First report on the antibody verification of HLA-ABC epitopes recorded in the website-based HLA Epitope Registry

Tissue Antigens

Volumn 83, Issue 6, 2014, Pages 391-400

  Duquesnoy, R J ^a   Marrari, M ^a   Mulder, A ^b   da Mata Sousa, L C D ^c   da Silva, A S ^c   do Monte, S J H ^c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

Author keywords

Antibody; Class I; Epitope; Eplet; Human leukocyte antigen

Indexed keywords

AMINO ACID; EPITOPE; HLA ANTIGEN; HLA B13 ANTIGEN; HLA B14 ANTIGEN; HLA B18 ANTIGEN; HLA B27 ANTIGEN; HLA B35 ANTIGEN; HLA B37 ANTIGEN; HLA B38 ANTIGEN; HLA B39 ANTIGEN; HLA B41 ANTIGEN; HLA B42 ANTIGEN; HLA B44 ANTIGEN; HLA B45 ANTIGEN; HLA B46 ANTIGEN; HLA B47 ANTIGEN; HLA B48 ANTIGEN; HLA B49 ANTIGEN; HLA B50 ANTIGEN; HLA B51 ANTIGEN; HLA B52 ANTIGEN; HLA B7 ANTIGEN; HLA B8 ANTIGEN; UNCLASSIFIED DRUG; ALLOANTIBODY; COMPLEMENTARITY DETERMINING REGION; MONOCLONAL ANTIBODY;

ARTICLE; GENE FREQUENCY; MOLECULAR MODEL; PRIORITY JOURNAL; REFERENCE DATABASE; REGISTER; ALLELE; AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; CHEMICAL STRUCTURE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; GENE; GENETICS; HISTOCOMPATIBILITY TEST; HUMAN; IMMUNOLOGY; PROCEDURES; PROTEIN CONFORMATION; PROTEIN DATABASE; SENSITIVITY AND SPECIFICITY;

ALLELES; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; COMPLEMENTARITY DETERMINING REGIONS; DATABASES, PROTEIN; EPITOPES; GENES, MHC CLASS I; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; ISOANTIBODIES; MODELS, MOLECULAR; PROTEIN CONFORMATION; REGISTRIES; SENSITIVITY AND SPECIFICITY;

EID: 84900390827     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/tan.12341     Document Type: Article

References (62)

1. Duquesnoy RJ, Marrari M, da Mata Sousa LCD et al. 16th IHIW: a website for the antibody-defined HLA Epitope Registry. Int J Immunogenet 2013: 40: 54-9.
2. Duquesnoy RJ, Marrari M, Tambur A, da Mata Sousa LCD, do Monte SJH. First report on the antibody verification of HLA-DR, HLA-DQ and HLA-DP epitopes recorded in the HLA Epitope Registry. Hum Immunol 2014 (in press).
3. Duquesnoy RJ, Marrari M, Mostecki J, da Mata Sousa LCD, do Monte SJH. First report on the antibody verification of MICA epitopes recorded in the HLA Epitope Registry. Int J Immunogenet 2014 (in press).
4. Duquesnoy RJ. Update of the HLA class I eplet database in the website based registry of antibody-defined HLA epitopes. Tissue Antigens 2014: 83: 382-90.
5. El-Awar N, Lee JH, Tarsitani C et al. HLA class I epitopes: recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens. Hum Immunol 2007: 68: 170-80.
6. El-Awar N, Terasaki M, Cai J et al. Epitopes of HLA-A, B, C, DR, DQ, DP and MICA antigens. Clin Transpl 2009: 2009: 295-321.
7. El-Awar NR, Akaza T, Terasaki PI, Nguyen A. Human leukocyte antigen class I epitopes: update to 103 total epitopes, including the C locus. Transplantation 2007: 84: 532-40.
8. El-Awar NR, Terasaki PI, Nguyen A, Lias M, Conger N. New HLA class I epitopes defined by murine monoclonal antibodies. Hum Immunol 2010: 71: 456-61.
9. El-Awar N, Terasaki P, Nguyen A et al. Epitopes of human leukocyte antigen class I antibodies found in sera of normal healthy males and cord blood. Hum Immunol 2009: 70: 844-53.
10. Fuller AA, Rodey GE, Parham P, Fuller TC. Epitope map of the HLA-B7 CREG using affinity-purified human alloantibody probes. Hum Immunol 1990: 28: 306-25.
11. Fuller AA, Trevithick JE, Rodey GE, Parham P, Fuller TC. Topographic map of the HLA-A2 CREG epitopes using human alloantibody probes. Hum Immunol 1990: 28: 284-305.
12. Van Rood J, Van Leeuwen A. Leukocyte grouping. A method and its application. J Clin Invest 1963: 42: 1382-90.
13. Lutz CT, Smith KD, Greazel NS et al. Bw4-reactive and Bw6-reactive antibodies recognize multiple distinct HLA structures that partially overlap in the alpha-1 helix. J Immunol 1994: 153: 4099-110.
14. Kabat EA. The structural basis of antibody complementarity. Adv Protein Chem 1978: 32: 1-75.
15. Chothia C, Lesk A, Tramontano A et al. Conformation of immunoglobulin hypervariable regions. Nature 1989: 342: 877-83.
16. Davies D, Padlan E, Sheriff S. Antibody-antigen complexes. Annu Rev Biochem 1990: 59: 439-73.
17. MacCallum RM, Martin ACR, Thornton JM. Antibody-antigen interactions: contact analysis and binding site topography. J Mol Biol 1996: 262: 732-45.
18. Novotny J. Protein antigenicity: a thermodynamic approach. Mol Immunol 1991: 28: 201-8.
19. Cunningham B, Wells J. Comparison of a structural and a functional epitope. J Mol Biol 1993: 234: 554-63.
20. Duquesnoy RJ. A structurally based approach to determine HLA compatibility at the humoral immune level. Hum Immunol 2006: 67: 847-62.
21. Duquesnoy RJ, Mulder A, Askar M, Fernandez-Vina M, Claas FHJ. HLAMatchmaker-based analysis of human monoclonal antibody reactivity demonstrates the importance of an additional contact site for specific recognition of triplet-defined epitopes. Hum Immunol 2005: 66: 749-61.
22. Marrari M, Mostecki J, Mulder A, Balazs I, Claas F, Duquesnoy R. Human monoclonal antibody reactivity with HLA class I epitopes defined by pairs of mismatched eplets and self eplets. Transplantation 2010: 90: 1468-72.
23. Duquesnoy R. The antibody response to an HLA mismatch: a model for nonself-self discrimination in relation to HLA epitope immunogenicity. Int J Immunogenet 2011: 39: 1-9.
24. Berek C, Milstein C. Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev 1987: 96: 23-41.
25. Duquesnoy RJ, Marrari M, Jelenik L, Zeevi A, Claas FHJ, Mulder A. Structural aspects of HLA class I epitopes reacting with human monoclonal antibodies in Ig-binding, C1q-binding and lymphocytotoxicity assays. Hum Immunol 2013: I74: 1271-9.
26. Wang J, Yu DT, Fukazawa T et al. A monoclonal antibody that recognizes HLA-B27 in the context of peptides. J Immunol 1994: 152: 1197-205.
27. Mulder M, Eijsink C, Kester MGD et al. Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies. J Immunol 2005: 175: 5950-7.
28. Fu X-T, Karr RW. HLA-DRα chain residues located on the outer loops are involved in nonpolymorphic and polymorphic antibody-binding epitopes. Hum Immunol 1994: 39: 253-60.
29. Akaza T, El-Awar N, Nguyen A et al. HLA class I epitopes: C-locus. Clin Transpl 2006: 95-102.
30. Duquesnoy R, Marrari M. Detection of antibodies against HLA-C epitopes in patients with rejected kidney transplants. Transpl Immunol 2011: 24: 164-71.
31. Fernandez-Vina M, Maiers M, Gutierrez M et al. 13th IHWS serology and HLA phenotypes joint report. In: Hansen JA, ed. Immunobiology of the Human MHC. Vojens: P.J. Schmidt A/S, 2006, 890-931.
32. Duquesnoy R, Marrari M, Mulder A, Claas F, Mostecki J, Balazs I. Structural aspects of HLA class I epitopes detected by human monoclonal antibodies. Hum Immunol 2012: 73: 267-77.
33. Tongio MM, Doxiadis I, Laforet M et al. 12th international histocompatibility workshop HLA class I monoclonal antibodies study. In: Charron D, ed. HLA: Genetic Diversity of HLA Functional and Medical Implication. Paris: EDK, 1997, 7-11.
34. Nelson K, Bodmer J, Martin A, Navarrete C, Strong DM. Micro EIA and monoclonal antibodies. In: Dupont B, ed. Immunobiology of HLA. New York, NY: Springer-Verlag, 1989, 292-301.
35. Kennedy LJ, Marsh SGE, Bodmer J. Cytotoxic monoclonal antibodies. In: Dupont B, ed. Immunobiology of HLA. New York, NY: Springer-Verlag, 1989, 301-5.
36. Claas F, Castelli-Visser R, Schreuder I, van Rood J. Allo-antibodies to an antigenic determinant shared by HLA-A2 and B17. Tissue Antigens 1982: 19: 388-91.
37. Santos-Aguado J, Barbosa JA, Biro PA, Strominger JL. Molecular characterization of serologic recognition sites in the human HLA-A2 molecule. J Immunol 1988: 141: 2811-8.
38. De Vito LD, Mason BP, Jankowska-Gan E et al. Epitope fine specificity of human anti-HLA-A2 antibodies. Identification of four epitopes including a haptenlike epitope on HLA-A2 at lysine 127. Hum Immunol 1993: 37: 165-77.
39. Mulder A, Kardol M, Regan J, Buelow R, Claas F. Reactivity of twenty-two cytotoxic human monoclonal HLA antibodies towards soluble HLA class I in an enzyme-linked immunosorbent assay (PRA-STAT). Hum Immunol 1997: 56: 106-13.
40. Kolstad A, Hannestad K. A supertypic HLA-DP specificity defined by two human-human hybridoma antibodies (TrB50; TrE11). Hum Immunol 1989: 25: 247-56.
41. Duquesnoy R, Marrari M. Correlations between Terasaki's HLA class I epitopes and HLAMatchmaker-defined eplets on HLA-A, -B and -C antigens. Tissue Antigens 2009: 74: 117-33.
42. Harpprecht J, Olde K, Westphal E, Muller-Ruchholtz W. Serological mapping of HLA-epitopes with monoclonal antibodies and its interpretation by sequenced HLA-molecules. Tissue Antigens 1989: 34: 170-8.
43. Marrari M, Mulder A, Duquesnoy RJ. HLA class I epitopes defined by human monoclonal antibodies tested in Luminex assays with single alleles. 2013. http://epregistry.com.br
44. Vilella R, Yague J, Vives J. Monoclonal antibody against HLA-Aw32 + A25. Is HLA-Aw32 an allele with no unique antigenic determinant? Hum Immunol 1983: 6: 53-62.
45. Bacheleta T, Couzia L, Guidicelli G et al. Anti-Cw donor-specific alloantibodies can lead to positive flow cytometry crossmatch and irreversible acute antibody-mediated rejection. Am J Transpl 2011: 11: 1543-4.
46. Tahara T, Yang SY, Khan R, Abish S, Hammerling GJ, Hammerling U. HLA antibody responses in HLA class I transgenic mice. Immunogenetics 1990: 32: 351-60.
47. Harpprecht J, Westphal E, Muller-Ruchholtz W. Production and applications of new monoclonal antibodies against human lymphocyte antigen-A and -B antigens. Diagn Clin Immunol 1988: 5: 388-92.
48. Layet C, Kahn-Perles B, Pontarotti P, Ferrier P, Sire J, Lemonnier FA. Creation of an HLA-A2/HLA-Aw69 alloantigenic determinant on an HLA-A3 molecule by site-directed mutagenesis. J Immunol 1987: 138: 2197-201.
49. Laundy GJ, Bradley BA, Rees BM, Younie M, Hows JM. Incidence and specificity of HLA antibodies in multitransfused patients with acquired aplastic anemia. Transfusion 2004: 44: 814-25.
50. Hogan KT, Clayberger C, Bernhard EJ et al. Identification by site-directed mutagenesis of amino acid residues contributing to serologic and CTL-defined epitope differences between HLA-A2.1 and HLA-A2.3. J Immunol 1988: 141: 2519-25.
51. Mulder A, Kardol M, Blom J, Jolley W, Melief C, Bruning H. A human monoclonal antibody, produced following in vitro immunization, recognizing an epitope shared by HLA-A2 subtypes and HLA-A28. Tissue Antigens 1993: 42: 27-34.
52. Adeyi OE, Girnita A, Awadalla Y et al. Serum analysis after kidney transplant nephrectomy reveals restricted antibody specificity patterns against donor HLA class I antigens. Transpl Immunol 2005: 14: 53-62.
53. Pistillo MP, Bini D, Pozzi S, Ferrara GB. A cytotoxic human monoclonal antibody that can discriminate HLA-A*3002 from HLA-A*3001 subtypes. Tissue Antigens 1995: 46: 327-9.
54. Lomago J, Jelenik L, Zern D et al. How did a patient who types for HLA-B*4403 develop antibodies that react with HLA-B*4402? Hum Immunol 2010: 71: 176-8.
55. Ge J, Hannestad K. A cytotoxic human hybridoma monoclonal antibody (TrJ5) specific for HLA-B38(16) and -B39(16). Hum Immunol 1993: 36: 168-71.
56. Mulder A, Kardol MJ, Uit het Broek CM, Tanke-Visser J, Young NT, Claas FH. A human monoclonal antibody against HLA-Cw1 and a human monoclonal antibody against an HLA-A locus determinant derived from a single uniparous female. Tissue Antigens 1998: 52: 393-6.
57. McCutcheon JA, Lutz CT. Mutagenesis around residue 176 on HLA-B*0702 characterizes multiple distinct epitopes for anti-HLA antibodies. Hum Immunol 1992: 35: 125-31.
58. Smith KD, Mace BE, Valenzuela A et al. Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies. J Immunol 1996: 157: 2470-8.
59. Parham P. Changes in conformation with loss of alloantigenic determinants of a histocompatibility antigen (HLA-B7) induced by monoclonal antibodies. J Immunol 1984: 132: 2975-83.
60. El-Awar N, Terasaki PI, Cai J et al. Epitopes of the HLA-A, B, C, DR, DQ and MICA antigens. Clin Transpl 2007: 175-94.
61. Muller C, Ziegler A, Muller G, Schunter F, Wernet P. Monoclonal antibody (Tu48) defining alloantigenic class I determinants specific for HLA-Bw4 and HLA-Aw23, -Aw24 as well as -Aw32. Hum Immunol 1982: 5: 269-81.
62. Marrari M, Conca R, Praticò-Barbato L, Amoroso A, Duquesnoy R. Brief report: why did two patients who type for HLA-B13 have antibodies that react with all Bw4 antigens except HLA-B13? Transpl Immunol 2011: 25: 217-20.