Comprehensive behavioral study of mGluR3 knockout mice: Implication in schizophrenia related endophenotypes

Molecular Brain

Volumn 7, Issue 1, 2014, Pages

  Fujioka, Ryuta ^a   Nii, Takenobu ^a   Iwaki, Akiko ^a   Shibata, Atsushi ^a   Ito, Isao ^a   Kitaichi, Kiyoyuki ^b,c   Nomura, Masatoshi ^d   Hattori, Satoko ^e,f   Takao, Keizo ^f,g   Miyakawa, Tsuyoshi ^e,f,g   Fukumaki, Yasuyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NAGASAKI INTERNATIONAL UNIVERSITY   (Japan)

^c GIFU UNIVERSITY HOSPITAL   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e FUJITA HEALTH UNIVERSITY   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^g NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Contextual memory; Grm3; Hyperactivity; Knockout mice; LTP; Metabotropic glutamate receptors; Microdialysis; Reference memory; Schizophrenia; Working memory

Indexed keywords

DOPAMINE; METABOTROPIC RECEPTOR 3; METHAMPHETAMINE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIORAL SCIENCE; BRAIN FUNCTION; CONTEXTUAL MEMORY; CONTROLLED STUDY; CUED AND CONTEXTUAL FEAR CONDITIONING TEST; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; EMBRYO; EMBRYONIC STEM CELL; ENDOPHENOTYPE; EXPLORATORY BEHAVIOR TEST; FEMALE; FORCED SWIM TEST; GENOTYPE; HIPPOCAMPAL CA1 REGION; HYPERACTIVITY; IN VIVO STUDY; LEARNING AND MEMORY TEST; LIGHT-DARK TEST; LONG TERM POTENTIATION; MALE; MEMORY; MEMORY DISORDER; METABOTROPIC RECEPTOR 3 GENE; MICRODIALYSIS; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEUS ACCUMBENS; OPEN FIELD TEST; PATHOGENESIS; PRIORITY JOURNAL; REFERENCE MEMORY; SCHIZOPHRENIA; T-MAZE TEST; TWENTY FOUR HOUR HOME CAGE MONITORING TEST; WILD TYPE; WORKING MEMORY;

MUS;

ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CONDITIONING (PSYCHOLOGY); CUES; DOPAMINE; ENDOPHENOTYPES; FEAR; GAIT; HIPPOCAMPUS; INHIBITION (PSYCHOLOGY); LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY, SHORT-TERM; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; NUCLEUS ACCUMBENS; RECEPTORS, METABOTROPIC GLUTAMATE; SCHIZOPHRENIA; SOCIAL BEHAVIOR; STARTLE REACTION; SWIMMING; TASK PERFORMANCE AND ANALYSIS;

EID: 84899976761     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-7-31     Document Type: Article

References (45)

1. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. Meldrum BS, J Nutr 2000 130 1007S 1015S 10736372
2. Pharmacology and functions of metabotropic glutamate receptors. Conn PJ, Pin JP, Annu Rev Pharmacol Toxicol 1997 37 205 237 10.1146/annurev.pharmtox.37. 1.205 9131252
3. A family of metabotropic glutamate receptors. Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S, Neuron 1992 8 169 179 10.1016/0896-6273(92)90118-W 1309649
4. Molecular determinants of metabotropic glutamate receptor signaling. De Blasi A, Conn PJ, Pin JP, Nicoletti F, Trends Pharmacol Sci 2001 22 114 120 10.1016/S0165-6147(00)01635-7 11239574
5. The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia. Harrison PJ, Lyon L, Sartorius LJ, Burnet PW, Lane TA, Psychopharmacology 2008 22 308 322 10.1177/0269881108089818
6. Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Anwyl R, Brain Res Rev 1999 29 83 120 10.1016/S0165-0173(98) 00050-2 9974152
7. Beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor. Lea PM, Wroblewska B, Sarvey JM, Neale JH, J Neurophysiol 2001 85 1097 1106 11247980
8. The metabotropic glutamate receptor mGluR3 in critically required for hippocampal long-term depression and modulates long-term potentiation in the dentate gyrus of freely moving rats. Pöschel B, Wroblewska B, Heinemann U, Manahan-Vaughan D, Cereb Cortex 2005 15 1414 1423 15635057
9. Regulation of neurotransmitter release by metabotropic glutamate receptors. Cartmell J, Schoepp DD, J Neurochem 2000 75 889 907 10936169
10. Glutamate as a therapeutic target in psychiatric disorders. Javitt DC, Mol Psychiatry 2004 9 984 997 10.1038/sj.mp.4001551 15278097
11. Recent advances in the phencyclidine model of schizophrenia. Javitt DC, Zukin SR, Am J Psychiatry 1991 148 1301 1308 1654746
12. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Moghaddam B, Adams BW, Science 1998 281 1349 1352 9721099
13. Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Fujii Y, Shibata H, Kikuta R, Makino C, Tani A, Hirata N, Shibata A, Ninomiya H, Tashiro N, Fukumaki Y, Psychiatr Genet 2003 13 71 76 12782962
14. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR, Proc Natl Acad Sci U S A 2004 101 12604 12609 10.1073/pnas.0405077101 15310849
15. A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population. Chen Q, He G, Chen Q, Wu S, Xu Y, Feng G, Li Y, Wang L, He L, Schizophr Res 2005 73 21 26 10.1016/j.schres.2004.07.002 15567072
16. Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. Nicodemus KK, Kolachana BS, Vakkalanka R, Straub RE, Giegling I, Egan MF, Rujescu D, Weinberger DR, Hum Genet 2007 120 889 906 10.1007/s00439-006-0257-3 17006672
17. Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia. Mössner R, Schuhmacher A, Schulze-Rauschenbach S, Kühn KU, Rujescu D, Rietschel M, Zobel A, Franke P, Wölwer W, Gaebel W, Häfner H, Wagner M, Maier W, Eur Neuropsychopharmacol 2008 18 768 772 10.1016/j.euroneuro.2008.05.007 18614340
18. No evidence for association between polymorphisms in GRM3 and schizophrenia. Norton N, Williams HJ, Dwyer S, Ivanov D, Preece AC, Gerrish A, Williams NM, Yerassimou P, Zammit S, O'Donovan MC, Owen MJ, BMC Psychiatr 2005 5 23 10.1186/1471-244X-5-23
19. DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study. Schwab SG, Plummer C, Albus M, Borrmann-Hassenbach M, Lerer B, Trixler M, Maier W, Wildenauer DB, Psychiatr Genet 2008 18 25 30 10.1097/YPG.0b013e3282ef48d9 18197082
20. Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population. Albalushi T, Horiuchi Y, Ishiguro H, Koga M, Inada T, Iwata N, Ozaki N, Ujike H, Watanabe Y, Someya T, Arinami T, Am J Med Genet B Neuropsychiatr Genet 2008 147 392 396 17948896
21. Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice. Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T, PLoS One 2010 5 3 9460 10.1371/journal.pone.0009460 20209163
22. Comprehensive behavioral study of GluR4 knockout mice: implication in cognitive function. Sagata N, Iwaki A, Aramaki T, Takao K, Kura S, Tsuzuki T, Kawakami R, Ito I, Kitamura T, Sugiyama H, Miyakawa T, Fukumaki Y, Genes Brain Behav 2010 9 899 909 10.1111/j.1601-183X.2010.00629.x 20662939
23. Animal behavior models of the mechanisms underlying antipsychotic atypicality. Geyer MA, Ellenbroek B, Prog Neuropsychopharmacol Biol Psychiatry 2003 27 1071 1079 10.1016/j.pnpbp.2003.09.003 14642967
24. Modeling madness in mice: one piece at a time. Arguello PA, Gogos JA, Neuron 2006 52 179 196 10.1016/j.neuron.2006.09.023 17015235
25. Genetic animal models: focus on schizophrenia. Gainetdinov RR, Mohn AR, Caron MG, Trends Neurosci 2001 24 527 533 10.1016/S0166-2236(00)01886-5 11506886
26. The endophenotype concept in psychiatry: etymology and strategic intentions. Gottesman II, Gould TD, Am J Psychiatry 2003 160 636 645 10.1176/appi.ajp.160.4.636 12668349
27. Mouse behavioral endophenotypes for schizophrenia. Amann LC, Gandal MJ, Halene TB, Ehrlichman RS, White SL, McCarren HS, Siegel SJ, Brain Res Bull 2010 83 147 161 10.1016/j.brainresbull.2010.04.008 20433908
28. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, Sklar P, The International Schizophrenia Consortium, Nature 2009 460 748 752 19571811
29. Impairement of hippocampal mossy fiber LTD in mice lacking mGluR2. Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, Katsuura G, Shigemoto R, Ohishi H, Nomura S, Nakamura K, Nakao K, Katsuki M, Nakanishi S, Science 1996 273 645 647 10.1126/science.273.5275.645 8662555
30. Striatal dopamine D1 receptor is essential for contextual fear conditioning. Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M, Sci Rep 2014 4 3976
31. Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S, Proc Natl Acad Sci U S A 2005 102 4170 4175 10.1073/pnas.0500914102 15753323
32. Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO. Seeman P, Battaglia G, Corti C, Corsi M, Bruno V, Synapse 2009 63 247 251 10.1002/syn.20607 19084908
33. Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex. Del Arco A, Mora F, Pharmacol Biochem Behav 2008 90 226 325 10.1016/j.pbb.2008.04.011 18508116
34. The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/ neuroprotection. Corti C, Battaglia G, Molinaro G, Riozzi B, Pittaluga A, Corsi M, Mugnaini M, Nicoletti F, Bruno V, J Neurosci 2007 27 8297 8308 10.1523/JNEUROSCI.1889-07.2007 17670976
35. Light/dark transition test for mice. Takao K, Miyakawa T, J Vis Exp 2006 1 104
36. Behavioral abnormalities observed in Zfhx2-deficient mice. Komine Y, Takao K, Miyakawa T, Yamamori T, PLoS One 2012 7 12 53114 10.1371/journal.pone. 0053114 23300874
37. T-maze forced alternation and left-right discrimination tasks for assessing working and reference memory in mice. Shoji H, Hagihara H, Takao K, Hattori S, Miyakawa T, J Vis Exp 2012 60 3300
38. Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor. Miyakawa T, Yamada M, Duttaroy A, Wess J, J Neurosci 2001 21 5239 5250 11438599
39. Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice. Yao I, Takao K, Miyakawa T, Ito S, Setou M, PLoS One 2011 6 2 17317 10.1371/journal.pone.0017317 21390313
40. Elevated plus maze for mice. Komada M, Takao K, Miyakawa T, J Vis Exp 2008 22 1088
41. Input-specific targeting of NMDA receptor subtypes at mouse hippocampal CA3 pyramidal neuron synapses. Ito I, Kawakami R, Sakimura K, Mishina M, Sugiyama H, Neuropharmacology 2000 39 943 951 10.1016/S0028-3908(99)00217-8 10727704
42. Asymmetrical allocation of NMDA receptor epsilon2 subunits in hippocampal circuitry. Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I, Science 2003 300 990 994 10.1126/science.1082609 12738868
43. Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Sakae N, Yamasaki N, Kitaichi K, Fukuda T, Yamada M, Yoshikawa H, Hiranita T, Tatsumi Y, Kira J, Yamamoto T, Miyakawa T, Nakayama K, Hum Mol Genet 2008 17 3191 3203 10.1093/hmg/ddn215 18647754
44. Behavioral profiles of three C57BL/6 substrains. Matsuo N, Takao K, Nakanishi K, Yamasaki N, Tanda K, Miyakawa T, Front Behav Neurosci 2010 4 29
45. Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Hampton TG, Stasko MR, Kale A, Amende I, Costa AC, Physiol Behav 2004 82 381 389 10.1016/j.physbeh.2004.04.006 15276802