Is there any benefit to adding intravenous ketamine to patient-controlled epidural analgesia after thoracic surgery? A randomized double-blind study

European Journal of Cardio-thoracic Surgery

Volumn 42, Issue 4, 2012, Pages

  Joseph, Catherine ^a   Gaillat, Françoise ^a   Duponq, Raphaele ^a   Lieven, Rémi ^a   Baumstarck, Karine ^c   Thomas, Pascal ^d   Penot ragon, Christine ^e   Kerbaul, François ^a,b  

^a TIMONE HOSPITAL   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c Laboratory of Public Health   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE   (France)

^e HÔPITAL SAINTE MARGUERITE   (France)

Author keywords

Epidural analgesia; Hyperalgesia; Ketamine; Lung function; Thoracotomy

Indexed keywords

KETAMINE; KETOPROFEN; NEFOPAM; PLACEBO; ROPIVACAINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EPIDURAL ANESTHESIA; EPIDURAL CATHETER; FEMALE; GENERAL ANESTHESIA; HEMODYNAMICS; HUMAN; HYPOTENSION; LOW DRUG DOSE; MALE; NAUSEA; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE ANALGESIA; POSTOPERATIVE NAUSEA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY FUNCTION; SPIROMETRY; THORACOTOMY; THORAX SURGERY; URINE RETENTION;

ADULT; AGED; AGED, 80 AND OVER; AMIDES; ANALGESIA, EPIDURAL; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; KETAMINE; LUNG; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PNEUMONECTOMY; POSTOPERATIVE CARE; PROSPECTIVE STUDIES; SPIROMETRY; THORACOTOMY; TREATMENT OUTCOME;

EID: 84873103970     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezs398     Document Type: Article

References (28)

1. Gottschalk A, Cohen SP, Yang S, Ochroch EA. Preventing and treating pain after thoracic surgery. Anesthesiology 2006;104:594-600.
2. Katz J, Jackson M, Kavanagh BP, Sandler AN. Acute pain after thoracic surgery predicts long-term post-thoracotomy pain. Clin J Pain 1996; 12:50-5.
3. Joshi GP, Bonnet F, Shah R, Wilkinson RC, Camu F, Fischer B et al. A systematic review of randomized trials evaluating regional techniques for postthoracotomy analgesia. Anesth Analg 2008;107:1026-40.
4. Davies RG, Myles PS, Graham JM. A comparison of the analgesic efficacy and side-effects of paravertebral vs epidural blockade for thoracotomy- a systematic review and meta-analysis of randomized trials. Br J Anaesth 2006;96:418-26.
5. De Kock M, Lavand'homme P, Waterloos H. 'Balanced analgesia' in the perioperative period: is there a place for ketamine? Pain 2001; 92:373-80.
6. Célèrier E, Rivat C, Jun Y, Laulin JP, Larcher A, Reynier P et al. Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 2000;92:465-72.
7. Argiriadou H, Papagiannopoulou P, Foroulis CN, Anastasiadis K, Thomaidou E, Papakonstantinou C et al. Intraoperative infusion of S (+)-ketamine enhances post-thoracotomy pain control compared with perioperative parecoxib when used in conjunction with thoracic paravertebral popivacaine infusion. J Cardiothorac Vasc Anesth 2011;25: 455-61.
8. Subramaniam K, Subramaniam B, Steinbrook RA. Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review. Anesth Analg 2004;99:482-95.
9. Mathisen LC, Aasbø V, Raeder J. Lack of pre-emptive analgesic effect of (R)-ketamine in laparoscopic cholecystectomy. Acta Anaesthesiol Scand 1999;43:220-4.
10. Bell RF, Dahl JB, Moore RA, Kalso E. Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review). Acta Anaesthesiol Scand 2005;49:1405-28.
11. Suzuki M, Haraguti S, Sugimoto K, Kikutani T, Shimada Y, Sakamoto A. Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy. Anesthesiology 2006;105:111-9.
12. Michelet P, Guervilly C, Hélaine A, Avaro JP, Blayac D, Gaillat F et al. Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation. Br J Anaesth 2007;99:396-403.
13. Mathews TJ, Churchhouse AMD, Housden T, Dunning J. Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain? Interact Cardiovasc Thorac Surg 2012;14:194-9.
14. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Br Med J 2010; 340:c332.
15. Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux PJ et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. Br Med J 2010; 340:c869.
16. Lavand'homme P, De Kock M, Waterloos H. Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. Anesthesiology 2005; 103:813-20.
17. Carstensen M, Møller AM. Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials. Br J Anaesth 2010;104:401-6.
18. Rockemann MG, Seeling W, Duschek S, Reinelt H, Steffen P, Georgieff M. Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and costidentification analysis. Anesth Analg 1997;85:864-9.
19. Laboureyras E, Chateauraynaud J, Richebé P, Simonnet G. Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. Anesth Analg 2009;109: 623-31.
20. Suzuki M, Kinoshita T, Kikutani T, Yokoyama K, Inagi T, Sugimoto K et al. Determining the plasma concentration of ketamine that enhances epidural bupivacaine- and-morphine-induced analgesia. Anesth Analg 2005;101:777-84.
21. Expert panel guidelines (2008). Postoperative pain management in adults and children. 17 SFAR Committees on Pain and Local Regional Anaesthesia and on Standards. Ann Fr Anesth Reanim 2009;28:403-9.
22. Elia N, Tramèr MR. Ketamine and postoperative pain-a quantitative systematic review of randomised trials. Pain 2005;113:61-70.
23. Kalso E, Perttunen K, Kaasinen S. Pain after thoracic surgery. Acta Anaesthesiol Scand 1992;36:96-100.
24. Sentürk M, Ozcan PE, Talu GK, Kiyan E, Camci E, Ozyalçin S et al. The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth Analg 2002;94:11-5.
25. Obata H, Saito S, Fujita N, Fuse Y, Ishizaki K, Goto F. Epidural block with mepivacaine before surgery reduces long-term post-thoracotomy pain. Can J Anaesth 1999;46:1127-32.
26. Dajczman E, Gordon A, Kreisman H, Wolkove N. Long-term postthoracotomy pain. Chest 1991;99:270-4.
27. Dualé C, Sibaud F, Guastella V, Vallet L, Gimbert YA, Taheri H et al. Perioperative ketamine does not prevent chronic pain after thoracotomy. Eur J Pain 2009;13:497-505.
28. Farrar JT, Berlin JA, Strom BL. Clinically important changes in acute pain outcome measures: a validation study. J Pain Symptom Manage 2003;25: 406-11.