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Volumn 52, Issue 10, 2006, Pages 1920-1925

Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN E; CHOLESTEROL; DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE; TRIACYLGLYCEROL; URIC ACID;

EID: 33749145610     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2006.069690     Document Type: Article
Times cited : (21)

References (31)
  • 1
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 2
    • 0036831967 scopus 로고    scopus 로고
    • Dyslipidemia of the metabolic syndrome
    • Ruotolo G, Howard BV. Dyslipidemia of the metabolic syndrome. Curr Cardiol Rep 2002;4:494-500.
    • (2002) Curr Cardiol Rep , vol.4 , pp. 494-500
    • Ruotolo, G.1    Howard, B.V.2
  • 4
    • 0031015407 scopus 로고    scopus 로고
    • Impaired glucose tolerance is normalized by treatment with the thiazolidinedione troglitazone
    • Antonucci T, Whitcomb R, McLain R, Lockwood D, Morris RM. Impaired glucose tolerance is normalized by treatment with the thiazolidinedione troglitazone. Diabetes Care 1997;20:188-193.
    • (1997) Diabetes Care , vol.20 , pp. 188-193
    • Antonucci, T.1    Whitcomb, R.2    McLain, R.3    Lockwood, D.4    Morris, R.M.5
  • 6
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator-activated receptor g (hPPARg) gene in diabetic Caucasians: Identification of a Pro12Ala PPARg 2 missense mutation
    • Yen C-J, Beamer BA, Negri C, Silver K, Brown KA, Yarnall DP, et al. Molecular scanning of the human peroxisome proliferator-activated receptor g (hPPARg) gene in diabetic Caucasians: identification of a Pro12Ala PPARg 2 missense mutation. Biochem Biophys Res Commun 1997;241:270-74.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 270-274
    • Yen, C.-J.1    Beamer, B.A.2    Negri, C.3    Silver, K.4    Brown, K.A.5    Yarnall, D.P.6
  • 7
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARg2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J, et al. A Pro12Ala substitution in PPARg2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet. 1998;20:284-87.
    • (1998) Nat Genet. , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3    Pihlajamaki, J.4    Mykkanen, L.5    Kuusisto, J.6
  • 8
    • 0031667127 scopus 로고    scopus 로고
    • Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma-2 gene with obesity in two Caucasian populations
    • Beamer BA, Yen CJ, Andersen BE, Muller D, Elahi D, Cheskin LJ, et al. Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma-2 gene with obesity in two Caucasian populations. Diabetes 1998;47:1806-8.
    • (1998) Diabetes , vol.47 , pp. 1806-1808
    • Beamer, B.A.1    Yen, C.J.2    Andersen, B.E.3    Muller, D.4    Elahi, D.5    Cheskin, L.J.6
  • 9
    • 0032781890 scopus 로고    scopus 로고
    • Homozygosity of the Pro12Ala variant of the peroxisome proliferation activated receptor-gamma-2 (PPAR-g): Divergent modulating effects on body mass index in obese and lean Caucasian men
    • Ek J, Urhammer SA, Sørensen TI, Andersen T, Auwerx J, Pedersen O. Homozygosity of the Pro12Ala variant of the peroxisome proliferation activated receptor-gamma-2 (PPAR-g): divergent modulating effects on body mass index in obese and lean Caucasian men. Diabetologia 1999;42:892-5.
    • (1999) Diabetologia , vol.42 , pp. 892-895
    • Ek, J.1    Urhammer, S.A.2    Sørensen, T.I.3    Andersen, T.4    Auwerx, J.5    Pedersen, O.6
  • 10
    • 0032500747 scopus 로고    scopus 로고
    • Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor gamma-2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men
    • Mori Y, Kim-Motoyama H, Katakura T, Yasuda K, Kadowaki H, Beamer BA, et al. Effect of the Pro12Ala variant of the human peroxisome proliferator- activated receptor gamma-2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men. Biochem Biophys Res Commun 1998;251:195-8.
    • (1998) Biochem Biophys Res Commun , vol.251 , pp. 195-198
    • Mori, Y.1    Kim-Motoyama, H.2    Katakura, T.3    Yasuda, K.4    Kadowaki, H.5    Beamer, B.A.6
  • 11
    • 0035062772 scopus 로고    scopus 로고
    • A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor gamma-2 is associated with combined hyperlipidaemia in obesity
    • Swarbrick MM, Chapman CM, McQuillan BM, Hung J, Thompson PL, Beilby JP. A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor gamma-2 is associated with combined hyperlipidaemia in obesity. Eur J Endocrinol 2001;144: 277-82.
    • (2001) Eur J Endocrinol , vol.144 , pp. 277-282
    • Swarbrick, M.M.1    Chapman, C.M.2    McQuillan, B.M.3    Hung, J.4    Thompson, P.L.5    Beilby, J.P.6
  • 12
    • 0036399092 scopus 로고    scopus 로고
    • Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma-2 gene in healthy individuals
    • Vaccaro O, Mancini FP, Ruffa G, Sabatino L, Iovine C, Masulli M, et al. Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma-2 gene in healthy individuals. Clin Endocrinol (Oxf) 2002;57:481-6.
    • (2002) Clin Endocrinol (Oxf) , vol.57 , pp. 481-486
    • Vaccaro, O.1    Mancini, F.P.2    Ruffa, G.3    Sabatino, L.4    Iovine, C.5    Masulli, M.6
  • 13
    • 18844363144 scopus 로고    scopus 로고
    • The apolipoprotein e genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndrome
    • Cardona F, Morcillo S, Gonzalo-Marin M, Tinahones F. The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndrome. J Clin Endocrinol Metab 2005;90:2972-5.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2972-2975
    • Cardona, F.1    Morcillo, S.2    Gonzalo-Marin, M.3    Tinahones, F.4
  • 14
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 15
    • 33646513959 scopus 로고    scopus 로고
    • Relation of postprandial hypertriglyceridemia with insulin resistance in patients with the metabolic syndrome: Postprandial hypertriglyceridemia and metabolic syndrome
    • Cardona F, Gonzalo-Marín M, Tinahones FJ. Relation of postprandial hypertriglyceridemia with insulin resistance in patients with the metabolic syndrome: postprandial hypertriglyceridemia and metabolic syndrome. Endocrinología Nutrición 2006;53:237-41.
    • (2006) Endocrinología Nutrición , vol.53 , pp. 237-241
    • Cardona, F.1    Gonzalo-Marín, M.2    Tinahones, F.J.3
  • 16
    • 0032806629 scopus 로고    scopus 로고
    • Hydrogen peroxide improves the efficiency of a peripheral blood PCR assay for diagnosis of human brucellosis
    • Queipo-Ortuno MI, Garcia-Ordonez MA, Colmenero JD, Morata P. Hydrogen peroxide improves the efficiency of a peripheral blood PCR assay for diagnosis of human brucellosis. Biotechniques 1999;27:248-250.
    • (1999) Biotechniques , vol.27 , pp. 248-250
    • Queipo-Ortuno, M.I.1    Garcia-Ordonez, M.A.2    Colmenero, J.D.3    Morata, P.4
  • 17
    • 0036937008 scopus 로고    scopus 로고
    • Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort
    • Nieters A, Becker N, Linseisen J. Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort. Eur J Nutr 2002;41:210-21.
    • (2002) Eur J Nutr , vol.41 , pp. 210-221
    • Nieters, A.1    Becker, N.2    Linseisen, J.3
  • 18
    • 0032589053 scopus 로고    scopus 로고
    • The PPARg2 amino acid polymorphism Pro12Ala is prevalent in offspring of type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects
    • Koch M, Rett K, Maerker E, Volk A, Haist K, Deninger M, et al. The PPARg2 amino acid polymorphism Pro12Ala is prevalent in offspring of type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. Diabetología 1999;42:758-62.
    • (1999) Diabetología , vol.42 , pp. 758-762
    • Koch, M.1    Rett, K.2    Maerker, E.3    Volk, A.4    Haist, K.5    Deninger, M.6
  • 20
    • 0033304551 scopus 로고    scopus 로고
    • Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women
    • Valve R, Sivenius K, Miettinen R, Pihlajamaki J, Rissanen A, Deeb SS, et al. Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women. J Clin Endocrinol Metab 1999;84: 3708-12.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3708-3712
    • Valve, R.1    Sivenius, K.2    Miettinen, R.3    Pihlajamaki, J.4    Rissanen, A.5    Deeb, S.S.6
  • 21
    • 0001491179 scopus 로고    scopus 로고
    • Impact of the peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus
    • Meirhaeghe A, Fajas L, Helbecque N, Cottel D, Auwerx J, Deeb SS, Amouyel P. Impact of the peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus. Int J Obes Relat Metab Disord 2000;24:195-9.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 195-199
    • Meirhaeghe, A.1    Fajas, L.2    Helbecque, N.3    Cottel, D.4    Auwerx, J.5    Deeb, S.S.6    Amouyel, P.7
  • 22
    • 0034745184 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ2 Pro12Ala variant: Association with type 2 diabetes and trait differences
    • Douglas JA, Erdos MR, Watanabe RM, Braun A, Johnston CL, Oeth P, et al. The peroxisome proliferator-activated receptor-γ2 Pro12Ala variant: association with type 2 diabetes and trait differences. Diabetes 2001;50:886-90.
    • (2001) Diabetes , vol.50 , pp. 886-890
    • Douglas, J.A.1    Erdos, M.R.2    Watanabe, R.M.3    Braun, A.4    Johnston, C.L.5    Oeth, P.6
  • 23
    • 0035062772 scopus 로고    scopus 로고
    • A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor gamma-2 is associated with combined hyperlipidaemia in obesity
    • Swarbrick MM, Chapman CM, McQuillan BM, Hung J, Thompson PL, Beilby JP. A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor gamma-2 is associated with combined hyperlipidaemia in obesity. Eur J Endocrinol 2001;144: 277-82.
    • (2001) Eur J Endocrinol , vol.144 , pp. 277-282
    • Swarbrick, M.M.1    Chapman, C.M.2    McQuillan, B.M.3    Hung, J.4    Thompson, P.L.5    Beilby, J.P.6
  • 24
    • 0034607051 scopus 로고    scopus 로고
    • Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor gamma-2 on thiazolidinedione-induced adipogenesis
    • Masugi J, Tamori Y, Mori H, Koike T, Kasuga M. Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor gamma-2 on thiazolidinedione-induced adipogenesis. Biochem Biophys Res Commun 2000;268:178-82.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 178-182
    • Masugi, J.1    Tamori, Y.2    Mori, H.3    Koike, T.4    Kasuga, M.5
  • 25
    • 0029791412 scopus 로고    scopus 로고
    • PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans K, Peinado-Onsurbe J, Lefebvre A-M, Heyman RA, Briggs M, Deeb S, et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996;15:5336-48.
    • (1996) EMBO J , vol.15 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-Onsurbe, J.2    Lefebvre, A.-M.3    Heyman, R.A.4    Briggs, M.5    Deeb, S.6
  • 26
    • 0025167797 scopus 로고
    • Phenotypic expression of heterozygous lipoprotein lipase deficiency in the extended pedigree of a proband homozygous for a missense mutation
    • Wilson DE, Emi M, Iverius PH, Hata A, Wu LL, Hillas E, et al. Phenotypic expression of heterozygous lipoprotein lipase deficiency in the extended pedigree of a proband homozygous for a missense mutation. J Clin Invest 1990;86:735-50.
    • (1990) J Clin Invest , vol.86 , pp. 735-750
    • Wilson, D.E.1    Emi, M.2    Iverius, P.H.3    Hata, A.4    Wu, L.L.5    Hillas, E.6
  • 27
    • 15144339953 scopus 로고    scopus 로고
    • Hyperinsulinemia and abdominal obesity affect the expression of hypertriglyceridemia in heterozygous familial lipoprotein lipase deficiency
    • Julien P, Vohl MC, Gaudet D, Gagne C, Levesque G, Despres JP, et al. Hyperinsulinemia and abdominal obesity affect the expression of hypertriglyceridemia in heterozygous familial lipoprotein lipase deficiency. Diabetes 1997;46:2063-8.
    • (1997) Diabetes , vol.46 , pp. 2063-2068
    • Julien, P.1    Vohl, M.C.2    Gaudet, D.3    Gagne, C.4    Levesque, G.5    Despres, J.P.6
  • 28
    • 15944392288 scopus 로고    scopus 로고
    • Rosiglitazone improves postprandial triacylglycerol and free fatty acid metabolism in type 2 diabetes
    • Van Wijk JP, de Koning EJ, Castro Cabezas M, Rabelink TJ. Rosiglitazone improves postprandial triacylglycerol and free fatty acid metabolism in type 2 diabetes. Diabetes Care 2005;28: 844-9.
    • (2005) Diabetes Care , vol.28 , pp. 844-849
    • Van Wijk, J.P.1    De Koning, E.J.2    Castro Cabezas, M.3    Rabelink, T.J.4
  • 30
    • 0036205326 scopus 로고    scopus 로고
    • Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    • Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, et al. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 2002;22:2607-19.
    • (2002) Mol Cell Biol , vol.22 , pp. 2607-2619
    • Akiyama, T.E.1    Sakai, S.2    Lambert, G.3    Nicol, C.J.4    Matsusue, K.5    Pimprale, S.6
  • 31
    • 0345097385 scopus 로고    scopus 로고
    • Gene-gene interaction of PPARG and ApoE affects coronary heart disease risk
    • Peng DQ, Zhao SP, Nie S, Li J. Gene-gene interaction of PPARG and ApoE affects coronary heart disease risk. Int J Cardiol 2003;92:257-63.
    • (2003) Int J Cardiol , vol.92 , pp. 257-263
    • Peng, D.Q.1    Zhao, S.P.2    Nie, S.3    Li, J.4


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