Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Cabrerizo, Romina ^a   Castaño, Gustavo O ^b,c   Burgueño, Adriana L ^a   Gianotti, Tomas Fernández ^a   Ledesma, María Mora Gonzalez Lopez ^d   Flichman, Diego ^d   Pirola, Carlos J ^a   Sookoian, Silvia ^a,b,c  

^a INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

^b Hospital General de Agudos Dr Abel Zubizarreta   (Argentina)

^c Research Council in Health ^*  (Argentina)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CHENODEOXYCHOLIC ACID; ESTRADIOL RECEPTOR; ESTROGEN RECEPTOR ALPHA; FARNESOID X RECEPTOR; GLYCOCHOLIC ACID; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; PREGNANE X RECEPTOR; TAUROCHENODEOXYCHOLIC ACID;

ABCC2 GENE; ADULT; ARTICLE; BILE ACID BLOOD LEVEL; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ESR1 GENE; FEMALE; FXR NR1H4 GENE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; HUMAN; INTRAHEPATIC CHOLESTASIS; MAJOR CLINICAL STUDY; NR1I3 GENE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PREGNANCY; PROMOTER REGION; PXR NR1I2 GENE;

ADULT; CELL LINE, TUMOR; CHOLESTASIS, INTRAHEPATIC; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HUMANS; MALE; PHENOTYPE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANOLONE; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION, GENETIC;

EID: 84900295654     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087697     Document Type: Article

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