Optimizing proteolytic digestion conditions for the analysis of serum albumin adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a potential human carcinogen formed in cooked meat

Journal of Proteomics

Volumn 103, Issue , 2014, Pages 267-278

  Peng, Lijuan ^a,b   Turesky, Robert J ^b,c  

^a WUHAN POLYTECHNIC UNIVERSITY   (China)

^b WADSWORTH CENTER   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Biomarkers; Food carcinogens; Protein adducts

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 3 CHLOROPERBENZOIC ACID; AMINOPEPTIDASE; CHYMOTRYPSIN; CHYMOTRYPSIN TRYPSIN; CYSTEINE; CYTOSOL AMINOPEPTIDASE; LEUCINE; PROTEINASE K; REACTIVE OXYGEN METABOLITE; SERUM ALBUMIN; 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE; CARCINOGEN; IMIDAZOLE DERIVATIVE; SULFONAMIDE; TRYPSIN;

ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HYDROLYSIS; ION TRAP MASS SPECTROMETRY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MEAT; METABOLIC ACTIVATION; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DENATURATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALYSIS; COOKING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; OXIDATION REDUCTION REACTION; PROCEDURES; SYNTHESIS;

CARCINOGENS; CHROMATOGRAPHY, LIQUID; CHYMOTRYPSIN; COOKING; HUMANS; IMIDAZOLES; MASS SPECTROMETRY; MEAT; OXIDATION-REDUCTION; SERUM ALBUMIN; SULFONAMIDES; TRYPSIN;

EID: 84900008694     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2014.03.023     Document Type: Article

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