-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61:69-90.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
77949405816
-
Incidence estimate of nonmelanoma skin cancer in the United States, 2006
-
Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol 2010; 146:283-287.
-
(2010)
Arch Dermatol
, vol.146
, pp. 283-287
-
-
Rogers, H.W.1
Weinstock, M.A.2
Harris, A.R.3
-
3
-
-
0031022619
-
Sunlight and skin cancer: Another link revealed
-
Kraemer KH. Sunlight and skin cancer: Another link revealed. Proc Natl Acad Sci USA 1997; 94:11-14.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11-14
-
-
Kraemer, K.H.1
-
4
-
-
35348854953
-
Interleukin-12 and photocarcinogenesis
-
Katiyar SK. Interleukin-12 and photocarcinogenesis. Toxicol Appl Pharmacol 2007; 224:220-227.
-
(2007)
Toxicol Appl Pharmacol
, vol.224
, pp. 220-227
-
-
Katiyar, S.K.1
-
5
-
-
41849095585
-
Skin DNA photodamage and its biological consequences
-
Marrot L, Meunier JR. Skin DNA photodamage and its biological consequences. J Am Acad Dermatol 2008; 58:S139-S148.
-
(2008)
J Am Acad Dermatol
, vol.58
-
-
Marrot, L.1
Meunier, J.R.2
-
6
-
-
35348892775
-
Photoageing: Mechanism, prevention and therapy
-
Yaar M, Gilchrest BA. Photoageing: Mechanism, prevention and therapy. Br J Dermatol 2007; 157:874-887.
-
(2007)
Br J Dermatol
, vol.157
, pp. 874-887
-
-
Yaar, M.1
Gilchrest, B.A.2
-
7
-
-
32844469322
-
Spectral and dose dependence of ultraviolet radiation-induced immunosuppression
-
Phan TA, Halliday GM, Barnetson RS, Damian DL. Spectral and dose dependence of ultraviolet radiation-induced immunosuppression. Front Biosci 2006; 11:394-411.
-
(2006)
Front Biosci
, vol.11
, pp. 394-411
-
-
Phan, T.A.1
Halliday, G.M.2
Barnetson, R.S.3
Damian, D.L.4
-
8
-
-
32044473986
-
Mechanisms of UV-induced immunosuppression
-
Schwarz T. Mechanisms of UV-induced immunosuppression. Keio J Med 2005; 54:165-171.
-
(2005)
Keio J Med
, vol.54
, pp. 165-171
-
-
Schwarz, T.1
-
9
-
-
33746581933
-
Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis
-
Moore JO, Wang Y, Stebbins WG, et al. Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis. Carcinogenesis 2006; 27:1627-1635.
-
(2006)
Carcinogenesis
, vol.27
, pp. 1627-1635
-
-
Moore, J.O.1
Wang, Y.2
Stebbins, W.G.3
-
10
-
-
0030112303
-
Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion
-
Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Investig Dermatol Symp Proc 1996; 1:136-142.
-
(1996)
J Investig Dermatol Symp Proc
, vol.1
, pp. 136-142
-
-
Brash, D.E.1
Ziegler, A.2
Jonason, A.S.3
Simon, J.A.4
Kunala, S.5
Leffell, D.J.6
-
11
-
-
37048999948
-
Gadd45a activation protects melanoma cells from ultraviolet B-induced apoptosis
-
Fayolle C, Pourchet J, de Fromentel CC, Puisieux A, Dore JF, Voeltzel T. Gadd45a activation protects melanoma cells from ultraviolet B-induced apoptosis. J Invest Dermatol 2008; 128:196-202.
-
(2008)
J Invest Dermatol
, vol.128
, pp. 196-202
-
-
Fayolle, C.1
Pourchet, J.2
de Fromentel, C.C.3
Puisieux, A.4
Dore, J.F.5
Voeltzel, T.6
-
12
-
-
13244265558
-
NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death
-
Thyss R, Virolle V, Imbert V, Peyron JF, Aberdam D, Virolle T. NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. EMBO J 2005; 24:128-137.
-
(2005)
EMBO J
, vol.24
, pp. 128-137
-
-
Thyss, R.1
Virolle, V.2
Imbert, V.3
Peyron, J.F.4
Aberdam, D.5
Virolle, T.6
-
13
-
-
0035925885
-
UVB irradiation suppresses cytokine production and innate cellular immune functions in mice
-
Kasahara S, Aizawa K, Okamiya M, et al. UVB irradiation suppresses cytokine production and innate cellular immune functions in mice. Cytokine 2001; 14:104-111.
-
(2001)
Cytokine
, vol.14
, pp. 104-111
-
-
Kasahara, S.1
Aizawa, K.2
Okamiya, M.3
-
14
-
-
0029933702
-
Interleukin-12 prevents ultraviolet B-induced local immunosuppression and overcomes UVB-induced tolerance
-
Schwarz A, Grabbe S, Aragane Y, et al. Interleukin-12 prevents ultraviolet B-induced local immunosuppression and overcomes UVB-induced tolerance. J Invest Dermatol 1996; 106:1187-1191.
-
(1996)
J Invest Dermatol
, vol.106
, pp. 1187-1191
-
-
Schwarz, A.1
Grabbe, S.2
Aragane, Y.3
-
15
-
-
0029012470
-
Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation
-
Schmitt DA, Owen-Schaub L, Ullrich SE. Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J Immunol 1995; 154:5114-5120.
-
(1995)
J Immunol
, vol.154
, pp. 5114-5120
-
-
Schmitt, D.A.1
Owen-Schaub, L.2
Ullrich, S.E.3
-
16
-
-
0037238548
-
IL-12 completely blocks ultraviolet-induced secretion of tumor necrosis factor alpha from cultured skin fibroblasts and keratinocytes
-
Werth VP, Bashir MM, Zhang W. IL-12 completely blocks ultraviolet-induced secretion of tumor necrosis factor alpha from cultured skin fibroblasts and keratinocytes. J Invest Dermatol 2003; 120:116-122.
-
(2003)
J Invest Dermatol
, vol.120
, pp. 116-122
-
-
Werth, V.P.1
Bashir, M.M.2
Zhang, W.3
-
17
-
-
0027239503
-
Antitumor and antimetastatic activity of interleukin 12 against murine tumors
-
Brunda MJ, Luistro L, Warrier RR, et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993; 178:1223-1230.
-
(1993)
J Exp Med
, vol.178
, pp. 1223-1230
-
-
Brunda, M.J.1
Luistro, L.2
Warrier, R.R.3
-
18
-
-
0029898839
-
Amount of interleukin 12 available at the tumor site is critical for tumor regression
-
Colombo MP, Vagliani M, Spreafico F, et al. Amount of interleukin 12 available at the tumor site is critical for tumor regression. Cancer Res 1996; 56:2531-2534.
-
(1996)
Cancer Res
, vol.56
, pp. 2531-2534
-
-
Colombo, M.P.1
Vagliani, M.2
Spreafico, F.3
-
19
-
-
0002325617
-
Interleukin 12: Basic biology and potential applications in cancer treatment
-
Robertson MJ, Ritz J. Interleukin 12: Basic biology and potential applications in cancer treatment. Oncologist 1996; 1:88-97.
-
(1996)
Oncologist
, vol.1
, pp. 88-97
-
-
Robertson, M.J.1
Ritz, J.2
-
20
-
-
13244295620
-
Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair
-
Schwarz A, Maeda A, Kernebeck K, van Steeg H, Beissert S, Schwarz T. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med 2005; 201:173-179.
-
(2005)
J Exp Med
, vol.201
, pp. 173-179
-
-
Schwarz, A.1
Maeda, A.2
Kernebeck, K.3
van Steeg, H.4
Beissert, S.5
Schwarz, T.6
-
21
-
-
41149172720
-
Green tea phenol extracts reduce UVB-induced DNA damage in human cells via interleukin-12
-
Schwarz A, Maeda A, Gan D, Mammone T, Matsui MS, Schwarz T. Green tea phenol extracts reduce UVB-induced DNA damage in human cells via interleukin-12. Photochem Photobiol 2008; 84:350-355.
-
(2008)
Photochem Photobiol
, vol.84
, pp. 350-355
-
-
Schwarz, A.1
Maeda, A.2
Gan, D.3
Mammone, T.4
Matsui, M.S.5
Schwarz, T.6
-
22
-
-
0036144597
-
Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
-
Schwarz A, Stander S, Berneburg M, et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 2002; 4:26-31.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 26-31
-
-
Schwarz, A.1
Stander, S.2
Berneburg, M.3
-
23
-
-
14644416024
-
Photochemoprevention of ultraviolet B signaling and photocarcinogenesis
-
Afaq F, Adhami VM, Mukhtar H. Photochemoprevention of ultraviolet B signaling and photocarcinogenesis. Mutat Res 2005; 571:153-173.
-
(2005)
Mutat Res
, vol.571
, pp. 153-173
-
-
Afaq, F.1
Adhami, V.M.2
Mukhtar, H.3
-
24
-
-
41049113125
-
Phytochemicals for prevention of solar ultraviolet radiation-induced damages
-
Adhami VM, Syed DN, Khan N, Afaq F. Phytochemicals for prevention of solar ultraviolet radiation-induced damages. Photochem Photobiol 2008; 84:489-500.
-
(2008)
Photochem Photobiol
, vol.84
, pp. 489-500
-
-
Adhami, V.M.1
Syed, D.N.2
Khan, N.3
Afaq, F.4
-
25
-
-
27644439523
-
Mechanisms and preclinical efficacy of silibinin in preventing skin cancer
-
Singh RP, Agarwal R. Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. Eur J Cancer 2005; 41:1969-1979.
-
(2005)
Eur J Cancer
, vol.41
, pp. 1969-1979
-
-
Singh, R.P.1
Agarwal, R.2
-
26
-
-
84857973987
-
Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45alpha-dependent manner
-
Roy S, Deep G, Agarwal C, Agarwal R. Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45alpha-dependent manner. Carcinogenesis 2012; 33:629-636.
-
(2012)
Carcinogenesis
, vol.33
, pp. 629-636
-
-
Roy, S.1
Deep, G.2
Agarwal, C.3
Agarwal, R.4
-
27
-
-
77957598340
-
Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer
-
Deep G, Agarwal R. Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev 2010; 29:447-463.
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 447-463
-
-
Deep, G.1
Agarwal, R.2
-
28
-
-
79951823058
-
Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: Potential of real-time micro-CT in lung cancer chemoprevention studies
-
Ramasamy K, Dwyer-Nield LD, Serkova NJ, et al. Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: Potential of real-time micro-CT in lung cancer chemoprevention studies. Clin Cancer Res 2011; 17:753-761.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 753-761
-
-
Ramasamy, K.1
Dwyer-Nield, L.D.2
Serkova, N.J.3
-
29
-
-
77950255061
-
Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin
-
Rajamanickam S, Velmurugan B, Kaur M, Singh RP, Agarwal R. Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin. Cancer Res 2010; 70:2368-2378.
-
(2010)
Cancer Res
, vol.70
, pp. 2368-2378
-
-
Rajamanickam, S.1
Velmurugan, B.2
Kaur, M.3
Singh, R.P.4
Agarwal, R.5
-
30
-
-
20144364293
-
Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells
-
Dhanalakshmi S, Agarwal C, Singh RP, Agarwal R. Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J Biol Chem 2005; 280:20375-20383.
-
(2005)
J Biol Chem
, vol.280
, pp. 20375-20383
-
-
Dhanalakshmi, S.1
Agarwal, C.2
Singh, R.P.3
Agarwal, R.4
-
31
-
-
18544383613
-
Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis
-
Gu M, Dhanalakshmi S, Singh RP, Agarwal R. Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Cancer Epidemiol Biomarkers Prev 2005; 14:1344-1349.
-
(2005)
Cancer Epidemiol Biomarkers Prev
, vol.14
, pp. 1344-1349
-
-
Gu, M.1
Dhanalakshmi, S.2
Singh, R.P.3
Agarwal, R.4
-
32
-
-
1642545610
-
Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes
-
Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes. Carcinogenesis 2004; 25:99-106.
-
(2004)
Carcinogenesis
, vol.25
, pp. 99-106
-
-
Dhanalakshmi, S.1
Mallikarjuna, G.U.2
Singh, R.P.3
Agarwal, R.4
-
33
-
-
34248192416
-
Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice
-
Gu M, Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Res 2007; 67:3483-3491.
-
(2007)
Cancer Res
, vol.67
, pp. 3483-3491
-
-
Gu, M.1
Singh, R.P.2
Dhanalakshmi, S.3
Agarwal, C.4
Agarwal, R.5
-
34
-
-
4344650392
-
Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis
-
Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis 2004; 25:1459-1465.
-
(2004)
Carcinogenesis
, vol.25
, pp. 1459-1465
-
-
Dhanalakshmi, S.1
Mallikarjuna, G.U.2
Singh, R.P.3
Agarwal, R.4
-
35
-
-
4344639798
-
Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling
-
Mallikarjuna G, Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res 2004; 64:6349-6356.
-
(2004)
Cancer Res
, vol.64
, pp. 6349-6356
-
-
Mallikarjuna, G.1
Dhanalakshmi, S.2
Singh, R.P.3
Agarwal, C.4
Agarwal, R.5
-
36
-
-
0042807487
-
Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells
-
Sharma G, Singh RP, Chan DC, Agarwal R. Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res 2003; 23:2649-2655.
-
(2003)
Anticancer Res
, vol.23
, pp. 2649-2655
-
-
Sharma, G.1
Singh, R.P.2
Chan, D.C.3
Agarwal, R.4
-
37
-
-
0026668607
-
Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice
-
Kripke ML, Cox PA, Alas LG, Yarosh DB. Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice. Proc Natl Acad Sci USA 1992; 89:7516-7520.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 7516-7520
-
-
Kripke, M.L.1
Cox, P.A.2
Alas, L.G.3
Yarosh, D.B.4
-
38
-
-
15944403227
-
The skin immune system and the challenge of tumour immunosurveillance
-
Woods GM, Malley RC, Muller HK. The skin immune system and the challenge of tumour immunosurveillance. Eur J Dermatol 2005; 15:63-69.
-
(2005)
Eur J Dermatol
, vol.15
, pp. 63-69
-
-
Woods, G.M.1
Malley, R.C.2
Muller, H.K.3
-
39
-
-
0024442538
-
Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation
-
Applegate LA, Ley RD, Alcalay J, Kripke ML. Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation. J Exp Med 1989; 170:1117-1131.
-
(1989)
J Exp Med
, vol.170
, pp. 1117-1131
-
-
Applegate, L.A.1
Ley, R.D.2
Alcalay, J.3
Kripke, M.L.4
-
40
-
-
0028135018
-
IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines
-
Aragane Y, Riemann H, Bhardwaj RS, et al. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol 1994; 153:5366-5372.
-
(1994)
J Immunol
, vol.153
, pp. 5366-5372
-
-
Aragane, Y.1
Riemann, H.2
Bhardwaj, R.S.3
-
41
-
-
0028130251
-
Identification and induction of human keratinocyte-derived IL-12
-
Muller G, Saloga J, Germann T, et al. Identification and induction of human keratinocyte-derived IL-12. J Clin Invest 1994; 94:1799-1805.
-
(1994)
J Clin Invest
, vol.94
, pp. 1799-1805
-
-
Muller, G.1
Saloga, J.2
Germann, T.3
-
42
-
-
33645519047
-
Enhanced photocarcinogenesis in interleukin-12-deficient mice
-
Maeda A, Schneider SW, Kojima M, Beissert S, Schwarz T, Schwarz A. Enhanced photocarcinogenesis in interleukin-12-deficient mice. Cancer Res 2006; 66:2962-2969.
-
(2006)
Cancer Res
, vol.66
, pp. 2962-2969
-
-
Maeda, A.1
Schneider, S.W.2
Kojima, M.3
Beissert, S.4
Schwarz, T.5
Schwarz, A.6
-
43
-
-
33646549560
-
Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas
-
Meeran SM, Mantena SK, Meleth S, Elmets CA, Katiyar SK. Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas. Mol Cancer Ther 2006; 5:825-832.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 825-832
-
-
Meeran, S.M.1
Mantena, S.K.2
Meleth, S.3
Elmets, C.A.4
Katiyar, S.K.5
-
44
-
-
77952317006
-
A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer
-
Flaig TW, Glode M, Gustafson D, et al. A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. Prostate 2010; 70:848-855.
-
(2010)
Prostate
, vol.70
, pp. 848-855
-
-
Flaig, T.W.1
Glode, M.2
Gustafson, D.3
-
45
-
-
33845899681
-
A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
-
Flaig TW, Gustafson DL, Su LJ, et al. A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Invest New Drugs 2007; 25:139-146.
-
(2007)
Invest New Drugs
, vol.25
, pp. 139-146
-
-
Flaig, T.W.1
Gustafson, D.L.2
Su, L.J.3
-
46
-
-
33646739493
-
Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: Silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences
-
Hoh C, Boocock D, Marczylo T, et al. Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: Silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. Clin Cancer Res 2006; 12:2944-2950.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2944-2950
-
-
Hoh, C.1
Boocock, D.2
Marczylo, T.3
|