Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp

Diabetologia

Volumn 48, Issue 5, 2005, Pages 862-867

  Zethelius, B ^a   Lithell, H ^a   Hales, C N ^b   Berne, C ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Coronary heart disease; Insulin; Predictor; Proinsulin; Risk factors

Indexed keywords

CHOLESTEROL; GLUCOSE; INSULIN; PROINSULIN;

ADULT; ARTICLE; BLOOD GLUCOSE MONITORING; BODY MASS; CAUSE OF DEATH; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; FOLLOW UP; GLUCOSE ASSAY; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HAZARD ASSESSMENT; HORMONE DETERMINATION; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MULTIVARIATE ANALYSIS; POPULATION RESEARCH; PREDICTION; PRIORITY JOURNAL; REGISTER; SMOKING; SYSTOLIC BLOOD PRESSURE;

AGED; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY MASS INDEX; CORONARY DISEASE; FOLLOW-UP STUDIES; GLUCOSE CLAMP TECHNIQUE; HEALTH SURVEYS; HUMANS; INSULIN; MALE; PROINSULIN; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS; SWEDEN;

EID: 20044368678     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1711-9     Document Type: Article

References (40)

1. Beckman JA, Creager MA, Libby P (2002) Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 287:2570-2581
2. Howard G, O'Leary DH, Zaccaro D et al (1996) Insulin sensitivity and atherosclerosis. The insulin resistance atherosclerosis study (IRAS) investigators. Circulation 93:1809-1817
3. Laakso M (1993) How good a marker is insulin level for insulin resistance? Am J Epidemiol 137:959-965
4. Despres JP, Lamarche B, Mauriege P et al (1996) Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 334:952-957
5. Reaven GM, Laws A (1994) Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease. Diabetologia 37:948-952
6. Wingard DL, Barrett-Connor EL, Ferrara A (1995) Is insulin really a heart disease risk factor? Diabetes Care 18:1299-1304
7. Ruige JB, Assendelft WJ, Dekker JM, Kostense PJ, Heine RJ, Bouter LM (1998) Insulin and risk of cardiovascular disease: a meta-analysis. Circulation 97:996-1001
8. Pyorala M, Miettinen H, Laakso M, Pyorala K (1998) Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki policemen study. Circulation 98:398-404
9. Kuusisto J, Mykkanen L, Pyorala K, Laakso M (1994) NIDDM and its metabolic control predict coronary heart disease in elderly subjects. Diabetes 43:960-967
10. Yudkin JS, May M, Elwood P, Yarnell JW, Greenwood R, Davey Smith G (2002) Concentrations of pro insulin-like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly study. Diabetologia 45:327-336
11. Zethelius B, Byberg L, Hales CN, Lithell H, Berne C (2002) Proinsulin is an independent predictor of coronary heart disease: report from a 27-year follow-up study. Circulation 105:2153-2158
12. Lindahl B, Dinesen B, Eliasson M et al (1999) High proinsulin concentration precedes acute myocardial infarction in a non-diabetic population. Metabolism 48:1197-1202
13. Lindahl B, Dinesen B, Eliasson M, Roder M, Hallmans G, Stegmayr B (2000) High proinsulin levels precede first-ever stroke in a nondiabetic population. Stroke 31:2936-2941
14. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
15. Sobey WJ, Beer SF, Carrington CA, Clark PMS, Hales CN (1989) Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. Biochem J 260:535-541
16. Hedstrand H (1975) A study of middle-aged men with particular reference to risk factors for cardiovascular disease. Uppsala J Med Sci 80(Suppl 19):1-61
17. Byberg L, McKeigue PM, Zethelius B, Lithell HO (2000) Birth weight and the insulin resistance syndrome: association of low birth weight with truncal obesity and raised plasminogen activator inhibitor-1 but not with abdominal obesity or plasma lipid disturbances. Diabetologia 43:54-60
18. Merlo J, Lindblad U, Pessah-Rasmussen H, et al (2000) Comparison of different procedures to identify probable cases of myocardial infarction and stroke in two Swedish prospective cohort studies using local and national routine registers. Eur J Epidemiol 16:235-243
19. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas AM, Pajak A (1994) Myocardial infarction and coronary deaths in the World Health Organization MONICA project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation 90:583-612
20. Zethelius B, Hales CN, Lithell HO, Berne C (2004) Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men. Diabetes Care 27:1433-1438
21. WHO (1999) Definition, diagnosis and classification of diabetes mellitus and its Complications: report of a WHO consultation. World Health Organization: Geneva. WHO/NCD/NCS/99.2
22. Stout RW (1996) Hyperinsulinemia and atherosclerosis. Diabetes 45(Suppl 3):S45-S46
23. Adler AI, Neil HA, Manley SE, Holman RR, Turner RC (1999) Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47). Am Heart J 138:353-359
24. Hanley AJ, Williams K, Stern MP, Haffner SM (2002) Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio heart study. Diabetes Care 25:1177-1184
25. Resnick HE, Jones K, Ruotolo G et al (2003) Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic American Indians: the strong heart study. Diabetes Care 26:861-867
26. Coutinho M, Gerstein HC, Wang Y, Yusuf S (1999) The relationship between glucose and incident cardiovascular events. A meta-regression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care 22:233-240
27. Boden G (1997) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10
28. Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G, Baron AD (1996) Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 97:2601-2610
29. Salonen JT, Lakka TA, Lakka HM, Valkonen VP, Everson SA, Kaplan GA (1998) Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men. Diabetes 47:270-275
30. Yudkin JS (2002) Increased proinsulin concentrations and excess risk of coronary heart disease in patients with diabetes and prediabetes. Circulation 106:e202
31. Bavenholm P, Proudler A, Tornvall P et al (1995) Insulin, intact and split proinsulin, and coronary artery disease in young men. Circulation 92:1422-1429
32. Haffner SM, D'Agostino R, Mykkanen L et al (1998) Proinsulin and insulin concentrations in relation to carotid wall thickness: Insulin Resistance Atherosclerosis Study. Stroke 29:1498-1503
33. Galloway JA, Hooper SA, Spradlin CT et al (1992) Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience. Diabetes Care 15:666-692
34. Nordt TK, Schneider DJ, Sobel BE (1994) Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin. A potential risk factor for vascular disease. Circulation 89:321-330
35. Festa A, D. Agostino R J, Mykkanen L et al (1999) Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The insulin resistance atherosclerosis study (IRAS). Arterioscler Thromb Vasc Biol 19:562-568
36. Kohler HP, Grant PJ (2000) Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med 342:1792-1801
37. Jehle PM, Lutz MP, Fussgaenger RD (1996) High affinity binding sites for proinsulin in human IM-9 lymphoblasts. Diabetologia 39:421-432
38. Khaw KT, Wareham N, Luben R et al (2001) Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European prospective investigation of cancer and nutrition (EPIC-Norfolk). BMJ 322:15-28
39. Temple RC, Carrington CA, Luzio SD et al (1989) Insulin deficiency in non-insulin-dependent diabetes. Lancet 1:293-295
40. Oh JY, Barrett-Connor E, Wedick NM (2002) Sex differences in the association between proinsulin and intact insulin with coronary heart disease in nondiabetic older adults: the Rancho Bernardo study. Circulation 105:1311-1316