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Volumn 1, Issue 1-2, 1996, Pages 88-97

Interleukin 12: Basic biology and potential applications in cancer treatment

Author keywords

Antitumor immunity; Biologic therapy; Cytokine therapy; Immunotherapy; Interleukin 12 (IL 12); Tumor immunology

Indexed keywords


EID: 0002325617     PISSN: 10837159     EISSN: None     Source Type: Journal    
DOI: 10.1634/theoncologist.1-1-88     Document Type: Article
Times cited : (94)

References (18)
  • 1
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
    • Kobayashi M, Fitz L, Ryan M et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989;170:827-845.
    • (1989) J Exp Med , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3
  • 2
    • 0025875022 scopus 로고
    • Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple effects on T and natural killer cells
    • Wolf SF, Temple PA, Kobayashi M et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple effects on T and natural killer cells. J Immunol 1991;146:3074-3081.
    • (1991) J Immunol , vol.146 , pp. 3074-3081
    • Wolf, S.F.1    Temple, P.A.2    Kobayashi, M.3
  • 3
    • 0025028960 scopus 로고
    • Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-Iymphoblastoid cells
    • Stern AS, Podlaski FJ, Hulmes JD et al. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-Iymphoblastoid cells. Proc Natl Acad Sci USA 1990;87:6808-6812.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6808-6812
    • Stern, A.S.1    Podlaski, F.J.2    Hulmes, J.D.3
  • 4
    • 0025808629 scopus 로고
    • Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
    • Gubler U, Chua AO, Schoenhaut DA et al. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 1991;88:4143-4147.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4143-4147
    • Gubler, U.1    Chua, A.O.2    Schoenhaut, D.A.3
  • 5
    • 0028043326 scopus 로고
    • Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994;84:4008-4027.
    • (1994) Blood , vol.84 , pp. 4008-4027
    • Trinchieri, G.1
  • 6
    • 0028281585 scopus 로고
    • Interleukin 12: A key modulator of immune function
    • Wolf SF, Sieburth D, Sypek J. Interleukin 12: a key modulator of immune function. STEM CELLS 1994;12:154-168.
    • (1994) Stem Cells , vol.12 , pp. 154-168
    • Wolf, S.F.1    Sieburth, D.2    Sypek, J.3
  • 7
    • 0029047009 scopus 로고
    • Interleukin-12: Biologic activity, therapeutic utility, and role in disease
    • Hendrzak JA, Brunda MJ. Interleukin-12: biologic activity, therapeutic utility, and role in disease. Lab Invest 1995;72:619-637.
    • (1995) Lab Invest , vol.72 , pp. 619-637
    • Hendrzak, J.A.1    Brunda, M.J.2
  • 8
    • 0029188099 scopus 로고
    • Interleukin-12: Potential role in cancer therapy
    • DeVita VT, Hellman S, Rosenberg SA, eds. Philadelphia: J. B. Lippincott
    • Brunda MJ, Gately MK. Interleukin-12: potential role in cancer therapy. In: DeVita VT, Hellman S, Rosenberg SA, eds. Important Advances in Oncology 1995. Philadelphia: J. B. Lippincott, 1995:3-18.
    • (1995) Important Advances in Oncology 1995 , pp. 3-18
    • Brunda, M.J.1    Gately, M.K.2
  • 9
  • 10
    • 0025783528 scopus 로고
    • Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor
    • Gearing DP, Cosman D. Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 1991;66:9-10.
    • (1991) Cell , vol.66 , pp. 9-10
    • Gearing, D.P.1    Cosman, D.2
  • 11
    • 0026567028 scopus 로고
    • Sequence similarity between NKSF and the IL-6/G-CSF family
    • Merberg DM, Wolf SF, Clark SC. Sequence similarity between NKSF and the IL-6/G-CSF family. Immunol Today 1992;13:77-78.
    • (1992) Immunol Today , vol.13 , pp. 77-78
    • Merberg, D.M.1    Wolf, S.F.2    Clark, S.C.3
  • 12
    • 0026523212 scopus 로고
    • IL-12 receptor: I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts
    • Chizzonite R, Truitt T, Desai BB et al. IL-12 receptor: I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts. J Immunol 1992;148:3117-3124.
    • (1992) J Immunol , vol.148 , pp. 3117-3124
    • Chizzonite, R.1    Truitt, T.2    Desai, B.B.3
  • 13
    • 0026605457 scopus 로고
    • IL-12 receptor: II. Distribution and regulation of receptor expression
    • Desai BB, Quinn PM, Wolitzky AG et al. IL-12 receptor: II. Distribution and regulation of receptor expression. J Immunol 1992;148:3125-3132.
    • (1992) J Immunol , vol.148 , pp. 3125-3132
    • Desai, B.B.1    Quinn, P.M.2    Wolitzky, A.G.3
  • 14
    • 0027532502 scopus 로고
    • Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation
    • Naume B, Gately MK, Desai BB et al. Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation. Cytokine 1993;5:38-46.
    • (1993) Cytokine , vol.5 , pp. 38-46
    • Naume, B.1    Gately, M.K.2    Desai, B.B.3
  • 15
    • 0028235663 scopus 로고
    • Expression cloning of a human IL-12 receptor component: A new member of the cytokine receptor superfamily with strong homology to gp130
    • Chua AO, Chizzonite R, Desai BB et al. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol 1994;153:128-136.
    • (1994) J Immunol , vol.153 , pp. 128-136
    • Chua, A.O.1    Chizzonite, R.2    Desai, B.B.3
  • 16
    • 0028014296 scopus 로고
    • Interleukin-12 induces tyrosine phosphorylation and activation of 44-kD mitogen-activated protein kinase in human T cells
    • Pignata C, Sanghera JS, Cossette L et al. Interleukin-12 induces tyrosine phosphorylation and activation of 44-kD mitogen-activated protein kinase in human T cells. Blood 1994;83:184-190.
    • (1994) Blood , vol.83 , pp. 184-190
    • Pignata, C.1    Sanghera, J.S.2    Cossette, L.3
  • 17
    • 0028828062 scopus 로고
    • Phosphorylation of srcfamily lck tyrosine kinase following interleukin-12 activation of human natural killer cells
    • Pignata C, Prasad KVS, Hallek M et al. Phosphorylation of srcfamily lck tyrosine kinase following interleukin-12 activation of human natural killer cells. Cell Immunol 1995;165:211-216.
    • (1995) Cell Immunol , vol.165 , pp. 211-216
    • Pignata, C.1    Prasad, K.V.S.2    Hallek, M.3
  • 18
    • 0028933799 scopus 로고
    • Signaling through the hematopoietic cytokine receptors
    • Ihle JN, Witthuhn BA, Quelle FW et al. Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol 1995;13:369-398.
    • (1995) Annu Rev Immunol , vol.13 , pp. 369-398
    • Ihle, J.N.1    Witthuhn, B.A.2    Quelle, F.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.