No evidence for association between polymorphism in GRM3 and schizophrenia

BMC Psychiatry

Volumn 5, Issue , 2005, Pages

  Norton, Nadine ^a   Williams, Hywel J ^a   Dwyer, Sarah ^a   Ivanov, Dobril ^a   Preece, Anna C ^a   Gerrish, Amy ^a   Williams, Nigel M ^a   Yerassimou, Pamela ^a   Zammit, Stanley ^a   O'Donovan, Michael C ^a   Owen, Michael J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR 3; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 5;

ADULT; ARTICLE; CASE CONTROL STUDY; DATA ANALYSIS; DISEASE ASSOCIATION; EUROPE; EUROPEAN AMERICAN; FEMALE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM; CAUCASIAN; COMPARATIVE STUDY; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE;

ADULT; CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, METABOTROPIC GLUTAMATE; SCHIZOPHRENIA;

EID: 26844450276     PISSN: 1471244X     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-5-23     Document Type: Article

References (18)

1. Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmuller B: Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 1980, 20:379-382.
2. Javitt DC, Zukin SR: Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991, 148:1301-1308.
3. Goff DC, Wine L: Glutamate in schizophrenia: clinical and research implications. Schizophr Res 1997, 27:157-168.
4. Moghaddam B, Adams BW: Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 1998, 281:1349-1352.
5. Marti SB, Cichon S, Propping P, Nothen M: Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. Am J Med Genet 2002, 114:46-50.
6. Fujii Y, Shibata H, Kikuta R, Makino C, Tani A, Hirata N, Shibata A, Ninomiya H, Tashiro N, Fukumaki Y: Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Psychiatr Genet 2003, 13:71-76.
7. Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR: Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci USA 2004, 101:12604-12609.
8. Chen Q, He G, Chen Q, Wu S, Xu Y, Feng G, Li Y, Wang L, He L: A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population. Schizophr Res 2005, 73:21-26.
9. Wing JK, Cooper JE, Satorius N: The Measurement and Classification of Psychiatric illness Cambridge, UK: Cambridge University Press; 1974.
10. Wing JK, Babor T, Brugha T: SCAN: Schedules for the clinical assessment in neuropsychiatry. Archives of General Psychiatry 1990, 47:589-593.
11. Owen MJ, Holmans P, McGuffin P: Association studies in psychiatric genetics. Mol Psychiatry 1997, 2:270-273.
12. International Hapmap Project [http://www.hapmap.org/]
13. Zhao JH, Curtis D, Sham PC: Model-free analysis and permutation tests for allelic associations. Hum Hered 2000, 50:133-139.
14. Abecasis GR, Cookson WO: GOLD-graphical overview of linkage disequilibrium. Bioinformatics 2000, 16:182-183.
15. Cardon LR, Bell JI: Association study designs for complex diseases. Nat Rev Genet 2001, 2:91-99.
16. Harrison PJ, Weinberger DR: Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005, 10:40-68.
17. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN: Metaanalysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003, 33:177-182.
18. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D: The structure of haplotype blocks in the human genome. Science 2002, 296:2225-2229.