Irreversible alkylation of human serum albumin by zileuton metabolite 2-acetylbenzothiophene-S-oxide: A potential model for hepatotoxicity

Chemical Research in Toxicology

Volumn 20, Issue 12, 2007, Pages 1854-1861

  Li, Fengping ^a   Chordia, Mahendra D ^a   Woodling, Kellie A ^a   Macdonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETYLBENZOTHIOPHENE S OXIDE; ACETONITRILE; CYSTEINE; HUMAN SERUM ALBUMIN; PHOSPHATE BUFFERED SALINE; UNCLASSIFIED DRUG; WARFARIN; ZILEUTON;

ALKYLATION; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONJUGATION; CONTROLLED STUDY; COVALENT BOND; DRUG DECOMPOSITION; DRUG ELIMINATION; DRUG STABILITY; HALF LIFE TIME; HUMAN; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MASS SPECTROMETRY; METABOLITE; OXIDATION; POLYMERIZATION; PROTEIN INTERACTION;

ALKYLATION; ANTI-ASTHMATIC AGENTS; BINDING, COMPETITIVE; CHROMATOGRAPHY, LIQUID; HALF-LIFE; HEPATITIS, TOXIC; HUMANS; HYDROXYUREA; IBUPROFEN; MODELS, BIOLOGICAL; SERUM ALBUMIN; TANDEM MASS SPECTROMETRY; THIOPHENES; WARFARIN;

EID: 38149106764     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx7001417     Document Type: Article

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