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Volumn 2, Issue 3, 2012, Pages 115-125

A review of modafinil and armodafinil as add-on therapy in antipsychotic-treated patients with schizophrenia

Author keywords

armodafinil; cognitive disturbances; fatigue; inactiveness; modafinil; schizophrenia

Indexed keywords

ARMODAFINIL; CLOZAPINE; MODAFINIL;

EID: 84998166025     PISSN: 20451253     EISSN: 20451261     Source Type: Journal    
DOI: 10.1177/2045125312441815     Document Type: Review
Times cited : (18)

References (50)
  • 1
    • 75449104636 scopus 로고    scopus 로고
    • Psychotic relapse in a patient with schizophrenia associated with modafinil therapy
    • Aggarwal A. Garg A. Jiloha R.C. (2009) Psychotic relapse in a patient with schizophrenia associated with modafinil therapy. Primary Psychiatry 16: 26–27.
    • (2009) Primary Psychiatry , vol.16 , pp. 26-27
    • Aggarwal, A.1    Garg, A.2    Jiloha, R.C.3
  • 2
    • 0025959490 scopus 로고
    • Clozapine. A novel antipsychotic agent
    • Baldessarini R.J. Frankenburg F.R. (1991) Clozapine. A novel antipsychotic agent. N Engl J Med 324: 746–754.
    • (1991) N Engl J Med , vol.324 , pp. 746-754
    • Baldessarini, R.J.1    Frankenburg, F.R.2
  • 3
    • 79960315525 scopus 로고    scopus 로고
    • The effect of adjunctive armodafinil on cognitive performance and psychopathology in antipsychotic-treated patients with schizophrenia/schizoaffective disorder: A randomized, double-blind, placebo-controlled trial
    • Bobo W.V. Woodward N.D. Sim M.Y. Jayathilake K. Meltzer H.Y. (2011) The effect of adjunctive armodafinil on cognitive performance and psychopathology in antipsychotic-treated patients with schizophrenia/schizoaffective disorder: A randomized, double-blind, placebo-controlled trial. Schizophr Res 130: 106–113.
    • (2011) Schizophr Res , vol.130 , pp. 106-113
    • Bobo, W.V.1    Woodward, N.D.2    Sim, M.Y.3    Jayathilake, K.4    Meltzer, H.Y.5
  • 4
    • 0027517834 scopus 로고
    • Treatment of clozapine sedation
    • Burke M. Sebastian C.S. (1993) Treatment of clozapine sedation. Am J Psychiatry 150: 1900–1901.
    • (1993) Am J Psychiatry , vol.150 , pp. 1900-1901
    • Burke, M.1    Sebastian, C.S.2
  • 5
    • 4444259725 scopus 로고    scopus 로고
    • Stimulant psychosis: systematic review
    • Curran C. Byrappa N. McBride A. (2004) Stimulant psychosis: systematic review. Br J Psychiatry 185: 196–204.
    • (2004) Br J Psychiatry , vol.185 , pp. 196-204
    • Curran, C.1    Byrappa, N.2    McBride, A.3
  • 6
    • 78649620604 scopus 로고    scopus 로고
    • Pharmacokinetics of armodafinil and modafinil after single and multiple doses in patients with excessive sleepiness associated with treated obstructive sleep apnea: a randomized, open-label, crossover study
    • Darwish M. Kirby M. D’Andrea D.M. Yang R. Hellriegel E.T. Robertson P. Jr (2010) Pharmacokinetics of armodafinil and modafinil after single and multiple doses in patients with excessive sleepiness associated with treated obstructive sleep apnea: a randomized, open-label, crossover study. Clin Ther 32: 2074–2087.
    • (2010) Clin Ther , vol.32 , pp. 2074-2087
    • Darwish, M.1    Kirby, M.2    D’Andrea, D.M.3    Yang, R.4    Hellriegel, E.T.5    Robertson, P.6
  • 7
    • 84860136775 scopus 로고    scopus 로고
    • Modafinil reverses phencyclidine-Induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity
    • DOI: 10.1093/schbul/sbq09010.1093/schbul/sbq090
    • Dawson N. Thompson R.J. McVie A. Thomson D.M. Morris B.J. Pratt J.A. (2010) Modafinil reverses phencyclidine-Induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity. Schizophr Bull, DOI: 10.1093/schbul/sbq09010.1093/schbul/sbq090.
    • (2010) Schizophr Bull
    • Dawson, N.1    Thompson, R.J.2    McVie, A.3    Thomson, D.M.4    Morris, B.J.5    Pratt, J.A.6
  • 8
    • 0035900454 scopus 로고    scopus 로고
    • Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats
    • de Saint Hilaire Z. Orosco M. Rouch C. Blanc G. Nicolaidis S. (2001) Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats. Neuroreport 12: 3533–3537.
    • (2001) Neuroreport , vol.12 , pp. 3533-3537
    • de Saint Hilaire, Z.1    Orosco, M.2    Rouch, C.3    Blanc, G.4    Nicolaidis, S.5
  • 9
    • 0036303309 scopus 로고    scopus 로고
    • Modafinil-associated clozapine toxicity
    • DeQuardo J.R. (2002) Modafinil-associated clozapine toxicity. Am J Psychiatry 159: 1243–1244.
    • (2002) Am J Psychiatry , vol.159 , pp. 1243-1244
    • DeQuardo, J.R.1
  • 10
    • 1842855903 scopus 로고    scopus 로고
    • Modafinil and antipsychotic induced sedation
    • DeQuardo J.R. (2004) Modafinil and antipsychotic induced sedation. J Clin Psychiatry 65: 278–279.
    • (2004) J Clin Psychiatry , vol.65 , pp. 278-279
    • DeQuardo, J.R.1
  • 11
    • 34548319169 scopus 로고    scopus 로고
    • Psychiatric symptoms and quality of life in schizophrenia: a meta-analysis
    • Eack S.M. Newhill C.E. (2007) Psychiatric symptoms and quality of life in schizophrenia: a meta-analysis. Schizophr Bull 33: 1225–1237.
    • (2007) Schizophr Bull , vol.33 , pp. 1225-1237
    • Eack, S.M.1    Newhill, C.E.2
  • 12
    • 33750590845 scopus 로고    scopus 로고
    • Modafinil and unconstrained motor activity in schizophrenia
    • Farrow T.F.D. Hunter M.D. Haque R. Spence S.A. (2006) Modafinil and unconstrained motor activity in schizophrenia. Br J Psychiatry 189: 461–462.
    • (2006) Br J Psychiatry , vol.189 , pp. 461-462
    • Farrow, T.F.D.1    Hunter, M.D.2    Haque, R.3    Spence, S.A.4
  • 13
    • 0030875892 scopus 로고    scopus 로고
    • The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus
    • Ferraro L. Antonelli T. O’Connor W.T. Tanganelli S. Rambert F. Fuxe K. (1997) The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus. Neuroreport 8: 2883–2887.
    • (1997) Neuroreport , vol.8 , pp. 2883-2887
    • Ferraro, L.1    Antonelli, T.2    O’Connor, W.T.3    Tanganelli, S.4    Rambert, F.5    Fuxe, K.6
  • 14
    • 42549123708 scopus 로고    scopus 로고
    • Clozapine levels lowered by modafinil: a case report and brief review of modafinil in schizophrenia
    • Fischer B.A. Weiner E. (2008) Clozapine levels lowered by modafinil: a case report and brief review of modafinil in schizophrenia. Clin Schizophr Rel Psych 2: 88–90.
    • (2008) Clin Schizophr Rel Psych , vol.2 , pp. 88-90
    • Fischer, B.A.1    Weiner, E.2
  • 15
    • 74549156560 scopus 로고    scopus 로고
    • Modafinil for clozapine-treated schizophrenia patients: a double-blind, placebo-controlled pilot trial
    • Freudenreich O. Henderson D.C. Macklin E.A. Evins A.E. Fan X. Cather C. et al. (2009) Modafinil for clozapine-treated schizophrenia patients: a double-blind, placebo-controlled pilot trial. J Clin Psychiatry 70: 1674–1680.
    • (2009) J Clin Psychiatry , vol.70 , pp. 1674-1680
    • Freudenreich, O.1    Henderson, D.C.2    Macklin, E.A.3    Evins, A.E.4    Fan, X.5    Cather, C.6
  • 16
    • 2442696834 scopus 로고    scopus 로고
    • Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study
    • Gallopin T. Luppi P.H. Rambert F.A. Frydman A. Fort P. (2004) Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study. Sleep 27: 19–25.
    • (2004) Sleep , vol.27 , pp. 19-25
    • Gallopin, T.1    Luppi, P.H.2    Rambert, F.A.3    Frydman, A.4    Fort, P.5
  • 17
    • 59449101039 scopus 로고    scopus 로고
    • Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study
    • Goetghebeur P. Dias R. (2009) Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study. Psychopharmacology 202: 287–293.
    • (2009) Psychopharmacology , vol.202 , pp. 287-293
    • Goetghebeur, P.1    Dias, R.2
  • 19
    • 79960295026 scopus 로고    scopus 로고
    • Effects of modafinil on weight, glucose and lipid metabolism in clozapine-treated patients with schizophrenia
    • Henderson D.C. Freudenreich O. Borba C.P. Wang X. Copeland P.M. Macklin E. et al. (2011) Effects of modafinil on weight, glucose and lipid metabolism in clozapine-treated patients with schizophrenia. Schizophr Res 130: 53–56.
    • (2011) Schizophr Res , vol.130 , pp. 53-56
    • Henderson, D.C.1    Freudenreich, O.2    Borba, C.P.3    Wang, X.4    Copeland, P.M.5    Macklin, E.6
  • 20
    • 0025963243 scopus 로고
    • Awakening properties of modafinil: effect on nocturnal activity in monkeys (Macaca mulatta) after acute and repeated administration
    • Hermant J.F. Rambert F.A. Duteil J. (1991) Awakening properties of modafinil: effect on nocturnal activity in monkeys (Macaca mulatta) after acute and repeated administration. Psychopharmacology 103: 28–32.
    • (1991) Psychopharmacology , vol.103 , pp. 28-32
    • Hermant, J.F.1    Rambert, F.A.2    Duteil, J.3
  • 21
    • 46849095050 scopus 로고    scopus 로고
    • Oculomotor and neuropsychological effects of antipsychotic treatment for schizophrenia
    • Hill S.K. Reilly J.L. Harris M.S. Khine T. Sweeney J.A. (2008) Oculomotor and neuropsychological effects of antipsychotic treatment for schizophrenia. Schizophr Bull 34: 494–506.
    • (2008) Schizophr Bull , vol.34 , pp. 494-506
    • Hill, S.K.1    Reilly, J.L.2    Harris, M.S.3    Khine, T.4    Sweeney, J.A.5
  • 22
    • 33750597116 scopus 로고    scopus 로고
    • Impact of modafinil on prefrontal executive function in schizophrenia
    • Hunter M.D. Ganesan V. Wilkinson I.D. Spence S.A. (2006) Impact of modafinil on prefrontal executive function in schizophrenia. Am J Psychiatry 163: 2184–2186.
    • (2006) Am J Psychiatry , vol.163 , pp. 2184-2186
    • Hunter, M.D.1    Ganesan, V.2    Wilkinson, I.D.3    Spence, S.A.4
  • 23
    • 0037457359 scopus 로고    scopus 로고
    • Modafinil increases histamine release in the anterior hypothalamus of rats
    • Ishizuka T. Sakamoto Y. Sakurai T. Yamatodani A. (2003) Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett 339: 143–146.
    • (2003) Neurosci Lett , vol.339 , pp. 143-146
    • Ishizuka, T.1    Sakamoto, Y.2    Sakurai, T.3    Yamatodani, A.4
  • 24
    • 78649773228 scopus 로고    scopus 로고
    • Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study
    • Kane J.M. D’Souza D.C. Patkar A.A. Youakim J.M. Tiller J.M. Yang R. et al. (2010) Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study. J Clin Psychiatry 71: 1475–1481.
    • (2010) J Clin Psychiatry , vol.71 , pp. 1475-1481
    • Kane, J.M.1    D’Souza, D.C.2    Patkar, A.A.3    Youakim, J.M.4    Tiller, J.M.5    Yang, R.6
  • 25
    • 58049157203 scopus 로고    scopus 로고
    • Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
    • Leucht S. Corves C. Arbter D. Engel R.R. Li C. Davis J.M. (2009) Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373: 31–41.
    • (2009) Lancet , vol.373 , pp. 31-41
    • Leucht, S.1    Corves, C.2    Arbter, D.3    Engel, R.R.4    Li, C.5    Davis, J.M.6
  • 26
    • 33751186720 scopus 로고    scopus 로고
    • Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro
    • Madras B.K. Xie Z. Lin Z. Jassen A. Panas H. Lynch L. et al. (2006) Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther 319: 561–569.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 561-569
    • Madras, B.K.1    Xie, Z.2    Lin, Z.3    Jassen, A.4    Panas, H.5    Lynch, L.6
  • 27
    • 0037696255 scopus 로고    scopus 로고
    • Three case reports of modafinil use in treating sedation induced by antipsychotic medications
    • Makela E.H. Miller K. Cutlip W.D. (2003) Three case reports of modafinil use in treating sedation induced by antipsychotic medications. J Clin Psychiatry 64: 485–486.
    • (2003) J Clin Psychiatry , vol.64 , pp. 485-486
    • Makela, E.H.1    Miller, K.2    Cutlip, W.D.3
  • 28
    • 77951909776 scopus 로고    scopus 로고
    • Age-dependent effects of modafinil on acoustic startle and prepulse inhibition in rats
    • McFadden S.L. Zulas A.L. Morgan R.E. (2010) Age-dependent effects of modafinil on acoustic startle and prepulse inhibition in rats. Behav Brain Res 208: 118–123.
    • (2010) Behav Brain Res , vol.208 , pp. 118-123
    • McFadden, S.L.1    Zulas, A.L.2    Morgan, R.E.3
  • 29
    • 43049092201 scopus 로고    scopus 로고
    • Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: prospective data from phase 1
    • Meyer J.M. Davis V.G. Goff D.C. McEvoy J.P. Nasrallah H.A. Davis S.M. et al. (2008) Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: prospective data from phase 1. Schizophr Res 101: 273–286.
    • (2008) Schizophr Res , vol.101 , pp. 273-286
    • Meyer, J.M.1    Davis, V.G.2    Goff, D.C.3    McEvoy, J.P.4    Nasrallah, H.A.5    Davis, S.M.6
  • 30
    • 43649090464 scopus 로고    scopus 로고
    • Modafinil: a review of neurochemical actions and effects on cognition
    • Minzenberg M.J. Carter C.S. (2008) Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology 33: 1477–1502.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1477-1502
    • Minzenberg, M.J.1    Carter, C.S.2
  • 33
    • 77956259192 scopus 로고    scopus 로고
    • Hypomania in a schizophrenic patient treated with modafinil for clozapine-induced sedation
    • Ozer S. Demir B. (2010) Hypomania in a schizophrenic patient treated with modafinil for clozapine-induced sedation. Noropsikiyatri Arsivi 47: 171–173.
    • (2010) Noropsikiyatri Arsivi , vol.47 , pp. 171-173
    • Ozer, S.1    Demir, B.2
  • 34
    • 70350741207 scopus 로고    scopus 로고
    • Chronic infusion of PCP via osmotic mini-pumps: A new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performance
    • Pedersen C.S. Goetghebeur P. Dias R. (2009) Chronic infusion of PCP via osmotic mini-pumps: A new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performance. J Neurosci Methods 185: 66–69.
    • (2009) J Neurosci Methods , vol.185 , pp. 66-69
    • Pedersen, C.S.1    Goetghebeur, P.2    Dias, R.3
  • 35
    • 34249661792 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of Modafinil for negative symptoms in schizophrenia
    • Pierre J.M. Peloian J.H. Wirshing D.A. Wirshing W.C. Marder S.R. (2007) A randomized, double-blind, placebo-controlled trial of Modafinil for negative symptoms in schizophrenia. J Clin Psychiatry 68: 705–710.
    • (2007) J Clin Psychiatry , vol.68 , pp. 705-710
    • Pierre, J.M.1    Peloian, J.H.2    Wirshing, D.A.3    Wirshing, W.C.4    Marder, S.R.5
  • 37
    • 84998101482 scopus 로고    scopus 로고
    • Translational aspects of the novel object recognition task in rats abstinent following subchronic treatment with phencyclidine (PCP): effects of modafinil and relevance to cognitive deficits in schizophrenia
    • Redrobe J.P. Bull S. Plath N. (2010) Translational aspects of the novel object recognition task in rats abstinent following subchronic treatment with phencyclidine (PCP): effects of modafinil and relevance to cognitive deficits in schizophrenia. Nihon Yakurigaku Zasshi 136: 133–136.
    • (2010) Nihon Yakurigaku Zasshi , vol.136 , pp. 133-136
    • Redrobe, J.P.1    Bull, S.2    Plath, N.3
  • 38
    • 0034048206 scopus 로고    scopus 로고
    • In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil
    • Robertson P. Decory H.H. Madan A. Parkinson A. (2000) In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil. Drug Metab Dispos 28: 664–671.
    • (2000) Drug Metab Dispos , vol.28 , pp. 664-671
    • Robertson, P.1    Decory, H.H.2    Madan, A.3    Parkinson, A.4
  • 39
    • 1442275580 scopus 로고    scopus 로고
    • Benefits of adjunct modafinil in an open-label, pilot study in patients with schizophrenia
    • Rosenthal M.H. Bryant S.L. (2004) Benefits of adjunct modafinil in an open-label, pilot study in patients with schizophrenia. Clin Neuropharmacol 27: 38–43.
    • (2004) Clin Neuropharmacol , vol.27 , pp. 38-43
    • Rosenthal, M.H.1    Bryant, S.L.2
  • 41
    • 70349124929 scopus 로고    scopus 로고
    • Antipsychotic drugs for first-episode schizophrenia: a comparative review
    • Salimi K. Jarskog L.F. Lieberman J.A. (2009) Antipsychotic drugs for first-episode schizophrenia: a comparative review. CNS Drugs 23: 837–855.
    • (2009) CNS Drugs , vol.23 , pp. 837-855
    • Salimi, K.1    Jarskog, L.F.2    Lieberman, J.A.3
  • 43
    • 34247538931 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor (SSRI) add-on therapy for the negative symptoms of schizophrenia: a meta-analysis
    • Sepehry A.A. Potvin S. Elie R. Stip E. (2007) Selective serotonin reuptake inhibitor (SSRI) add-on therapy for the negative symptoms of schizophrenia: a meta-analysis. J Clin Psychiatry 68: 604–610.
    • (2007) J Clin Psychiatry , vol.68 , pp. 604-610
    • Sepehry, A.A.1    Potvin, S.2    Elie, R.3    Stip, E.4
  • 44
    • 22744432869 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled study of modafinil for fatigue and cognition in schizophrenia patients treated with psychotropic medications
    • Sevy S. Rosenthal M.H. Alvir J. Meyer S. Visweswaraiah H. Gunduz-Bruce H. et al. (2005) Double-blind, placebo-controlled study of modafinil for fatigue and cognition in schizophrenia patients treated with psychotropic medications. J Clin Psychiatry 66: 839–843.
    • (2005) J Clin Psychiatry , vol.66 , pp. 839-843
    • Sevy, S.1    Rosenthal, M.H.2    Alvir, J.3    Meyer, S.4    Visweswaraiah, H.5    Gunduz-Bruce, H.6
  • 45
    • 22344450188 scopus 로고    scopus 로고
    • Modafinil modulates anterior cingulate function in chronic schizophrenia
    • Spence S.A. Green R.D. Wilkinson I.D. Hunter M.D. (2005) Modafinil modulates anterior cingulate function in chronic schizophrenia. Br J Psychiatry 187: 55–61.
    • (2005) Br J Psychiatry , vol.187 , pp. 55-61
    • Spence, S.A.1    Green, R.D.2    Wilkinson, I.D.3    Hunter, M.D.4
  • 46
    • 9244243064 scopus 로고    scopus 로고
    • Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis
    • Tuominen H.J. Tiihonen J. Wahlbeck K. (2005) Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis. Schizophr Res 72: 225–234.
    • (2005) Schizophr Res , vol.72 , pp. 225-234
    • Tuominen, H.J.1    Tiihonen, J.2    Wahlbeck, K.3
  • 48
    • 35248826574 scopus 로고    scopus 로고
    • Modafinil in the treatment of excessive daytime sleepiness
    • 568–571
    • Valentino R.M. Foldvary-Schaefer N. (2007) Modafinil in the treatment of excessive daytime sleepiness. Cleve Clin J Med 74: 561–566, 568–571.
    • (2007) Cleve Clin J Med , vol.74 , pp. 561-566
    • Valentino, R.M.1    Foldvary-Schaefer, N.2
  • 50
    • 79955993476 scopus 로고    scopus 로고
    • Dopamine receptor mediation of the exploratory/hyperactivity effects of modafinil
    • Young J.W. Kooistra K. Geyer M.A. (2011) Dopamine receptor mediation of the exploratory/hyperactivity effects of modafinil. Neuropsychopharmacology 36: 1358–1396.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 1358-1396
    • Young, J.W.1    Kooistra, K.2    Geyer, M.A.3


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