomized, double-blind study
    • Lane HY, Liu YC, Huang CL, et al. Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study. Biol Psychiatry. 2008;63(1):9-12.
    • (2008) Biol Psychiatry. , vol.63 , Issue.1 , pp. 9-12
    • Lane, H.Y.1    Liu, Y.C.2    Huang, C.L.3
  • 87
    • 77953545879 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia
    • Lane HY, Lin CH, Huang YJ, et al. A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia. Int J Neuropsychopharmacol. 2010;13(4):451-460.
    • (2010) Int J Neuropsychopharmacol. , vol.13 , Issue.4 , pp. 451-460
    • Lane, H.Y.1    Lin, C.H.2    Huang, Y.J.3
  • 88
    • 0036641749 scopus 로고    scopus 로고
    • D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia
    • Evins AE, Amico E, Posever TA, Toker R, Goff DC. D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia. Schizophr Res. 2002;56(1-2):19-23.
    • (2002) Schizophr Res. , vol.56 , Issue.1-2 , pp. 19-23
    • Evins, A.E.1    Amico, E.2    Posever, T.A.3    Toker, R.4    Goff, D.C.5
  • 89
    • 0348047434 scopus 로고    scopus 로고
    • Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: A retrospective analysis
    • Heresco-Levy U, Javitt DC. Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis. Schizophr Res. 2004;66:89-96.
    • (2004) Schizophr Res. , vol.66 , pp. 89-96
    • Heresco-Levy, U.1    Javitt, D.C.2
  • 90
    • 0029658545 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia
    • Heresco-Levy U, Javitt DC, Ermilov M, et al. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. Br J Psychiatry. 1996;169:610-617.
    • (1996) Br J Psychiatry. , vol.169 , pp. 610-617
    • Heresco-Levy, U.1    Javitt, D.C.2    Ermilov, M.3
  • 91
    • 0032925438 scopus 로고    scopus 로고
    • Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia
    • Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 1999;56(1):29-36.
    • (1999) Arch Gen Psychiatry. , vol.56 , Issue.1 , pp. 29-36
    • Heresco-Levy, U.1    Javitt, D.C.2    Ermilov, M.3
  • 93
    • 84890018607 scopus 로고    scopus 로고
    • Add-on treatment of benzoate for schizophrenia: A randomized, double-blind, placebo-controlled trial of d-amino acid oxidase inhibitor
    • Lane HY, Lin CH, Green MF, et al. Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of d-amino acid oxidase inhibitor. JAMA Psychiatry. 2013;70(12): 1267-1275.
    • (2013) JAMA Psychiatry. , vol.70 , Issue.12 , pp. 1267-1275
    • Lane, H.Y.1    Lin, C.H.2    Green, M.F.3
  • 94
    • 84886304673 scopus 로고    scopus 로고
    • Pomaglumetad methionil: No significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo
    • Stauffer VL, Millen BA, Andersen S, et al. Pomaglumetad methionil: No significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo. Schizophr Res. 2013;150(2-3):434-441.
    • (2013) Schizophr Res. , vol.150 , Issue.2-3 , pp. 434-441
    • Stauffer, V.L.1    Millen, B.A.2    Andersen, S.3
  • 97
    • 84878590414 scopus 로고    scopus 로고
    • A randomized exploratory trial of an alpha-7 nicotinic receptor agonist (TC-5619) for cognitive enhancement in schizophrenia
    • Lieberman JA, Dunbar G, Segreti AC, et al. A randomized exploratory trial of an alpha-7 nicotinic receptor agonist (TC-5619) for cognitive enhancement in schizophrenia. Neuropsychopharmacology. 2013;38(6):968-975.
    • (2013) Neuropsychopharmacology. , vol.38 , Issue.6 , pp. 968-975
    • Lieberman, J.A.1    Dunbar, G.2    Segreti, A.C.3
  • 99
    • 84883472062 scopus 로고    scopus 로고
    • Adjunctive pharmacotherapy for cognitive deficits in schizophrenia: Meta-analytical investigation of efficacy
    • Choi KH, Wykes T, Kurtz MM. Adjunctive pharmacotherapy for cognitive deficits in schizophrenia: meta-analytical investigation of efficacy. Br J Psychiatry. 2013;203:172-178.
    • (2013) Br J Psychiatry. , vol.203 , pp. 172-178
    • Choi, K.H.1    Wykes, T.2    Kurtz, M.M.3
  • 101
    • 84884288999 scopus 로고    scopus 로고
    • Adjunctive lisdexamfetamine dimesylate therapy in adult outpatients with predominant negative symptoms of schizophrenia: Open-label and randomized-withdrawal phases
    • Lasser RA, Dirks B, Nasrallah H, et al. Adjunctive lisdexamfetamine dimesylate therapy in adult outpatients with predominant negative symptoms of schizophrenia: open-label and randomized-withdrawal phases. Neuropsychopharmacology. 2013;38(11):2140-2149.
    • (2013) Neuropsychopharmacology. , vol.38 , Issue.11 , pp. 2140-2149
    • Lasser, R.A.1    Dirks, B.2    Nasrallah, H.3
  • 102
    • 84878967787 scopus 로고    scopus 로고
    • A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: Challenges and therapeutic opportunities
    • Lindenmayer JP, Nasrallah H, Pucci M, James S, Citrome L. A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: challenges and therapeutic opportunities. Schizophr Res. 2013;147(2-3):241-252.
    • (2013) Schizophr Res. , vol.147 , Issue.2-3 , pp. 241-252
    • Lindenmayer, J.P.1    Nasrallah, H.2    Pucci, M.3    James, S.4    Citrome, L.5
  • 103
    • 84998166025 scopus 로고    scopus 로고
    • A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia
    • Wittkampf LC, Arends J, Timmerman L, Lancel M. A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia. Ther Adv Psychopharmacol. 2012;2(3): 115-125.
    • (2012) Ther Adv Psychopharmacol. , vol.2 , Issue.3 , pp. 115-125
    • Wittkampf, L.C.1    Arends, J.2    Timmerman, L.3    Lancel, M.4
  • 104
    • 48749112603 scopus 로고    scopus 로고
    • N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial
    • Berk M, Copolov D, Dean O, et al. N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial. Biol Psychiatry. 2008;64(5):361-368.
    • (2008) Biol Psychiatry. , vol.64 , Issue.5 , pp. 361-368
    • Berk, M.1    Copolov, D.2    Dean, O.3
  • 105
    • 84864999825 scopus 로고    scopus 로고
    • Minocycline benefits negative symptoms in early schizophrenia: A randomised double-blind placebo-controlled clinical trial in patients on standard treatment
    • Chaudhry IB, Hallak J, Husain N, et al. Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment. J Psychopharmacol. 2012;26(9):1185-1193.
    • (2012) J Psychopharmacol. , vol.26 , Issue.9 , pp. 1185-1193
    • Chaudhry, I.B.1    Hallak, J.2    Husain, N.3
  • 106
    • 77649112679 scopus 로고    scopus 로고
    • A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia
    • Levkovitz Y, Mendlovich S, Riwkes S, et al. A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry. 2010;71(2):138-149.
    • (2010) J Clin Psychiatry. , vol.71 , Issue.2 , pp. 138-149
    • Levkovitz, Y.1    Mendlovich, S.2    Riwkes, S.3
  • 107
    • 84894226297 scopus 로고    scopus 로고
    • Selective serotonin 3 receptor antagonist treatment for schizophrenia: Meta-analysis and systematic review
    • Kishi T, Mukai T, Matsuda Y, Iwata N. Selective serotonin 3 receptor antagonist treatment for schizophrenia: Meta-analysis and systematic review. Neuromolecular Med. 2014;16(1):61-69.
    • (2014) Neuromolecular Med. , vol.16 , Issue.1 , pp. 61-69
    • Kishi, T.1    Mukai, T.2    Matsuda, Y.3    Iwata, N.4
  • 108
    • 62649086513 scopus 로고    scopus 로고
    • The efficacy of lamotrigine in clozapine-resistant schizophrenia: A systematic review and meta-analysis
    • Tiihonen J, Wahlbeck K, Kiviniemi V. The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis. Schizophr Res. 2009;109(1-3):10-14.
    • (2009) Schizophr Res. , vol.109 , Issue.1-3 , pp. 10-14
    • Tiihonen, J.1    Wahlbeck, K.2    Kiviniemi, V.3
  • 109
    • 84880133046 scopus 로고    scopus 로고
    • NMDA receptor antagonists interventions in schizophrenia: Meta-analysis of randomized, placebo-controlled trials
    • Kishi T, Iwata N. NMDA receptor antagonists interventions in schizophrenia: Meta-analysis of randomized, placebo-controlled trials. J Psychiatr Res. 2013;47(9):1143-1149.
    • (2013) J Psychiatr Res. , vol.47 , Issue.9 , pp. 1143-1149
    • Kishi, T.1    Iwata, N.2
  • 110
    • 62349116484 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia
    • for the MEM-MD-29 Study Group
    • Lieberman JA, Papadakis K, Csernansky J, et al; for the MEM-MD-29 Study Group. A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia. Neuropsychopharmacology. 2009;34(5):1322-1329.
    • (2009) Neuropsychopharmacology. , vol.34 , Issue.5 , pp. 1322-1329
    • Lieberman, J.A.1    Papadakis, K.2    Csernansky, J.3
  • 111
    • 67449123074 scopus 로고    scopus 로고
    • Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
    • Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology. 2009;34(8): 1885-1903.
    • (2009) Neuropsychopharmacology. , vol.34 , Issue.8 , pp. 1885-1903
    • Marx, C.E.1    Keefe, R.S.2    Buchanan, R.W.3
  • 112
    • 80052258839 scopus 로고    scopus 로고
    • Pregnenolone as a novel therapeutic candidate in schizophrenia: Emerging preclinical and clinical evidence
    • Marx CE, Bradford DW, Hamer RM, et al. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011;191:78-90.
    • (2011) Neuroscience. , vol.191 , pp. 78-90
    • Marx, C.E.1    Bradford, D.W.2    Hamer, R.M.3
  • 113
    • 59449098930 scopus 로고    scopus 로고
    • A placebo-controlled study of sildenafil effects on cognition in schizophrenia
    • Goff DC, Cather C, Freudenreich O, et al. A placebo-controlled study of sildenafil effects on cognition in schizophrenia. Psychopharmacology. 2009;202(1-3):411-417.
    • (2009) Psychopharmacology. , vol.202 , Issue.1-3 , pp. 411-417
    • Goff, D.C.1    Cather, C.2    Freudenreich, O.3
  • 114
    • 79952487439 scopus 로고    scopus 로고
    • Sildenafil adjunctive therapy to risperidone in the treatment of the negative symptoms of schizophrenia: A double-blind randomized placebo-controlled trial
    • Akhondzadeh S, Ghayyoumi R, Rezaei F, et al. Sildenafil adjunctive therapy to risperidone in the treatment of the negative symptoms of schizophrenia: a double-blind randomized placebo-controlled trial. Psychopharmacology. 2011;213(4):809-815.
    • (2011) Psychopharmacology. , vol.213 , Issue.4 , pp. 809-815
    • Akhondzadeh, S.1    Ghayyoumi, R.2    Rezaei, F.3
  • 115
    • 84876925332 scopus 로고    scopus 로고
    • Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia
    • Roffman JL, Lamberti JS, Achtyes E, et al. Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia. JAMA Psychiatry. 2013;70(5):481-489.
    • (2013) JAMA Psychiatry. , vol.70 , Issue.5 , pp. 481-489
    • Roffman, J.L.1    Lamberti, J.S.2    Achtyes, E.3
  • 117
    • 84884229725 scopus 로고    scopus 로고
    • Glycine reuptake inhibition: A promising therapeutic strategy in the treatment of schizophrenia?
    • Chue P, Baker GB. Glycine reuptake inhibition: a promising therapeutic strategy in the treatment of schizophrenia? Future Med Chem. 2013;5(13):1475-1477.
    • (2013) Future Med Chem. , vol.5 , Issue.13 , pp. 1475-1477
    • Chue, P.1    Baker, G.B.2
  • 118
    • 84876735618 scopus 로고    scopus 로고
    • Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: Focus on the glycine transporter 1 (GlyT1)
    • Chue P. Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr Pharm Des. 2013;19(7):1311-1320.
    • (2013) Curr Pharm Des. , vol.19 , Issue.7 , pp. 1311-1320
    • Chue, P.1
  • 119
    • 77956648156 scopus 로고    scopus 로고
    • N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?
    • Kantrowitz JT, Javitt DC. N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia? Brain Res Bull. 2010;83:108-121.
    • (2010) Brain Res Bull. , vol.83 , pp. 108-121
    • Kantrowitz, J.T.1    Javitt, D.C.2
  • 120
    • 84900414433 scopus 로고    scopus 로고
    • Hoffmann-La Roche. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated January 6, 2014]. Available from NLM identifier: NCT01192906. Accessed March 10, 2014
    • Hoffmann-La Roche. A Study of RO4917838 (Bitopertin) in Patients With Persistent, Predominant Negative Symptoms of Schizophrenia (WN25309). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010 [updated January 6, 2014]. Available from http://clinicaltrials.gov/ct2/show/NCT01192906. NLM identifier: NCT01192906. Accessed March 10, 2014.
    • (2010) A Study of RO4917838 (Bitopertin) in Patients With Persistent, Predominant Negative Symptoms of Schizophrenia (WN25309).
  • 121
    • 84900414433 scopus 로고    scopus 로고
    • Hoffmann-La Roche. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated March 3, 2014]. Available from. NLM identifier: NCT01192880. Accessed March 10, 2014
    • Hoffmann-La Roche. A Study of RO4917838 (Bitopertin) in Patients With Persistent, Predominant Negative Symptoms of Schizophrenia (WN25308). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010 [updated March 3, 2014]. Available from http://clinicaltrials.gov/ct2/show/NCT01192880?term=NCT01192880&rank=1. NLM identifier: NCT01192880. Accessed March 10, 2014.
    • (2010) A Study of RO4917838 (Bitopertin) in Patients With Persistent, Predominant Negative Symptoms of Schizophrenia (WN25308).
  • 122
    • 84900416942 scopus 로고    scopus 로고
    • Hoffmann-La Roche. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated January 13, 2014]. Available from NLM identifier: NCT01192867. Accessed March 10, 2104
    • Hoffmann-La Roche. A Study of RO4917838 in Patients With Persistent, Predominant Negative Symptoms of Schizophrenia (NN25310). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010 [updated January 13, 2014]. Available from http://clinicaltrials.gov/ct2/show/NCT01192867?term=NCT01192867&rank=1. NLM identifier: NCT01192867. Accessed March 10, 2104.
    • (2010) A Study of RO4917838 in Patients With Persistent, Predominant Negative Symptoms of Schizophrenia (NN25310).
  • 123
    • 84900412998 scopus 로고    scopus 로고
    • Hoffmann-La Roche. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated March 3, 2014]. Available from NLM identifier: NCT01235559. Accessed March 3, 2014
    • Hoffmann-La Roche. A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25305). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010 [updated March 3, 2014]. Available from http://clinicaltrials.gov/ct2/show/NCT01235559?term=nCT01235559&rank=1. NLM identifier: NCT01235559. Accessed March 3, 2014.
    • (2010) A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25305).
  • 124
    • 84900412998 scopus 로고    scopus 로고
    • In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated March 3, 2014]. Hoffmann-La Roche. Available from NLM identifier: NCT01235585. Accessed March 10, 2014
    • Hoffmann-La Roche. A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25306). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010 [updated March 3, 2014]. Available from http://clinicaltrials.gov/ct2/show/NCT01235585?term=NCT01235585&rank=1. NLM identifier: NCT01235585. Accessed March 10, 2014.
    • (2010) A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25306).
  • 125
    • 84900402337 scopus 로고    scopus 로고
    • Hoffmann-La Roche. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010 [updated January 20, 2014]. Available from NLM identifier: NCT01235520. Accessed March 10, 2014
    • Hoffmann-La Roche. A Study of RO4917838 in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (NN25307). In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2010 [updated January 20, 2014]. Available from http://clinicaltrials.gov/ct2/show/NCT01235520?term=NCT01235520&rank=1. NLM identifier: NCT01235520. Accessed March 10, 2014.
    • A Study of RO4917838 in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (NN25307).
  • 126
    • 84900446228 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive bitopertin (5 and 10 mg) versus placebo in subjects with persistent predominant negative symptoms of schizophrenia treated with antipsychotics-Results from the Phase III DayLyte study
    • Poster presented at: April 5-9, Florence, Italy
    • Arango C, Nasrallah H, Lawrie S, et al. Efficacy and safety of adjunctive bitopertin (5 and 10 mg) versus placebo in subjects with persistent predominant negative symptoms of schizophrenia treated with antipsychotics-Results from the Phase III DayLyte study. Poster presented at: 4th Biennial Schizophrenia International Research Society Conference, April 5-9, 2014, Florence, Italy.
    • (2014) 4th Biennial Schizophrenia International Research Society Conference
    • Arango, C.1    Nasrallah, H.2    Lawrie, S.3
  • 127
    • 84900433651 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive bitopertin (10 and 20 mg) versus placebo in subjects with persistent predominant negative symptoms of schizophrenia treated with antipsychotics-Results from the Phase III FlashLyte study
    • Poster presented at: April 5-9, Florence, Italy
    • Blaettler T, Bugarski-Kirola D, Fleischhacker W, et al. Efficacy and safety of adjunctive bitopertin (10 and 20 mg) versus placebo in subjects with persistent predominant negative symptoms of schizophrenia treated with antipsychotics-Results from the Phase III FlashLyte study. Poster presented at: 4th Biennial Schizophrenia International Research Society Conference, April 5-9, 2014, Florence, Italy.
    • (2014) 4th Biennial Schizophrenia International Research Society Conference
    • Blaettler, T.1    Bugarski-Kirola, D.2    Fleischhacker, W.3
  • 128
    • 84900424635 scopus 로고    scopus 로고
    • Efficacy and Safety of Adjunctive Bitopertin versus Placebo in Subjects with Persistent Predominant Negative Symptoms of Schizophrenia Treated with Antipsychotics-Update from the SearchLyte Programme
    • Bugarski-Kirola D, Arango C, Fleischhacker W, et al. Efficacy and Safety of Adjunctive Bitopertin versus Placebo in Subjects with Persistent Predominant Negative Symptoms of Schizophrenia Treated with Antipsychotics-Update from the SearchLyte Programme. Schizophr Res. 2014;153(Suppl 1):S29.
    • (2014) Schizophr Res. , vol.153 , Issue.SUUPL. 1
    • Bugarski-Kirola, D.1    Arango, C.2    Fleischhacker, W.3
  • 129
    • 84900420231 scopus 로고    scopus 로고
    • Janssen Research & Development, LLC. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated December 24, 2013]. Available from NLM identifier: NCT01323205. Accessed March 10, 2014
    • Janssen Research & Development, LLC. Investigation of the Safety, Tolerability and Potential Therapeutic Effects of JNJ-40411813 in Patients With Schizophrenia. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011 [updated December 24, 2013]. Available from http://clinicaltrials.gov/show/NCT01323205. NLM identifier: NCT01323205. Accessed March 10, 2014.
    • (2011) Investigation of the Safety, Tolerability and Potential Therapeutic Effects of JNJ-40411813 in Patients With Schizophrenia.
  • 130
    • 84900424781 scopus 로고    scopus 로고
    • EnVivo Pharmaceuticals, Inc. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated February 12, 2014]. Available from NLM identifier: NCT01714661. Accessed March 10, 2014
    • EnVivo Pharmaceuticals, Inc. Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated February 12, 2014]. Available from http://clinicaltrials.gov/ct2/show/NCT01714661?term=NCT01714661&rank=1. NLM identifier: NCT01714661. Accessed March 10, 2014.
    • (2012) Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy.
  • 131
    • 84900388567 scopus 로고    scopus 로고
    • EnVivo Pharmaceuticals, Inc. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated February 12, 2014]. Available from NLM identifier: NCT01714713. Accessed March 10, 2014
    • EnVivo Pharmaceuticals, Inc. A 26-Week Extension Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2012 [updated February 12, 2014]. Available from http://clinicaltrials.gov/ct2/show/NCT01714713?term=NCT01714713&rank=1. NLM identifier: NCT01714713. Accessed March 10, 2014.
    • (2012) A 26-Week Extension Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy.
  • 132
    • 84900455450 scopus 로고    scopus 로고
    • Targacept Inc. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; [updated December 6, 2013]. Available from NLM identifier: NCT01488929. Accessed March 10, 2014
    • Targacept Inc. Efficacy, Safety, and Tolerability of TC-5619 as Augmentation Therapy to Improve Negative Symptoms and Cognition in Outpatients With Schizophrenia. In: ClinicalTrials. gov [website on the Internet]. Bethesda, MD: US National Library of Medicine; 2011 [updated December 6, 2013]. Available from http://clinicaltrials.gov/ct2/show/NCT01488929?term=NCT01488929&rank=1. NLM identifier: NCT01488929. Accessed March 10, 2014.
    • (2011) Efficacy, Safety, and Tolerability of TC-5619 as Augmentation Therapy to Improve Negative Symptoms and Cognition in Outpatients With Schizophrenia.
  • 135
    • 78249290706 scopus 로고    scopus 로고
    • Qualitative methods in early-phase drug trials: Broadening the scope of data and methods from and RCT of N-acetylcysteine in schizophrenia
    • Berk M, Munib A, Dean O, et al. Qualitative methods in early-phase drug trials: broadening the scope of data and methods from and RCT of N-acetylcysteine in schizophrenia. J Clin Psychiatry. 2011;72(7): 909-913.
    • (2011) J Clin Psychiatry. , vol.72 , Issue.7 , pp. 909-913
    • Berk, M.1    Munib, A.2    Dean, O.3
  • 136
    • 79953111745 scopus 로고    scopus 로고
    • N-acetylcysteine in psychiatry: Current therapeutic evidence and potential mechanisms of action
    • Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci. 2011;36(2):78-86.
    • (2011) J Psychiatry Neurosci. , vol.36 , Issue.2 , pp. 78-86
    • Dean, O.1    Giorlando, F.2    Berk, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.