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Volumn 53, Issue 6, 2014, Pages 471-479

Silibinin inhibits ultraviolet B radiation-induced DNA-damage and apoptosis by enhancing interleukin-12 expression in JB6 cells and SKH-1 hairless mouse skin

Author keywords

Apoptosis; Cyclobutane pyrimidine dimers; DNA damage and repair; Non melanoma skin cancer; Silibinin

Indexed keywords

CASPASE 3; INTERLEUKIN 12; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PYRIMIDINE DIMER; RECOMBINANT INTERLEUKIN 12; SILIBININ;

EID: 84899989399     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22000     Document Type: Article
Times cited : (22)

References (46)
  • 2
    • 77949405816 scopus 로고    scopus 로고
    • Incidence estimate of nonmelanoma skin cancer in the United States, 2006
    • Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol 2010; 146:283-287.
    • (2010) Arch Dermatol , vol.146 , pp. 283-287
    • Rogers, H.W.1    Weinstock, M.A.2    Harris, A.R.3
  • 3
    • 0031022619 scopus 로고    scopus 로고
    • Sunlight and skin cancer: Another link revealed
    • Kraemer KH. Sunlight and skin cancer: Another link revealed. Proc Natl Acad Sci USA 1997; 94:11-14.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11-14
    • Kraemer, K.H.1
  • 4
    • 35348854953 scopus 로고    scopus 로고
    • Interleukin-12 and photocarcinogenesis
    • Katiyar SK. Interleukin-12 and photocarcinogenesis. Toxicol Appl Pharmacol 2007; 224:220-227.
    • (2007) Toxicol Appl Pharmacol , vol.224 , pp. 220-227
    • Katiyar, S.K.1
  • 5
    • 41849095585 scopus 로고    scopus 로고
    • Skin DNA photodamage and its biological consequences
    • Marrot L, Meunier JR. Skin DNA photodamage and its biological consequences. J Am Acad Dermatol 2008; 58:S139-S148.
    • (2008) J Am Acad Dermatol , vol.58
    • Marrot, L.1    Meunier, J.R.2
  • 6
    • 35348892775 scopus 로고    scopus 로고
    • Photoageing: Mechanism, prevention and therapy
    • Yaar M, Gilchrest BA. Photoageing: Mechanism, prevention and therapy. Br J Dermatol 2007; 157:874-887.
    • (2007) Br J Dermatol , vol.157 , pp. 874-887
    • Yaar, M.1    Gilchrest, B.A.2
  • 7
    • 32844469322 scopus 로고    scopus 로고
    • Spectral and dose dependence of ultraviolet radiation-induced immunosuppression
    • Phan TA, Halliday GM, Barnetson RS, Damian DL. Spectral and dose dependence of ultraviolet radiation-induced immunosuppression. Front Biosci 2006; 11:394-411.
    • (2006) Front Biosci , vol.11 , pp. 394-411
    • Phan, T.A.1    Halliday, G.M.2    Barnetson, R.S.3    Damian, D.L.4
  • 8
    • 32044473986 scopus 로고    scopus 로고
    • Mechanisms of UV-induced immunosuppression
    • Schwarz T. Mechanisms of UV-induced immunosuppression. Keio J Med 2005; 54:165-171.
    • (2005) Keio J Med , vol.54 , pp. 165-171
    • Schwarz, T.1
  • 9
    • 33746581933 scopus 로고    scopus 로고
    • Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis
    • Moore JO, Wang Y, Stebbins WG, et al. Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis. Carcinogenesis 2006; 27:1627-1635.
    • (2006) Carcinogenesis , vol.27 , pp. 1627-1635
    • Moore, J.O.1    Wang, Y.2    Stebbins, W.G.3
  • 12
    • 13244265558 scopus 로고    scopus 로고
    • NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death
    • Thyss R, Virolle V, Imbert V, Peyron JF, Aberdam D, Virolle T. NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. EMBO J 2005; 24:128-137.
    • (2005) EMBO J , vol.24 , pp. 128-137
    • Thyss, R.1    Virolle, V.2    Imbert, V.3    Peyron, J.F.4    Aberdam, D.5    Virolle, T.6
  • 13
    • 0035925885 scopus 로고    scopus 로고
    • UVB irradiation suppresses cytokine production and innate cellular immune functions in mice
    • Kasahara S, Aizawa K, Okamiya M, et al. UVB irradiation suppresses cytokine production and innate cellular immune functions in mice. Cytokine 2001; 14:104-111.
    • (2001) Cytokine , vol.14 , pp. 104-111
    • Kasahara, S.1    Aizawa, K.2    Okamiya, M.3
  • 14
    • 0029933702 scopus 로고    scopus 로고
    • Interleukin-12 prevents ultraviolet B-induced local immunosuppression and overcomes UVB-induced tolerance
    • Schwarz A, Grabbe S, Aragane Y, et al. Interleukin-12 prevents ultraviolet B-induced local immunosuppression and overcomes UVB-induced tolerance. J Invest Dermatol 1996; 106:1187-1191.
    • (1996) J Invest Dermatol , vol.106 , pp. 1187-1191
    • Schwarz, A.1    Grabbe, S.2    Aragane, Y.3
  • 15
    • 0029012470 scopus 로고
    • Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation
    • Schmitt DA, Owen-Schaub L, Ullrich SE. Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J Immunol 1995; 154:5114-5120.
    • (1995) J Immunol , vol.154 , pp. 5114-5120
    • Schmitt, D.A.1    Owen-Schaub, L.2    Ullrich, S.E.3
  • 16
    • 0037238548 scopus 로고    scopus 로고
    • IL-12 completely blocks ultraviolet-induced secretion of tumor necrosis factor alpha from cultured skin fibroblasts and keratinocytes
    • Werth VP, Bashir MM, Zhang W. IL-12 completely blocks ultraviolet-induced secretion of tumor necrosis factor alpha from cultured skin fibroblasts and keratinocytes. J Invest Dermatol 2003; 120:116-122.
    • (2003) J Invest Dermatol , vol.120 , pp. 116-122
    • Werth, V.P.1    Bashir, M.M.2    Zhang, W.3
  • 17
    • 0027239503 scopus 로고
    • Antitumor and antimetastatic activity of interleukin 12 against murine tumors
    • Brunda MJ, Luistro L, Warrier RR, et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993; 178:1223-1230.
    • (1993) J Exp Med , vol.178 , pp. 1223-1230
    • Brunda, M.J.1    Luistro, L.2    Warrier, R.R.3
  • 18
    • 0029898839 scopus 로고    scopus 로고
    • Amount of interleukin 12 available at the tumor site is critical for tumor regression
    • Colombo MP, Vagliani M, Spreafico F, et al. Amount of interleukin 12 available at the tumor site is critical for tumor regression. Cancer Res 1996; 56:2531-2534.
    • (1996) Cancer Res , vol.56 , pp. 2531-2534
    • Colombo, M.P.1    Vagliani, M.2    Spreafico, F.3
  • 19
    • 0002325617 scopus 로고    scopus 로고
    • Interleukin 12: Basic biology and potential applications in cancer treatment
    • Robertson MJ, Ritz J. Interleukin 12: Basic biology and potential applications in cancer treatment. Oncologist 1996; 1:88-97.
    • (1996) Oncologist , vol.1 , pp. 88-97
    • Robertson, M.J.1    Ritz, J.2
  • 20
    • 13244295620 scopus 로고    scopus 로고
    • Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair
    • Schwarz A, Maeda A, Kernebeck K, van Steeg H, Beissert S, Schwarz T. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med 2005; 201:173-179.
    • (2005) J Exp Med , vol.201 , pp. 173-179
    • Schwarz, A.1    Maeda, A.2    Kernebeck, K.3    van Steeg, H.4    Beissert, S.5    Schwarz, T.6
  • 21
    • 41149172720 scopus 로고    scopus 로고
    • Green tea phenol extracts reduce UVB-induced DNA damage in human cells via interleukin-12
    • Schwarz A, Maeda A, Gan D, Mammone T, Matsui MS, Schwarz T. Green tea phenol extracts reduce UVB-induced DNA damage in human cells via interleukin-12. Photochem Photobiol 2008; 84:350-355.
    • (2008) Photochem Photobiol , vol.84 , pp. 350-355
    • Schwarz, A.1    Maeda, A.2    Gan, D.3    Mammone, T.4    Matsui, M.S.5    Schwarz, T.6
  • 22
    • 0036144597 scopus 로고    scopus 로고
    • Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
    • Schwarz A, Stander S, Berneburg M, et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 2002; 4:26-31.
    • (2002) Nat Cell Biol , vol.4 , pp. 26-31
    • Schwarz, A.1    Stander, S.2    Berneburg, M.3
  • 23
    • 14644416024 scopus 로고    scopus 로고
    • Photochemoprevention of ultraviolet B signaling and photocarcinogenesis
    • Afaq F, Adhami VM, Mukhtar H. Photochemoprevention of ultraviolet B signaling and photocarcinogenesis. Mutat Res 2005; 571:153-173.
    • (2005) Mutat Res , vol.571 , pp. 153-173
    • Afaq, F.1    Adhami, V.M.2    Mukhtar, H.3
  • 24
    • 41049113125 scopus 로고    scopus 로고
    • Phytochemicals for prevention of solar ultraviolet radiation-induced damages
    • Adhami VM, Syed DN, Khan N, Afaq F. Phytochemicals for prevention of solar ultraviolet radiation-induced damages. Photochem Photobiol 2008; 84:489-500.
    • (2008) Photochem Photobiol , vol.84 , pp. 489-500
    • Adhami, V.M.1    Syed, D.N.2    Khan, N.3    Afaq, F.4
  • 25
    • 27644439523 scopus 로고    scopus 로고
    • Mechanisms and preclinical efficacy of silibinin in preventing skin cancer
    • Singh RP, Agarwal R. Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. Eur J Cancer 2005; 41:1969-1979.
    • (2005) Eur J Cancer , vol.41 , pp. 1969-1979
    • Singh, R.P.1    Agarwal, R.2
  • 26
    • 84857973987 scopus 로고    scopus 로고
    • Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45alpha-dependent manner
    • Roy S, Deep G, Agarwal C, Agarwal R. Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45alpha-dependent manner. Carcinogenesis 2012; 33:629-636.
    • (2012) Carcinogenesis , vol.33 , pp. 629-636
    • Roy, S.1    Deep, G.2    Agarwal, C.3    Agarwal, R.4
  • 27
    • 77957598340 scopus 로고    scopus 로고
    • Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer
    • Deep G, Agarwal R. Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev 2010; 29:447-463.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 447-463
    • Deep, G.1    Agarwal, R.2
  • 28
    • 79951823058 scopus 로고    scopus 로고
    • Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: Potential of real-time micro-CT in lung cancer chemoprevention studies
    • Ramasamy K, Dwyer-Nield LD, Serkova NJ, et al. Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: Potential of real-time micro-CT in lung cancer chemoprevention studies. Clin Cancer Res 2011; 17:753-761.
    • (2011) Clin Cancer Res , vol.17 , pp. 753-761
    • Ramasamy, K.1    Dwyer-Nield, L.D.2    Serkova, N.J.3
  • 29
    • 77950255061 scopus 로고    scopus 로고
    • Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin
    • Rajamanickam S, Velmurugan B, Kaur M, Singh RP, Agarwal R. Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin. Cancer Res 2010; 70:2368-2378.
    • (2010) Cancer Res , vol.70 , pp. 2368-2378
    • Rajamanickam, S.1    Velmurugan, B.2    Kaur, M.3    Singh, R.P.4    Agarwal, R.5
  • 30
    • 20144364293 scopus 로고    scopus 로고
    • Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells
    • Dhanalakshmi S, Agarwal C, Singh RP, Agarwal R. Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J Biol Chem 2005; 280:20375-20383.
    • (2005) J Biol Chem , vol.280 , pp. 20375-20383
    • Dhanalakshmi, S.1    Agarwal, C.2    Singh, R.P.3    Agarwal, R.4
  • 31
    • 18544383613 scopus 로고    scopus 로고
    • Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis
    • Gu M, Dhanalakshmi S, Singh RP, Agarwal R. Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Cancer Epidemiol Biomarkers Prev 2005; 14:1344-1349.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 1344-1349
    • Gu, M.1    Dhanalakshmi, S.2    Singh, R.P.3    Agarwal, R.4
  • 32
    • 1642545610 scopus 로고    scopus 로고
    • Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes
    • Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes. Carcinogenesis 2004; 25:99-106.
    • (2004) Carcinogenesis , vol.25 , pp. 99-106
    • Dhanalakshmi, S.1    Mallikarjuna, G.U.2    Singh, R.P.3    Agarwal, R.4
  • 33
    • 34248192416 scopus 로고    scopus 로고
    • Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice
    • Gu M, Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Res 2007; 67:3483-3491.
    • (2007) Cancer Res , vol.67 , pp. 3483-3491
    • Gu, M.1    Singh, R.P.2    Dhanalakshmi, S.3    Agarwal, C.4    Agarwal, R.5
  • 34
    • 4344650392 scopus 로고    scopus 로고
    • Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis
    • Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis 2004; 25:1459-1465.
    • (2004) Carcinogenesis , vol.25 , pp. 1459-1465
    • Dhanalakshmi, S.1    Mallikarjuna, G.U.2    Singh, R.P.3    Agarwal, R.4
  • 35
    • 4344639798 scopus 로고    scopus 로고
    • Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling
    • Mallikarjuna G, Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res 2004; 64:6349-6356.
    • (2004) Cancer Res , vol.64 , pp. 6349-6356
    • Mallikarjuna, G.1    Dhanalakshmi, S.2    Singh, R.P.3    Agarwal, C.4    Agarwal, R.5
  • 36
    • 0042807487 scopus 로고    scopus 로고
    • Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells
    • Sharma G, Singh RP, Chan DC, Agarwal R. Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res 2003; 23:2649-2655.
    • (2003) Anticancer Res , vol.23 , pp. 2649-2655
    • Sharma, G.1    Singh, R.P.2    Chan, D.C.3    Agarwal, R.4
  • 37
    • 0026668607 scopus 로고
    • Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice
    • Kripke ML, Cox PA, Alas LG, Yarosh DB. Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice. Proc Natl Acad Sci USA 1992; 89:7516-7520.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7516-7520
    • Kripke, M.L.1    Cox, P.A.2    Alas, L.G.3    Yarosh, D.B.4
  • 38
    • 15944403227 scopus 로고    scopus 로고
    • The skin immune system and the challenge of tumour immunosurveillance
    • Woods GM, Malley RC, Muller HK. The skin immune system and the challenge of tumour immunosurveillance. Eur J Dermatol 2005; 15:63-69.
    • (2005) Eur J Dermatol , vol.15 , pp. 63-69
    • Woods, G.M.1    Malley, R.C.2    Muller, H.K.3
  • 39
    • 0024442538 scopus 로고
    • Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation
    • Applegate LA, Ley RD, Alcalay J, Kripke ML. Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation. J Exp Med 1989; 170:1117-1131.
    • (1989) J Exp Med , vol.170 , pp. 1117-1131
    • Applegate, L.A.1    Ley, R.D.2    Alcalay, J.3    Kripke, M.L.4
  • 40
    • 0028135018 scopus 로고
    • IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines
    • Aragane Y, Riemann H, Bhardwaj RS, et al. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol 1994; 153:5366-5372.
    • (1994) J Immunol , vol.153 , pp. 5366-5372
    • Aragane, Y.1    Riemann, H.2    Bhardwaj, R.S.3
  • 41
    • 0028130251 scopus 로고
    • Identification and induction of human keratinocyte-derived IL-12
    • Muller G, Saloga J, Germann T, et al. Identification and induction of human keratinocyte-derived IL-12. J Clin Invest 1994; 94:1799-1805.
    • (1994) J Clin Invest , vol.94 , pp. 1799-1805
    • Muller, G.1    Saloga, J.2    Germann, T.3
  • 43
    • 33646549560 scopus 로고    scopus 로고
    • Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas
    • Meeran SM, Mantena SK, Meleth S, Elmets CA, Katiyar SK. Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas. Mol Cancer Ther 2006; 5:825-832.
    • (2006) Mol Cancer Ther , vol.5 , pp. 825-832
    • Meeran, S.M.1    Mantena, S.K.2    Meleth, S.3    Elmets, C.A.4    Katiyar, S.K.5
  • 44
    • 77952317006 scopus 로고    scopus 로고
    • A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer
    • Flaig TW, Glode M, Gustafson D, et al. A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. Prostate 2010; 70:848-855.
    • (2010) Prostate , vol.70 , pp. 848-855
    • Flaig, T.W.1    Glode, M.2    Gustafson, D.3
  • 45
    • 33845899681 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
    • Flaig TW, Gustafson DL, Su LJ, et al. A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Invest New Drugs 2007; 25:139-146.
    • (2007) Invest New Drugs , vol.25 , pp. 139-146
    • Flaig, T.W.1    Gustafson, D.L.2    Su, L.J.3
  • 46
    • 33646739493 scopus 로고    scopus 로고
    • Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: Silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences
    • Hoh C, Boocock D, Marczylo T, et al. Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: Silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. Clin Cancer Res 2006; 12:2944-2950.
    • (2006) Clin Cancer Res , vol.12 , pp. 2944-2950
    • Hoh, C.1    Boocock, D.2    Marczylo, T.3


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