Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery

British Journal of Anaesthesia

Volumn 81, Issue 5, 1998, Pages 707-712

  Ilkjaær, Susanne ^a   Nikouvjsen, Lone ^a   Hansen, Troels Martin ^a   Wernberg, Mogens ^a   Brenntjm, Jannick ^b   Dahl, Jørgen Berg ^c  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Rigshospitalet   (Denmark)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Anaesthetic techniques, epidural; Anaesthetics i.v., ketamine; Anaesthetics local, bupivacaine; Analgesics opioid, morphine; Pain, postoperative; Surgery, urological

Indexed keywords

BUPIVACAINE; KETAMINE; MORPHINE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; EPIDURAL ANESTHESIA; EPIDURAL DRUG ADMINISTRATION; FEMALE; GENERAL ANESTHESIA; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY SURGERY; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; POSTOPERATIVE CARE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SEDATION; STATISTICAL ANALYSIS; WOUND HEALING;

EID: 0031794965     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/81.5.707     Document Type: Article

References (36)

1. Dickenson AH. NMDA receptor antagonists as analgesics. In: Fields HL, Liebskind JC, eds. Pharmacological Approches to the Treatment of Chronic Pain: New Concepts and Critical Issues (Progress in Pain research and Management, vol. 1.). Seattle: IASP Press, 1994; 173-187.
2. Yaksh T. Epidural ketamine: A useful, mechanistically novel adjuvant for epidural morphine? Regional Anesthesia 1996; 21: 508-513.
3. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259-285.
4. Nikolajsen L, Hansen CL, Nielsen J, Keller J, Arendt-Nielsen L, Jensen TS.The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input. Pain 1996; 67:69-77
5. Stannard CF, Porter GE. Ketamine hydrochloride in the treatment of phantom limb pain. Pain 1993; 54: 227-230.
6. Anis NA, Berry SC, Burton NR, Lodge D. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N- methyl-D-aspanaterBnmA Journal of Pharmacology 1983; 79: 565-575.
7. Davies SN, Lodge D. Evidence for involvement of N-methyl - D-aspartate receptors in "wind-up" of class 2 neurones in the dorsal horn of the rat. Brain Research 1987; 424: 402-406.
8. Dickenson AH, Sullivan AF. Evidence for a role of the NMDA-receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology 1987; 26: 1235-1238.
9. Ilkjaer S, Petersen KL, Brennum J, Wernberg M, Dahl JB. Effect of systemic N-methyl-D-aspartate receptor antagonist (ketamine) on primary and secondary hyperalgesia in humans. British Journal of Anaesthesia 1996; 76: 829-834.
10. Park KM, Max MB, Robinovitz E, Gracely RH, Bennet GJ. Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects. Pain 1995; 63: 163-172.
11. Arendt-Nielsen L, Petersen-Felix S, Fisher M, Bak P, Bjerring P., Zbinden AM. The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo controlled experimental human study. Anesthesia and Analgesia 1995; 81: 63-68.
12. Ilkjaer S, Dirks J, Brennum J, Wernberg M, Dahl JB. Effect of N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in man. British Journal of Anaesthesia 1997; 79: 600-605.
13. Andersen OK, Felsby S, Nikolajsen L, Bjerring P, JensenTS, Arendt-Nielsen L. The effect of ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin-A double blind, placebo-controlled, human experimental study. Pain 1996; 66: 51-62.
14. Warncke T, Stubhaug A, Jørum E. Ketamine, an NMDA receptor antagonist, suppresses spatial and temporal properties of burn-induced secondary hyperalgesia in man: a doubleblind, cross-over comparison with morphine and placebo. Pain 1997; 72: 99-106.
15. Price DD, Mao J, Frenk H, Mayer DJ. The N-methyl-D-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man. Pain 1994; 59: 165-174.
16. Woolf CJ, Thompson SWN.The induction and maintenance of central sensitization is dependent on the N-methyl-D-aspartatic acid receptor activation; implications for the treatment of postinjury pain hypersensitivity states. Pain 1991; 44: 293-299.
17. Chapman V, Dickenson AH. The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn. Brain Research 1992; 573: 321-323.
18. Yamamoto T, Yaksh T Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in the rat model of sciatic mononeuropathy. Neuroscience Letters 1992; 135: 67-70.
19. Wong CS, LiawWJ, Tung CS, SuYF, Ho ST. Ketamine potentiates analgesic effect of morphine in postoperative epidural pain control. Regional Anesthesia 1996; 21: 534-541.
20. Javery KB, Ussery TW, Steger HG, Colclough GW. Comparison of morphine and morphine with ketamine for postoperative analgesia. Canadian Journal of Anaesthesia 1996; 43:212-215.
21. Lee KG, Wilder RT, Smith RL, Berde CB. Thermal hyperalgesia accelerates and MK-801 prevents the development of tachyphylaxis to rat sciatic nerve blockade. Anesthesiology 1994; 81: 1284-1293.
22. Cook B, Grubb DJ, Aldridge LA, Doyle E. Comparison of the effects of adrenaline, clonidine and ketamine on the duration of caudal analgesia produced by bupivacaine in children. British Journal of Anaesthesia 1995; 75: 698-701.
23. Naguib M, Sharif AMY, Seraj M, El Gammal M, Dawlatly AA. Ketamine for caudal analgesia in children: comparison with caudal bupivacaine. British Journal of Anaesthesia 1991; 67: 559-564.
24. Yanli Y, Eren A. The effect of extradural ketamine on onset time and sensory block in extradural anaesthesia with bupivacaine. Anaesthesia 1996; 51:84-86.
25. Price DD, Mao J, Lu J, Caruso FS, Frenk H, Mayer DJ. Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats. Pain 1996; 68: 119-127.
26. Manning BH, Mao J, Frenk H, Price DD, Mayer DJ. Continuous co-administration of dextromethorphan or MK-801 with morphine: attenuation of morphine dependence and naloxone-reversible attenuation of morphine tolerance. Pain 1996; 67: 79-88.
27. Sadove MS, Shulman M, Hatano S, Fevold N. Analgesic effects of ketamine administered in subdissociative doses. Anesthesia and Analgesia 1971; 3:452-458.
28. Clausen L, Sinclair DM, van Hasselt CH. Intravenous ketamine for postoperative analgesia. South African Medical Journal 1915; 49: 1437-1441.
29. Joachimsson PO, Hedstrand U, Eklund A. Low-dose ketamine infusion for analgesia during postoperative ventilatory treatment. Acta Anaesthesiologica Scandinavica 1986; 30: 697-702.
30. Roytblat L, Korotkoruchko A, Katz J, Glazer M, Greemberg L, Fisher A. Postoperative pain: The effect of low-dose ketamine in addition to general anesthesia. Anesthesia and Analgesia 1993; 77: 1161-1165.
31. Kee WDN, Khaw KS, Ma ML, Mainland P-A, Gin T. Postoperative analgesic requirement after cesarean section: A comparison of anesthetic induction with ketamine or thiopental. Anesthesia and Analgesia 1997; 85: 1294-1298.
32. Stubhaug A, Breivik H, Eide PK, Kreunen M, Foss A. Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesihesiologica Scandinavie 1997; 41: 1124-1132.
33. Edwards ND, Fletcher A, Cole JR, Peacock JE. Combined infusions of morphine and ketamine for postoperative pain in elderly patients. Anaesthesia 1993; 48: 124-127.
34. Kawana Y, Sato H, Shimada H, Fujita N, Ueda Y, Hayashi A, Araki Y. Epidural ketamine for postoperative pain relief after gynecologic operations: a double-blind study and comparison with epidural morphine. Anesthesia and Analgesia 1987; 66: 735-738.
35. Weir PS, Fee JPH. Double-blind comparison of extradural block with three bupivacaine-ketamine mixtures in knee arthroplasty. British Journal of Anaesthesia 1998; 80: 299-301.
36. Bion JF. Intrathecal ketamine for war surgery. A preliminary study under field conditions. Anaesthesia 1984; 39: 1023-1028.