Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery

Paediatric Anaesthesia

Volumn 24, Issue 6, 2014, Pages 582-590

  Pestieau, Sophie R ^a   Finkel, Julia C ^a   Junqueira, Mariana M ^a   Cheng, Yao ^a   Lovejoy, John F ^a   Wang, Jichuan ^a   Quezado, Zenaide ^a  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

children; hyperalgesia; ketamine; opioid; scoliosis; tolerance

Indexed keywords

KETAMINE; MORPHINE; OPIATE; REMIFENTANIL; ANESTHETIC AGENT; NARCOTIC ANALGESIC AGENT;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GENERAL ANESTHESIA; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCOLIOSIS; SCORING SYSTEM; SEDATION; SPINE FUSION; YOUNG ADULT; COMPLICATION; DRUG TOLERANCE; EARLY TERMINATION OF CLINICAL TRIAL; HYPERALGESIA; INTRAVENOUS DRUG ADMINISTRATION; ORTHOPEDIC SURGERY; PAIN, POSTOPERATIVE;

ADOLESCENT; ANALGESICS, OPIOID; ANESTHETICS, DISSOCIATIVE; CHILD; DOUBLE-BLIND METHOD; DRUG TOLERANCE; EARLY TERMINATION OF CLINICAL TRIALS; FEMALE; HUMANS; HYPERALGESIA; INFUSIONS, INTRAVENOUS; KETAMINE; MALE; ORTHOPEDIC PROCEDURES; PAIN, POSTOPERATIVE; PERIOPERATIVE CARE; SCOLIOSIS;

EID: 84900400878     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/pan.12417     Document Type: Article

References (31)

1. Gaukroger PB, Tomkins DP, van der Walt JH,. Patient-controlled analgesia in children. Anaesth Intensive Care 1989; 17: 264-268.
2. Crawford MW, Hickey C, Zaarour C, et al,. Development of acute opioid tolerance during infusion of remifentanil for pediatric scoliosis surgery. Anesth Analg 2006; 102: 1662-1667.
3. De Kock M, Lavand'homme P, Waterloos H.,. 'Balanced analgesia' in the perioperative period: is there a place for ketamine? Pain 2001; 92: 373-380.
4. Himmelseher S, Durieux ME,. Ketamine for perioperative pain management. Anesthesiology 2005; 102: 211-220.
5. Suzuki M, Haraguti S, Sugimoto K, et al,. Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy. Anesthesiology 2006; 105: 111-119.
6. Dahl V, Ernoe PE, Steen T, et al,. Does ketamine have preemptive effects in women undergoing abdominal hysterectomy procedures? Anesth Analg 2000; 90: 1419-1422.
7. Ilkjaer S, Nikolajsen L, Hansen TM, et al,. Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery. Br J Anaesth 1998; 81: 707-712.
8. Becke K, Albrecht S, Schmitz B, et al,. Intraoperative low-dose S-ketamine has no preventive effects on postoperative pain and morphine consumption after major urological surgery in children. Pediatr Anesth 2005; 15: 484-490.
9. Joseph C, Gaillat F, Duponq R, et al,. Is there any benefit to adding intravenous ketamine to patient-controlled epidural analgesia after thoracic surgery? A randomized double-blind study. Euro J Card-Thor Surg 2012; 42: e58-e65.
10. Engelhardt T, Zaarour C, Naser B, et al,. Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery. Anesth Analg 2008; 107: 1170-1175.
11. Mercadante S, Ferrera P, Villari P, et al,. Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit. J Pain Symptom Manage 2009; 37: 632-641.
12. Rubin DB,. Matching to remove bias in observational studies. Biometrics 1973; 29: 159-183.
13. Raudenbush SW, Bryk AS,. Hierarchical Linear Models, 2nd edn. London: Sage Publications, 2002.
14. ®. Berlin: Higher Education Press and Walter de Gruyter GmbH & Co. KG, 2012.
15. Joly V, Richebe P, Guignard B, et al,. Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology 2005; 103: 147-155.
16. Koppert W, Sittl R, Scheuber K, et al,. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology 2003; 99: 152-159.
17. Angst MS, Clark JD,. Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology 2006; 104: 570-587.
18. Ilkjaer S, Dirks J, Brennum J, et al,. Effect of systemic N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in humans. Br J Anaesth 1997; 79: 600-605.
19. White PF,. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg 2005; 101: S5-S22.
20. Dahmani S, Michelet D, Abback PS, et al,. Ketamine for perioperative pain management in children: a meta-analysis of published studies. Pediatr Anesth 2011; 21: 636-652.
21. Remerand F, Le Tendre C, Baud A, et al,. The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesth Analg 2009; 109: 1963-1971.
22. Guillou N, Tanguy M, Seguin P, et al,. The effects of small-dose ketamine on morphine consumption in surgical intensive care unit patients after major abdominal surgery. Anesth Analg 2003; 97: 843-847.
23. Hayes C, Armstrong-Brown A, Burstal R,. Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial. Anaesth Intensive Care 2004; 32: 330-338.
24. Dallimore D, Anderson BJ, Short TG, et al,. Ketamine anesthesia in children-exploring infusion regimens. Pediatr Anesth 2008; 18: 708-714.
25. Idvall J, Ahlgren I, Aronsen KR, et al,. Ketamine infusions: pharmacokinetics and clinical effects. Br J Anaesth 1979; 51: 1167-1173.
26. Grant IS, Nimmo WS, McNicol LR, et al,. Ketamine disposition in children and adults. Br J Anaesth 1983; 55: 1107-1111.
27. Aubrun F, Salvi N, Coriat P, et al,. Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology 2005; 103: 156-160.
28. Manson JE,. Pain: sex differences and implications for treatment. Metab: Clin Exp 2010; 59 (Suppl. 1): S16-S20.
29. Sadhasivam S, Krekels EH, Chidambaran V, et al,. Morphine clearance in children: does race or genetics matter? J Opioid Manag 2012; 8: 217-226.
30. Verma K, Lonner B, Hoashi JS, et al,. Demographic factors affect Scoliosis Research Society-22 performance in healthy adolescents: a comparative baseline for adolescents with idiopathic scoliosis. Spine 2010; 35: 2134-2139.
31. Zavatsky JM, Peters AJ, Nahvi FA, et al,. Disease severity and treatment in adolescent idiopathic scoliosis: the impact of race and economic status. 2013, doi: 10.1016/j.spinee.2013.06.043. [Epub ahead of print].