IL-12 completely blocks ultraviolet-induced secretion of tumor necrosis factor α from cultured skin fibroblasts and keratinocytes

Journal of Investigative Dermatology

Volumn 120, Issue 1, 2003, Pages 116-122

  Werth, Victoria P ^a,b,c   Bashir, Muhammad M ^a   Zhang, Wei ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Philadelphia VA Hospital   (United States)

^c 2 Rhoads Pavilion ^*  (United States)

Author keywords

Cytokines; Fibroblasts; Lupus; Th1; Th2

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; COLLAGENASE; CYTOKINE ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; KERATINOCYTE; MOLECULAR MECHANICS; PRIORITY JOURNAL; SECRETION; SKIN CELL; SKIN FIBROBLAST; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; WILD TYPE;

EID: 0037238548     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12012.x     Document Type: Article

References (43)

1. Adorini L: Interleukin-12, a key cytokine in Th1-mediated autoimmune diseases. Cell Mol Life Sci 55:10-25, 1999
2. Bromberg JS, Chavin KD, Kunkel SL: Anti-tumor necrosis factor antibodies suppress cell-mediated immunity in vivo. J Immunol 148:3412-3417, 1992
3. Brown EL, Rivas JM, Ullrich SE, Young CR, Norris SJ, Kripke ML: Modulation of immunity to Borrelia burgdorferi by ultraviolet irradiation: differential effect on Th1 and Th2 immune responses. Eur J Immunol 25:3017-3022, 1995
4. Chung JH, Youn SH, Koh WS, Eun HC, Cho KH, Park KC, Youn JI: Ultraviolet B irradiation-enhanced interleukin (IL)-6 production and mRNA expression are mediated by IL-1α in cultured human keratinocytes. J Invest Dermatol 106:715- 720, 1996
5. DeKruyff RH, Fang Y, Wolf SF, Utmetsu DT: IL-12 inhibits IL-4 synthesis in key-hole limpet hemocyanin-primed CD4 + T cells through an effect on antigen presenting cells. J Immunol 154:2578-2587, 1995
6. Eberlein-Konig B, Jager C, Przybilla B: Ultraviolet B radiation-induced production of interleukin 1 alpha and interleukin 6 in a human squamous carcinoma cell line is wavelength-dependent and can be inhibited by pharmacological agents. Br J Dermatol 139:415-421, 1998
7. Enk CD, Sredni D, Blauvelt A, Katz SI: Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro. J Immunol 154:4851- 4856, 1995
8. Fujisawa H, Wang B, Kondo S, Shivji GM, Sauder DN: Costimulation with ultraviolet B and interleukin-1 alpha dramatically increases tumor necrosis factor-α production in human dermal fibroblasts. J Interferon Cytokine Res 17:307-313, 1997
9. Grewe M, Gyufko K, Krutmann J: Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. J Invest Dermatol 104:3-6, 1995
10. Kibitel J, Hejmadi V, Alas L, O'Connor A, Sutherland BM,Yarosh D: UV-DNA damage in mouse and human cells induces the expression of tumor necrosis factor α. Photochem Photobiol 67:541-546, 1998
11. Kock A, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC, Luger TA: Human keratinocytes are a source for tumor necrosis factor α: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609-1614, 1990
12. Kondo S, Kono T, Sauder DN, Mckenzie RC: IL-8 gene expression and production in human keratinocytes and their modulation by UVB. J Invest Dermatol 101:690-694, 1993
13. Kostense S, Sun WH, Cottey R, et al: Interleukin 12 administration enhances Th1 activity but delays recovery from influenza A virus infection in mice. Antiviral Res 38:117-130, 1998
14. Kremer IB, Hilkens CM, Sylva-Steenland RM, Koomen CW, Kapsenberg ML, Bos JD, Teunissen MB: Reduced IL-12 production by monocytes upon ultraviolet-B irradiation selectively limits activation of T helper-1 cells. J Immunol 157:1913-1918, 1996
15. Kurimoti I, Streilein JW: Tumor necrosis factor-α impairs contact hypersensitivity induction after ultraviolet B radiation via TNF-receptor 2. Exp Dermatol 8:495-500, 1999
16. Ma X: TNF-α and IL-12: a balancing act in macrophage functioning. Microbes Infection 3:121-129, 2001
17. Marshall JD, Secrist H, DeKruyff RH, Wolf SF, Umetso, DT: IL-12 inhibits the production of IL-4 and IL-10 in allergen specific human CD4 + T lymphocytes. J Immunol 155:111-117, 1995
18. Matsuo R, Kobayashi M, Herndon DN, Pollard RB, Suzuki F: Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection. J Leukoc Biol 59:623-630, 1996
19. McGrath H Jr: Ultraviolet-A1 irradiation decreases clinical disease activity and auto-antibodies in patients with systemic lupus erythematosus. Clin Exp Rheumatol 12:129-135, 1994
20. Mohamadzadeh M, Takashima A, Dougherty I, Knop J, Bergstresser PR, Cruz PD Jr: Ultraviolet B radiation up-regulates the expression of IL-15 in human skin. J Immunol 155:4492-4496, 1995
21. Nagayama H, Sato K, Kawasaki H, et al: IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells. J Im-munol 165:59-66, 2000
22. Nishigori C, Yarosh DB, Ullrich SE, Vink AA, Bucana CD, Roza L, Kripke ML: Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes. Proc Natl Acad Sci USA 93:10354-10359, 1996
23. Pachman LM, Liotta-Davis MR, Hong DK, Kinsella TR, Mendez EP, Kinder JM, Chen EH: TNFα-308A allele in juvenile dermatomyositis: association with increased production of tumor necrosis factor α, disease duration, and pathologic calcifications. Arthr Rheumatol 43:2368-2377, 2000
24. Reeve VE, Bosnic M, Boehm-Wilcox C, Nishimura N, Ley RD: Ultraviolet A radiation (320-400 nm) protects hairless mice from immunosuppression induced by ultraviolet B radiation (280-320 nm) or cis-urocanic acid. Int Arch Allergy Immunol 115:316-322, 1998
25. Rivas JM, Ullrich SE: Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J Immunol 149:3865-3871, 1992
26. Schmitt DA, Owen-Schaub L, Ullrich SE: Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J Immunol 154:5114-5120, 1995
27. Schmitt DA, Ullrich SE: Exposure to ultraviolet radiation causes dendritic cells/macrophages to secrete immune-suppressive IL-12p40 homodimers. J Immunol 165:3162-3167, 2000
28. Schmitt DA, Walterscheid JP, Ullrich SE: Reversal of ultraviolet radiation-induced immune suppression by recombinant interleukin-12: Suppression of cytokine production. Immunology 101:90-96, 2000
29. Schwarz A, Grabbe S, AraganeY, et al: Interleukin-12 prevents ultraviolet B-induced local immunosuppression and overcomes UVB-induced tolerance. J Invest Dermatol 106:1187-1191, 1996
30. Schwarz A, Stander S, Berneburg M, et al: Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nature Cell Biol 4:26-31, 2002
31. Seder RA, Gazzinelli R, Sher A, Paul WE: Interleukin 12 acts directly on CD4 + T cells to enhance priming for interferon gamma production and diminishes in-terleukin 4 inhibition of such priming. Proc Natl Acad Sci USA 90:10188-10192, 1993
32. Stobie L, Guranathan S, Prussin C, Sacks DL, Glaichenhaus N, Wu CY, Seder RA: The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc Natl Acad Sci USA 97:8427-8432, 2000
33. Sullivan KE, Wooten C, Schmeckpeper BJ, Goldman D, Petri MA: A promoter polymorphism of tumor necrosis factor α associated with systemic lupus erythematosus in African-Americans. Arthr Rheum 40:2207-2211, 1997
34. Ullrich SE: Does exposure to UV radiation induce a shift to a Th-2-like immune reaction? Photochem Photobiol 64:254-258, 1996
35. de Vos S, Brach M, Budnik A, Grewe M, Herrmann F, Krutmann J: Post-transcriptional regulation of interleukin-6 gene expression in human keratinocytes by ultraviolet B radiation. J Invest Dermatol 103:92-96, 1994
36. Werth VP, Zhang W: Wavelength-specific synergy between ultraviolet radiation and interleukin-1α in the regulation of matrix-related genes: mechanistic role for tumor necrosis factor-α. J Invest Dermatol 113:196-201, 1999
37. Werth VP, Williams KJ, Fisher EA, Bashir M, Rosenbloom JR, Shi X: UVB irradiation alters cellular responses to cytokines: role in extracellular matrix gene expression. J Invest Dermatol 108:290-294, 1997
38. Werth VP, Zhang W, Dortzbach K, Sullivan K: Association of a promoter polymorphism of TNFα with subacute cutaneous lupus erythematosus and distinct photoregulation of transcription. J Invest Dermatol 115:726-730, 2000
39. Werth VP, Callen JP, Ang G, Sullivan KE: Associations of tumor necrosis factor-α (TNFα) and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesis. J Invest Dermatol 119:617-620, 2002
40. Wolf P, Maier H, Mullegger RR, et al: Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-α. J Invest Dermatol 114:149-156, 2000
41. Xing Z, Zganiacz A, Santosuosso M: Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-α induction. J Leukoc Biol 68:897- 902, 2000
42. Yoshikawa T, Rae V, Bruins-Slot W, Van den Berg JW, Taylor JR, Streilein JW: Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans. J Invest Dermatol 95:530-536, 1990
43. Yoshikawa T, Kurimoto I, Streilein JW: Tumour necrosis factor-a mediates ultraviolet light B-enhanced expression of contact hypersensitivity. Immunology 76:264-271, 1992